Author results

6H4O
  • Download 6h4o
  • View 6h4o
Molmil generated image of 6h4o
CRYSTAL STRUCTURE OF HUMAN KDM4A IN COMPLEX WITH COMPOUND 18A
Descriptor:Lysine-specific demethylase 4A, ZINC ION, 8-[4-[2-[4-[3-(trifluoromethyl)phenyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, ...
Authors:Le Bihan, Y.V., van Montfort, R.L.M.
Deposit date:2018-07-23
Release date:2019-06-12
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Eur.J.Med.Chem., 177, 2019
6H4P
  • Download 6h4p
  • View 6h4p
Molmil generated image of 6h4p
CRYSTAL STRUCTURE OF HUMAN KDM4A IN COMPLEX WITH COMPOUND 16A
Descriptor:Lysine-specific demethylase 4A, ZINC ION, 8-[4-[2-[4-(3-chlorophenyl)piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, ...
Authors:Le Bihan, Y.V., van Montfort, R.L.M.
Deposit date:2018-07-23
Release date:2019-06-12
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Eur.J.Med.Chem., 177, 2019
6H4Q
  • Download 6h4q
  • View 6h4q
Molmil generated image of 6h4q
CRYSTAL STRUCTURE OF HUMAN KDM4A IN COMPLEX WITH COMPOUND 34A
Descriptor:Lysine-specific demethylase 4A, ZINC ION, 8-[4-(1-methylpiperidin-4-yl)pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, ...
Authors:Le Bihan, Y.V., van Montfort, R.L.M.
Deposit date:2018-07-23
Release date:2019-06-12
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Eur.J.Med.Chem., 177, 2019
6H4R
  • Download 6h4r
  • View 6h4r
Molmil generated image of 6h4r
CRYSTAL STRUCTURE OF HUMAN KDM4A IN COMPLEX WITH COMPOUND 17F
Descriptor:Lysine-specific demethylase 4A, ZINC ION, 8-[4-[2-[4-[4-[2-(dimethylamino)ethyl]phenyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, ...
Authors:Le Bihan, Y.V., van Montfort, R.L.M.
Deposit date:2018-07-23
Release date:2019-06-12
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Eur.J.Med.Chem., 177, 2019
6H4S
  • Download 6h4s
  • View 6h4s
Molmil generated image of 6h4s
CRYSTAL STRUCTURE OF HUMAN KDM4A IN COMPLEX WITH COMPOUND 16M
Descriptor:Lysine-specific demethylase 4A, ZINC ION, 8-[4-[2-[4-[3-[2-(dimethylamino)ethyl]phenyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, ...
Authors:Le Bihan, Y.V., van Montfort, R.L.M.
Deposit date:2018-07-23
Release date:2019-06-12
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Eur.J.Med.Chem., 177, 2019
6H4T
  • Download 6h4t
  • View 6h4t
Molmil generated image of 6h4t
CRYSTAL STRUCTURE OF HUMAN KDM4A IN COMPLEX WITH COMPOUND 19A
Descriptor:Lysine-specific demethylase 4A, ZINC ION, 8-[4-(2-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylethyl)pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, ...
Authors:Le Bihan, Y.V., van Montfort, R.L.M.
Deposit date:2018-07-23
Release date:2019-06-12
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Eur.J.Med.Chem., 177, 2019
6H4U
  • Download 6h4u
  • View 6h4u
Molmil generated image of 6h4u
CRYSTAL STRUCTURE OF HUMAN KDM4A IN COMPLEX WITH COMPOUND 34B
Descriptor:Lysine-specific demethylase 4A, ZINC ION, 8-[4-(1-methylpiperidin-4-yl)pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, ...
Authors:Le Bihan, Y.V., van Montfort, R.L.M.
Deposit date:2018-07-23
Release date:2019-06-12
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Eur.J.Med.Chem., 177, 2019
6H4V
  • Download 6h4v
  • View 6h4v
Molmil generated image of 6h4v
CRYSTAL STRUCTURE OF HUMAN KDM4A IN COMPLEX WITH COMPOUND 34G
Descriptor:Lysine-specific demethylase 4A, ZINC ION, 8-[4-(1-cyclopentylpiperidin-4-yl)pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, ...
Authors:Le Bihan, Y.V., van Montfort, R.L.M.
Deposit date:2018-07-23
Release date:2019-06-12
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Eur.J.Med.Chem., 177, 2019
6H4W
  • Download 6h4w
  • View 6h4w
Molmil generated image of 6h4w
CRYSTAL STRUCTURE OF HUMAN KDM4A IN COMPLEX WITH COMPOUND 19D
Descriptor:Lysine-specific demethylase 4A, ZINC ION, 8-[4-[2-[4-(3-chlorophenyl)-4-methyl-piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, ...
Authors:Le Bihan, Y.V., van Montfort, R.L.M.
Deposit date:2018-07-23
Release date:2019-06-12
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Eur.J.Med.Chem., 177, 2019
6H4X
  • Download 6h4x
  • View 6h4x
Molmil generated image of 6h4x
CRYSTAL STRUCTURE OF HUMAN KDM4A IN COMPLEX WITH COMPOUND 17B
Descriptor:Lysine-specific demethylase 4A, ZINC ION, 8-[4-[2-[4-(4-pyridin-3-ylphenyl)piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, ...
Authors:Le Bihan, Y.V., van Montfort, R.L.M.
Deposit date:2018-07-23
Release date:2019-06-12
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Eur.J.Med.Chem., 177, 2019
6H4Y
  • Download 6h4y
  • View 6h4y
Molmil generated image of 6h4y
CRYSTAL STRUCTURE OF HUMAN KDM4A IN COMPLEX WITH COMPOUND 17E
Descriptor:Lysine-specific demethylase 4A, ZINC ION, 8-[4-[2-[4-[4-(2-morpholin-4-ylethyl)phenyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, ...
Authors:Le Bihan, Y.V., van Montfort, R.L.M.
Deposit date:2018-07-23
Release date:2019-06-12
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Eur.J.Med.Chem., 177, 2019
6H4Z
  • Download 6h4z
  • View 6h4z
Molmil generated image of 6h4z
CRYSTAL STRUCTURE OF HUMAN KDM5B IN COMPLEX WITH COMPOUND 16A
Descriptor:Lysine-specific demethylase 5B,Lysine-specific demethylase 5B, ZINC ION, MANGANESE (II) ION, ...
Authors:Le Bihan, Y.V., Velupillai, S., van Montfort, R.L.M.
Deposit date:2018-07-23
Release date:2019-06-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Eur.J.Med.Chem., 177, 2019
6H50
  • Download 6h50
  • View 6h50
Molmil generated image of 6h50
CRYSTAL STRUCTURE OF HUMAN KDM5B IN COMPLEX WITH COMPOUND 34A
Descriptor:Lysine-specific demethylase 5B,Lysine-specific demethylase 5B, ZINC ION, MANGANESE (II) ION, ...
Authors:Le Bihan, Y.V., Velupillai, S., van Montfort, R.L.M.
Deposit date:2018-07-23
Release date:2019-06-12
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Eur.J.Med.Chem., 177, 2019
6H51
  • Download 6h51
  • View 6h51
Molmil generated image of 6h51
CRYSTAL STRUCTURE OF HUMAN KDM5B IN COMPLEX WITH COMPOUND 34F
Descriptor:Lysine-specific demethylase 5B,Lysine-specific demethylase 5B, ZINC ION, MANGANESE (II) ION, ...
Authors:Le Bihan, Y.V., Velupillai, S., van Montfort, R.L.M.
Deposit date:2018-07-23
Release date:2019-06-12
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Eur.J.Med.Chem., 177, 2019
6H52
  • Download 6h52
  • View 6h52
Molmil generated image of 6h52
CRYSTAL STRUCTURE OF HUMAN KDM5B IN COMPLEX WITH COMPOUND 34G
Descriptor:Lysine-specific demethylase 5B,Lysine-specific demethylase 5B, ZINC ION, MANGANESE (II) ION, ...
Authors:Le Bihan, Y.V., Velupillai, S., van Montfort, R.L.M.
Deposit date:2018-07-23
Release date:2019-06-12
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Eur.J.Med.Chem., 177, 2019
6H1H
  • Download 6h1h
  • View 6h1h
Molmil generated image of 6h1h
CRYSTAL STRUCTURE OF HUMAN PIRIN IN COMPLEX WITH COMPOUND 7 (PLX4720)
Descriptor:Pirin, FE (III) ION, [3-azanyl-2,6-bis(fluoranyl)phenyl]-(5-chloranyl-1~{H}-pyrrolo[2,3-b]pyridin-3-yl)methanone, ...
Authors:Ali, S., Le Bihan, Y.V., van Montfort, R.L.M.
Deposit date:2018-07-11
Release date:2018-11-28
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Privileged Structures and Polypharmacology within and between Protein Families.
ACS Med Chem Lett, 9, 2018
6H1I
  • Download 6h1i
  • View 6h1i
Molmil generated image of 6h1i
CRYSTAL STRUCTURE OF HUMAN PIRIN IN COMPLEX WITH BISAMIDE COMPOUND 2
Descriptor:Pirin, FE (III) ION, GLYCEROL, ...
Authors:Ali, S., Le Bihan, Y.V., van Montfort, R.L.M.
Deposit date:2018-07-11
Release date:2018-11-28
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Privileged Structures and Polypharmacology within and between Protein Families.
ACS Med Chem Lett, 9, 2018
6H3K
  • Download 6h3k
  • View 6h3k
Molmil generated image of 6h3k
INTRODUCTION OF A METHYL GROUP CURBS METABOLISM OF PYRIDO[3,4-D]PYRIMIDINE MPS1 INHIBITORS AND ENABLES THE DISCOVERY OF THE PHASE 1 CLINICAL CANDIDATE BOS172722.
Descriptor:Dual specificity protein kinase TTK, ~{N}8-(2,2-dimethylpropyl)-~{N}2-[2-ethoxy-4-(4-methyl-1,2,4-triazol-3-yl)phenyl]-6-methyl-pyrido[3,4-d]pyrimidine-2,8-diamine, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL
Authors:Woodward, H.L., Hoelder, S.
Deposit date:2018-07-19
Release date:2018-09-19
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N8-neopentylpyrido[3,4- d]pyrimidine-2,8-diamine (BOS172722).
J. Med. Chem., 61, 2018
5MHQ
  • Download 5mhq
  • View 5mhq
Molmil generated image of 5mhq
CCT068127 IN COMPLEX WITH CDK2
Descriptor:Cyclin-dependent kinase 2, (2~{R},3~{S})-3-[[9-propan-2-yl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]pentan-2-ol
Authors:Whittaker, S.R., Barlow, C., Martin, M.P., Mancusi, C., Wagner, S., Barrie, E., te Poele, R., Sharp, S., Brown, N., Wilson, S., Clarke, P., Walton, M.I., MacDonald, E., Blagg, J., Noble, M.E.M., Garrett, M.D., Workman, P.
Deposit date:2016-11-25
Release date:2017-12-20
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor.
Mol Oncol, 12, 2018
5ICP
  • Download 5icp
  • View 5icp
Molmil generated image of 5icp
CDK8-CYCC IN COMPLEX WITH [(S)-2-(4-CHLORO-PHENYL)-PYRROLIDIN-1-YL]-(5-METHYL-IMIDAZO[5,1-B][1,3,4]THIADIAZOL-2-YL)-METHANONE
Descriptor:Cyclin-dependent kinase 8, Cyclin-C, [(2S)-2-(4-chlorophenyl)pyrrolidin-1-yl](5-methylimidazo[5,1-b][1,3,4]thiadiazol-2-yl)methanone, ...
Authors:Musil, D., Blagg, J., Mallinger, A., Czodrowski, P., Schiemann, K.
Deposit date:2016-02-23
Release date:2016-12-21
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening.
J. Med. Chem., 59, 2016
5IDN
  • Download 5idn
  • View 5idn
Molmil generated image of 5idn
CDK8-CYCC IN COMPLEX WITH [(S)-2-(4-CHLORO-PHENYL)-PYRROLIDIN-1-YL]-(3-METHYL-1H-PYRAZOLO[3,4-B]PYRIDIN-5-YL)-METHANONE
Descriptor:Cyclin-dependent kinase 8, Cyclin-C, [(2S)-2-(4-chlorophenyl)pyrrolidin-1-yl](3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone, ...
Authors:Musil, D., Blagg, J., Mallinger, A., Czodrowski, P., Schiemann, K.
Deposit date:2016-02-24
Release date:2016-12-21
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening.
J. Med. Chem., 59, 2016
5IDP
  • Download 5idp
  • View 5idp
Molmil generated image of 5idp
CDK8-CYCC IN COMPLEX WITH (3-AMINO-1H-INDAZOL-5-YL)-[(S)-2-(4-FLUORO-PHENYL)-PIPERIDIN-1-YL]-METHANONE
Descriptor:Cyclin-dependent kinase 8, Cyclin-C, (3-amino-1H-indazol-5-yl)[(2S)-2-(4-fluorophenyl)piperidin-1-yl]methanone, ...
Authors:Musil, D., Blagg, J., Mallinger, A., Czodrowski, P., Schiemann, K.
Deposit date:2016-02-24
Release date:2016-12-21
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening.
J. Med. Chem., 59, 2016
5EHL
  • Download 5ehl
  • View 5ehl
Molmil generated image of 5ehl
RAPID DISCOVERY OF PYRIDO[3,4-D]PYRIMIDINE INHIBITORS OF MONOPOLAR SPINDLE KINASE 1 (MPS1) USING A STRUCTURE-BASED HYDRIDIZATION APPROACH
Descriptor:Dual specificity protein kinase TTK, 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea
Authors:Innocenti, P., Woodward, H.L., Solanki, S., Naud, N., Westwood, I.M., Cronin, N., Hayes, A., Roberts, J., Henley, A.T., Baker, R., Faisal, A., Mak, G., Box, G., Valenti, M., De Haven Brandon, A., O'Fee, L., Saville, J., Schmitt, J., Burke, R., van Montfort, R.L.M., Raymaud, F.I., Eccles, S.A., Linardopoulos, S., Blagg, J., Hoelder, S.
Deposit date:2015-10-28
Release date:2016-11-09
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach
To Be Published
5EHO
  • Download 5eho
  • View 5eho
Molmil generated image of 5eho
RAPID DISCOVERY OF PYRIDO[3,4-D]PYRIMIDINE INHIBITORS OF MONOPOLAR SPINDLE KINASE 1 (MPS1) USING A STRUCTURE-BASED HYDRIDIZATION APPROACH
Descriptor:Dual specificity protein kinase TTK, ~{N}8-cyclohexyl-~{N}2-[2-methoxy-4-(1-methylpyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamine, DIMETHYL SULFOXIDE
Authors:Innocenti, P., Woodward, H.L., Solanki, S., Naud, N., Westwood, I.M., Cronin, N., Hayes, A., Roberts, J., Henley, A.T., Baker, R., Faisal, A., Mak, G., Box, G., Valenti, M., De Haven Brandon, A., O'Fee, L., Saville, J., Schmitt, J., Burke, R., van Montfort, R.L.M., Raymaud, F.I., Eccles, S.A., Linardopoulos, S., Blagg, J., Hoelder, S.
Deposit date:2015-10-28
Release date:2016-11-09
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach
To Be Published
5HNB
  • Download 5hnb
  • View 5hnb
Molmil generated image of 5hnb
CDK8-CYCC IN COMPLEX WITH [6-HYDROXY-3-(3-METHYL-BENZYL)-1H-INDAZOL-5-YL]-((S)-3-HYDROXY-PYRROLIDIN-1-YL)-METHANONE
Descriptor:Cyclin-dependent kinase 8, Cyclin-C, [6-hydroxy-3-(3-methylbenzyl)-1H-indazol-5-yl][(3S)-3-hydroxypyrrolidin-1-yl]methanone, ...
Authors:Musil, D., Blagg, J., Schiemann, K.
Deposit date:2016-01-18
Release date:2016-04-27
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:CDK8-CYCC IN COMPLEX WITH [6-Hydroxy-3-(3-methyl-benzyl)-1H-indazol-5-yl]-((S)-3-hydroxy-pyrrolidin-1-yl)-methanone
To Be Published