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2JH1
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CRYSTAL STRUCTURE OF TOXOPLASMA GONDII MICRONEMAL PROTEIN 1
Descriptor:MICRONEMAL PROTEIN 1, ACETATE ION, CHLORIDE ION, ...
Authors:Blumenschein, T.M.A., Friedrich, N., Childs, R.A., Saouros, S., Carpenter, E.P., Campanero-Rhodes, M.A., Simpson, P., Koutroukides, T., Blackman, M.J., Feizi, T., Soldati-Favre, D., Matthews, S.
Deposit date:2007-02-19
Release date:2007-05-22
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Atomic Resolution Insight Into Host Cell Recognition by Toxoplasma Gondii.
Embo J., 26, 2007
2JH7
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CRYSTAL STRUCTURE OF TOXOPLASMA GONDII MICRONEMAL PROTEIN 1 BOUND TO 6'-SIALYL-N-ACETYLLACTOSAMINE
Descriptor:MICRONEMAL PROTEIN 1, O-SIALIC ACID, BETA-D-GALACTOSE, ...
Authors:Blumenschein, T.M.A., Friedrich, N., Childs, R.A., Saouros, S., Carpenter, E.P., Campanero-Rhodes, M.A., Simpson, P., Koutroukides, T., Blackman, M.J., Feizi, T., Soldati-Favre, D., Matthews, S.
Deposit date:2007-02-20
Release date:2007-05-22
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Atomic Resolution Insight Into Host Cell Recognition by Toxoplasma Gondii.
Embo J., 26, 2007
2JHD
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CRYSTAL STRUCTURE OF TOXOPLASMA GONDII MICRONEMAL PROTEIN 1 BOUND TO 3'-SIALYL-N-ACETYLLACTOSAMINE
Descriptor:MICRONEMAL PROTEIN 1, O-SIALIC ACID, BETA-D-GALACTOSE, ...
Authors:Blumenschein, T.M.A., Friedrich, N., Childs, R.A., Saouros, S., Carpenter, E.P., Campanero-Rhodes, M.A., Simpson, P., Koutroukides, T., Blackman, M.J., Feizi, T., Soldati-Favre, D., Matthews, S.
Deposit date:2007-02-21
Release date:2007-05-22
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Atomic Resolution Insight Into Host Cell Recognition by Toxoplasma Gondii.
Embo J., 26, 2007
2RJI
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MALARIAL EBA-175 REGION VI CRYSTALLOGRAPHIC STRUCTURE REVEALS A KIX-LIKE BINDING INTERFACE
Descriptor:Erythrocyte binding antigen 175, CALCIUM ION
Authors:Withers-Martinez, C., Blackman, M.J.
Deposit date:2007-10-15
Release date:2007-11-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Malarial EBA-175 Region VI Crystallographic Structure Reveals a KIX-Like Binding Interface
J.Mol.Biol., 375, 2008
4LVN
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CRYSTAL STRUCTURE OF PFSUB1-PRODOMAIN-NIMP.M7 FAB COMPLEX
Descriptor:Subtilisin-like serine protease, NIMP.M7 Fab light chain, NIMP.M7 Fab heavy chain, ...
Authors:Withers-Martinez, C., Blackman, M.J.
Deposit date:2013-07-26
Release date:2014-05-07
Last modified:2014-06-11
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin.
Nat Commun, 5, 2014
4LVO
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CRYSTAL STRUCTURE OF PFSUB1-PRODOMAIN-NIMP.M7 FAB COMPLEX WITH ADDED CACL2
Descriptor:Subtilisin-like serine protease, NIMP.M7 Fab light chain, NIMP.M7 Fab heavy chain, ...
Authors:Withers-Martinez, C., Blackman, M.J.
Deposit date:2013-07-26
Release date:2014-05-07
Last modified:2014-06-11
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin.
Nat Commun, 5, 2014
2K2S
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STRUCTURE OF THE MIC1-GLD/MIC6-EGF COMPLEX FROM TOXOPLASMA GONDII
Descriptor:Micronemal protein 1, Micronemal protein 6
Authors:Matthews, S.
Deposit date:2008-04-11
Release date:2009-02-24
Last modified:2011-07-27
Method:SOLUTION NMR
Cite:Structural insights into microneme protein assembly reveal a new mode of EGF domain recognition
Embo Rep., 9, 2008
2K2T
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EPIDERMAL GROWTH FACTOR-LIKE DOMAIN 2 FROM TOXOPLASMA GONDII MICRONEME PROTEIN 6
Descriptor:Micronemal protein 6
Authors:Sawmynaden, K., Saouros, S., Marchant, J., Simpson, P., Matthews, S.
Deposit date:2008-04-11
Release date:2009-02-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural insights into microneme protein assembly reveal a new mode of EGF domain recognition.
Embo Rep., 9, 2008
4CKU
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THREE DIMENSIONAL STRUCTURE OF PLASMEPSIN II IN COMPLEX WITH HYDROXYETHYLAMINE-BASED INHIBITOR
Descriptor:PLASMEPSIN-2, 5-[1,1-bis(oxidanylidene)-1,2-thiazinan-2-yl]-N3-[(2S,3R)-4-[2-(3-methoxyphenyl)propan-2-ylamino]-3-oxidanyl-1-phenyl-butan-2-yl]-N1,N1-dipropyl-benzene-1,3-dicarboxamide
Authors:Tars, K., Leitans, J., Jaudzems, K.
Deposit date:2014-01-08
Release date:2014-06-18
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Plasmepsin Inhibitory Activity and Structure-Guided Optimization of a Potent Hydroxyethylamine-Based Antimalarial Hit.
Acs Med.Chem.Lett., 5, 2014
4Z22
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STRUCTURE OF PLASMEPSIN II FROM PLASMODIUM FALCIPARUM COMPLEXED WITH INHIBITOR DR718A
Descriptor:Plasmepsin-2, 2-amino-7-phenyl-3-{[(2R,5S)-5-phenyltetrahydrofuran-2-yl]methyl}quinazolin-4(3H)-one
Authors:Recacha, R., Leitans, J., Tars, K., Jaudzems, K.
Deposit date:2015-03-28
Release date:2016-01-13
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV.
J.Med.Chem., 59, 2016
5DYK
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CRYSTAL STRUCTURE OF THE CGMP-DEPENDENT PROTEIN KINASE PKG FROM PLASMODIUM FALCIPARUM - APO FORM
Descriptor:CGMP-dependent protein kinase, 1,2-ETHANEDIOL, SULFATE ION, ...
Authors:Wernimont, A.K., Tempel, W., He, H., Seitova, A., Hills, T., Neculai, A.M., Baker, D.A., Flueck, C., Kettleborough, C.A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Hui, R., Hutchinson, A., El Bakkouri, M., Structural Genomics Consortium (SGC)
Deposit date:2015-09-24
Release date:2015-11-04
Last modified:2019-07-03
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation
Proc.Natl.Acad.Sci.USA, 2019
5DYL
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CRYSTAL STRUCTURE OF THE CGMP-DEPENDENT PROTEIN KINASE PKG FROM PLASMODIUM VIVAX - APO FORM
Descriptor:cGMP-dependent protein kinase, putative
Authors:Wernimont, A.K., Tempel, W., He, H., Seitova, A., Hills, T., Neculai, A.M., Baker, D.A., Flueck, C., Kettleborough, C.A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Hui, R., Hutchinson, A., El Bakkouri, M., Structural Genomics Consortium (SGC)
Deposit date:2015-09-24
Release date:2015-11-04
Last modified:2019-07-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation
Proc.Natl.Acad.Sci.USA, 2019
5DZC
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CRYSTAL STRUCTURE OF THE CGMP-DEPENDENT PROTEIN KINASE PKG FROM PLASMODIUM VIVAX - AMPPNP BOUND
Descriptor:cGMP-dependent protein kinase, putative, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Walker, J.R., El Bakkouri, M., Loppnau, P., Graslund, S., He, H., Seitova, A., Hutchinson, A., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Hui, R., Amani, M., Structural Genomics Consortium (SGC)
Deposit date:2015-09-25
Release date:2015-10-14
Last modified:2019-07-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation
Proc.Natl.Acad.Sci.USA, 2019
5E16
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CO-CRYSTAL STRUCTURE OF THE N-TERMIAL CGMP BINDING DOMAIN OF PLASMODIUM FALCIPARUM PKG WITH CGMP
Descriptor:CGMP-dependent protein kinase, CYCLIC GUANOSINE MONOPHOSPHATE
Authors:El Bakkouri, M., Walker, J.R., Loppnau, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Hui, R., Structural Genomics Consortium (SGC)
Deposit date:2015-09-29
Release date:2015-11-04
Last modified:2019-07-03
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation
Proc.Natl.Acad.Sci.USA, 2019
2J4W
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STRUCTURE OF A PLASMODIUM VIVAX APICAL MEMBRANE ANTIGEN 1-FAB F8.12.19 COMPLEX
Descriptor:APICAL MEMBRANE ANTIGEN 1, FAB FRAGMENT OF MONOCLONAL ANTIBODY F8.12.19
Authors:Igonet, S., Vulliez-Le Normand, B., Faure, G., Riottot, M.M., Kocken, C.H.M., Thomas, A.W., Bentley, G.A.
Deposit date:2006-09-07
Release date:2007-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Cross-Reactivity Studies of an Anti-Plasmodium Vivax Apical Membrane Antigen 1 Monoclonal Antibody: Binding and Structural Characterisation.
J.Mol.Biol., 366, 2007
3F53
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CRYSTAL STRUCTURE OF TOXOPLASMA GONDII MICRONEMAL PROTEIN 1 BOUND TO 2F-3'SIALACNAC
Descriptor:Micronemal protein 1, CHLORIDE ION, O-SIALIC ACID, ...
Authors:Garnett, J.A.
Deposit date:2008-11-03
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Detailed insights from microarray and crystallographic studies into carbohydrate recognition by microneme protein 1 (MIC1) of Toxoplasma gondii.
Protein Sci., 18, 2009
3F5A
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CRYSTAL STRUCTURE OF TOXOPLASMA GONDII MICRONEMAL PROTEIN 1 BOUND TO 3'SIALACNAC1-3
Descriptor:Micronemal protein 1, CHLORIDE ION, O-SIALIC ACID, ...
Authors:Garnett, J.A., Liu, Y., Feizi, T., Matthews, S.J.
Deposit date:2008-11-03
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Detailed insights from microarray and crystallographic studies into carbohydrate recognition by microneme protein 1 (MIC1) of Toxoplasma gondii.
Protein Sci., 18, 2009
3F5E
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CRYSTAL STRUCTURE OF TOXOPLASMA GONDII MICRONEMAL PROTEIN 1 BOUND TO 2'F-3'SIALACNAC1-3
Descriptor:Micronemal protein 1, CHLORIDE ION, O-SIALIC ACID, ...
Authors:Garnett, J.A., Liu, Y., Feizi, T., Matthews, S.J.
Deposit date:2008-11-03
Release date:2009-07-28
Last modified:2016-02-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Detailed insights from microarray and crystallographic studies into carbohydrate recognition by microneme protein 1 (MIC1) of Toxoplasma gondii.
Protein Sci., 18, 2009
4Y6M
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STRUCTURE OF PLASMEPSIN II FROM PLASMODIUM FALCIPARUM COMPLEXED WITH INHIBITOR PG418
Descriptor:Plasmepsin-2, ~{N}1-[(~{Z},3~{R})-4-[2-(3-methoxyphenyl)propan-2-ylamino]-3-oxidanyl-1-phenyl-but-1-en-2-yl]-5-piperidin-1-yl-~{N}3,~{N}3-dipropyl-benzene-1,3-dicarboxamide, GLYCEROL
Authors:Recacha, R., Akopjana, I., Tars, K., Jaudzems, K.
Deposit date:2015-02-13
Release date:2015-12-09
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structures of plasmepsin II from Plasmodium falciparum in complex with two hydroxyethylamine-based inhibitors.
Acta Crystallogr.,Sect.F, 71, 2015