Author results

1FHI
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SUBSTRATE ANALOG (IB2) COMPLEX WITH THE FRAGILE HISTIDINE TRIAD PROTEIN, FHIT
Descriptor:FRAGILE HISTIDINE TRIAD PROTEIN, P1-P2-METHYLENE-P3-THIO-DIADENOSINE TRIPHOSPHATE
Authors:Pace, H.C., Garrison, P.N., Barnes, L.D., Draganescu, A., Rosler, A., Blackburn, G.M., Siprashvili, Z., Croce, C.M., Huebner, K., Brenner, C.
Deposit date:1997-12-11
Release date:1998-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit.
Proc.Natl.Acad.Sci.USA, 95, 1998
1KTG
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CRYSTAL STRUCTURE OF A C. ELEGANS AP4A HYDROLASE BINARY COMPLEX
Descriptor:Diadenosine Tetraphosphate Hydrolase, PHOSPHATE ION, HYDROXIDE ION, ...
Authors:Bailey, S., Sedelnikova, S.E., Blackburn, G.M., Abdelghany, H.M., Baker, P.J., McLennan, A.G., Rafferty, J.B.
Deposit date:2002-01-16
Release date:2002-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The crystal structure of diadenosine tetraphosphate hydrolase from Caenorhabditis elegans in free and binary complex forms
Structure, 10, 2002
2FHI
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SUBSTRATE ANALOG (IB2) COMPLEX WITH THE HIS 96 ASN SUBSTITUTION OF THE FRAGILE HISTIDINE TRIAD PROTEIN, FHIT
Descriptor:FRAGILE HISTIDINE TRIAD PROTEIN, P1-P2-METHYLENE-P3-THIO-DIADENOSINE TRIPHOSPHATE
Authors:Pace, H.C., Garrison, P.N., Robinson, A.K., Barnes, L.D., Draganescu, A., Rosler, A., Blackburn, G.M., Siprashvili, Z., Croce, C.M., Heubner, K., Brenner, C.
Deposit date:1998-04-01
Release date:1998-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit.
Proc.Natl.Acad.Sci.USA, 95, 1998
1EMH
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CRYSTAL STRUCTURE OF HUMAN URACIL-DNA GLYCOSYLASE BOUND TO UNCLEAVED SUBSTRATE-CONTAINING DNA
Descriptor:DNA (5'-D(*TP*GP*TP*(P2U)P*AP*TP*CP*TP*T)-3'), DNA (5'-D(*AP*AP*AP*GP*AP*TP*AP*AP*CP*A)-3'), URACIL-DNA GLYCOSYLASE
Authors:Parikh, S.S., Slupphaug, G., Krokan, H.E., Blackburn, G.M., Tainer, J.A.
Deposit date:2000-03-16
Release date:2000-05-16
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects.
Proc.Natl.Acad.Sci.USA, 97, 2000
1EMJ
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URACIL-DNA GLYCOSYLASE BOUND TO DNA CONTAINING A 4'-THIO-2'DEOXYURIDINE ANALOG PRODUCT
Descriptor:DNA (5'-D(*TP*GP*TP*(ASU)P*AP*TP*CP*TP*T)-3'), DNA (5'-D(*AP*AP*AP*GP*AP*TP*AP*AP*CP*A)-3'), URACIL-DNA GLYCOSYLASE, ...
Authors:Parikh, S.S., Walcher, G., Jones, G.D., Slupphaug, G., Krokan, H.E., Blackburn, G.M., Tainer, J.A.
Deposit date:2000-03-16
Release date:2000-05-16
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects.
Proc.Natl.Acad.Sci.USA, 97, 2000
1F3Y
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SOLUTION STRUCTURE OF THE NUDIX ENZYME DIADENOSINE TETRAPHOSPHATE HYDROLASE FROM LUPINUS ANGUSTIFOLIUS L.
Descriptor:DIADENOSINE 5',5'''-P1,P4-TETRAPHOSPHATE HYDROLASE
Authors:Swarbrick, J.D., Bashtannyk, T., Maksel, D., Zhang, X.R., Blackburn, G.M., Gayler, K.R., Gooley, P.R.
Deposit date:2000-06-06
Release date:2001-06-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The three-dimensional structure of the Nudix enzyme diadenosine tetraphosphate hydrolase from Lupinus angustifolius L.
J.Mol.Biol., 302, 2000
1H3I
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CRYSTAL STRUCTURE OF THE HISTONE METHYLTRANSFERASE SET7/9
Descriptor:HISTONE H3 LYSINE 4 SPECIFIC METHYLTRANSFERASE, MAGNESIUM ION
Authors:Wilson, J.R., Jing, C., Walker, P.A., Martin, S.R., Howell, S.A., Blackburn, G.M., Gamblin, S.J., Xiao, B.
Deposit date:2002-09-04
Release date:2002-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure and Functional Analysis of the Histone Methyltransferase Set7/9
Cell(Cambridge,Mass.), 111, 2002
1J98
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THE 1.2 ANGSTROM STRUCTURE OF BACILLUS SUBTILIS LUXS
Descriptor:AUTOINDUCER-2 PRODUCTION PROTEIN LUXS, ZINC ION
Authors:Ruzheinikov, S.N., Das, S.K., Sedelnikova, S.E., Hartley, A., Foster, S.J., Horsburgh, M.J., Cox, A.G., McCleod, C.W., Mekhalfia, A., Blackburn, G.M., Rice, D.W., Baker, P.J.
Deposit date:2001-05-24
Release date:2001-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:The 1.2 A Structure of a Novel Quorum-Sensing Protein, Bacillus subtilis LuxS
J.Mol.Biol., 313, 2001
1JQW
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THE 2.3 ANGSTROM RESOLUTION STRUCTURE OF BACILLUS SUBTILIS LUXS/HOMOCYSTEINE COMPLEX
Descriptor:Autoinducer-2 production protein luxS, ZINC ION, 2-AMINO-4-MERCAPTO-BUTYRIC ACID
Authors:Ruzheinikov, S.N., Das, S.K., Sedelnikova, S.E., Hartley, A., Foster, S.J., Horsburgh, M.J., Cox, A.G., McCleod, C.W., Mekhalfia, A., Blackburn, G.M., Rice, D.W., Baker, P.J.
Deposit date:2001-08-09
Release date:2001-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The 1.2 A structure of a novel quorum-sensing protein, Bacillus subtilis LuxS
J.Mol.Biol., 313, 2001
1JVI
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THE 2.2 ANGSTROM RESOLUTION STRUCTURE OF BACILLUS SUBTILIS LUXS/RIBOSILHOMOCYSTEINE COMPLEX
Descriptor:Autoinducer-2 production protein luxS, ZINC ION, SULFATE ION, ...
Authors:Ruzheinikov, S.N., Das, S.K., Sedelnikova, S.E., Hartley, A., Foster, S.J., Horsburgh, M.J., Cox, A.G., McCleod, C.W., Mekhalfia, A., Blackburn, G.M., Rice, D.W., Baker, P.J.
Deposit date:2001-08-30
Release date:2001-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The 1.2 A structure of a novel quorum-sensing protein, Bacillus subtilis LuxS
J.Mol.Biol., 313, 2001
1KT9
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CRYSTAL STRUCTURE OF C. ELEGANS AP4A HYDROLASE
Descriptor:Diadenosine Tetraphosphate Hydrolase
Authors:Bailey, S., Sedelnikova, S.E., Blackburn, G.M., Abdelghany, H.M., Baker, P.J., McLennan, A.G., Rafferty, J.B.
Deposit date:2002-01-15
Release date:2002-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:The crystal structure of diadenosine tetraphosphate hydrolase from Caenorhabditis elegans in free and binary complex forms
Structure, 10, 2002
1MH5
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THE STRUCTURE OF THE COMPLEX OF THE FAB FRAGMENT OF THE ESTEROLYTIC ANTIBODY MS6-164 AND A TRANSITION-STATE ANALOG
Descriptor:IMMUNOGLOBULIN MS6-164, SULFATE ION, N-{[2-({[1-(4-CARBOXYBUTANOYL)AMINO]-2-PHENYLETHYL}-HYDROXYPHOSPHINYL)OXY]ACETYL}-2-PHENYLETHYLAMINE
Authors:Ruzheinikov, S.N., Muranova, T.A., Sedelnikova, S.E., Partridge, L.J., Blackburn, G.M., Murray, I.A., Kakinuma, H., Takashi, N., Shimazaki, K., Sun, J., Nishi, Y., Rice, D.W.
Deposit date:2002-08-19
Release date:2003-09-23
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:High-resolution crystal structure of the Fab-fragments of a family of mouse catalytic antibodies with esterase activity
J.Mol.Biol., 332, 2003
1MIE
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CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF ESTEROLYTIC ANTIBODY MS5-393
Descriptor:IMMUNOGLOBULIN MS5-393
Authors:Ruzheinikov, S.N., Muranova, T.A., Sedelnikova, S.E., Partridge, L.J., Blackburn, G.M., Murray, I.A., Kakinuma, H., Takashi, N., Shimazaki, K., Sun, J., Nishi, Y., Rice, D.W.
Deposit date:2002-08-23
Release date:2003-09-23
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:High-resolution crystal structure of the Fab-fragments of a family of mouse catalytic antibodies with esterase activity
J.Mol.Biol., 332, 2003
1MJ7
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CRYSTAL STRUCTURE OF THE COMPLEX OF THE FAB FRAGMENT OF ESTEROLYTIC ANTIBODY MS5-393 AND A TRANSITION-STATE ANALOG
Descriptor:IMMUNOGLOBULIN MS5-393, N-{[2-({[1-(4-CARBOXYBUTANOYL)AMINO]-2-PHENYLETHYL}-HYDROXYPHOSPHINYL)OXY]ACETYL}-2-PHENYLETHYLAMINE
Authors:Ruzheinikov, S.N., Muranova, T.A., Sedelnikova, S.E., Partridge, L.J., Blackburn, G.M., Murray, I.A., Kakinuma, H., Takashi, N., Shimazaki, K., Sun, J., Nishi, Y., Rice, D.W.
Deposit date:2002-08-27
Release date:2003-09-23
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:High-resolution crystal structure of the Fab-fragments of a family of mouse catalytic antibodies with esterase activity
J.Mol.Biol., 332, 2003
1MJ8
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HIGH RESOLUTION CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE ESTEROLYTIC ANTIBODY MS6-126
Descriptor:IMMUNOGLOBULIN MS6-126, PHOSPHATE ION, GLYCEROL
Authors:Ruzheinikov, S.N., Muranova, T.A., Sedelnikova, S.E., Partridge, L.J., Blackburn, G.M., Murray, I.A., Kakinuma, H., Takashi, N., Shimazaki, K., Sun, J., Nishi, Y., Rice, D.W.
Deposit date:2002-08-27
Release date:2003-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:High-resolution crystal structure of the Fab-fragments of a family of mouse catalytic antibodies with esterase activity
J.Mol.Biol., 332, 2003
1MJJ
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HIGH RESOLUTION CRYSTAL STRUCTURE OF THE COMPLEX OF THE FAB FRAGMENT OF ESTEROLYTIC ANTIBODY MS6-12 AND A TRANSITION-STATE ANALOG
Descriptor:IMMUNOGLOBULIN MS6-12, SULFATE ION, N-{[2-({[1-(4-CARBOXYBUTANOYL)AMINO]-2-PHENYLETHYL}-HYDROXYPHOSPHINYL)OXY]ACETYL}-2-PHENYLETHYLAMINE
Authors:Ruzheinikov, S.N., Muranova, T.A., Sedelnikova, S.E., Partridge, L.J., Blackburn, G.M., Murray, I.A., Kakinuma, H., Takashi, N., Shimazaki, K., Sun, J., Nishi, Y., Rice, D.W.
Deposit date:2002-08-28
Release date:2003-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:High-resolution crystal structure of the Fab-fragments of a family of mouse catalytic antibodies with esterase activity
J.Mol.Biol., 332, 2003
1MJU
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1.22 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF ESTEROLYTIC ANTIBODY MS6-12
Descriptor:IMMUNOGLOBULIN MS6-12, GLYCEROL
Authors:Ruzheinikov, S.N., Muranova, T.A., Sedelnikova, S.E., Partridge, L.J., Blackburn, G.M., Murray, I.A., Kakinuma, H., Takashi, N., Shimazaki, K., Sun, J., Nishi, Y., Rice, D.W.
Deposit date:2002-08-28
Release date:2003-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:High-resolution crystal structure of the Fab-fragments of a family of mouse catalytic antibodies with esterase activity
J.Mol.Biol., 332, 2003
1O9S
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CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF THE HUMAN HISTONE METHYLTRANSFERASE SET7/9
Descriptor:HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-4 SPECIFIC, GENE FRAGMENT FOR HISTONE H3, ...
Authors:Xiao, B., Jing, C., Wilson, J.R., Walker, P.A., Vasisht, N., Kelly, G., Howell, S., Taylor, I.A., Blackburn, G.M., Gamblin, S.J.
Deposit date:2002-12-18
Release date:2003-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure and Catalytic Mechanism of the Human Histone Methyltransferase Set7/9
Nature, 421, 2003
1RZY
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CRYSTAL STRUCTURE OF RABBIT HINT COMPLEXED WITH N-ETHYLSULFAMOYLADENOSINE
Descriptor:Histidine triad nucleotide-binding protein 1, 5'-O-(N-ETHYL-SULFAMOYL)ADENOSINE
Authors:Krakowiak, A.K., Pace, H.C., Blackburn, G.M., Adams, M., Mekhalfia, A., Kaczmarek, R., Baraniak, J., Stec, W.J., Brenner, C.
Deposit date:2003-12-29
Release date:2004-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Biochemical, crystallographic, and mutagenic characterization of hint, the AMP-lysine hydrolase, with novel substrates and inhibitors
J.Biol.Chem., 279, 2004
1X7N
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THE CRYSTAL STRUCTURE OF PYROCOCCUS FURIOSUS PHOSPHOGLUCOSE ISOMERASE WITH BOUND 5-PHOSPHO-D-ARABINONATE AND MANGANESE
Descriptor:Glucose-6-phosphate isomerase, MANGANESE (II) ION, 5-PHOSPHOARABINONIC ACID
Authors:Berrisford, J.M., Akerboom, J., Brouns, S., Sedelnikova, S.E., Turnbull, A.P., van der Oost, J., Salmon, L., Hardre, R., Murray, I.A., Blackburn, G.M., Rice, D.W., Baker, P.J.
Deposit date:2004-08-16
Release date:2004-10-12
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:The structures of inhibitor complexes of Pyrococcus furiosus phosphoglucose isomerase provide insights into substrate binding and catalysis.
J.Mol.Biol., 343, 2004
1X82
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CRYSTAL STRUCTURE OF PHOSPHOGLUCOSE ISOMERASE FROM PYROCOCCUS FURIOSUS WITH BOUND 5-PHOSPHO-D-ARABINONATE
Descriptor:Glucose-6-phosphate isomerase, 5-PHOSPHOARABINONIC ACID
Authors:Berrisford, J.M., Akerboom, J., Brouns, S., Sedelnikova, S.E., Turnbull, A.P., van der Oost, J., Salmon, L., Hardre, R., Murray, I.A., Blackburn, G.M., Rice, D.W., Baker, P.J.
Deposit date:2004-08-17
Release date:2004-10-12
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The structures of inhibitor complexes of Pyrococcus furiosus phosphoglucose isomerase provide insights into substrate binding and catalysis.
J.Mol.Biol., 343, 2004
1X8E
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CRYSTAL STRUCTURE OF PYROCOCCUS FURIOSUS PHOSPHOGLUCOSE ISOMERASE FREE ENZYME
Descriptor:Glucose-6-phosphate isomerase
Authors:Berrisford, J.M., Akerboom, J., Brouns, S., Sedelnikova, S.E., Turnbull, A.P., van der Oost, J., Salmon, L., Hardre, R., Murray, I.A., Blackburn, G.M., Rice, D.W., Baker, P.J.
Deposit date:2004-08-18
Release date:2004-10-12
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The structures of inhibitor complexes of Pyrococcus furiosus phosphoglucose isomerase provide insights into substrate binding and catalysis.
J.Mol.Biol., 343, 2004
2AIO
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METALLO BETA LACTAMASE L1 FROM STENOTROPHOMONAS MALTOPHILIA COMPLEXED WITH HYDROLYZED MOXALACTAM
Descriptor:Metallo-beta-lactamase L1, ZINC ION, SULFATE ION, ...
Authors:Spencer, J., Read, J., Sessions, R.B., Howell, S., Blackburn, G.M., Gamblin, S.J.
Deposit date:2005-07-30
Release date:2005-10-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Antibiotic Recognition by Binuclear Metallo-beta-Lactamases Revealed by X-ray Crystallography
J.Am.Chem.Soc., 127, 2005
2EU2
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HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH NOVEL INHIBITORS
Descriptor:Carbonic anhydrase 2, ZINC ION, (R)-1-AMINO-1-[5-(DIMETHYLAMINO)-1,3,4-THIADIAZOL-2-YL]METHANESULFONAMIDE
Authors:Fisher, S.Z., Govindasamy, L., Boyle, N., Agbandje-McKenna, M., Silverman, D.N., Blackburn, G.M., McKenna, R.
Deposit date:2005-10-28
Release date:2006-07-11
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes.
Acta Crystallogr.,Sect.F, 62, 2006
2EU3
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HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH NOVEL INHIBITORS
Descriptor:Carbonic anhydrase 2, ZINC ION, 1-(5-AMINO-1,3,4-THIADIAZOL-2-YL)-1,1-DIFLUOROMETHANESULFONAMIDE
Authors:Fisher, S.Z., Govindasamy, L., Boyle, N., Agbandje-McKenna, M., Silverman, D.N., Blackburn, G.M., McKenna, R.
Deposit date:2005-10-28
Release date:2006-07-11
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes.
Acta Crystallogr.,Sect.F, 62, 2006
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