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1YSD
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BU of 1ysd by Molmil
Yeast Cytosine Deaminase Double Mutant
Descriptor: CALCIUM ION, Cytosine deaminase, ZINC ION
Authors:Korkegian, A, Black, M.E, Baker, D, Stoddard, B.L.
Deposit date:2005-02-08
Release date:2005-05-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Computational thermostabilization of an enzyme.
Science, 308, 2005
1YSB
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BU of 1ysb by Molmil
Yeast Cytosine Deaminase Triple Mutant
Descriptor: CALCIUM ION, Cytosine deaminase, ZINC ION
Authors:Korkegian, A, Black, M.E, Baker, D, Stoddard, B.L.
Deposit date:2005-02-08
Release date:2005-05-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Computational thermostabilization of an enzyme.
Science, 308, 2005
1K6W
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BU of 1k6w by Molmil
The Structure of Escherichia coli Cytosine Deaminase
Descriptor: Cytosine Deaminase, FE (III) ION
Authors:Ireton, G.C, McDermott, G, Black, M.E, Stoddard, B.L.
Deposit date:2001-10-17
Release date:2002-02-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The structure of Escherichia coli cytosine deaminase.
J.Mol.Biol., 315, 2002
1K70
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BU of 1k70 by Molmil
The Structure of Escherichia coli Cytosine Deaminase bound to 4-Hydroxy-3,4-Dihydro-1H-Pyrimidin-2-one
Descriptor: 4-HYDROXY-3,4-DIHYDRO-1H-PYRIMIDIN-2-ONE, Cytosine Deaminase, FE (III) ION
Authors:Ireton, G.C, McDermott, G, Black, M.E, Stoddard, B.L.
Deposit date:2001-10-17
Release date:2002-02-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structure of Escherichia coli cytosine deaminase.
J.Mol.Biol., 315, 2002
1OX7
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BU of 1ox7 by Molmil
Crystal structure of yeast cytosine deaminase apo-enzyme: inorganic zinc bound
Descriptor: CALCIUM ION, Cytosine deaminase, ZINC ION
Authors:Ireton, G.C, Black, M.E, Stoddard, B.L.
Deposit date:2003-04-01
Release date:2003-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:The 1.14 a crystal structure of yeast Cytosine deaminase. Evolution of nucleotide salvage enzymes and implications for genetic chemotherapy.
Structure, 11, 2003
1P6O
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BU of 1p6o by Molmil
The crystal structure of yeast cytosine deaminase bound to 4(R)-hydroxyl-3,4-dihydropyrimidine at 1.14 angstroms.
Descriptor: 4-HYDROXY-3,4-DIHYDRO-1H-PYRIMIDIN-2-ONE, ACETIC ACID, CALCIUM ION, ...
Authors:Ireton, G.C, Black, M.E, Stoddard, B.L.
Deposit date:2003-04-29
Release date:2003-08-19
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:The 1.14 a crystal structure of yeast Cytosine deaminase. Evolution of nucleotide salvage enzymes and implications for genetic chemotherapy.
Structure, 11, 2003
1R9Y
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BU of 1r9y by Molmil
Bacterial cytosine deaminase D314A mutant.
Descriptor: Cytosine deaminase, FE (III) ION, GLYCEROL, ...
Authors:Mahan, S.D, Ireton, G.C, Stoddard, B.L, Black, M.E.
Deposit date:2003-10-31
Release date:2004-10-05
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy.
Protein Eng.Des.Sel., 17, 2004
1R9X
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BU of 1r9x by Molmil
Bacterial cytosine deaminase D314G mutant.
Descriptor: Cytosine deaminase, FE (III) ION, GLYCEROL, ...
Authors:Mahan, S.D, Ireton, G.C, Stoddard, B.L, Black, M.E.
Deposit date:2003-10-31
Release date:2004-10-05
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy.
Protein Eng.Des.Sel., 17, 2004
1RAK
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BU of 1rak by Molmil
Bacterial cytosine deaminase D314S mutant bound to 5-fluoro-4-(S)-hydroxyl-3,4-dihydropyrimidine.
Descriptor: (4S)-5-FLUORO-4-HYDROXY-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE, Cytosine deaminase, FE (III) ION, ...
Authors:Mahan, S.D, Ireton, G.C, Stoddard, B.L, Black, M.E.
Deposit date:2003-10-31
Release date:2004-10-05
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy.
Protein Eng.Des.Sel., 17, 2004
1RA0
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BU of 1ra0 by Molmil
Bacterial cytosine deaminase D314G mutant bound to 5-fluoro-4-(S)-hydroxy-3,4-dihydropyrimidine.
Descriptor: (4S)-5-FLUORO-4-HYDROXY-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE, Cytosine deaminase, FE (III) ION
Authors:Mahan, S.D, Ireton, G.C, Stoddard, B.L, Black, M.E.
Deposit date:2003-10-31
Release date:2004-10-05
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy.
Protein Eng.Des.Sel., 17, 2004
1R9Z
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BU of 1r9z by Molmil
Bacterial cytosine deaminase D314S mutant.
Descriptor: Cytosine deaminase, FE (III) ION, GLYCEROL, ...
Authors:Mahan, S.D, Ireton, G.C, Stoddard, B.L, Black, M.E.
Deposit date:2003-10-31
Release date:2004-10-05
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy.
Protein Eng.Des.Sel., 17, 2004
1RA5
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BU of 1ra5 by Molmil
Bacterial cytosine deaminase D314A mutant bound to 5-fluoro-4-(S)-hydroxyl-3,4-dihydropyrimidine.
Descriptor: (4S)-5-FLUORO-4-HYDROXY-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE, Cytosine deaminase, FE (III) ION, ...
Authors:Mahan, S.D, Ireton, G.C, Stoddard, B.L, Black, M.E.
Deposit date:2003-10-31
Release date:2004-10-05
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy.
Protein Eng.Des.Sel., 17, 2004
3G77
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BU of 3g77 by Molmil
Bacterial cytosine deaminase V152A/F316C/D317G mutant
Descriptor: Cytosine deaminase, FE (III) ION
Authors:Stoddard, B, Zhao, L.
Deposit date:2009-02-09
Release date:2009-09-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Bacterial cytosine deaminase mutants created by molecular engineering show improved 5-fluorocytosine-mediated cell killing in vitro and in vivo.
Cancer Res., 69, 2009
2O3K
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BU of 2o3k by Molmil
Yeast Cytosine Deaminase D92E Triple Mutant bound to transition state analogue HPY
Descriptor: 4-HYDROXY-3,4-DIHYDRO-1H-PYRIMIDIN-2-ONE, CALCIUM ION, Cytosine deaminase, ...
Authors:Korkegian, A.M, Stoddard, B.L.
Deposit date:2006-12-01
Release date:2007-10-16
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of Yeast Cytosine Deaminase D92E Triple Mutant bound to transition state analogue HPY
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PDB entries from 2024-03-27

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