Author results

1RG8
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HUMAN ACIDIC FIBROBLAST GROWTH FACTOR (HAFGF-1) AT 1.10 ANGSTROM RESOLUTION (140 AMINO ACID FORM)
Descriptor:Heparin-binding growth factor 1, FORMIC ACID
Authors:Bernett, M.J., Somasundaram, T., Blaber, M.
Deposit date:2003-11-11
Release date:2004-10-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:An atomic resolution structure for human fibroblast growth factor 1.
Proteins, 57, 2004
3P6I
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CRYSTAL STRUCTURE OF SYMFOIL-4T PERMUTATION #2: DE NOVO DESIGNED BETA-TREFOIL ARCHITECTURE WITH SYMMETRIC PRIMARY STRUCTURE
Descriptor:de novo designed beta-trefoil architecture with symmetric primary structure, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION
Authors:Blaber, M., Lee, J.
Deposit date:2010-10-11
Release date:2011-10-12
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Permutations study of de novo designed symmetric beta-trefoil architecture
To be Published
3P6J
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CRYSTAL STRUCTURE OF SYMFOIL-4T PERMUTATION #3: DE NOVO DESIGNED BETA-TREFOIL ARCHITECTURE WITH SYMMETRIC PRIMARY STRUCTURE
Descriptor:de novo designed beta-trefoil architecture with symmetric primary structure
Authors:Blaber, M., Lee, J.
Deposit date:2010-10-11
Release date:2011-10-12
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Permutations study of de novo designed symmetric beta-trefoil architecture
To be Published
3Q7X
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CRYSTAL STRUCTURE OF SYMFOIL-4P/PV1: DE NOVO DESIGNED BETA-TREFOIL ARCHITECTURE WITH SYMMETRIC PRIMARY STRUCTURE, PRIMITIVE VERSION 1
Descriptor:de novo designed beta-trefoil architecture with symmetric primary structure, SULFATE ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Blaber, M., Lee, J.
Deposit date:2011-01-05
Release date:2012-01-11
Last modified:2013-02-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Simplified protein design biased for prebiotic amino acids yields a foldable, halophilic protein.
Proc.Natl.Acad.Sci.USA, 110, 2013
3O49
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CRYSTAL STRUCTURE OF SYMFOIL-1: DE NOVO DESIGNED BETA-TREFOIL ARCHITECTURE WITH SYMMETRIC PRIMARY STRUCTURE
Descriptor:de novo designed beta-trefoil architecture with symmetric primary structure, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION
Authors:Lee, J., Blaber, M.
Deposit date:2010-07-26
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Experimental support for the evolution of symmetric protein architecture from a simple peptide motif.
Proc.Natl.Acad.Sci.USA, 108, 2011
3O4A
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CRYSTAL STRUCTURE OF SYMFOIL-2: DE NOVO DESIGNED BETA-TREFOIL ARCHITECTURE WITH SYMMETRIC PRIMARY STRUCTURE
Descriptor:de novo designed beta-trefoil architecture with symmetric primary structure, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION
Authors:Lee, J., Blaber, M.
Deposit date:2010-07-26
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Experimental support for the evolution of symmetric protein architecture from a simple peptide motif.
Proc.Natl.Acad.Sci.USA, 108, 2011
3Q7Y
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CRYSTAL STRUCTURE OF K15R/E18D/Y22W/H41G/F44W/E51D/E53P/K57R/E60D/Y64W/H82G/F85W/E90D/E94P/K98R/E101D/Y108W/H129G/F132W/E137D SYMFOIL-4P: DE NOVO DESIGNED BETA-TREFOIL ARCHITECTURE WITH SYMMETRIC PRIMARY STRUCTURE
Descriptor:De novo designed beta-trefoil architecture with symmetric primary structure
Authors:Blaber, M., Lee, J.
Deposit date:2011-01-05
Release date:2012-01-11
Last modified:2013-12-18
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Simplified protein design biased for prebiotic amino acids yields a foldable, halophilic protein.
Proc.Natl.Acad.Sci.USA, 110, 2013
3OL0
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CRYSTAL STRUCTURE OF MONOFOIL-4P HOMO-TRIMER: DE NOVO DESIGNED MONOMER TREFOIL-FOLD SUB-DOMAIN WHICH FORMS HOMO-TRIMER ASSEMBLY
Descriptor:de novo designed monomer trefoil-fold sub-domain which forms homo-trimer assembly, SULFATE ION
Authors:Lee, J., Blaber, M.
Deposit date:2010-08-25
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.483 Å)
Cite:Experimental support for the evolution of symmetric protein architecture from a simple peptide motif.
Proc.Natl.Acad.Sci.USA, 108, 2011
4QC4
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CRYSTAL STRUCTURE OF C117S MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Fibroblast growth factor 1, CITRATE ANION, SODIUM ION, ...
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-09
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.491 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QBV
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CRYSTAL STRUCTURE OF C117T MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR IN SODIUM CITRATE BUFFER
Descriptor:Fibroblast growth factor 1, CITRATE ANION
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-08
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.497 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
3BB2
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CRYSTAL STRUCTURE OF L26D/D28N MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Heparin-binding growth factor 1, SULFATE ION, FORMIC ACID
Authors:Lee, J., Blaber, M.
Deposit date:2007-11-09
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A logical OR redundancy within the Asx-Pro-Asx-Gly type I beta-turn motif.
J.Mol.Biol., 377, 2008
3Q7W
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CRYSTAL STRUCTURE OF SYMFOIL-4P/PV1: DE NOVO DESIGNED BETA-TREFOIL ARCHITECTURE WITH SYMMETRIC PRIMARY STRUCTURE, PRIMITIVE VERSION 1
Descriptor:de novo designed beta-trefoil architecture with symmetric primary structure, SULFATE ION
Authors:Blaber, M., Lee, J.
Deposit date:2011-01-05
Release date:2012-01-11
Last modified:2013-02-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Simplified protein design biased for prebiotic amino acids yields a foldable, halophilic protein.
Proc.Natl.Acad.Sci.USA, 110, 2013
4QAL
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CRYSTAL STRUCTURE OF C117A MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Fibroblast growth factor 1, CITRATE ANION
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-05
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QBC
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CRYSTAL STRUCTURE OF C117T MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR IN SODIUM FORMATE BUFFER
Descriptor:Fibroblast growth factor 1, SULFATE ION, FORMIC ACID
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-07
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.519 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
3B9U
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CRYSTAL STRUCTURE OF L26N/D28N/H93G MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Heparin-binding growth factor 1, SULFATE ION
Authors:Blaber, M., Lee, J.
Deposit date:2007-11-06
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:A logical OR redundancy within the Asx-Pro-Asx-Gly type I beta-turn motif.
J.Mol.Biol., 377, 2008
3BAO
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CRYSTAL STRUCTURE OF L26N MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Heparin-binding growth factor 1, SULFATE ION, FORMIC ACID
Authors:Lee, J., Blaber, M.
Deposit date:2007-11-08
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:A logical OR redundancy within the Asx-Pro-Asx-Gly type I beta-turn motif.
J.Mol.Biol., 377, 2008
4Q9G
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CRYSTAL STRUCTURE OF K12V/C16S/C117V/P134V MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Fibroblast growth factor 1, FORMIC ACID, PHOSPHATE ION
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-01
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.554 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
1LO6
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HUMAN KALLIKREIN 6 (HK6) ACTIVE FORM WITH BENZAMIDINE INHIBITOR AT 1.56 A RESOLUTION
Descriptor:Kallikrein 6, MAGNESIUM ION, BENZAMIDINE
Authors:Bernett, M.J., Blaber, S.I., Scarisbrick, I.A., Dhanarajan, P., Thompson, S.M., Blaber, M.
Deposit date:2002-05-06
Release date:2002-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Crystal structure and biochemical characterization of human kallikrein 6 reveals a trypsin-like kallikrein is expressed in the central nervous system
To be Published
1P63
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HUMAN ACIDIC FIBROBLAST GROWTH FACTOR. 140 AMINO ACID FORM WITH AMINO TERMINAL HIS TAG AND LEU111 REPLACED WITH ILE (L111I)
Descriptor:ACIDIC FIBROBLAST GROWTH FACTOR, SULFATE ION, FORMIC ACID
Authors:Brych, S.R., Kim, J., Logan, T.M., Blaber, M.
Deposit date:2003-04-28
Release date:2004-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Accommodation of a highly symmetric core within a symmetric protein superfold
Protein Sci., 12, 2003
2HW9
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CRYSTAL STRUCTURE OF LYS12CYS/CYS117VAL MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR AT 1.60 ANGSTROM RESOLUTION.
Descriptor:Heparin-binding growth factor 1, SULFATE ION, FORMIC ACID
Authors:Dubey, V.K., Lee, J., Somasundaram, T., Blaber, M.
Deposit date:2006-08-01
Release date:2007-06-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Spackling the crack: stabilizing human fibroblast growth factor-1 by targeting the N and C terminus beta-strand interactions.
J.Mol.Biol., 371, 2007
2HWM
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CRYSTAL STRUCTURE OF LYS12VAL/CYS117VAL MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR AT 1.60 ANGSTROM RESOLUTION
Descriptor:Heparin-binding growth factor 1, FORMIC ACID
Authors:Dubey, V.K., Lee, J., Somasundaram, T., Blaber, M.
Deposit date:2006-08-01
Release date:2007-06-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Spackling the crack: stabilizing human fibroblast growth factor-1 by targeting the N and C terminus beta-strand interactions.
J.Mol.Biol., 371, 2007
3BA7
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CRYSTAL STRUCTURE OF L26N/D28A MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Heparin-binding growth factor 1, SULFATE ION, FORMIC ACID
Authors:Blaber, M., Lee, J.
Deposit date:2007-11-07
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A logical OR redundancy within the Asx-Pro-Asx-Gly type I beta-turn motif.
J.Mol.Biol., 377, 2008
3BAU
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CRYSTAL STRUCTURE OF K12V/L26D/D28A MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Heparin-binding growth factor 1, SULFATE ION, FORMIC ACID
Authors:Lee, J., Blaber, M.
Deposit date:2007-11-08
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A logical OR redundancy within the Asx-Pro-Asx-Gly type I beta-turn motif.
J.Mol.Biol., 377, 2008
3O3Q
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CRYSTAL STRUCTURE OF "L44F/M67I/L73V/A103G/DELETION 104-106/F108Y/V109L/L111I/C117V/R119G/DELETION 120-122" MUTANT FORM OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Heparin-binding growth factor 1, GLYCEROL
Authors:Lee, J., Blaber, M.
Deposit date:2010-07-25
Release date:2011-02-23
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A polypeptide "building block"top-down symmetric deconstruction".
J.Mol.Biol., 407, 2011
3BAV
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CRYSTAL STRUCTURE OF L26A/D28N MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Heparin-binding growth factor 1, SULFATE ION, FORMIC ACID
Authors:Lee, J., Blaber, M.
Deposit date:2007-11-08
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:A logical OR redundancy within the Asx-Pro-Asx-Gly type I beta-turn motif.
J.Mol.Biol., 377, 2008