Author results

1JKH
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CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)
Descriptor:HIV-1 RT, A-CHAIN, B-CHAIN, ...
Authors:Ren, J., Nichols, C., Bird, L., Chamberlain, P., Weaver, K., Short, S., Stuart, D.I., Stammers, D.K.
Deposit date:2001-07-12
Release date:2001-10-03
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors.
J.Mol.Biol., 312, 2001
1JLA
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CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH TNK-651
Descriptor:HIV-1 RT A-chain, HIV-1 RT B-chain, 6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL URACIL
Authors:Ren, J., Nichols, C., Bird, L., Chamberlain, P., Weaver, K., Short, S., Stuart, D.I., Stammers, D.K.
Deposit date:2001-07-16
Release date:2001-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors.
J.Mol.Biol., 312, 2001
1JLB
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CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
Descriptor:HIV-1 RT A-chain, HIV-1 RT B-chain, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE
Authors:Ren, J., Nichols, C., Bird, L., Chamberlain, P., Weaver, K., Short, S., Stuart, D.I., Stammers, D.K.
Deposit date:2001-07-16
Release date:2001-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors.
J.Mol.Biol., 312, 2001
1JLC
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CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-2
Descriptor:HIV-1 RT A-chain, HIV-1 RT B-chain, N-[[3-FLUORO-4-ETHOXY-PYRID-2-YL]ETHYL]-N'-[5-CHLORO-PYRIDYL]-THIOUREA
Authors:Ren, J., Nichols, C., Bird, L., Chamberlain, P., Weaver, K., Short, S., Stuart, D.I., Stammers, D.K.
Deposit date:2001-07-16
Release date:2001-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors.
J.Mol.Biol., 312, 2001
1JLE
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CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE
Descriptor:HIV-1 RT, A-CHAIN, B-CHAIN
Authors:Ren, J., Nichols, C., Bird, L., Chamberlain, P., Weaver, K., Short, S., Stuart, D.I., Stammers, D.K.
Deposit date:2001-07-16
Release date:2001-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors.
J.Mol.Biol., 312, 2001
1JLF
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CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
Descriptor:HIV-1 RT A-chain, HIV-1 RT B-chain, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE
Authors:Ren, J., Nichols, C., Bird, L., Chamberlain, P., Weaver, K., Short, S., Stuart, D.I., Stammers, D.K.
Deposit date:2001-07-16
Release date:2001-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors.
J.Mol.Biol., 312, 2001
1JLG
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CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH UC-781
Descriptor:HIV-1 RT A-chain, HIV-1 RT B-chain, 2-METHYL-FURAN-3-CARBOTHIOIC ACID [4-CHLORO-3-(3-METHYL-BUT-2-ENYLOXY)-PHENYL]-AMIDE
Authors:Ren, J., Nichols, C., Bird, L., Chamberlain, P., Weaver, K., Short, S., Stuart, D.I., Stammers, D.K.
Deposit date:2001-07-16
Release date:2001-10-03
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors.
J.Mol.Biol., 312, 2001
5CXQ
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CRYSTAL STRUCTURE OF ISOFORM 2 OF PURINE NUCLEOSIDE PHOSPHORYLASE FROM SCHISTOSOMA MANSONI IN APO FORM
Descriptor:Purine nucleoside phosphorylase
Authors:Torini, J.R., Romanello, L., Bird, L., Owens, R., Brandao-Neto, J., Pereira, H.M.
Deposit date:2015-07-29
Release date:2016-08-03
Last modified:2018-09-26
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:The molecular structure of Schistosoma mansoni PNP isoform 2 provides insights into the nucleoside selectivity of PNPs.
PLoS ONE, 13, 2018
5CXS
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CRYSTAL STRUCTURE OF ISOFORM 2 OF PURINE NUCLEOSIDE PHOSPHORYLASE COMPLEXED WITH MES
Descriptor:Purine nucleoside phosphorylase, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Torini, J.R., Romanello, L., Bird, L., Owens, R., Brandao-Neto, J., Pereira, H.M.
Deposit date:2015-07-29
Release date:2016-08-03
Last modified:2018-09-26
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The molecular structure of Schistosoma mansoni PNP isoform 2 provides insights into the nucleoside selectivity of PNPs.
PLoS ONE, 13, 2018
5KO5
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CRYSTAL STRUCTURE OF ISOFORM 2 OF PURINE NUCLEOSIDE PHOSPHORYLASE FROM SCHISTOSOMA MANSONI IN COMPLEX WITH CYTOSINE
Descriptor:Purine nucleoside phosphorylase, 6-AMINOPYRIMIDIN-2(1H)-ONE, 1,2-ETHANEDIOL
Authors:Torini, J.R., Romanello, L., Bird, L., Owens, R., Brandao-Neto, J., Pereira, H.M.
Deposit date:2016-06-29
Release date:2017-08-09
Last modified:2018-09-26
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:The molecular structure of Schistosoma mansoni PNP isoform 2 provides insights into the nucleoside selectivity of PNPs.
PLoS ONE, 13, 2018
5KO6
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CRYSTAL STRUCTURE OF ISOFORM 2 OF PURINE NUCLEOSIDE PHOSPHORYLASE FROM SCHISTOSOMA MANSONI IN COMPLEX WITH CYTOSINE AND RIBOSE-1-PHOSPHATE
Descriptor:Purine nucleoside phosphorylase, 6-AMINOPYRIMIDIN-2(1H)-ONE, RIBOSE-1-PHOSPHATE
Authors:Torini, J.R., Romanello, L., Bird, L., Owens, R., Brandao-Neto, J., Pereira, H.M.
Deposit date:2016-06-29
Release date:2017-08-09
Last modified:2018-09-26
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:The molecular structure of Schistosoma mansoni PNP isoform 2 provides insights into the nucleoside selectivity of PNPs.
PLoS ONE, 13, 2018
3OC2
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CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA
Descriptor:Penicillin-binding protein 3, CHLORIDE ION
Authors:Sainsbury, S., Bird, L., Stuart, D.I., Owens, R.J., Ren, J., Oxford Protein Production Facility (OPPF)
Deposit date:2010-08-09
Release date:2010-11-10
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (1.968 Å)
Cite:Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms
J.Mol.Biol., 405, 2011
3OCL
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CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH CARBENICILLIN
Descriptor:Penicillin-binding protein 3, CHLORIDE ION, (2R,4S)-2-[(1R)-1-{[(2S)-2-carboxy-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, ...
Authors:Sainsbury, S., Bird, L., Stuart, D.I., Owens, R.J., Ren, J., Oxford Protein Production Facility (OPPF)
Deposit date:2010-08-10
Release date:2010-11-10
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms
J.Mol.Biol., 405, 2011
3OCN
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CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 3 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH CEFTAZIDIME
Descriptor:penicillin-binding protein 3, 1-({(2R)-2-[(1R)-1-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-2-oxoethyl]-4-carboxy-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium
Authors:Sainsbury, S., Bird, L., Stuart, D.I., Owens, R.J., Ren, J., Oxford Protein Production Facility (OPPF)
Deposit date:2010-08-10
Release date:2010-11-10
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms
J.Mol.Biol., 405, 2011
4AV2
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SINGLE PARTICLE ELECTRON MICROSCOPY OF PILQ DODECAMERIC COMPLEXES FROM NEISSERIA MENINGITIDIS.
Descriptor:TYPE IV PILUS BIOGENESIS AND COMPETENCE PROTEIN PILQ, PILP PROTEIN
Authors:Berry, J.L., Phelan, M.M., Collins, R.F., Adomavicius, T., Tonjum, T., Frye, S.A., Bird, L., Owens, R., Ford, R.C., Lian, L.Y., Derrick, J.P.
Deposit date:2012-05-23
Release date:2012-10-17
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (26 Å)
Cite:Structure and Assembly of a Trans-Periplasmic Channel for Type Iv Pili in Neisseria Meningitidis.
Plos Pathog., 8, 2012
6AWE
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CRYSTAL STRUCTURE OF PURINE NUCLEOSIDE PHOSPHORYLASE ISOFORM 2 FROM SCHISTOSOMA MANSONI IN COMPLEX WITH 2-FLUORO-6-(2-PYRIDIN-2-YLETHYLAMINO)BENZONITRILE
Descriptor:Purine nucleoside phosphorylase, DIMETHYL SULFOXIDE, 2-fluoro-6-{[2-(pyridin-2-yl)ethyl]amino}benzonitrile
Authors:Faheem, M., Neto, J.B., Collins, P., Pearce, N.M., Valadares, N.F., Bird, L., Pereira, H.M., Delft, F.V., Barbosa, J.A.R.G.
Deposit date:2017-09-05
Release date:2018-09-12
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with 2-fluoro-6-(2-pyridin-2-ylethylamino)benzonitrile
To Be Published
6AXA
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CRYSTAL STRUCTURE OF PURINE NUCLEOSIDE PHOSPHORYLASE ISOFORM 2 FROM SCHISTOSOMA MANSONI IN COMPLEX WITH (3S)-5-FLUORO-3-HYDROXY-1,3-DIHYDROINDOL-2-ONE
Descriptor:Purine nucleoside phosphorylase, DIMETHYL SULFOXIDE, (3S)-5-fluoro-3-hydroxy-1,3-dihydro-2H-indol-2-one
Authors:Faheem, M., Neto, J.B., Collins, P., Pearce, N.M., Valadares, N.F., Bird, L., Pereira, H.M., Delft, F.V., Barbosa, J.A.R.G.
Deposit date:2017-09-06
Release date:2018-09-12
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with 5-fluoro-3-hydroxy-1,3-dihydroindol-2-one
To Be Published
6B2L
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CRYSTAL STRUCTURE OF PURINE NUCLEOSIDE PHOSPHORYLASE ISOFORM 2 FROM SCHISTOSOMA MANSONI IN COMPLEX WITH PIPERIDIN-2-IMINE
Descriptor:Purine nucleoside phosphorylase, DIMETHYL SULFOXIDE, PIPERIDIN-2-IMINE
Authors:Faheem, M., Neto, J.B., Collins, P., Pearce, N.M., Valadares, N.F., Bird, L., Pereira, H.M., Delft, F.V., Barbosa, J.A.R.G.
Deposit date:2017-09-20
Release date:2018-09-26
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with piperidin-2-Imine
To Be Published
6B37
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CRYSTAL STRUCTURE OF PURINE NUCLEOSIDE PHOSPHORYLASE ISOFORM 2 FROM SCHISTOSOMA MANSONI IN COMPLEX WITH 1,3-BENZOTHIAZOL-2-OL
Descriptor:Purine nucleoside phosphorylase, DIMETHYL SULFOXIDE, 1,3-benzothiazol-2-ol
Authors:Faheem, M., Neto, J.B., Collins, P., Pearce, N.M., Valadares, N.F., Bird, L., Pereira, H.M., Delft, F.V., Barbosa, J.A.R.G.
Deposit date:2017-09-21
Release date:2018-09-26
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with 1,3-benzothiazol-2-ol
To Be Published
6B3L
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CRYSTAL STRUCTURE OF PURINE NUCLEOSIDE PHOSPHORYLASE ISOFORM 2 FROM SCHISTOSOMA MANSONI IN COMPLEX WITH 2,3-DIHYDRO-1H-INDEN-2-AMINE
Descriptor:Purine nucleoside phosphorylase, DIMETHYL SULFOXIDE, INDAN-2-AMINE
Authors:Faheem, M., Neto, J.B., Collins, P., Pearce, N.M., Valadares, N.F., Bird, L., Pereira, H.M., Delft, F.V., Barbosa, J.A.R.G.
Deposit date:2017-09-22
Release date:2018-09-26
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with 2,3-dihydro-1H-inden-2-amine
To Be Published
6B4Q
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CRYSTAL STRUCTURE OF PURINE NUCLEOSIDE PHOSPHORYLASE ISOFORM 2 FROM SCHISTOSOMA MANSONI IN COMPLEX WITH PYRIDIN-4-OL
Descriptor:Purine nucleoside phosphorylase, DIMETHYL SULFOXIDE, pyridin-4-ol
Authors:Faheem, M., Neto, J.B., Collins, P., Pearce, N.M., Valadares, N.F., Bird, L., Pereira, H.M., Delft, F.V., Barbosa, J.A.R.G.
Deposit date:2017-09-27
Release date:2018-10-03
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with pyridine-4-ol
To Be Published
6B4T
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CRYSTAL STRUCTURE OF PURINE NUCLEOSIDE PHOSPHORYLASE ISOFORM 2 FROM SCHISTOSOMA MANSONI IN COMPLEX WITH 4-METHYLPYRIDIN-2-OL
Descriptor:Purine nucleoside phosphorylase, DIMETHYL SULFOXIDE, 4-methylpyridin-2-ol
Authors:Faheem, M., Neto, J.B., Collins, P., Pearce, N.M., Valadares, N.F., Bird, L., Pereira, H.M., Delft, F.V., Barbosa, J.A.R.G.
Deposit date:2017-09-27
Release date:2018-10-03
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with 4-methylpyridin-2-ol
To Be Published
6B56
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CRYSTAL STRUCTURE OF PURINE NUCLEOSIDE PHOSPHORYLASE ISOFORM 2 FROM SCHISTOSOMA MANSONI IN COMPLEX WITH 5-BUTYLPYRIDINE-2-CARBOXYLIC ACID
Descriptor:Purine nucleoside phosphorylase, DIMETHYL SULFOXIDE, 5-butylpyridine-2-carboxylic acid
Authors:Faheem, M., Neto, J.B., Collins, P., Pearce, N.M., Valadares, N.F., Bird, L., Pereira, H.M., Delft, F.V., Barbosa, J.A.R.G.
Deposit date:2017-09-28
Release date:2018-10-03
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with 5-butylpyridine-2-carboxylic acid
To Be Published
6B6K
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CRYSTAL STRUCTURE OF PURINE NUCLEOSIDE PHOSPHORYLASE ISOFORM 2 FROM SCHISTOSOMA MANSONI IN COMPLEX WITH 6-METHYL-2,3-DIHYDROPYRIDAZIN-3-ONE
Descriptor:Purine nucleoside phosphorylase, DIMETHYL SULFOXIDE, 6-methylpyridazin-3-ol
Authors:Faheem, M., Neto, J.B., Collins, P., Pearce, N.M., Valadares, N.F., Bird, L., Pereira, H.M., Delft, F.V., Barbosa, J.A.R.G.
Deposit date:2017-10-02
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with 3-methylpyridazin-1-ium-6-olate
To Be Published
6B71
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CRYSTAL STRUCTURE OF PURINE NUCLEOSIDE PHOSPHORYLASE ISOFORM 2 FROM SCHISTOSOMA MANSONI IN COMPLEX WITH3-(4-CHLOROPHENYL)-5H,6H-IMIDAZO[2,1-B][1,3]THIAZOLE
Descriptor:Purine nucleoside phosphorylase, DIMETHYL SULFOXIDE, 3-(4-chlorophenyl)-5,6-dihydroimidazo[2,1-b][1,3]thiazole
Authors:Faheem, M., Neto, J.B., Collins, P., Pearce, N.M., Valadares, N.F., Bird, L., Pereira, H.M., Delft, F.V., Barbosa, J.A.R.G.
Deposit date:2017-10-03
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with 3-(4-chlorophenyl)-5H,6H-imidazo[2,1-b][1,3]thiazole
To Be Published
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