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2VYA
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CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE CONJUGATED WITH THE DRUG-LIKE INHIBITOR PF-750
Descriptor:FATTY-ACID AMIDE HYDROLASE 1, UNKNOWN ATOM OR ION, 4-(quinolin-3-ylmethyl)piperidine-1-carboxylic acid, ...
Authors:Mileni, M., Johnson, D.S., Wang, Z., Everdeen, D.S., Liimatta, M., Pabst, B., Bhattacharya, K., Nugent, R.A., Kamtekar, S., Cravatt, B.F., Ahn, K., Stevens, R.C.
Deposit date:2008-07-22
Release date:2008-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure-Guided Inhibitor Design for Human Faah by Interspecies Active Site Conversion.
Proc.Natl.Acad.Sci.USA, 105, 2008
2WAP
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3D-CRYSTAL STRUCTURE OF HUMANIZED-RAT FATTY ACID AMIDE HYDROLASE (FAAH) CONJUGATED WITH THE DRUG-LIKE UREA INHIBITOR PF-3845
Descriptor:FATTY-ACID AMIDE HYDROLASE 1, 4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzyl)piperidine-1-carboxylic acid, CHLORIDE ION, ...
Authors:Mileni, M., Kamtekar, S., Stevens, R.C.
Deposit date:2009-02-11
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery and Characterization of a Highly Selective Faah Inhibitor that Reduces Inflammatory Pain.
Chem.Biol., 16, 2009