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1Q5K
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BU of 1q5k by Molmil
crystal structure of Glycogen synthase kinase 3 in complexed with inhibitor
Descriptor: Glycogen synthase kinase-3 beta, N-(4-METHOXYBENZYL)-N'-(5-NITRO-1,3-THIAZOL-2-YL)UREA
Authors:Bhat, R, Xue, Y, Berg, S, Hellberg, S, Ormo, M, Nilsson, Y, Radesater, A.C, Jerning, E, Markgren, P.O, Borgegard, T, Nylof, M, Gimenez-Cassina, A, Hernandez, F, Lucas, J.J, Diaz-Mido, J, Avila, J.
Deposit date:2003-08-08
Release date:2004-08-10
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418.
J.Biol.Chem., 278, 2003
4ACM
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BU of 4acm by Molmil
CDK2 IN COMPLEX WITH 3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}-PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE
Descriptor: 3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE, CYCLIN-DEPENDENT KINASE 2, GLYCEROL
Authors:Berg, S, Bhat, R, Anderson, M, Bergh, M, Brassington, C, Hellberg, S, Jerning, E, Hogdin, K, Lo-Alfredsson, Y, Neelissen, J, Nilsson, Y, Ormo, M, Soderman, P, Stanway, J, Tucker, J, von Berg, S, Weigelt, T, Xue, Y.
Deposit date:2011-12-16
Release date:2012-05-16
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Discovery of novel potent and highly selective glycogen synthase kinase-3 beta (GSK3 beta ) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines.
J. Med. Chem., 55, 2012
4ACH
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BU of 4ach by Molmil
GSK3b in complex with inhibitor
Descriptor: 3-AMINO-N-(3-METHOXYPROPYL)-6-{4-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}PYRAZINE-2-CARBOXAMIDE, GLYCOGEN SYNTHASE KINASE-3 BETA
Authors:Xue, Y, Ormo, M.
Deposit date:2011-12-15
Release date:2012-05-16
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of novel potent and highly selective glycogen synthase kinase-3 beta (GSK3 beta ) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines.
J. Med. Chem., 55, 2012
4ACG
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BU of 4acg by Molmil
GSK3b in complex with inhibitor
Descriptor: 2-AMINO-5-{4-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-N-[4-(PYRROLIDIN-1-YLMETHYL)PYRIDIN-3-YL]PYRIDINE-3-CARBOXAMIDE, GLYCOGEN SYNTHASE KINASE-3 BETA
Authors:Xue, Y, Ormo, M.
Deposit date:2011-12-15
Release date:2012-05-16
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of novel potent and highly selective glycogen synthase kinase-3 beta (GSK3 beta ) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines.
J. Med. Chem., 55, 2012
4ACC
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BU of 4acc by Molmil
GSK3b in complex with inhibitor
Descriptor: 3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE, DIMETHYL SULFOXIDE, GLYCOGEN SYNTHASE KINASE-3 BETA
Authors:Xue, Y, Ormo, M.
Deposit date:2011-12-14
Release date:2012-05-16
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Discovery of novel potent and highly selective glycogen synthase kinase-3 beta (GSK3 beta ) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines.
J. Med. Chem., 55, 2012
4ACD
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BU of 4acd by Molmil
GSK3b in complex with inhibitor
Descriptor: 3-AMINO-6-{4-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE, GLYCOGEN SYNTHASE KINASE-3 BETA
Authors:Xue, Y, Ormo, M.
Deposit date:2011-12-15
Release date:2012-05-16
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of novel potent and highly selective glycogen synthase kinase-3 beta (GSK3 beta ) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines.
J. Med. Chem., 55, 2012

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