Author results

1PNN
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PEPTIDE NUCLEIC ACID (PNA) COMPLEXED WITH DNA
Descriptor:PNA (NH2-P(*C*T*C*T*T*C*T*T*C-HIS-GLY-SER-SER-GLY-HIS-C*T*T*C*T*T*C*T*C)-COOH), DNA (5'-D(GP*AP*AP*GP*AP*AP*GP*AP*G)-3')
Authors:Betts, L., Veal, J.M.
Deposit date:1995-10-13
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Nucleic Acid Triple Helix Formed by a Peptide Nucleic Acid-DNA Complex
Science, 270, 1995
2FFD
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FIBRINOGEN FRAGMENT D WITH "A" KNOB PEPTIDE MIMIC GPRVVE
Descriptor:Fibrinogen alpha/alpha-E Chain, Fibrinogen beta chain, Fibrinogen gamma chain, ...
Authors:Betts, L.
Deposit date:2005-12-19
Release date:2006-07-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:The structure of fibrinogen fragment D with the 'A' knob peptide GPRVVE.
THROMB.HAEMOST., 4, 2006
2PZ1
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CRYSTAL STRUCTURE OF AUTO-INHIBITED ASEF
Descriptor:Rho guanine nucleotide exchange factor 4
Authors:Betts, L., Sondek, J., Rossman, K.L.
Deposit date:2007-05-17
Release date:2007-08-21
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression.
Nat.Struct.Mol.Biol., 14, 2007
2QUO
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CRYSTAL STRUCTURE OF C TERMINAL FRAGMENT OF CLOSTRIDIUM PERFRINGENS ENTEROTOXIN
Descriptor:Heat-labile enterotoxin B chain, SULFATE ION
Authors:Betts, L., Van Itallie, C.M.
Deposit date:2007-08-06
Release date:2007-10-30
Last modified:2018-06-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure of the claudin-binding domain of Clostridium perfringens enterotoxin
J.Biol.Chem., 283, 2008
3NTE
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CRYSTAL STRUCTURE OF THE WILD-TYPE FULL-LENGTH HIV-1 CAPSID PROTEIN
Descriptor:HIV-1 capsid protein, IODIDE ION, Tri-iodode Anion, ...
Authors:Betts, L., Yeh, J.I.
Deposit date:2010-07-03
Release date:2010-12-01
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of the HIV-1 full-length capsid protein in a conformationally trapped unassembled state induced by small-molecule binding.
J.Mol.Biol., 406, 2011
4HTE
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF NICKING ENZYME FROM STAPHYLOCOCCUS AUREUS
Descriptor:Nicking enzyme, CALCIUM ION
Authors:Betts, L.
Deposit date:2012-11-01
Release date:2013-01-30
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus.
Proc.Natl.Acad.Sci.USA, 110, 2013
4K59
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA RSMF
Descriptor:RNA BINDING PROTEIN RsmF
Authors:Betts, L., Walton, W.G., Redinbo, M.R.
Deposit date:2013-04-14
Release date:2013-08-28
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:An unusual CsrA family member operates in series with RsmA to amplify posttranscriptional responses in Pseudomonas aeruginosa.
Proc.Natl.Acad.Sci.USA, 110, 2013
4KGH
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CRYSTAL STRUCTURE OF HUMAN SPLUNC1 LACKING THE SECRETION SIGNAL SEQUENCE
Descriptor:BPI fold-containing family A member 1, NITRATE ION, AMMONIUM ION, ...
Authors:Betts, L., Walton, W.G.
Deposit date:2013-04-29
Release date:2013-09-25
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.806 Å)
Cite:Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways.
Proc.Natl.Acad.Sci.USA, 110, 2013
4KGO
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CRYSTAL STRUCTURE OF DOUBLE LEUCINE TO METHIONINE MUTANT HUMAN SPLUNC1 LACKING THE SECRETION SIGNAL SEQUENCE
Descriptor:BPI fold-containing family A member 1
Authors:Betts, L., Walton, W.G.
Deposit date:2013-04-29
Release date:2013-09-25
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.194 Å)
Cite:Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways.
Proc.Natl.Acad.Sci.USA, 110, 2013
5C7L
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STRUCTURE OF HUMAN TESTIS-SPECIFIC GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE APO FORM
Descriptor:Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Authors:Betts, L., Machius, M., Danshina, P., O'Brien, D.
Deposit date:2015-06-24
Release date:2016-03-09
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.862 Å)
Cite:Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme.
Mol. Hum. Reprod., 22, 2016
5C7O
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STRUCTURE OF HUMAN TESTIS-SPECIFIC GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE HOLO FORM WITH NAD+
Descriptor:Glyceraldehyde-3-phosphate dehydrogenase, testis-specific, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Betts, L., Machius, M., Danshina, P., O'Brien, D.
Deposit date:2015-06-24
Release date:2016-03-09
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (1.729 Å)
Cite:Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme.
Mol. Hum. Reprod., 22, 2016
1KJY
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CRYSTAL STRUCTURE OF HUMAN G[ALPHA]I1 BOUND TO THE GOLOCO MOTIF OF RGS14
Descriptor:GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-1 SUBUNIT, REGULATOR OF G-PROTEIN SIGNALING 14, ...
Authors:Kimple, R.J., Kimple, M.E., Betts, L., Sondek, J., Siderovski, D.P.
Deposit date:2001-12-05
Release date:2002-05-08
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits.
Nature, 416, 2002
1LB1
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CRYSTAL STRUCTURE OF THE DBL AND PLECKSTRIN HOMOLOGY DOMAINS OF DBS IN COMPLEX WITH RHOA
Descriptor:Guanine nucleotide exchange factor DBS, Transforming protein RhoA
Authors:Snyder, J.T., Worthylake, D.K., Rossman, K.L., Betts, L., Pruitt, W.M., Siderovski, D.P., Der, C.J., Sondek, J.
Deposit date:2002-04-01
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Nat.Struct.Biol., 9, 2002
1LT9
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CRYSTAL STRUCTURE OF RECOMBINANT HUMAN FIBRINOGEN FRAGMENT D
Descriptor:Fibrinogen alpha/alpha-E chain, Fibrinogen beta chain, Fibrinogen gamma chain, ...
Authors:Kostelansky, M.S., Betts, L., Gorkun, O.V., Lord, S.T.
Deposit date:2002-05-20
Release date:2002-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:2.8 A Crystal Structures of Recombinant Fibrinogen Fragment D with and without Two Peptide Ligands: GHRP Binding to the "b" Site Disrupts Its Nearby Calcium-binding Site.
Biochemistry, 41, 2002
1LTJ
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CRYSTAL STRUCTURE OF RECOMBINANT HUMAN FIBRINOGEN FRAGMENT D WITH THE PEPTIDE LIGANDS GLY-PRO-ARG-PRO-AMIDE AND GLY-HIS-ARG-PRO-AMIDE
Descriptor:Fibrinogen alpha/alpha-E chain, Fibrinogen Beta chain, Fibrinogen Gamma chain, ...
Authors:Kostelansky, M.S., Betts, L., Gorkun, O.V., Lord, S.T.
Deposit date:2002-05-20
Release date:2002-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:2.8 A Crystal Structures of Recombinant Fibrinogen Fragment D with and without Two Peptide Ligands: GHRP Binding to the "b" Site Disrupts Its Nearby Calcium-binding Site.
Biochemistry, 41, 2002
1MIH
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A ROLE FOR CHEY GLU 89 IN CHEZ-MEDIATED DEPHOSPHORYLATION OF THE E. COLI CHEMOTAXIS RESPONSE REGULATOR CHEY
Descriptor:Chemotaxis protein cheY, MANGANESE (II) ION, SULFATE ION, ...
Authors:Silversmith, R.E., Guanga, G.P., Betts, L., Chu, C., Zhao, R., Bourret, R.B.
Deposit date:2002-08-23
Release date:2003-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:CheZ-mediated dephosphorylation of the Escherichia coli chemotaxis response regulator CheY: role for CheY glutamate 89.
J.Bacteriol., 185, 2003
1RE3
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CRYSTAL STRUCTURE OF FRAGMENT D OF BBETAD398A FIBRINOGEN WITH THE PEPTIDE LIGAND GLY-HIS-ARG-PRO-AMIDE
Descriptor:Fibrinogen alpha/alpha-E chain, Fibrinogen beta chain, Fibrinogen gamma chain, ...
Authors:Kostelansky, M.S., Betts, L., Gorkun, O.V., Lord, S.T.
Deposit date:2003-11-06
Release date:2004-05-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:BbetaGlu397 and BbetaAsp398 but not BbetaAsp432 are required for "B:b" interactions.
Biochemistry, 43, 2004
1RE4
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CRYSTAL STRUCTURE OF FRAGMENT D OF BBETAD398A FIBRINOGEN
Descriptor:Fibrinogen alpha/alpha-E chain, Fibrinogen beta chain, Fibrinogen gamma chain, ...
Authors:Kostelansky, M.S., Betts, L., Gorkun, O.V., Lord, S.T.
Deposit date:2003-11-06
Release date:2004-05-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:BbetaGlu397 and BbetaAsp398 but not BbetaAsp432 are required for "B:b" interactions.
Biochemistry, 43, 2004
1S21
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CRYSTAL STRUCTURE OF AVRPPHF ORF2, A TYPE III EFFECTOR FROM P. SYRINGAE
Descriptor:ORF2
Authors:Singer, A.U., Desveaux, D., Betts, L., Chang, J.H., Nimchuk, Z., Grant, S.R., Dangl, J.K., Sondek, J.
Deposit date:2004-01-07
Release date:2004-09-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of the Type III Effector Protein AvrPphF and Its Chaperone Reveal Residues Required for Plant Pathogenesis
Structure, 12, 2004
1S28
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CRYSTAL STRUCTURE OF AVRPPHF ORF1, THE CHAPERONE FOR THE TYPE III EFFECTOR AVRPPHF ORF2 FROM P. SYRINGAE
Descriptor:ORF1, SULFATE ION
Authors:Singer, A.U., Desveaux, D., Betts, L., Chang, J.H., Nimchuk, Z., Grant, S.R., Dangl, J.L., Sondek, J.
Deposit date:2004-01-08
Release date:2004-09-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structures of the Type III Effector Protein AvrPphF and Its Chaperone Reveal Residues Required for Plant Pathogenesis
Structure, 12, 2004
1XO5
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CRYSTAL STRUCTURE OF CIB1, AN EF-HAND, INTEGRIN AND KINASE-BINDING PROTEIN
Descriptor:Calcium and integrin-binding protein 1, CALCIUM ION
Authors:Gentry, H.R., Singer, A.U., Betts, L., Yang, C., Ferrara, J.D., Parise, L.V., Sondek, J.
Deposit date:2004-10-05
Release date:2004-12-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural and Biochemical Characterization of CIB1 Delineates a New Family of EF-hand-containing Proteins
J.Biol.Chem., 280, 2005
2NZ8
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N-TERMINAL DHPH CASSETTE OF TRIO IN COMPLEX WITH NUCLEOTIDE-FREE RAC1
Descriptor:ras-related C3 botulinum toxin substrate 1 isoform Rac1, triple functional domain protein
Authors:Chhatriwala, M.K., Betts, L., Worthylake, D.K., Sondek, J.
Deposit date:2006-11-22
Release date:2007-04-10
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation
J.Mol.Biol., 368, 2007
3BVH
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CRYSTAL STRUCTURE OF RECOMBINANT GAMMAD364A FIBRINOGEN FRAGMENT D WITH THE PEPTIDE LIGAND GLY-PRO-ARG-PRO-AMIDE
Descriptor:Fibrinogen alpha chain, Fibrinogen beta chain, Fibrinogen gamma chain, ...
Authors:Bowley, S.R., Merenbloom, B.K., Betts, L., Okumura, N., Heroux, A., Gorkun, O.V., Lord, S.T.
Deposit date:2008-01-07
Release date:2008-09-02
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Polymerization-defective fibrinogen variant gammaD364A binds knob "A" peptide mimic.
Biochemistry, 47, 2008
3DR9
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INCREASED DISTAL HISTIDINE CONFORMATIONAL FLEXIBILITY IN THE DEOXY FORM OF DEHALOPEROXIDASE FROM AMPHITRITE ORNATA
Descriptor:Dehaloperoxidase A, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
Authors:Chen, X., de Serrano, V.S., Betts, L., Franzen, S.
Deposit date:2008-07-10
Release date:2009-01-27
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Distal histidine conformational flexibility in dehaloperoxidase from Amphitrite ornata.
Acta Crystallogr.,Sect.D, 65, 2009
3GRE
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CRYSTAL STRUCTURE OF SACCHAROMYCES CEREVISIAE VPS15 WD REPEAT DOMAIN
Descriptor:Serine/threonine-protein kinase VPS15
Authors:Vanhooke, J.L., Sondek, J., Betts, L.
Deposit date:2009-03-25
Release date:2009-07-28
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and function of Vps15 in the endosomal G protein signaling pathway.
Biochemistry, 48, 2009
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