Author results

1NHU
  • Download 1nhu
  • View 1nhu
Molmil generated image of 1nhu
HEPATITIS C VIRUS RNA POLYMERASE IN COMPLEX WITH NON-NUCLEOSIDE ANALOGUE INHIBITOR
Descriptor:HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE, (2S)-2-[(2,4-DICHLORO-BENZOYL)-(3-TRIFLUOROMETHYL-BENZYL)-AMINO]-3-PHENYL-PROPIONIC ACID
Authors:Wang, M., Ng, K.K.S., Cherney, M.M., Chan, L., Yannopoulos, C.G., Bedard, J., Morin, N., Nguyen-Ba, N., Alaoui-Ismaili, M.H., Bethell, R.C., James, M.N.G.
Deposit date:2002-12-19
Release date:2003-03-18
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Non-Nucleoside Analogue Inhibitors Bind to an Allosteric Site on HCV NS5B Polymerase: Crystal Structures and Mechanism of Inhibition
J.Biol.Chem., 278, 2003
1NHV
  • Download 1nhv
  • View 1nhv
Molmil generated image of 1nhv
HEPATITIS C VIRUS RNA POLYMERASE IN COMPLEX WITH NON-NUCLEOSIDE ANALOGUE INHIBITOR
Descriptor:HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE, (2S)-2-[(5-BENZOFURAN-2-YL-THIOPHEN-2-YLMETHYL)-(2,4-DICHLORO-BENZOYL)-AMINO]-3-PHENYL-PROPIONIC ACID
Authors:Wang, M., Ng, K.K.S., Cherney, M.M., Chan, L., Yannopoulos, C.G., Bedard, J., Morin, N., Nguyen-Ba, N., Alaoui-Ismaili, M.H., Bethell, R.C., James, M.N.G.
Deposit date:2002-12-19
Release date:2003-03-18
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Non-Nucleoside Analogue Inhibitors Bind to an Allosteric Site on HCV NS5B Polymerase: Crystal Structures and Mechanism of Inhibition
J.Biol.Chem., 278, 2003
1NNC
  • Download 1nnc
  • View 1nnc
Molmil generated image of 1nnc
INFLUENZA VIRUS NEURAMINIDASE SUBTYPE N9 (TERN) COMPLEXED WITH 4-GUANIDINO-NEU5AC2EN INHIBITOR
Descriptor:NEURAMINIDASE N9, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N., Colman, P.M.
Deposit date:1995-03-15
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Three-dimensional structure of the complex of 4-guanidino-Neu5Ac2en and influenza virus neuraminidase.
Protein Sci., 4, 1995
2QWA
  • Download 2qwa
  • View 2qwa
Molmil generated image of 2qwa
THE X-RAY STRUCTURE OF A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N.
Deposit date:1998-04-07
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWB
  • Download 2qwb
  • View 2qwb
Molmil generated image of 2qwb
THE X-RAY STRUCTURE OF A COMPLEX OF SIALIC ACID AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N.
Deposit date:1998-04-07
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWC
  • Download 2qwc
  • View 2qwc
Molmil generated image of 2qwc
THE X-RAY STRUCTURE OF A COMPLEX OF NEU5AC2EN AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N.
Deposit date:1998-04-07
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWD
  • Download 2qwd
  • View 2qwd
Molmil generated image of 2qwd
THE X-RAY STRUCTURE OF A COMPLEX OF 4-AMINO-NEU5AC2EN AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N.
Deposit date:1998-04-07
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWE
  • Download 2qwe
  • View 2qwe
Molmil generated image of 2qwe
THE X-RAY STRUCTURE OF A COMPLEX OF 4-GUANIDINO-NEU5AC2EN AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N.
Deposit date:1998-04-07
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWF
  • Download 2qwf
  • View 2qwf
Molmil generated image of 2qwf
THE X-RAY STRUCTURE OF A COMPLEX OF N-ACETYL-4-GUANIDINO-6-METHYL(PROPYL)CARBOXAMIDE-4,5-DIHYDRO-2H-PYRAN-2-CARBOXYLIC ACID AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N.
Deposit date:1998-04-07
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWG
  • Download 2qwg
  • View 2qwg
Molmil generated image of 2qwg
THE X-RAY STRUCTURE OF A COMPLEX OF 5-N-ACETYL-4-AMINO-6-DIETHYLCARBOXAMIDE-4,5-DIHYDRO-2H-PYRAN-2-CARBOXYLIC ACID AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N.
Deposit date:1998-04-07
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWH
  • Download 2qwh
  • View 2qwh
Molmil generated image of 2qwh
THE X-RAY STRUCTURE OF A COMPLEX OF 5-N-ACETYL-5-AMINO-3-(1-ETHYLPROPOXY)-1-CYCLOHEXENE-1-CARBOXYLIC ACID (GS4071) AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N.
Deposit date:1998-04-07
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWI
  • Download 2qwi
  • View 2qwi
Molmil generated image of 2qwi
THE X-RAY STRUCTURE OF A COMPLEX OF N-ACETYL-4-GUANIDINO-6-METHYL(PROPYL)CARBOXAMIDE-4,5-DIHYDRO-2H-PYRAN-2-CARBOXYLIC ACID AND WILDTYPE TERN N9 INFLUENZA VIRUS NEURAMINIDASE
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N.
Deposit date:1998-04-07
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWJ
  • Download 2qwj
  • View 2qwj
Molmil generated image of 2qwj
THE X-RAY STRUCTURE OF A COMPLEX OF 5-N-ACETYL-4-AMINO-6-DIETHYLCARBOXAMIDE-4,5-DIHYDRO-2H-PYRAN-2-CARBOXYLIC ACID AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N.
Deposit date:1998-04-07
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998
2QWK
  • Download 2qwk
  • View 2qwk
Molmil generated image of 2qwk
THE X-RAY STRUCTURE OF A COMPLEX OF 5-N-ACETYL-5-AMINO-3-(1-ETHYLPROPOXY)-1-CYCLOHEXENE-1-CARBOXYLIC ACID (GS4071) AND WILDTYPE TERN N9 INFLUENZA VIRUS NEURAMINIDASE
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Varghese, J.N.
Deposit date:1998-04-07
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6, 1998