Author results

3PTY
  • Download 3pty
  • View 3pty
Molmil generated image of 3pty
CRYSTAL STRUCTURE OF THE C-TERMINAL EXTRACELLULAR DOMAIN OF MYCOBACTERIUM TUBERCULOSIS EMBC
Descriptor:Arabinosyltransferase C, octyl alpha-D-arabinofuranoside, CALCIUM ION, ...
Authors:Alderwick, L.J., Besra, G.S., Futterer, K.
Deposit date:2010-12-03
Release date:2010-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The C-Terminal Domain of the Arabinosyltransferase Mycobacterium tuberculosis EmbC Is a Lectin-Like Carbohydrate Binding Module.
Plos Pathog., 7, 2011
1R88
  • Download 1r88
  • View 1r88
Molmil generated image of 1r88
THE CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MPT51 (FBPC1)
Descriptor:MPT51/MPB51 antigen
Authors:Wilson, R.A., Maughan, W.N., Kremer, L., Besra, G.S., Futterer, K.
Deposit date:2003-10-23
Release date:2003-12-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:The structure of Mycobacterium tuberculosis MPT51 (FbpC1) defines a new family of non-catalytic alpha/beta hydrolases.
J.Mol.Biol., 335, 2004
1SFR
  • Download 1sfr
  • View 1sfr
Molmil generated image of 1sfr
CRYSTAL STRUCTURE OF THE MYCOBACTERIUM TUBERCULOSIS ANTIGEN 85A PROTEIN
Descriptor:Antigen 85-A
Authors:Ronning, D.R., Vissa, V., Besra, G.S., Belisle, J.T., Sacchettini, J.C., TB Structural Genomics Consortium (TBSGC)
Deposit date:2004-02-20
Release date:2004-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mycobacterium tuberculosis Antigen 85A and 85C Structures Confirm Binding Orientation and Conserved Substrate Specificity
J.Biol.Chem., 279, 2004
1T56
  • Download 1t56
  • View 1t56
Molmil generated image of 1t56
CRYSTAL STRUCTURE OF TETR FAMILY REPRESSOR M. TUBERCULOSIS ETHR
Descriptor:EthR repressor, 1,4-DIETHYLENE DIOXIDE, GLYCEROL
Authors:Dover, L.G., Corsino, P.E., Daniels, I.R., Cocklin, S.L., Tatituri, V., Besra, G.S., Futterer, K.
Deposit date:2004-05-03
Release date:2004-07-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of the TetR/CamR Family Repressor Mycobacterium tuberculosis EthR Implicated in Ethionamide Resistance.
J.Mol.Biol., 340, 2004
1UQS
  • Download 1uqs
  • View 1uqs
Molmil generated image of 1uqs
THE CRYSTAL STRUCTURE OF HUMAN CD1B WITH A BOUND BACTERIAL GLYCOLIPID
Descriptor:T-CELL SURFACE GLYCOPROTEIN CD1B, BETA-2-MICROGLOBULIN, GLUCOSE MONOMYCOLATE
Authors:Batuwangala, T., Shepherd, D., Gadola, S.D., Gibson, K.J.C., Zaccai, N.R., Besra, G.S., Cerundolo, V., Jones, E.Y.
Deposit date:2003-10-16
Release date:2003-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The Crystal Structure of Human Cd1B with a Bound Bacterial Glycolipid
J.Immunol., 172, 2004
1VA5
  • Download 1va5
  • View 1va5
Molmil generated image of 1va5
ANTIGEN 85C WITH OCTYLTHIOGLUCOSIDE IN ACTIVE SITE
Descriptor:Antigen 85-C, 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL
Authors:Ronning, D.R., Vissa, V., Besra, G.S., Belisle, J.T., Sacchettini, J.C., TB Structural Genomics Consortium (TBSGC)
Deposit date:2004-02-11
Release date:2004-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Mycobacterium tuberculosis Antigen 85A and 85C Structures Confirm Binding Orientation and Conserved Substrate Specificity
J.Biol.Chem., 279, 2004
1ZT4
  • Download 1zt4
  • View 1zt4
Molmil generated image of 1zt4
THE CRYSTAL STRUCTURE OF HUMAN CD1D WITH AND WITHOUT ALPHA-GALACTOSYLCERAMIDE
Descriptor:T-cell surface glycoprotein CD1d, Beta-2-microglobulin, N-{(1S,2R,3S)-1-[(ALPHA-D-GALACTOPYRANOSYLOXY)METHYL]-2,3-DIHYDROXYHEPTADECYL}HEXACOSANAMIDE
Authors:Koch, M., Stronge, V.S., Shepherd, D., Gadola, S.D., Mathew, B., Ritter, G., Fersht, A.R., Besra, G.S., Schmidt, R.R., Jones, E.Y., Cerundolo, V., Structural Proteomics in Europe (SPINE)
Deposit date:2005-05-26
Release date:2005-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The crystal structure of human CD1d with and without alpha-galactosylceramide
Nat.Immunol., 6, 2005
2AHB
  • Download 2ahb
  • View 2ahb
Molmil generated image of 2ahb
X-RAY CRYSTAL STRUCTURE OF R46A,R161A MUTANT OF MYCOBACTERIUM TUBERCULOSIS FABH
Descriptor:Beta- ketoacyl-ACP synthase III
Authors:Brown, A.K., Sridharan, S., Kremer, L., Lindenberg, S., Dover, L.G., Sacchettini, J.C., Besra, G.S.
Deposit date:2005-07-27
Release date:2005-08-23
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Probing the Mechanism of the Mycobacterium tuberculosis {beta}-Ketoacyl-Acyl Carrier Protein Synthase III mtFabH: FACTORS INFLUENCING CATALYSIS AND SUBSTRATE SPECIFICITY
J.Biol.Chem., 280, 2005
2AJ9
  • Download 2aj9
  • View 2aj9
Molmil generated image of 2aj9
X-RAY CRYSTAL STRUCTURE OF W42A,R161A DOUBLE MUTANT OF MYCOBACTERIUM TUBERCULOSIS BETA-KETOACYL-ACP SYNTHASE III
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase III
Authors:Brown, A.K., Sridharan, S., Kremer, L., Lindenberg, S., Dover, L.G., Sacchettini, J.C., Besra, G.S.
Deposit date:2005-08-01
Release date:2005-08-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Probing the Mechanism of the Mycobacterium tuberculosis beta-Ketoacyl-Acyl Carrier Protein Synthase III mtFabH: Factors Influencing Catalysis And Substrate Specificity.
J.Biol.Chem., 280, 2005
2FEZ
  • Download 2fez
  • View 2fez
Molmil generated image of 2fez
MYCOBACTERIUM TUBERCULOSIS EMBR
Descriptor:Probable regulatory protein embR
Authors:Futterer, K., Alderwick, L.J., Besra, G.S.
Deposit date:2005-12-17
Release date:2006-01-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis
Proc.Natl.Acad.Sci.Usa, 103, 2006
2FF4
  • Download 2ff4
  • View 2ff4
Molmil generated image of 2ff4
MYCOBACTERIUM TUBERCULOSIS EMBR IN COMPLEX WITH LOW AFFINITY PHOSPHOPEPTIDE
Descriptor:Probable regulatory protein embR, DNA repair protein RAD9
Authors:Futterer, K., Alderwick, L.J., Besra, G.S.
Deposit date:2005-12-19
Release date:2006-01-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2Q74
  • Download 2q74
  • View 2q74
Molmil generated image of 2q74
MYCOBACTERIUM TUBERCULOSIS SUHB
Descriptor:Inositol-1-monophosphatase
Authors:Brown, A.K., Meng, G., Ghadbane, H., Besra, G.S., Futterer, K.
Deposit date:2007-06-06
Release date:2007-10-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg2+
Bmc Struct.Biol., 7, 2007
2QJ3
  • Download 2qj3
  • View 2qj3
Molmil generated image of 2qj3
MYCOBACTERIUM TUBERCULOSIS FABD
Descriptor:Malonyl CoA-acyl carrier protein transacylase, NICKEL (II) ION
Authors:Ghadbane, H., Brown, A.K., Kremer, L., Besra, G.S., Futterer, K.
Deposit date:2007-07-06
Release date:2007-09-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of Mycobacterium tuberculosis mtFabD, a malonyl-CoA:acyl carrier protein transacylase (MCAT).
Acta Crystallogr.,Sect.F, 63, 2007
3FVE
  • Download 3fve
  • View 3fve
Molmil generated image of 3fve
CRYSTAL STRUCTURE OF DIAMINOPIMELATE EPIMERASE MYCOBACTERIUM TUBERCULOSIS DAPF
Descriptor:Diaminopimelate epimerase, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, GLYCEROL
Authors:Usha, V., Dover, L.G., Roper, D.I., Futterer, K., Besra, G.S.
Deposit date:2009-01-15
Release date:2009-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the diaminopimelate epimerase DapF from Mycobacterium tuberculosis
Acta Crystallogr.,Sect.D, 65, 2009
3OKA
  • Download 3oka
  • View 3oka
Molmil generated image of 3oka
CRYSTAL STRUCTURE OF CORYNEBACTERIUM GLUTAMICUM PIMB' IN COMPLEX WITH GDP-MAN (TRICLINIC CRYSTAL FORM)
Descriptor:GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase, N-terminal His-affinity tag, SULFATE ION, ...
Authors:Batt, S.M., Jabeen, T., Besra, G.S., Futterer, K.
Deposit date:2010-08-24
Release date:2010-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Acceptor substrate discrimination in phosphatidyl-myo-inositol mannoside synthesis: structural and mutational analysis of mannosyltransferase Corynebacterium glutamicum PimB'.
J.Biol.Chem., 285, 2010
3OKC
  • Download 3okc
  • View 3okc
Molmil generated image of 3okc
CRYSTAL STRUCTURE OF CORYNEBACTERIUM GLUTAMICUM PIMB' BOUND TO GDP (ORTHORHOMBIC CRYSTAL FORM)
Descriptor:GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase, GUANOSINE-5'-DIPHOSPHATE
Authors:Batt, S.M., Jabeen, T., Besra, G.S., Futterer, K.
Deposit date:2010-08-24
Release date:2010-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Acceptor substrate discrimination in phosphatidyl-myo-inositol mannoside synthesis: structural and mutational analysis of mannosyltransferase Corynebacterium glutamicum PimB'.
J.Biol.Chem., 285, 2010
3OKP
  • Download 3okp
  • View 3okp
Molmil generated image of 3okp
CRYSTAL STRUCTURE OF CORYNEBACTERIUM GLUTAMICUM PIMB' BOUND TO GDP-MAN (ORTHORHOMBIC CRYSTAL FORM)
Descriptor:GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase, GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE
Authors:Batt, S.M., Jabeen, T., Besra, G.S., Futterer, K.
Deposit date:2010-08-25
Release date:2010-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Acceptor substrate discrimination in phosphatidyl-myo-inositol mannoside synthesis: structural and mutational analysis of mannosyltransferase Corynebacterium glutamicum PimB'.
J.Biol.Chem., 285, 2010
4FDN
  • Download 4fdn
  • View 4fdn
Molmil generated image of 4fdn
MYCOBACTERIUM TUBERCULOSIS DPRE1 IN COMPLEX WITH CT325 - HEXAGONAL CRYSTAL FORM
Descriptor:oxidoreductase DprE1, FLAVIN-ADENINE DINUCLEOTIDE, 3-(hydroxyamino)-N-[(1R)-1-phenylethyl]-5-(trifluoromethyl)benzamide
Authors:Batt, S.M., Besra, G.S., Futterer, K.
Deposit date:2012-05-29
Release date:2012-07-04
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FDO
  • Download 4fdo
  • View 4fdo
Molmil generated image of 4fdo
MYCOBACTERIUM TUBERCULOSIS DPRE1 IN COMPLEX WITH CT319
Descriptor:oxidoreductase DprE1, FLAVIN-ADENINE DINUCLEOTIDE, 3-nitro-N-[(1R)-1-phenylethyl]-5-(trifluoromethyl)benzamide
Authors:Batt, S.M., Besra, G.S., Futterer, K.
Deposit date:2012-05-29
Release date:2012-07-04
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (2.403 Å)
Cite:Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FDP
  • Download 4fdp
  • View 4fdp
Molmil generated image of 4fdp
MYCOBACTERIUM TUBERCULOSIS DPRE1 - MONOCLINIC CRYSTAL FORM
Descriptor:oxidoreductase DprE1, FLAVIN-ADENINE DINUCLEOTIDE, IMIDAZOLE
Authors:Batt, S.M., Besra, G.S., Futterer, K.
Deposit date:2012-05-29
Release date:2012-07-04
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FEH
  • Download 4feh
  • View 4feh
Molmil generated image of 4feh
MYCOBACTERIUM TUBERCULOSIS DPRE1 - HEXAGONAL CRYSTAL FORM
Descriptor:oxidoreductase DprE1, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Batt, S.M., Besra, G.S., Futterer, K.
Deposit date:2012-05-30
Release date:2012-07-04
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (2.035 Å)
Cite:Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FF6
  • Download 4ff6
  • View 4ff6
Molmil generated image of 4ff6
MYCOBACTERIUM TUBERCULOSIS DPRE1 IN COMPLEX WITH CT325 - MONOCLINIC CRYSTAL FORM
Descriptor:Probable decaprenylphosphoryl-beta-D-ribose oxidase, FLAVIN-ADENINE DINUCLEOTIDE, 3-(hydroxyamino)-N-[(1R)-1-phenylethyl]-5-(trifluoromethyl)benzamide, ...
Authors:Batt, S.M., Besra, G.S., Futterer, K.
Deposit date:2012-05-31
Release date:2012-07-04
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors.
Proc.Natl.Acad.Sci.USA, 109, 2012
4KW5
  • Download 4kw5
  • View 4kw5
Molmil generated image of 4kw5
M. TUBERCULOSIS DPRE1 IN COMPLEX WITH INHIBITOR TCA1
Descriptor:Oxidoreductase, FLAVIN-ADENINE DINUCLEOTIDE, ethyl ({2-[(1,3-benzothiazol-2-ylcarbonyl)amino]thiophen-3-yl}carbonyl)carbamate, ...
Authors:Batt, S.M., Besra, G.S., Futterer, K.
Deposit date:2013-05-23
Release date:2013-07-10
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.612 Å)
Cite:Identification of a small molecule with activity against drug-resistant and persistent tuberculosis.
Proc.Natl.Acad.Sci.USA, 110, 2013
4LXF
  • Download 4lxf
  • View 4lxf
Molmil generated image of 4lxf
CRYSTAL STRUCTURE OF M. TUBERCULOSIS TRES
Descriptor:Trehalose synthase, CALCIUM ION, GLYCEROL, ...
Authors:Roy, R., Besra, G.S., Futterer, K.
Deposit date:2013-07-29
Release date:2013-08-21
Last modified:2013-12-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Synthesis of alpha-glucan in mycobacteria involves a hetero-octameric complex of trehalose synthase TreS and Maltokinase Pep2.
Acs Chem.Biol., 8, 2013
4RMF
  • Download 4rmf
  • View 4rmf
Molmil generated image of 4rmf
BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF MYCOBACTERIAL ASPARTYL-TRNA SYNTHETASE ASPS, A PROMISING TB DRUG TARGET
Descriptor:Aspartate--tRNA(Asp/Asn) ligase, 2,2-bis(hydroxymethyl)propane-1,3-diol, FORMIC ACID
Authors:Cox, J.A.G., Gurcha, S.S., Veeraraghavan, U., Besra, G.S., Futterer, K.
Deposit date:2014-10-21
Release date:2014-11-19
Last modified:2014-12-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Biochemical and Structural Characterization of Mycobacterial Aspartyl-tRNA Synthetase AspS, a Promising TB Drug Target.
Plos One, 9, 2014