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3ZHX
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STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DXR IN COMPLEX WITH A FOSMIDOMYCIN ANALOGUE
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, MANGANESE (II) ION, [(1S)-1-(3,4-dichlorophenyl)-3-[oxidanyl(phenylcarbonyl)amino]propyl]phosphonic acid
Authors:Bjorkelid, C., Jansson, A.M., Bergfors, T., Unge, T., Mowbray, S.L., Jones, T.A.
Deposit date:2012-12-30
Release date:2013-10-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Dxr Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues.
J.Med.Chem., 56, 2013
3ZHY
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STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DXR IN COMPLEX WITH A DI- SUBSTITUTED FOSMIDOMYCIN ANALOGUE
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, MANGANESE (II) ION, [(1S)-1-(3,4-dichlorophenyl)-3-[oxidanyl(phenylcarbonyl)amino]propyl]phosphonic acid, ...
Authors:Bjorkelid, C., Jansson, A.M., Bergfors, T., Unge, T., Mowbray, S.L., Jones, T.A.
Deposit date:2012-12-30
Release date:2013-10-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Dxr Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues.
J.Med.Chem., 56, 2013
3ZHZ
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STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DXR IN COMPLEX WITH A FOSMIDOMYCIN ANALOGUE
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, [(1S)-1-(3,4-dichlorophenyl)-3-[oxidanyl-[2-[[3-(trifluoromethyl)phenyl]amino]phenyl]carbonyl-amino]propyl]phosphonic acid
Authors:Bjorkelid, C., Jansson, A.M., Bergfors, T., Unge, T., Mowbray, S.L., Jones, T.A.
Deposit date:2012-12-30
Release date:2013-10-09
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Dxr Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues.
J.Med.Chem., 56, 2013
3ZI0
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STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DXR IN COMPLEX WITH A FOSMIDOMYCIN ANALOGUE
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, [(1S)-1-(3,4-dichlorophenyl)-3-{hydroxy[2-(1H-1,2,4-triazol-1-ylmethyl)benzoyl]amino}propyl]phosphonic acid, MANGANESE (II) ION
Authors:Bjorkelid, C., Jansson, A.M., Bergfors, T., Unge, T., Mowbray, S.L., Jones, T.A.
Deposit date:2012-12-30
Release date:2013-10-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Dxr Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues.
J.Med.Chem., 56, 2013
1CBQ
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CRYSTAL STRUCTURE OF CELLULAR RETINOIC-ACID-BINDING PROTEINS I AND II IN COMPLEX WITH ALL-TRANS-RETINOIC ACID AND A SYNTHETIC RETINOID
Descriptor:CELLULAR RETINOIC ACID BINDING PROTEIN TYPE II, PHOSPHATE ION, 6-(2,3,4,5,6,7-HEXAHYDRO-2,4,4-TRIMETHYL-1-METYLENEINDEN-2-YL)-3-METHYLHEXA-2,4-DIENOIC ACID
Authors:Kleywegt, G.J., Bergfors, T., Jones, T.A.
Deposit date:1994-09-28
Release date:1995-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of cellular retinoic acid binding proteins I and II in complex with all-trans-retinoic acid and a synthetic retinoid.
Structure, 2, 1994
1CBR
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CRYSTAL STRUCTURE OF CELLULAR RETINOIC-ACID-BINDING PROTEINS I AND II IN COMPLEX WITH ALL-TRANS-RETINOIC ACID AND A SYNTHETIC RETINOID
Descriptor:CELLULAR RETINOIC ACID BINDING PROTEIN TYPE I, RETINOIC ACID
Authors:Kleywegt, G.J., Bergfors, T., Jones, T.A.
Deposit date:1994-09-28
Release date:1995-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structures of cellular retinoic acid binding proteins I and II in complex with all-trans-retinoic acid and a synthetic retinoid.
Structure, 2, 1994
1CBS
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CRYSTAL STRUCTURE OF CELLULAR RETINOIC-ACID-BINDING PROTEINS I AND II IN COMPLEX WITH ALL-TRANS-RETINOIC ACID AND A SYNTHETIC RETINOID
Descriptor:CELLULAR RETINOIC ACID BINDING PROTEIN TYPE II, RETINOIC ACID
Authors:Kleywegt, G.J., Bergfors, T., Jones, T.A.
Deposit date:1994-09-28
Release date:1995-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of cellular retinoic acid binding proteins I and II in complex with all-trans-retinoic acid and a synthetic retinoid.
Structure, 2, 1994
2CBR
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CELLULAR RETINOIC ACID BINDING PROTEIN I IN COMPLEX WITH A RETINOBENZOIC ACID (AM80)
Descriptor:PROTEIN (CRABP-I), 4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl]benzoic acid
Authors:Chaudhuri, B., Kleywegt, G.J., Bergfors, T., Jones, T.A.
Deposit date:1999-02-22
Release date:1999-12-21
Last modified:2011-10-05
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of cellular retinoic acid binding proteins I and II in complex with synthetic retinoids.
Acta Crystallogr.,Sect.D, 55, 1999
2CBS
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CELLULAR RETINOIC ACID BINDING PROTEIN II IN COMPLEX WITH A SYNTHETIC RETINOIC ACID (RO-13 6307)
Descriptor:PROTEIN (CRABP-II), 3-METHYL-7-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL) -OCTA-2,4,6-TRIENOIC ACID
Authors:Chaudhuri, B., Kleywegt, G.J., Bergfors, T., Jones, T.A.
Deposit date:1999-02-22
Release date:1999-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of cellular retinoic acid binding proteins I and II in complex with synthetic retinoids.
Acta Crystallogr.,Sect.D, 55, 1999
3CBS
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CELLULAR RETINOIC ACID BINDING PROTEIN II IN COMPLEX WITH A SYNTHETIC RETINOIC ACID (RO-12 7310)
Descriptor:PROTEIN (CRABP-II), (2E,4E,6E,8E)-9-(4-hydroxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
Authors:Chaudhuri, B., Kleywegt, G.J., Bergfors, T., Jones, T.A.
Deposit date:1999-02-22
Release date:1999-12-22
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of cellular retinoic acid binding proteins I and II in complex with synthetic retinoids.
Acta Crystallogr.,Sect.D, 55, 1999
5JAZ
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STRUCTURE OF PLASMODIUM FALCIPARUM DXR IN COMPLEX WITH A BETA-SUBSTITUTED FOSMIDOMYCIN ANALOGUE, LC51 AND MANGANESE
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic, [(2R)-2-{2-[hydroxy(methyl)amino]-2-oxoethyl}-5-(naphthalen-1-yl)pentyl]phosphonic acid, ...
Authors:Sooriyaarachchi, S., Bergfors, T., Jones, T.A., Mowbray, S.L.
Deposit date:2016-04-12
Release date:2016-08-24
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with beta-Arylpropyl Analogues of Fosmidomycin.
Chemmedchem, 11, 2016
5JBI
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STRUCTURE OF PLASMODIUM FALCIPARUM DXR IN COMPLEX WITH A BETA-SUBSTITUTED FOSMIDOMYCIN ANALOGUE, LC52 AND MANGANESE
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic, [(2R)-2-{2-[hydroxy(methyl)amino]-2-oxoethyl}-5-(4-methoxyphenyl)pentyl]phosphonic acid, ...
Authors:Sooriyaarachchi, S., Bergfors, T., Jones, T.A., Mowbray, S.L.
Deposit date:2016-04-13
Release date:2016-08-24
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with beta-Arylpropyl Analogues of Fosmidomycin.
Chemmedchem, 11, 2016
5JC1
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STRUCTURE OF PLASMODIUM FALCIPARUM DXR IN COMPLEX WITH A BETA-SUBSTITUTED FOSMIDOMYCIN ANALOGUE, LC55 AND MANGANESE
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic, [(2R)-2-{2-[hydroxy(methyl)amino]-2-oxoethyl}-5-(3-methoxyphenyl)pentyl]phosphonic acid, ...
Authors:Sooriyaarachchi, S., Bergfors, T., Jones, T.A., Mowbray, S.L.
Deposit date:2016-04-14
Release date:2016-08-24
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with beta-Arylpropyl Analogues of Fosmidomycin.
Chemmedchem, 11, 2016
5JMP
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STRUCTURE OF PLASMODIUM FALCIPARUM DXR IN COMPLEX WITH A BETA-SUBSTITUTED FOSMIDOMYCIN ANALOGUE, LC57 AND MANGANESE
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic, [(2R)-5-(3-fluorophenyl)-2-{2-[hydroxy(methyl)amino]-2-oxoethyl}pentyl]phosphonic acid, ...
Authors:Sooriyaarachchi, S., Bergfors, T., Jones, T.A., Mowbray, S.L.
Deposit date:2016-04-29
Release date:2016-08-24
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with beta-Arylpropyl Analogues of Fosmidomycin.
Chemmedchem, 11, 2016
5JMW
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STRUCTURE OF PLASMODIUM FALCIPARUM DXR IN COMPLEX WITH A BETA-SUBSTITUTED FOSMIDOMYCIN ANALOGUE, LC50 AND MANGANESE
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic, [(2R)-2-{2-[hydroxy(methyl)amino]-2-oxoethyl}-5-(4-methylphenyl)pentyl]phosphonic acid, ...
Authors:Sooriyaarachchi, S., Bergfors, T., Jones, T.A., Mowbray, S.L.
Deposit date:2016-04-29
Release date:2016-08-24
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with beta-Arylpropyl Analogues of Fosmidomycin.
Chemmedchem, 11, 2016
5JNL
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STRUCTURE OF PLASMODIUM FALCIPARUM DXR IN COMPLEX WITH A BETA-SUBSTITUTED FOSMIDOMYCIN ANALOGUE, LC54 AND MANGANESE
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic, {(2R)-2-{2-[hydroxy(methyl)amino]-2-oxoethyl}-5-[4-(trifluoromethyl)phenyl]pentyl}phosphonic acid, ...
Authors:Sooriyaarachchi, S., Bergfors, T., Jones, T.A., Mowbray, S.L.
Deposit date:2016-04-30
Release date:2016-08-24
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with beta-Arylpropyl Analogues of Fosmidomycin.
Chemmedchem, 11, 2016
5JO0
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STRUCTURE OF PLASMODIUM FALCIPARUM DXR IN COMPLEX WITH A BETA-SUBSTITUTED FOSMIDOMYCIN ANALOGUE, LC56 AND MANGANESE
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic, [(2R)-2-{2-[hydroxy(methyl)amino]-2-oxoethyl}-5-(3-methylphenyl)pentyl]phosphonic acid, ...
Authors:Sooriyaarachchi, S., Bergfors, T., Jones, T.A., Mowbray, S.L.
Deposit date:2016-05-01
Release date:2016-08-24
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with beta-Arylpropyl Analogues of Fosmidomycin.
Chemmedchem, 11, 2016
1YLK
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CRYSTAL STRUCTURE OF RV1284 FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH THIOCYANATE
Descriptor:Hypothetical protein Rv1284/MT1322, ZINC ION, THIOCYANATE ION
Authors:Covarrubias, A.S., Larsson, A.M., Hogbom, M., Lindberg, J., Bergfors, T., Bjorkelid, C., Mowbray, S.L., Unge, T., Jones, T.A., Structural Proteomics in Europe (SPINE)
Deposit date:2005-01-19
Release date:2005-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and function of carbonic anhydrases from Mycobacterium tuberculosis.
J.Biol.Chem., 280, 2005
1YM3
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CRYSTAL STRUCTURE OF CARBONIC ANHYDRASE RV3588C FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE), ZINC ION, MAGNESIUM ION
Authors:Covarrubias, A.S., Larsson, A.M., Hogbom, M., Lindberg, J., Bergfors, T., Bjorkelid, C., Mowbray, S.L., Unge, T., Jones, T.A., Structural Proteomics in Europe (SPINE)
Deposit date:2005-01-20
Release date:2005-03-08
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure and function of carbonic anhydrases from Mycobacterium tuberculosis.
J.Biol.Chem., 280, 2005
2BNG
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STRUCTURE OF AN M.TUBERCULOSIS LEH-LIKE EPOXIDE HYDROLASE
Descriptor:MB2760, CALCIUM ION
Authors:Johansson, P., Arand, M., Unge, T., Bergfors, T., Jones, T.A., Mowbray, S.L.
Deposit date:2005-03-24
Release date:2005-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of an Atypical Epoxide Hydrolase from Mycobacterium Tuberculosis Gives Insights Into its Function.
J.Mol.Biol., 351, 2005
2XWL
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CRYSTAL STRUCTURE OF ISPD FROM MYCOBACTERIUM SMEGMATIS IN COMPLEX WITH CTP AND MG
Descriptor:2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE, MAGNESIUM ION, CYTIDINE-5'-TRIPHOSPHATE
Authors:Bjorkelid, C., Bergfors, T., Unge, T., Jones, T.A.
Deposit date:2010-11-04
Release date:2011-04-27
Last modified:2012-02-01
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Structural and Functional Studies on Mycobacterial Ispd Enzymes
Acta Crystallogr.,Sect.D, 67, 2011
2XWM
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CRYSTAL STRUCTURE OF ISPD FROM MYCOBACTERIUM SMEGMATIS IN COMPLEX WITH CMP
Descriptor:2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE, CYTIDINE-5'-MONOPHOSPHATE
Authors:Bjorkelid, C., Bergfors, T., Unge, T., Jones, T.A.
Deposit date:2010-11-04
Release date:2011-04-27
Last modified:2012-02-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and Functional Studies on Mycobacterial Ispd Enzymes
Acta Crystallogr.,Sect.D, 67, 2011
2XWN
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CRYSTAL STRUCTURE OF ISPD FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH CTP AND MG
Descriptor:2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE, MAGNESIUM ION, CYTIDINE-5'-TRIPHOSPHATE
Authors:Bjorkelid, C., Bergfors, T., Unge, T., Jones, T.A.
Deposit date:2010-11-04
Release date:2011-04-27
Last modified:2012-02-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural and Functional Studies on Mycobacterial Ispd Enzymes
Acta Crystallogr.,Sect.D, 67, 2011
2Y1C
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X-RAY STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, DXR, RV2870C, FROM MYCOBACTERIUM TUBERCULOSIS, IN COMPLEX WITH MANGANESE.
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, MANGANESE (II) ION
Authors:Henriksson, L.M., Larsson, A.M.S., Bergfors, T., Bjorkelid, C., Unge, T., Mowbray, S.L., Jones, T.A.
Deposit date:2010-12-08
Release date:2011-06-29
Last modified:2011-08-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design, Synthesis and X-Ray Crystallographic Studies of Alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium Tuberculosis 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase
J.Med.Chem, 54, 2011
2Y1D
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X-RAY STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, DXR, RV2870C, FROM MYCOBACTERIUM TUBERCULOSIS, IN COMPLEX WITH A 3,4- DICHLOROPHENYL-SUBSTITUTED FOSMIDOMYCIN ANALOGUE AND MANGANESE.
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, (1S)-1-(3,4-DICHLOROPHENYL)-3-[FORMYL(HYDROXY)AMINO]PROPYL}PHOSPHONIC ACID, MANGANESE (II) ION
Authors:Henriksson, L.M., Larsson, A.M.S., Bergfors, T., Bjorkelid, C., Unge, T., Mowbray, S.L., Jones, T.A.
Deposit date:2010-12-08
Release date:2011-06-29
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Design, Synthesis and X-Ray Crystallographic Studies of Alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium Tuberculosis 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase
J.Med.Chem, 54, 2011
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