Author results

5G3J
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DISCOVERY OF NEW SELECTIVE GLUCOCORTICOID RECEPTOR AGONIST LEADS
分子名称:GLUCOCORTICOID RECEPTOR, NUCLEAR RECEPTOR COACTIVATOR 2, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ...
著者Berger, M., Edman, K., Wissler, L., Neuhaus, R., Rehwinkel, H., Schacke, H., Jaroch, S.
登録日2016-04-27
公開日2017-02-15
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Discovery of New Selective Glucocorticoid Receptor Agonist Leads.
Bioorg.Med.Chem.Lett., 27, 2017
5G5W
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STRUCTURE GUIDED DESIGN AND DISCOVERY OF INDAZOLE ETHERS AS HIGHLY POTENT, NON-STEROIDAL GLUCOCORTICOID RECEPTOR MODULATORS
分子名称:GLUCOCORTICOID RECEPTOR, NUCLEAR RECEPTOR COACTIVATOR 2, 1,2-ETHANEDIOL, ...
著者Hemmerling, M., Edman, K., Lepisto, M., Eriksson, A., Ivanova, S., Dahmen, J., Rehwinkel, H., Berger, M., Hendrickx, R., Dearman, M., Jellesmark-Jensen, T., Wissler, L., Hansson, T.
登録日2016-06-08
公開日2017-02-15
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of Indazole Ethers as Novel, Potent, Non-Steroidal Glucocorticoid Receptor Modulators.
Bioorg.Med.Chem.Lett., 26, 2017
2CH5
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CRYSTAL STRUCTURE OF HUMAN N-ACETYLGLUCOSAMINE KINASE IN COMPLEX WITH N-ACETYLGLUCOSAMINE
分子名称:NAGK PROTEIN, N-ACETYL-D-GLUCOSAMINE, GLYCEROL, ...
著者Weihofen, W.A., Berger, M., Chen, H., Saenger, W., Hinderlich, S.
登録日2006-03-13
公開日2006-09-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structures of Human N-Acetylglucosamine Kinase in Two Complexes with N-Acetylglucosamine and with Adp/Glucose: Insights Into Substrate Specificity and Regulation.
J.Mol.Biol., 364, 2006
2CH6
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CRYSTAL STRUCTURE OF HUMAN N-ACETYLGLUCOSAMINE KINASE IN COMPLEX WITH ADP AND GLUCOSE
分子名称:N-ACETYL-D-GLUCOSAMINE KINASE, ADENOSINE-5'-DIPHOSPHATE, ALPHA-D-GLUCOSE
著者Weihofen, W.A., Berger, M., Chen, H., Saenger, W., Hinderlich, S.
登録日2006-03-13
公開日2006-09-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.72 Å)
主引用文献Structures of Human N-Acetylglucosamine Kinase in Two Complexes with N-Acetylglucosamine and with Adp/Glucose: Insights Into Substrate Specificity and Regulation.
J.Mol.Biol., 364, 2006
5IJB
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THE LIGAND-FREE STRUCTURE OF THE MOUSE TLR4/MD-2 COMPLEX
分子名称:Toll-like receptor 4, Variable lymphocyte receptor B chimera, Lymphocyte antigen 96, ...
著者Wang, Y., Su, L., Morin, M.D., Jones, B.T., Whitby, L.R., Surakattula, M., Huang, H., Shi, H., Choi, J.H., Wang, K., Moresco, E.M., Berger, M., Zhan, X., Zhang, H., Boger, D.L., Beutler, B.
登録日2016-03-01
公開日2016-04-27
最終更新日2016-05-04
実験手法X-RAY DIFFRACTION (2.91 Å)
主引用文献TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.
Proc.Natl.Acad.Sci.USA, 113, 2016
5IJC
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THE CRYSTAL STRUCTURE OF MOUSE TLR4/MD-2/NEOSEPTIN-3 COMPLEX
分子名称:Toll-like receptor 4, Variable lymphocyte receptor B chimera, Lymphocyte antigen 96, ...
著者Wang, Y., Su, L., Morin, M.D., Jones, B.T., Whitby, L.R., Surakattula, M., Huang, H., Shi, H., Choi, J.H., Wang, K., Moresco, E.M., Berger, M., Zhan, X., Zhang, H., Boger, D.L., Beutler, B.
登録日2016-03-01
公開日2016-04-27
最終更新日2016-05-04
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.
Proc.Natl.Acad.Sci.USA, 113, 2016
5IJD
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THE CRYSTAL STRUCTURE OF MOUSE TLR4/MD-2/LIPID A COMPLEX
分子名称:Toll-like receptor 4, Variable lymphocyte receptor B chimera, Lymphocyte antigen 96, ...
著者Wang, Y., Su, L., Morin, M.D., Jones, B.T., Whitby, L.R., Surakattula, M., Huang, H., Shi, H., Choi, J.H., Wang, K., Moresco, E.M., Berger, M., Zhan, X., Zhang, H., Boger, D.L., Beutler, B.
登録日2016-03-01
公開日2016-04-27
最終更新日2016-05-04
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.
Proc.Natl.Acad.Sci.USA, 113, 2016
6F99
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SOLUTION STRUCTURE OF THE MRH DOMAIN OF YOS9
分子名称:ER quality-control lectin
著者Kniss, A., Kazemi, S., Lohr, F., Guntert, P., Dotsch, V.
登録日2017-12-14
公開日2019-01-30
実験手法SOLUTION NMR
主引用文献Solution structure of the MRH domain of Yos9
To Be Published
6F9A
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SOLUTION STRUCTURE OF THE MRH DOMAIN OF YOS9 COMPLEXED WITH ALPHA3,ALPHA6-MAN5
分子名称:ER quality-control lectin
著者Kniss, A., Kazemi, S., Lohr, F., Guntert, P., Dotsch, V.
登録日2017-12-14
公開日2019-01-30
実験手法SOLUTION NMR
主引用文献Solution structure of the MRH domain of Yos9 complexed with alpha3,alpha6-Man5
To Be Published
5NFP
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GLUCOCORTICOID RECEPTOR IN COMPLEX WITH BUDESONIDE
分子名称:Glucocorticoid receptor, Nuclear receptor coactivator 2, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ...
著者Edman, K., Wissler, L.
登録日2017-03-15
公開日2017-10-04
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases.
J. Med. Chem., 60, 2017
5NFT
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GLUCOCORTICOID RECEPTOR IN COMPLEX WITH AZD5423
分子名称:Glucocorticoid receptor, Nuclear receptor coactivator 2, 1,2-ETHANEDIOL, ...
著者Edman, K., Wissler, L.
登録日2017-03-15
公開日2017-10-04
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases.
J. Med. Chem., 60, 2017
6EL6
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GLUCOCORTICOID RECEPTOR IN COMPLEX WITH COMPOUND 4
分子名称:Glucocorticoid receptor, Nuclear receptor coactivator 2, 1,2-ETHANEDIOL, ...
著者Edman, K., Wissler, L.
登録日2017-09-28
公開日2018-02-21
最終更新日2018-03-21
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile.
J. Med. Chem., 61, 2018
6EL7
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GLUCOCORTICOID RECEPTOR IN COMPLEX WITH COMPOUND 31
分子名称:Glucocorticoid receptor, Nuclear receptor coactivator 2, 1,2-ETHANEDIOL, ...
著者Edman, K., Wissler, L.
登録日2017-09-28
公開日2018-02-21
最終更新日2018-03-21
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile.
J. Med. Chem., 61, 2018
6EL9
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GLUCOCORTICOID RECEPTOR IN COMPLEX WITH AZD9567
分子名称:Glucocorticoid receptor, Nuclear receptor coactivator 2, 1,2-ETHANEDIOL, ...
著者Edman, K., Wissler, L.
登録日2017-09-28
公開日2018-02-21
最終更新日2018-03-21
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile.
J. Med. Chem., 61, 2018