Author results

2IZ9
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MS2-RNA HAIRPIN (4ONE -5) COMPLEX
Descriptor:MS2 COAT PROTEIN, 5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*U ONEP *AP*CP*CP*CP*AP*UP*GP*U)-3'
Authors:Grahn, E., Stonehouse, N.J., Adams, C.J., Fridborg, K., Beigelman, L., Matulic-Adamic, J., Warriner, S.L., Stockley, P.G., Liljas, L.
Deposit date:2006-07-25
Release date:2006-07-27
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Deletion of a Single Hydrogen Bonding Atom from the MS2 RNA Operator Leads to Dramatic Rearrangements at the RNA-Coat Protein Interface
Nucleic Acids Res., 28, 2000
379D
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THE STRUCTURAL BASIS OF HAMMERHEAD RIBOZYME SELF-CLEAVAGE
Descriptor:RNA (5'-R(*GP*UP*GP*GP*UP*CP*UP*GP*AP*UP*GP*AP*GP*GP*CP*C)-3'), RNA (5'-R(*GP*GP*CP*CP*GP*AP*AP*AP*CP*UP*CP*GP*UP*AP*AP*GP*A P*GP*UP*CP*AP*CP*CP*AP*C)-3'), COBALT (II) ION
Authors:Murray, J.B., Terwey, D.P., Maloney, L., Karpeisky, A., Usman, N., Beigelman, L., Scott, W.G.
Deposit date:1998-02-05
Release date:1998-02-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The structural basis of hammerhead ribozyme self-cleavage.
Cell(Cambridge,Mass.), 92, 1998
1G2J
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RNA OCTAMER R(CCCP*GGGG) CONTAINING PHENYL RIBONUCLEOTIDE
Descriptor:5'-R(*CP*CP*CP*(PYY)P*GP*GP*GP*G)-3', CALCIUM ION
Authors:Minasov, G., Matulic-Adamic, J., Wilds, C.J., Haeberli, P., Usman, N., Beigelman, L., Egli, M.
Deposit date:2000-10-20
Release date:2000-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Crystal structure of an RNA duplex containing phenyl-ribonucleotides, hydrophobic isosteres of the natural pyrimidines.
RNA, 6, 2000
3H98
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CRYSTAL STRUCTURE OF HCV NS5B 1B WITH (1,1-DIOXO-2H-[1,2,4]BENZOTHIADIAZIN-3-YL) AZOLO[1,5-A]PYRIMIDINE DERIVATIVE
Descriptor:RNA-directed RNA polymerase, N-{3-[5-hydroxy-8-(3-methylbutyl)-7-oxo-7,8-dihydroimidazo[1,2-a]pyrimidin-6-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, GLYCEROL
Authors:Wang, G., Lei, H., Wang, X., Das, D., Mackinnon, C., Montalbetti, C.A.G., Mears, R., Gai, X., Bailey, S., Ruhrmund, D., Hooi, L., Misialek, S., Rajagopalan, R., Cheng, R.K.Y., Barker, J.L., Felicetti, B., Stoycheva, A., Buckman, B., Kossen, K., Seiwert, S., Beigelmana, L.
Deposit date:2009-04-30
Release date:2009-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives.
Bioorg.Med.Chem.Lett., 19, 2009
4WXP
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X-RAY CRYSTAL STRUCTURE OF NS3 HELICASE FROM HCV WITH A BOUND FRAGMENT INHIBITOR AT 2.08 A RESOLUTION
Descriptor:NS3-4 protease, SODIUM ION, CHLORIDE ION, ...
Authors:Davies, D.R.
Deposit date:2014-11-14
Release date:2015-12-23
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:crystal structure of NS3 Helicase from HCV with a bound fragment inhibitor
TO BE PUBLISHED
4WXR
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X-RAY CRYSTAL STRUCTURE OF NS3 HELICASE FROM HCV WITH A BOUND INHIBITOR AT 2.42 A RESOLUTION
Descriptor:NS3, {6-(3,5-diaminophenyl)-1-[4-(propan-2-yl)benzyl]-1H-indol-3-yl}acetic acid
Authors:Davies, D.R., Kim, H., Lorimer, D.
Deposit date:2014-11-14
Release date:2015-12-23
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:crystal structure of NS3 Helicase from HCV with a bound inhibitor
TO BE PUBLISHED
4KTC
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NS3/NS4A PROTEASE WITH INHIBITOR
Descriptor:Serine protease NS3, NS4A peptide, ZINC ION, ...
Authors:Zhang, H., Ballard, J., Vigers, G.P.A., Brandhuber, B.J.
Deposit date:2013-05-20
Release date:2013-08-07
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of Danoprevir (ITMN-191/R7227), a Highly Selective and Potent Inhibitor of Hepatitis C Virus (HCV) NS3/4A Protease.
J.Med.Chem., 57, 2014