Author results

2GF7
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DOUBLE TUDOR DOMAIN STRUCTURE
Descriptor:Jumonji domain-containing protein 2A, SULFATE ION
Authors:Huang, Y., Fang, J., Bedford, M.T., Zhang, Y., Xu, R.M.
Deposit date:2006-03-21
Release date:2006-05-02
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A
Science, 312, 2006
2GFA
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DOUBLE TUDOR DOMAIN COMPLEX STRUCTURE
Descriptor:Jumonji domain-containing protein 2A, peptide
Authors:Huang, Y., Fang, J., Bedford, M.T., Zhang, Y., Xu, R.M.
Deposit date:2006-03-21
Release date:2006-05-02
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A
Science, 312, 2006
2JTF
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SOLUTION STRUCTURE OF THE PHF20L1 MBT DOMAIN
Descriptor:PHD finger protein 20-like 1
Authors:Brockmann, C., Iberg, A.N., Rehbein, K., Diehl, A., Bedford, M.T., Oschkinat, H.
Deposit date:2007-07-30
Release date:2008-08-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural Analysis of Histone H4K20 Methyllysine Recognition by the MBT Domain of PHF20L1
To be Published
3HFH
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CRYSTAL STRUCTURE OF TANDEM FF DOMAINS
Descriptor:Transcription elongation regulator 1
Authors:Lu, M., Yang, J., Ren, Z., Subir, S., Bedford, M.T., Jacobson, R.H., McMurray, J.S., Chen, X.
Deposit date:2009-05-11
Release date:2009-08-18
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:Crystal Structure of the Three Tandem FF Domains of the Transcription Elongation Regulator CA150.
J.Mol.Biol., 393, 2009
3QO2
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STRUCTURAL INSIGHTS FOR MPP8 CHROMODOMAIN INTERACTION WITH HISTONE H3 LYSINE 9
Descriptor:M-phase phosphoprotein 8, Histone H3 peptide, 1,2-ETHANEDIOL
Authors:Chang, Y., Horton, J.R., Bedford, M.T., Zhang, X., Cheng, X.
Deposit date:2011-02-09
Release date:2011-04-06
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding.
J.Mol.Biol., 408, 2011
5AFW
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ASSEMBLY OF METHYLATED LSD1 AND CHD1 DRIVES AR-DEPENDENT TRANSCRIPTION AND TRANSLOCATION
Descriptor:CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, 1,2-ETHANEDIOL, ...
Authors:Metzger, E., Willmann, D., McMillan, J., Petroll, K., Metzger, P., Gerhardt, S., vonMaessenhausen, A., Schott, A.K., Espejo, A., Eberlin, A., Wohlwend, D., Schuele, K.M., Schleicher, M., Perner, S., Bedford, M.T., Dengjel, J., Flaig, R., Einsle, O., Schuele, R.
Deposit date:2015-01-26
Release date:2016-01-13
Last modified:2016-03-02
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Assembly of Methylated Kdm1A and Chd1 Drives Androgen Receptor-Dependent Transcription and Translocation.
Nat.Struct.Mol.Biol., 23, 2016
2LDM
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SOLUTION STRUCTURE OF HUMAN PHF20 TUDOR2 DOMAIN BOUND TO A P53 SEGMENT CONTAINING A DIMETHYLLYSINE ANALOG P53K370ME2
Descriptor:Uncharacterized protein
Authors:Cui, G., Botuyan, M., Mer, G.
Deposit date:2011-05-30
Release date:2012-05-30
Last modified:2012-10-03
Method:SOLUTION NMR
Cite:PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.
Nat.Struct.Mol.Biol., 19, 2012
3FPD
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G9A-LIKE PROTEIN LYSINE METHYLTRANSFERASE INHIBITION BY BIX-01294
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Chang, Y., Zhang, X., Horton, J.R., Cheng, X.
Deposit date:2009-01-05
Release date:2009-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294.
Nat.Struct.Mol.Biol., 16, 2009
3MO0
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HUMAN G9A-LIKE (GLP, ALSO KNOWN AS EHMT1) IN COMPLEX WITH INHIBITOR E11
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Chang, Y., Horton, J.R., Cheng, X.
Deposit date:2010-04-22
Release date:2010-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases.
J.Mol.Biol., 400, 2010
3MO2
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HUMAN G9A-LIKE (GLP, ALSO KNOWN AS EHMT1) IN COMPLEX WITH INHIBITOR E67
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, ZINC ION, ...
Authors:Chang, Y., Horton, J.R., Cheng, X.
Deposit date:2010-04-22
Release date:2010-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases.
J.Mol.Biol., 400, 2010
3MO5
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HUMAN G9A-LIKE (GLP, ALSO KNOWN AS EHMT1) IN COMPLEX WITH INHIBITOR E72
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, ZINC ION, ...
Authors:Chang, Y., Horton, J.R., Cheng, X.
Deposit date:2010-04-22
Release date:2010-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases.
J.Mol.Biol., 400, 2010
3P8D
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CRYSTAL STRUCTURE OF THE SECOND TUDOR DOMAIN OF HUMAN PHF20 (HOMODIMER FORM)
Descriptor:Medulloblastoma antigen MU-MB-50.72
Authors:Cui, G., Lee, J., Thompson, J.R., Botuyan, M.V., Mer, G.
Deposit date:2010-10-13
Release date:2011-06-22
Last modified:2012-09-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.
Nat.Struct.Mol.Biol., 19, 2012
3PMT
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CRYSTAL STRUCTURE OF THE TUDOR DOMAIN OF HUMAN TUDOR DOMAIN-CONTAINING PROTEIN 3
Descriptor:Tudor domain-containing protein 3, TETRAETHYLENE GLYCOL
Authors:Lam, R., Bian, C.B., Guo, Y.H., Xu, C., Kania, J., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2010-11-18
Release date:2010-12-01
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of TDRD3 and Methyl-Arginine Binding Characterization of TDRD3, SMN and SPF30.
Plos One, 7, 2012
3S6W
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CRYSTAL STRUCTURE OF TUDOR DOMAIN OF HUMAN TDRD3
Descriptor:Tudor domain-containing protein 3, ISOPROPYL ALCOHOL
Authors:Liu, H.P., Xu, R.M.
Deposit date:2011-05-26
Release date:2012-03-07
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Crystal structure of TDRD3 and methyl-arginine binding characterization of TDRD3, SMN and SPF30
Plos One, 7, 2012
3SD4
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CRYSTAL STRUCTURE OF THE FIRST TUDOR DOMAIN OF HUMAN PHF20
Descriptor:PHD finger protein 20
Authors:Cui, G., Botuyan, M.V., Thompson, J.R., Mer, G.
Deposit date:2011-06-08
Release date:2011-06-22
Last modified:2012-09-26
Method:X-RAY DIFFRACTION (1.928 Å)
Cite:PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.
Nat.Struct.Mol.Biol., 19, 2012
3SVM
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HUMAN MPP8 - HUMAN DNMT3AK47ME2 PEPTIDE
Descriptor:M-phase phosphoprotein 8, DNA (cytosine-5)-methyltransferase 3A
Authors:Chang, Y., Horton, J.R., Zhang, X., Cheng, X.
Deposit date:2011-07-12
Release date:2011-11-30
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a.
Nat Commun, 2, 2011
3SW9
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GLP (G9A-LIKE PROTEIN) SET DOMAIN IN COMPLEX WITH DNMT3AK44ME0 PEPTIDE
Descriptor:Histone-lysine N-methyltransferase EHMT1, DNA (cytosine-5)-methyltransferase 3A, ZINC ION, ...
Authors:Chang, Y., Horton, J.R., Zhang, X., Cheng, X.
Deposit date:2011-07-13
Release date:2011-12-07
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a.
Nat Commun, 2, 2011
3SWC
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GLP (G9A-LIKE PROTEIN) SET DOMAIN IN COMPLEX WITH DNMT3AK44ME2 PEPTIDE
Descriptor:Histone-lysine N-methyltransferase EHMT1, DNA (cytosine-5)-methyltransferase 3A, ZINC ION, ...
Authors:Chang, Y., Horton, J.R., Zhang, X., Cheng, X.
Deposit date:2011-07-13
Release date:2011-11-30
Method:X-RAY DIFFRACTION (2.332 Å)
Cite:MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a.
Nat Commun, 2, 2011
4CRI
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CRYSTAL STRUCTURE OF 53BP1 TANDEM TUDOR DOMAINS IN COMPLEX WITH METHYLATED K810 RB PEPTIDE
Descriptor:TUMOR SUPPRESSOR P53-BINDING PROTEIN 1, RB1 PROTEIN
Authors:Krojer, T., Johansson, C., Gileadi, C., Fedorov, O., Carr, S., La Thangue, N.B., Vollmar, M., Crawley, L., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Oppermann, U.
Deposit date:2014-02-26
Release date:2014-08-06
Last modified:2014-08-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Lysine Methylation-Dependent Binding of 53BP1 to the Prb Tumor Suppressor.
Proc.Natl.Acad.Sci.USA, 111, 2014
4FL6
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CRYSTAL STRUCTURE OF THE COMPLEX OF THE 3-MBT REPEAT DOMAIN OF L3MBTL3 AND UNC1215
Descriptor:Lethal(3)malignant brain tumor-like protein 3, [2-(phenylamino)benzene-1,4-diyl]bis{[4-(pyrrolidin-1-yl)piperidin-1-yl]methanone}, UNKNOWN ATOM OR ION
Authors:Zhong, N., Tempel, W., Ravichandran, M., Dong, A., Ingerman, L.A., Graslund, S., Frye, S.V., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
Deposit date:2012-06-14
Release date:2012-06-27
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain.
Nat. Chem. Biol., 9, 2013
5EPK
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CRYSTAL STRUCTURE OF CHROMODOMAIN OF CBX2 IN COMPLEX WITH INHIBITOR UNC3866
Descriptor:Chromobox protein homolog 2, unc3866, UNKNOWN ATOM OR ION
Authors:Liu, Y., Tempel, W., Walker, J.R., Stuckey, J.I., Dickson, B.M., James, L.I., Frye, S.V., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2015-11-11
Release date:2015-12-23
Last modified:2016-02-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1.
Nat.Chem.Biol., 12, 2016
5EPL
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CRYSTAL STRUCTURE OF CHROMODOMAIN OF CBX4 IN COMPLEX WITH INHIBITOR UNC3866
Descriptor:E3 SUMO-protein ligase CBX4, unc3866, UNKNOWN ATOM OR ION
Authors:Liu, Y., Tempel, W., Walker, J.R., Stuckey, J.I., Dickson, B.M., James, L.I., Frye, S.V., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2015-11-11
Release date:2015-12-23
Last modified:2016-02-24
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1.
Nat.Chem.Biol., 12, 2016
5EQ0
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CRYSTAL STRUCTURE OF CHROMODOMAIN OF CBX8 IN COMPLEX WITH INHIBITOR UNC3866
Descriptor:Chromobox protein homolog 8, unc3866, UNKNOWN ATOM OR ION
Authors:Liu, Y., Tempel, W., Walker, J.R., Stuckey, J.I., Dickson, B.M., James, L.I., Frye, S.V., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2015-11-12
Release date:2015-12-23
Last modified:2016-02-24
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1.
Nat.Chem.Biol., 12, 2016
5JSG
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CRYSTAL STRUCTURE OF SPINDLIN1 BOUND TO COMPOUND EML405
Descriptor:Spindlin-1, [2-(phenylamino)-1,4-phenylene]bis({4-[2-(pyrrolidin-1-yl)ethyl]piperidin-1-yl}methanone), MAGNESIUM ION, ...
Authors:Su, X., Li, H.
Deposit date:2016-05-08
Release date:2017-05-10
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Developing Spindlin1 small-molecule inhibitors by using protein microarrays
Nat. Chem. Biol., 13, 2017
5JSJ
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CRYSTAL STRUCTURE OF SPINDLIN1 BOUND TO COMPOUND EML631
Descriptor:Spindlin-1, [4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]-[4-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]carbonyl-3-[[4-(pyrrolidin-1-ylmethoxy)phenyl]amino]phenyl]methanone, MAGNESIUM ION, ...
Authors:Su, X., Li, H.
Deposit date:2016-05-08
Release date:2017-05-24
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.348 Å)
Cite:Developing Spindlin1 small-molecule inhibitors by using protein microarrays
Nat. Chem. Biol., 13, 2017