Author results

4Q1S
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YEAST 20S PROTEASOME IN COMPLEX WITH KENDOMYCIN
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Beck, P., Heinemeyer, W., Spaeth, A., Elnakady, Y., Mueller, R., Groll, M.
Deposit date:2014-04-04
Release date:2014-07-30
Last modified:2015-02-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Interactions of the natural product kendomycin and the 20S proteasome.
J.Mol.Biol., 426, 2014
4RUR
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YEAST 20S PROTEASOME IN COMPLEX WITH THE ALKALOID INDOLO-PHAKELLIN (4)
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Beck, P., Lansdell, T.A., Hewlett, N.M., Tepe, J.J., Groll, M.
Deposit date:2014-11-21
Release date:2014-12-10
Last modified:2015-03-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Indolo-Phakellins as beta 5-Specific Noncovalent Proteasome Inhibitors.
Angew.Chem.Int.Ed.Engl., 54, 2015
5BOU
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YEAST 20S PROTEASOME IN COMPLEX WITH A BETA1 / BETA2 SPECIFIC NON-PEPTIDIC SULFONAMIDE LIGAND
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Beck, P., Groll, M.
Deposit date:2015-05-27
Release date:2015-08-19
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Identification of a beta 1/ beta 2-Specific Sulfonamide Proteasome Ligand by Crystallographic Screening.
Angew.Chem.Int.Ed.Engl., 54, 2015
5DKI
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YEAST 20S PROTEASOME IN COMPLEX WITH ALKYNE-PI
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Beck, P., Cui, H., Groll, M.
Deposit date:2015-09-03
Release date:2015-10-28
Last modified:2016-01-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Targeted Delivery of Proteasome Inhibitors to Somatostatin-Receptor-Expressing Cancer Cells by Octreotide Conjugation.
Chemmedchem, 10, 2015
5DKJ
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YEAST 20S PROTEASOME IN COMPLEX WITH OCTREOTIDE-PI
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Beck, P., Cui, H., Groll, M.
Deposit date:2015-09-03
Release date:2015-10-28
Last modified:2016-01-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Targeted Delivery of Proteasome Inhibitors to Somatostatin-Receptor-Expressing Cancer Cells by Octreotide Conjugation.
Chemmedchem, 10, 2015
3SHJ
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PROTEASOME IN COMPLEX WITH HYDROXYUREA DERIVATIVE HU10
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Gallastegui, N., Beck, P., Arciniega, M., Hillebrand, S., Huber, R., Groll, M.
Deposit date:2011-06-16
Release date:2011-12-07
Last modified:2012-01-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Hydroxyureas as noncovalent proteasome inhibitors.
Angew.Chem.Int.Ed.Engl., 51, 2012
4FFL
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PYLC IN COMPLEX WITH L-LYSINE
Descriptor:PylC, LYSINE, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Quitterer, F., List, A., Beck, P., Bacher, A., Groll, M.
Deposit date:2012-06-01
Release date:2012-09-19
Last modified:2013-06-12
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Biosynthesis of the 22nd genetically encoded amino acid pyrrolysine: structure and reaction mechanism of PylC at 1.5A resolution.
J.Mol.Biol., 424, 2012
4FFM
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PYLC IN COMPLEX WITH L-LYSINE-NE-D-ORNITHINE (COCRYSTALLIZED WITH L-LYSINE-NE-D-ORNITHINE)
Descriptor:PylC, N~6~-D-ornithyl-L-lysine, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Quitterer, F., List, A., Beck, P., Bacher, A., Groll, M.
Deposit date:2012-06-01
Release date:2012-09-19
Last modified:2013-03-27
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Biosynthesis of the 22nd genetically encoded amino acid pyrrolysine: structure and reaction mechanism of PylC at 1.5A resolution.
J.Mol.Biol., 424, 2012
4FFN
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PYLC IN COMPLEX WITH D-ORNITHINE AND AMPPNP
Descriptor:PylC, D-ORNITHINE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Quitterer, F., List, A., Beck, P., Bacher, A., Groll, M.
Deposit date:2012-06-01
Release date:2012-09-19
Last modified:2013-03-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Biosynthesis of the 22nd genetically encoded amino acid pyrrolysine: structure and reaction mechanism of PylC at 1.5A resolution.
J.Mol.Biol., 424, 2012
4FFO
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PYLC IN COMPLEX WITH PHOSPHORYLATED D-ORNITHINE
Descriptor:PylC, (2R)-2,5-diaminopentanoyl dihydrogen phosphate, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Quitterer, F., List, A., Beck, P., Bacher, A., Groll, M.
Deposit date:2012-06-01
Release date:2012-09-19
Last modified:2013-03-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Biosynthesis of the 22nd genetically encoded amino acid pyrrolysine: structure and reaction mechanism of PylC at 1.5A resolution.
J.Mol.Biol., 424, 2012
4FFP
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PYLC IN COMPLEX WITH L-LYSINE-NE-D-ORNITHINE (COCRYSTALLIZED WITH L-LYSINE AND D-ORNITHINE)
Descriptor:Putative uncharacterized protein, N~6~-D-ornithyl-L-lysine, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Quitterer, F., List, A., Beck, P., Bacher, A., Groll, M.
Deposit date:2012-06-01
Release date:2012-09-19
Last modified:2013-03-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Biosynthesis of the 22nd genetically encoded amino acid pyrrolysine: structure and reaction mechanism of PylC at 1.5A resolution.
J.Mol.Biol., 424, 2012
4FFR
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SEMET-LABELED PYLC (REMOTE)
Descriptor:PylC, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Quitterer, F., List, A., Beck, P., Bacher, A., Groll, M.
Deposit date:2012-06-01
Release date:2012-09-19
Last modified:2013-03-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Biosynthesis of the 22nd genetically encoded amino acid pyrrolysine: structure and reaction mechanism of PylC at 1.5A resolution.
J.Mol.Biol., 424, 2012
4FZC
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20S YEAST PROTEASOME IN COMPLEX WITH CEPAFUNGIN I
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Stein, M., Beck, P., Kaiser, M., Dudler, R., Becker, C.F.W., Groll, M.
Deposit date:2012-07-06
Release date:2012-10-24
Last modified:2012-12-05
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:One-shot NMR analysis of microbial secretions identifies highly potent proteasome inhibitor.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FZG
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20S YEAST PROTEASOME IN COMPLEX WITH GLIDOBACTIN
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Stein, M., Beck, P., Kaiser, M., Dudler, R., Becker, C.F.W., Groll, M.
Deposit date:2012-07-06
Release date:2012-10-24
Last modified:2012-12-05
Method:X-RAY DIFFRACTION (3 Å)
Cite:One-shot NMR analysis of microbial secretions identifies highly potent proteasome inhibitor.
Proc.Natl.Acad.Sci.USA, 109, 2012
4J43
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PYLD HOLOENZYME
Descriptor:PylD, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION, ...
Authors:Quitterer, F., Beck, P., Bacher, A., Groll, M.
Deposit date:2013-02-06
Release date:2013-06-12
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and Reaction Mechanism of Pyrrolysine Synthase (PylD).
Angew.Chem.Int.Ed.Engl., 52, 2013
4J49
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PYLD HOLOENZYME SOAKED WITH L-LYSINE-NE-D-ORNITHINE
Descriptor:PylD, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION, ...
Authors:Quitterer, F., Beck, P., Bacher, A., Groll, M.
Deposit date:2013-02-06
Release date:2013-06-12
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and Reaction Mechanism of Pyrrolysine Synthase (PylD).
Angew.Chem.Int.Ed.Engl., 52, 2013
4J4B
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PYLD IN COMPLEX WITH L-LYSINE-NE-D-ORNITHINE AND NADH
Descriptor:PylD, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, SODIUM ION, ...
Authors:Quitterer, F., Beck, P., Bacher, A., Groll, M.
Deposit date:2013-02-06
Release date:2013-06-12
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and Reaction Mechanism of Pyrrolysine Synthase (PylD).
Angew.Chem.Int.Ed.Engl., 52, 2013
4J4H
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PYLD IN COMPLEX WITH PYRROLINE-CARBOXY-LYSINE AND NADH
Descriptor:PylD, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, N~6~-[(2R)-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]-L-lysine, ...
Authors:Quitterer, F., Beck, P., Bacher, A., Groll, M.
Deposit date:2013-02-06
Release date:2013-06-12
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and Reaction Mechanism of Pyrrolysine Synthase (PylD).
Angew.Chem.Int.Ed.Engl., 52, 2013
4JK3
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PYLD HOLOENZYME (SEMET)
Descriptor:PylD, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION, ...
Authors:Quitterer, F., Beck, P., Bacher, A., Groll, M.
Deposit date:2013-03-09
Release date:2013-06-12
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure and Reaction Mechanism of Pyrrolysine Synthase (PylD).
Angew.Chem.Int.Ed.Engl., 52, 2013
4NNN
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YCP IN COMPLEX WITH MG132
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Stein, M.L., Cui, H., Beck, P., Dubiella, C., Voss, C., Krueger, A., Schmidt, B., Groll, M.
Deposit date:2013-11-18
Release date:2014-02-12
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif.
Angew.Chem.Int.Ed.Engl., 53, 2014
4NNW
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YCP IN COMPLEX WITH Z-LEU-LEU-LEU-KETOALDEHYDE
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Stein, M.L., Cui, H., Beck, P., Dubiella, C., Voss, C., Krueger, A., Schmidt, B., Groll, M.
Deposit date:2013-11-19
Release date:2014-02-12
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif.
Angew.Chem.Int.Ed.Engl., 53, 2014
4NO1
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YCP IN COMPLEX WITH Z-LEU-LEU-LEU-B(OH)2
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Stein, M.L., Cui, H., Beck, P., Dubiella, C., Voss, C., Krueger, A., Schmidt, B., Groll, M.
Deposit date:2013-11-19
Release date:2014-02-12
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif.
Angew.Chem.Int.Ed.Engl., 53, 2014
4NO6
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YCP IN COMPLEX WITH Z-LEU-LEU-LEU-VINYLSULFONE
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Stein, M.L., Cui, H., Beck, P., Dubiella, C., Voss, C., Krueger, A., Schmidt, B., Groll, M.
Deposit date:2013-11-19
Release date:2014-02-12
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (3 Å)
Cite:Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif.
Angew.Chem.Int.Ed.Engl., 53, 2014
4NO8
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YCP IN COMPLEX WITH Z-LEU-LEU-LEU-KETOAMIDE
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Stein, M.L., Cui, H., Beck, P., Dubiella, C., Voss, C., Krueger, A., Schmidt, B., Groll, M.
Deposit date:2013-11-19
Release date:2014-02-12
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif.
Angew.Chem.Int.Ed.Engl., 53, 2014
4NO9
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YCP IN COMPLEX WITH Z-LEU-LEU-LEU-EPOXYKETONE
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Stein, M.L., Cui, H., Beck, P., Dubiella, C., Voss, C., Krueger, A., Schmidt, B., Groll, M.
Deposit date:2013-11-19
Release date:2014-02-12
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif.
Angew.Chem.Int.Ed.Engl., 53, 2014
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