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1G84
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BU of 1g84 by Molmil
THE SOLUTION STRUCTURE OF THE C EPSILON2 DOMAIN FROM IGE
Descriptor: IMMUNOGLOBULIN E
Authors:McDonnell, J.M, Cowburn, D, Gould, H.J, Sutton, B.J, Calvert, R, Beavil, R.E, Beavil, A.J, Henry, A.J.
Deposit date:2000-11-16
Release date:2001-05-16
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:The structure of the IgE Cepsilon2 domain and its role in stabilizing the complex with its high-affinity receptor FcepsilonRIalpha.
Nat.Struct.Biol., 8, 2001
1O0V
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BU of 1o0v by Molmil
The crystal structure of IgE Fc reveals an asymmetrically bent conformation
Descriptor: GLYCEROL, Immunoglobulin heavy chain epsilon-1, SULFATE ION, ...
Authors:Wan, T, Beavil, R.L, Fabiane, S.M, Beavil, A.J, Sohi, M.K, Keown, M, Young, R.J, Henry, A.J, Owens, R.J, Gould, H.J, Sutton, B.J.
Deposit date:2002-09-06
Release date:2002-09-18
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structure of IgE Fc reveals an asymmetrically bent conformation
NAT.IMMUNOL., 3, 2002
5G64
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BU of 5g64 by Molmil
The complex between human IgE-Fc and two anti-IgE Fab fragments
Descriptor: FAB FRAGMENT, IG EPSILON CHAIN C REGION, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Davies, A.M, Allan, E.G, Keeble, A.H, Delgado, J, Cossins, B.P, Mitropoulou, A.N, Pang, M.O.Y, Ceska, T, Beavil, A.J, Craggs, G, Westwood, M, Henry, A.J, McDonnell, J.M, Sutton, B.J.
Deposit date:2016-06-14
Release date:2017-05-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.715 Å)
Cite:Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab.
J. Biol. Chem., 292, 2017
6EYO
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BU of 6eyo by Molmil
Structure of extended IgE-Fc in complex with two anti-IgE Fabs
Descriptor: 8D6 Fab heavy chain, 8D6 Fab light chain, Immunoglobulin heavy constant epsilon, ...
Authors:Chen, J.B, Ramadani, F, Pang, M.O.Y, Beavil, R.L, Holdom, M.D, Mitropoulou, A.N, Beavil, A.J, Gould, H.J, Chang, T.W, Sutton, B.J, McDonnell, J.M, Davies, A.M.
Deposit date:2017-11-13
Release date:2018-08-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody.
Sci Rep, 8, 2018
6EYN
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BU of 6eyn by Molmil
Structure of the 8D6 (anti-IgE) Fab
Descriptor: 1,2-ETHANEDIOL, 8D6 Fab heavy chain, 8D6 Fab light chain, ...
Authors:Chen, J.B, Ramadani, F, Pang, M.O.Y, Beavil, R.L, Holdom, M.D, Mitropoulou, A.N, Beavil, A.J, Gould, H.J, Chang, T.W, Sutton, B.J, McDonnell, J.M, Davies, A.M.
Deposit date:2017-11-13
Release date:2018-08-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody.
Sci Rep, 8, 2018
2WQR
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BU of 2wqr by Molmil
The high resolution crystal structure of IgE Fc
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, IG EPSILON CHAIN C REGION, ...
Authors:Dhaliwal, B, Sutton, B.J, Beavil, A.J.
Deposit date:2009-08-26
Release date:2010-11-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Conformational Changes in Ige Contribute to its Uniquely Slow Dissociation Rate from Receptor Fceri
Nat.Struct.Mol.Biol., 18, 2011
2Y7Q
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THE HIGH-AFFINITY COMPLEX BETWEEN IGE AND ITS RECEPTOR FC EPSILON RI
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR SUBUNIT ALPHA, IG EPSILON CHAIN C REGION, ...
Authors:Davies, A.M, Holdom, M.D, Nettleship, J.E, Beavil, A.J, Owens, R.J, Sutton, B.J.
Deposit date:2011-02-01
Release date:2011-04-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Conformational Changes in Ige Contribute to its Uniquely Slow Dissociation Rate from Receptor Fceri
Nat.Struct.Mol.Biol., 18, 2011
5OTJ
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BU of 5otj by Molmil
Monomeric polcalcin (Phl p 7) in complex with two identical allergen-specific antibodies
Descriptor: 1,2-ETHANEDIOL, 102.1F10 Fab heavy chain, 102.1F10 Fab light chain, ...
Authors:Mitropoulou, A.N, Davies, A.M, Beavil, A.J, McDonnell, J.M, Sutton, B.J.
Deposit date:2017-08-22
Release date:2018-09-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6TCN
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BU of 6tcn by Molmil
Crystal structure of the omalizumab Fab - crystal form II
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Mitropoulou, A.N, Ceska, T, Beavil, A.J, Henry, A.J, McDonnell, J.M, Sutton, B.J, Davies, A.M.
Deposit date:2019-11-06
Release date:2020-03-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization.
Acta Crystallogr.,Sect.F, 76, 2020
6TCP
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BU of 6tcp by Molmil
Crystal structure of the omalizumab Fab Leu158Pro light chain mutant - crystal form II
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, Omalizumab Fab Leu158Pro light chain mutant, ...
Authors:Mitropoulou, A.N, Ceska, T, Beavil, A.J, Henry, A.J, McDonnell, J.M, Sutton, B.J, Davies, A.M.
Deposit date:2019-11-06
Release date:2020-03-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization.
Acta Crystallogr.,Sect.F, 76, 2020
6TCR
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BU of 6tcr by Molmil
Crystal structure of the omalizumab Fab Ser81Arg, Gln83Arg and Leu158Pro light chain mutant
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Omalizumab Fab Ser81Arg, ...
Authors:Mitropoulou, A.N, Ceska, T, Beavil, A.J, Henry, A.J, McDonnell, J.M, Sutton, B.J, Davies, A.M.
Deposit date:2019-11-06
Release date:2020-03-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization.
Acta Crystallogr.,Sect.F, 76, 2020
6TCO
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BU of 6tco by Molmil
Crystal structure of the omalizumab Fab Leu158Pro light chain mutant - crystal form I
Descriptor: 1,2-ETHANEDIOL, Omalizumab Fab Leu158Pro light chain mutant, SULFATE ION
Authors:Mitropoulou, A.N, Ceska, T, Beavil, A.J, Henry, A.J, McDonnell, J.M, Sutton, B.J, Davies, A.M.
Deposit date:2019-11-06
Release date:2020-03-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization.
Acta Crystallogr.,Sect.F, 76, 2020
6TCM
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BU of 6tcm by Molmil
Crystal structure of the omalizumab Fab - crystal form I
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, GLYCEROL, Omalizumab Fab, ...
Authors:Mitropoulou, A.N, Ceska, T, Beavil, A.J, Henry, A.J, McDonnell, J.M, Sutton, B.J, Davies, A.M.
Deposit date:2019-11-06
Release date:2020-03-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization.
Acta Crystallogr.,Sect.F, 76, 2020
6TCS
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BU of 6tcs by Molmil
Crystal structure of the omalizumab scFv
Descriptor: DI(HYDROXYETHYL)ETHER, Omalizumab scFv
Authors:Mitropoulou, A.N, Ceska, T, Beavil, A.J, Henry, A.J, McDonnell, J.M, Sutton, B.J, Davies, A.M.
Deposit date:2019-11-06
Release date:2020-03-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization.
Acta Crystallogr.,Sect.F, 76, 2020
6TCQ
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BU of 6tcq by Molmil
Crystal structure of the omalizumab Fab Ser81Arg and Gln83Arg light chain mutant
Descriptor: GLYCEROL, Omalizumab Fab Ser81Arg and Gln83Arg light chain mutant
Authors:Mitropoulou, A.N, Ceska, T, Beavil, A.J, Henry, A.J, McDonnell, J.M, Sutton, B.J, Davies, A.M.
Deposit date:2019-11-06
Release date:2020-03-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization.
Acta Crystallogr.,Sect.F, 76, 2020
2VUO
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BU of 2vuo by Molmil
Crystal structure of the rabbit IgG Fc fragment
Descriptor: AZIDE ION, FORMIC ACID, GLYCEROL, ...
Authors:Girardi, E, Holdom, M.D, Davies, A.M, Sutton, B.J, Beavil, A.J.
Deposit date:2008-05-27
Release date:2008-09-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The Crystal Structure of Rabbit Igg-Fc.
Biochem.J., 417, 2009
5MOJ
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BU of 5moj by Molmil
Crystal structure of IgE-Fc epsilon 3-4
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Ig epsilon chain C region, ...
Authors:Dore, K.A, Davies, A.M, Drinkwater, N, Beavil, A.J, MacDonnell, J.M, Sutton, B.J.
Deposit date:2016-12-14
Release date:2018-01-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Thermal sensitivity and flexibility of the C epsilon 3 domains in immunoglobulin E.
Biochim. Biophys. Acta, 1865, 2017
5MOI
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Crystal structure of human IgE-Fc epsilon 3-4
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Ig epsilon chain C region, ...
Authors:Dore, K.A, Davies, A.M, Drinkwater, N, Beavil, A.J, McDonnell, J.M, Sutton, B.J.
Deposit date:2016-12-14
Release date:2018-01-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Thermal sensitivity and flexibility of the C epsilon 3 domains in immunoglobulin E.
Biochim. Biophys. Acta, 1865, 2017
5MOL
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BU of 5mol by Molmil
Human IgE-Fc crystal structure
Descriptor: 1,2-ETHANEDIOL, 2-(2-ETHOXYETHOXY)ETHANOL, 2-(2-METHOXYETHOXY)ETHANOL, ...
Authors:Dore, K.A, Davies, A.M, Drinkwater, N, Beavil, A.J, McDonnell, J.M, Sutton, B.J.
Deposit date:2016-12-14
Release date:2018-01-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Thermal sensitivity and flexibility of the C epsilon 3 domains in immunoglobulin E.
Biochim. Biophys. Acta, 1865, 2017
5MOK
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BU of 5mok by Molmil
Crystal structure of human IgE-Fc epsilon 3-4
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Ig epsilon chain C region, ...
Authors:Dore, K.A, Davies, A.M, Drinkwater, N, Beavil, A.J, McDonnell, J.M, Sutton, B.J.
Deposit date:2016-12-14
Release date:2018-01-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Thermal sensitivity and flexibility of the C epsilon 3 domains in immunoglobulin E.
Biochim. Biophys. Acta, 1865, 2017
4KI1
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BU of 4ki1 by Molmil
Primitive triclinic crystal form of the human IgE-Fc(epsilon)3-4 bound to its B cell receptor derCD23
Descriptor: IG EPSILON CHAIN C REGION, LOW AFFINITY IMMUNOGLOBULIN EPSILON FC RECEPTOR, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Dhaliwal, B, Pang, M.O.Y, Sutton, B.J, Beavil, A.J.
Deposit date:2013-05-01
Release date:2014-03-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A range of C3-C4 interdomain angles in IgE Fc accommodate binding to its receptor CD23.
Acta Crystallogr F Struct Biol Commun, 70, 2014
8OJU
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BU of 8oju by Molmil
Crystal structure of the human IgD Fab - structure Fab3
Descriptor: 1,2-ETHANEDIOL, Human IgD Fab heavy chain, Human IgD Fab light chain, ...
Authors:Davies, A.M, Beavil, R.L, McDonnell, J.M.
Deposit date:2023-03-24
Release date:2023-06-14
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structures of the human IgD Fab reveal insights into C H 1 domain diversity.
Mol.Immunol., 159, 2023
8OJV
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BU of 8ojv by Molmil
Crystal structure of the human IgD Fab - structure Fab4
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Davies, A.M, Beavil, R.L, McDonnell, J.M.
Deposit date:2023-03-24
Release date:2023-06-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of the human IgD Fab reveal insights into C H 1 domain diversity.
Mol.Immunol., 159, 2023
8OJS
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BU of 8ojs by Molmil
Crystal structure of the human IgD Fab - structure Fab1
Descriptor: 1,2-ETHANEDIOL, Human IgD Fab heavy chain, Human IgD Fab light chain, ...
Authors:Davies, A.M, Beavil, R.L, McDonnell, J.M.
Deposit date:2023-03-24
Release date:2023-06-14
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal structures of the human IgD Fab reveal insights into C H 1 domain diversity.
Mol.Immunol., 159, 2023
8OJT
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BU of 8ojt by Molmil
Crystal structure of the human IgD Fab - structure Fab2
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, AZIDE ION, ...
Authors:Davies, A.M, Beavil, R.L, McDonnell, J.M.
Deposit date:2023-03-24
Release date:2023-06-14
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structures of the human IgD Fab reveal insights into C H 1 domain diversity.
Mol.Immunol., 159, 2023

 

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