Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
6ZET
DownloadVisualize
BU of 6zet by Molmil
Crystal structure of proteinase K nanocrystals by electron diffraction with a 20 micrometre C2 condenser aperture
Descriptor: CALCIUM ION, Proteinase K
Authors:Evans, G, Zhang, P, Beale, E.V, Waterman, D.G.
Deposit date:2020-06-16
Release date:2020-10-14
Last modified:2024-02-14
Method:ELECTRON CRYSTALLOGRAPHY (2.701 Å)
Cite:A Workflow for Protein Structure Determination From Thin Crystal Lamella by Micro-Electron Diffraction.
Front Mol Biosci, 7, 2020
6ZEV
DownloadVisualize
BU of 6zev by Molmil
Crystal structure of proteinase K lamellae by electron diffraction with a 20 micrometre C2 condenser aperture
Descriptor: CALCIUM ION, Proteinase K
Authors:Evans, G, Zhang, P, Beale, E.V, Waterman, D.G.
Deposit date:2020-06-16
Release date:2020-10-14
Last modified:2024-02-14
Method:ELECTRON CRYSTALLOGRAPHY (2.4 Å)
Cite:A Workflow for Protein Structure Determination From Thin Crystal Lamella by Micro-Electron Diffraction.
Front Mol Biosci, 7, 2020
6ZEU
DownloadVisualize
BU of 6zeu by Molmil
Crystal structure of proteinase K lamella by electron diffraction with a 50 micrometre C2 condenser aperture
Descriptor: CALCIUM ION, Proteinase K
Authors:Evans, G, Zhang, P, Beale, E.V, Waterman, D.G.
Deposit date:2020-06-16
Release date:2020-10-14
Last modified:2024-02-14
Method:ELECTRON CRYSTALLOGRAPHY (2.004 Å)
Cite:A Workflow for Protein Structure Determination From Thin Crystal Lamella by Micro-Electron Diffraction.
Front Mol Biosci, 7, 2020
8OET
DownloadVisualize
BU of 8oet by Molmil
SFX structure of the class II photolyase complexed with a thymine dimer
Descriptor: DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, DNA (14-mer), Deoxyribodipyrimidine photo-lyase, ...
Authors:Lane, T.J, Christou, N.-E, Melo, D.V.M, Apostolopoulou, V, Pateras, A, Mashhour, A.R, Galchenkova, M, Gunther, S, Reinke, P, Kremling, V, Oberthuer, D, Henkel, A, Sprenger, J, Scheer, T.E.S, Lange, E, Yefanov, O.N, Middendorf, P, Sellberg, J.A, Schubert, R, Fadini, A, Cirelli, C, Beale, E.V, Johnson, P, Dworkowski, F, Ozerov, D, Bertrand, Q, Wranik, M, Zitter, E.D, Turk, D, Bajt, S, Chapman, H, Bacellar, C.
Deposit date:2023-03-12
Release date:2023-11-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Time-resolved crystallography captures light-driven DNA repair.
Science, 382, 2023
8OYC
DownloadVisualize
BU of 8oyc by Molmil
Time-resolved SFX structure of the class II photolyase complexed with a thymine dimer (100 microsecond timpeoint)
Descriptor: COUNTERSTRAND-OLIGONUCLEOTIDE, CPD-COMPRISING OLIGONUCLEOTIDE, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ...
Authors:Lane, T.J, Christou, N.-E, Melo, D.V.M, Apostolopoulou, V, Pateras, A, Mashhour, A.R, Galchenkova, M, Gunther, S, Reinke, P, Kremling, V, Oberthuer, D, Henkel, A, Sprenger, J, Scheer, T.E.S, Lange, E, Yefanov, O.N, Middendorf, P, Sellberg, J.A, Schubert, R, Fadini, A, Cirelli, C, Beale, E.V, Johnson, P, Dworkowski, F, Ozerov, D, Bertrand, Q, Wranik, M, Zitter, E.D, Turk, D, Bajt, S, Chapman, H, Bacellar, C.
Deposit date:2023-05-03
Release date:2023-11-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Time-resolved crystallography captures light-driven DNA repair.
Science, 382, 2023
8OY3
DownloadVisualize
BU of 8oy3 by Molmil
Time-resolved SFX structure of the class II photolyase complexed with a thymine dimer (3 picosecond pump-probe delay)
Descriptor: COUNTERSTRAND-OLIGONUCLEOTIDE, CPD-COMPRISING OLIGONUCLEOTIDE, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ...
Authors:Lane, T.J, Christou, N.-E, Melo, D.V.M, Apostolopoulou, V, Pateras, A, Mashhour, A.R, Galchenkova, M, Gunther, S, Reinke, P, Kremling, V, Oberthuer, D, Henkel, A, Sprenger, J, Scheer, T.E.S, Lange, E, Yefanov, O.N, Middendorf, P, Sellberg, J.A, Schubert, R, Fadini, A, Cirelli, C, Beale, E.V, Johnson, P, Dworkowski, F, Ozerov, D, Bertrand, Q, Wranik, M, Zitter, E.D, Turk, D, Bajt, S, Chapman, H, Bacellar, C.
Deposit date:2023-05-03
Release date:2023-11-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Time-resolved crystallography captures light-driven DNA repair.
Science, 382, 2023
8OYA
DownloadVisualize
BU of 8oya by Molmil
Time-resolved SFX structure of the class II photolyase complexed with a thymine dimer (10 microsecond pump probe delay)
Descriptor: COUNTERSTRAND-OLIGONUCLEOTIDE, CPD-COMPRISING OLIGONUCLEOTIDE, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ...
Authors:Lane, T.J, Christou, N.-E, Melo, D.V.M, Apostolopoulou, V, Pateras, A, Mashhour, A.R, Galchenkova, M, Gunther, S, Reinke, P, Kremling, V, Oberthuer, D, Henkel, A, Sprenger, J, Scheer, T.E.S, Lange, E, Yefanov, O.N, Middendorf, P, Sellberg, J.A, Schubert, R, Fadini, A, Cirelli, C, Beale, E.V, Johnson, P, Dworkowski, F, Ozerov, D, Bertrand, Q, Wranik, M, Zitter, E.D, Turk, D, Bajt, S, Chapman, H, Bacellar, C.
Deposit date:2023-05-03
Release date:2023-11-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Time-resolved crystallography captures light-driven DNA repair.
Science, 382, 2023
8OY5
DownloadVisualize
BU of 8oy5 by Molmil
Time-resolved SFX structure of the class II photolyase complexed with a thymine dimer (1 nanosecond pump-probe delay)
Descriptor: COUNTERSTRAND-OLIGONUCLEOTIDE, CPD-COMPRISING OLIGONUCLEOTIDE, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ...
Authors:Lane, T.J, Christou, N.-E, Melo, D.V.M, Apostolopoulou, V, Pateras, A, Mashhour, A.R, Galchenkova, M, Gunther, S, Reinke, P, Kremling, V, Oberthuer, D, Henkel, A, Sprenger, J, Scheer, T.E.S, Lange, E, Yefanov, O.N, Middendorf, P, Sellberg, J.A, Schubert, R, Fadini, A, Cirelli, C, Beale, E.V, Johnson, P, Dworkowski, F, Ozerov, D, Bertrand, Q, Wranik, M, Zitter, E.D, Turk, D, Bajt, S, Chapman, H, Bacellar, C.
Deposit date:2023-05-03
Release date:2023-11-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Time-resolved crystallography captures light-driven DNA repair.
Science, 382, 2023
8OY6
DownloadVisualize
BU of 8oy6 by Molmil
Time-resolved SFX structure of the class II photolyase complexed with a thymine dimer (3 nanosecond pump-probe delay)
Descriptor: COUNTERSTRAND-OLIGONUCLEOTIDE, CPD-COMPRISING OLIGONUCLEOTIDE, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ...
Authors:Lane, T.J, Christou, N.-E, Melo, D.V.M, Apostolopoulou, V, Pateras, A, Mashhour, A.R, Galchenkova, M, Gunther, S, Reinke, P, Kremling, V, Oberthuer, D, Henkel, A, Sprenger, J, Scheer, T.E.S, Lange, E, Yefanov, O.N, Middendorf, P, Sellberg, J.A, Schubert, R, Fadini, A, Cirelli, C, Beale, E.V, Johnson, P, Dworkowski, F, Ozerov, D, Bertrand, Q, Wranik, M, Zitter, E.D, Turk, D, Bajt, S, Chapman, H, Bacellar, C.
Deposit date:2023-05-03
Release date:2023-11-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Time-resolved crystallography captures light-driven DNA repair.
Science, 382, 2023
8OY7
DownloadVisualize
BU of 8oy7 by Molmil
Time-resolved SFX structure of the class II photolyase complexed with a thymine dimer (10 nanosecond pump-probe delay)
Descriptor: COUNTERSTRAND-OLIGONUCLEOTIDE, CPD-COMPRISING OLIGONUCLEOTIDE, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ...
Authors:Lane, T.J, Christou, N.-E, Melo, D.V.M, Apostolopoulou, V, Pateras, A, Mashhour, A.R, Galchenkova, M, Gunther, S, Reinke, P, Kremling, V, Oberthuer, D, Henkel, A, Sprenger, J, Scheer, T.E.S, Lange, E, Yefanov, O.N, Middendorf, P, Sellberg, J.A, Schubert, R, Fadini, A, Cirelli, C, Beale, E.V, Johnson, P, Dworkowski, F, Ozerov, D, Bertrand, Q, Wranik, M, Zitter, E.D, Turk, D, Bajt, S, Chapman, H, Bacellar, C.
Deposit date:2023-05-03
Release date:2023-11-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Time-resolved crystallography captures light-driven DNA repair.
Science, 382, 2023
8OY8
DownloadVisualize
BU of 8oy8 by Molmil
Time-resolved SFX structure of the class II photolyase complexed with a thymine dimer (30 nanosecond timepoint)
Descriptor: COUNTERSTRAND-OLIGONUCLEOTIDE, CPD-COMPRISING OLIGONUCLEOTIDE, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ...
Authors:Lane, T.J, Christou, N.-E, Melo, D.V.M, Apostolopoulou, V, Pateras, A, Mashhour, A.R, Galchenkova, M, Gunther, S, Reinke, P, Kremling, V, Oberthuer, D, Henkel, A, Sprenger, J, Scheer, T.E.S, Lange, E, Yefanov, O.N, Middendorf, P, Sellberg, J.A, Schubert, R, Fadini, A, Cirelli, C, Beale, E.V, Johnson, P, Dworkowski, F, Ozerov, D, Bertrand, Q, Wranik, M, Zitter, E.D, Turk, D, Bajt, S, Chapman, H, Bacellar, C.
Deposit date:2023-05-03
Release date:2023-11-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Time-resolved crystallography captures light-driven DNA repair.
Science, 382, 2023
8OY9
DownloadVisualize
BU of 8oy9 by Molmil
Time-resolved SFX structure of the class II photolyase complexed with a thymine dimer (1 microsecond pump-probe delay)
Descriptor: COUNTERSTRAND-OLIGONUCLEOTIDE, CPD-COMPRISING OLIGONUCLEOTIDE, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ...
Authors:Lane, T.J, Christou, N.-E, Melo, D.V.M, Apostolopoulou, V, Pateras, A, Mashhour, A.R, Galchenkova, M, Gunther, S, Reinke, P, Kremling, V, Oberthuer, D, Henkel, A, Sprenger, J, Scheer, T.E.S, Lange, E, Yefanov, O.N, Middendorf, P, Sellberg, J.A, Schubert, R, Fadini, A, Cirelli, C, Beale, E.V, Johnson, P, Dworkowski, F, Ozerov, D, Bertrand, Q, Wranik, M, Zitter, E.D, Turk, D, Bajt, S, Chapman, H, Bacellar, C.
Deposit date:2023-05-03
Release date:2023-11-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Time-resolved crystallography captures light-driven DNA repair.
Science, 382, 2023
8OYB
DownloadVisualize
BU of 8oyb by Molmil
Time-resolved SFX structure of the class II photolyase complexed with a thymine dimer (30 microsecond pump-probe delay)
Descriptor: COUNTERSTRAND-OLIGONUCLEOTIDE, CPD-COMPRISING OLIGONUCLEOTIDE, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ...
Authors:Lane, T.J, Christou, N.-E, Melo, D.V.M, Apostolopoulou, V, Pateras, A, Mashhour, A.R, Galchenkova, M, Gunther, S, Reinke, P, Kremling, V, Oberthuer, D, Henkel, A, Sprenger, J, Scheer, T.E.S, Lange, E, Yefanov, O.N, Middendorf, P, Sellberg, J.A, Schubert, R, Fadini, A, Cirelli, C, Beale, E.V, Johnson, P, Dworkowski, F, Ozerov, D, Bertrand, Q, Wranik, M, Zitter, E.D, Turk, D, Bajt, S, Chapman, H, Bacellar, C.
Deposit date:2023-05-03
Release date:2023-11-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Time-resolved crystallography captures light-driven DNA repair.
Science, 382, 2023
8OY4
DownloadVisualize
BU of 8oy4 by Molmil
Time-resolved SFX structure of the class II photolyase complexed with a thymine dimer (300 ps pump-probe delay)
Descriptor: COUNTERSTRAND-OLIGONUCLEOTIDE, CPD-COMPRISING OLIGONUCLEOTIDE, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ...
Authors:Lane, T.J, Christou, N.-E, Melo, D.V.M, Apostolopoulou, V, Pateras, A, Mashhour, A.R, Galchenkova, M, Gunther, S, Reinke, P, Kremling, V, Oberthuer, D, Henkel, A, Sprenger, J, Scheer, T.E.S, Lange, E, Yefanov, O.N, Middendorf, P, Sellberg, J.A, Schubert, R, Fadini, A, Cirelli, C, Beale, E.V, Johnson, P, Dworkowski, F, Ozerov, D, Bertrand, Q, Wranik, M, Zitter, E.D, Turk, D, Bajt, S, Chapman, H, Bacellar, C.
Deposit date:2023-05-03
Release date:2023-11-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Time-resolved crystallography captures light-driven DNA repair.
Science, 382, 2023
8C6B
DownloadVisualize
BU of 8c6b by Molmil
Light SFX structure of D.m(6-4)photolyase at 20ps time delay
Descriptor: Cryptochrome-1, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL
Authors:Cellini, A, Kumar, M, Nimmrich, A, Mutisya, J, Furrer, A, Beale, E.V, Carrillo, M, Malla, T.N, Maj, P, Dworkowskic, F, Cirelli, C, Ozerovi, D, Bacellar, C, Strandfuss, J, Weinert, T, Ihalainen, J.A, Yuan Wahlgren, W, Westenhoff, S.
Deposit date:2023-01-11
Release date:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Femtosecond serial crystallography resolves conformational changes which guide long-range electron transfer in a photolyase
To Be Published
8C6A
DownloadVisualize
BU of 8c6a by Molmil
Light SFX structure of D.m(6-4)photolyase at 1ps time delay
Descriptor: Cryptochrome-1, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL
Authors:Cellini, A, Kumar, M, Nimmrich, A, Mutisya, J, Furrer, A, Beale, E.V, Carrillo, M, Malla, T.N, Maj, P, Dworkowskic, F, Cirelli, C, Ozerovi, D, Bacellar, C, Strandfuss, J, Weinert, T, Ihalainen, J.A, Yuan Wahlgren, W, Westenhoff, S.
Deposit date:2023-01-11
Release date:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Femtosecond serial crystallography resolves conformational changes which guide long-range electron transfer in a photolyase
To Be Published
8C69
DownloadVisualize
BU of 8c69 by Molmil
Light SFX structure of D.m(6-4)photolyase at 100 microsecond time delay
Descriptor: Cryptochrome-1, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL
Authors:Cellini, A, Kumar, M, Nimmrich, A, Mutisya, J, Furrer, A, Beale, E.V, Carrillo, M, Malla, T.N, Maj, P, Dworkowskic, F, Cirelli, C, Ozerovi, D, Bacellar, C, Strandfuss, J, Weinert, T, Ihalainen, J.A, Yuan Wahlgren, W, Westenhoff, S.
Deposit date:2023-01-11
Release date:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Femtosecond serial crystallography resolves conformational changes which guide long-range electron transfer in a photolyase
To Be Published
8C6C
DownloadVisualize
BU of 8c6c by Molmil
Light SFX structure of D.m(6-4)photolyase at 300ps time delay
Descriptor: Cryptochrome-1, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL
Authors:Cellini, A, Kumar, M, Nimmrich, A, Mutisya, J, Furrer, A, Beale, E.V, Carrillo, M, Malla, T.N, Maj, P, Dworkowskic, F, Cirelli, C, Ozerovi, D, Bacellar, C, Strandfuss, J, Weinert, T, Ihalainen, J.A, Yuan Wahlgren, W, Westenhoff, S.
Deposit date:2023-01-11
Release date:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Femtosecond serial crystallography resolves conformational changes which guide long-range electron transfer in a photolyase
To Be Published
8C6H
DownloadVisualize
BU of 8c6h by Molmil
Light SFX structure of D.m(6-4)photolyase at 2ps time delay
Descriptor: Cryptochrome-1, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL
Authors:Cellini, A, Kumar, M, Nimmrich, A, Mutisya, J, Furrer, A, Beale, E.V, Carrillo, M, Malla, T.N, Maj, P, Dworkowskic, F, Cirelli, C, Ozerovi, D, Bacellar, C, Strandfuss, J, Weinert, T, Ihalainen, J.A, Yuan Wahlgren, W, Westenhoff, S.
Deposit date:2023-01-11
Release date:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Femtosecond serial crystallography resolves conformational changes which guide long-range electron transfer in a photolyase
To Be Published
8C1U
DownloadVisualize
BU of 8c1u by Molmil
SFX structure of D.m(6-4)photolyase
Descriptor: Cryptochrome-1, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL
Authors:Cellini, A, Kumar, M, Nimmrich, A, Mutisya, J, Furrer, A, Beale, E.V, Carrillo, M, Malla, T.N, Maj, P, Dworkowskic, F, Cirelli, C, Ozerovi, D, Bacellar, C, Strandfuss, J, Weinert, T, Ihalainen, J.A, Yuan Wahlgren, W, Westenhoff, S.
Deposit date:2022-12-21
Release date:2023-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Femtosecond serial crystallography resolves conformational changes which guide long-range electron transfer in a photolyase
To Be Published
8C6F
DownloadVisualize
BU of 8c6f by Molmil
Light SFX structure of D.m(6-4)photolyase at 400fs time delay
Descriptor: Cryptochrome-1, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL
Authors:Cellini, A, Kumar, M, Nimmrich, A, Mutisya, J, Furrer, A, Beale, E.V, Carrillo, M, Malla, T.N, Maj, P, Dworkowskic, F, Cirelli, C, Ozerovi, D, Bacellar, C, Strandfuss, J, Weinert, T, Ihalainen, J.A, Yuan Wahlgren, W, Westenhoff, S.
Deposit date:2023-01-11
Release date:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Femtosecond serial crystallography resolves conformational changes which guide long-range electron transfer in a photolyase
To Be Published
8CL8
DownloadVisualize
BU of 8cl8 by Molmil
Krokinobacter eikastus rhodopsin 2 (KR2) extrapolated map 1us after light activation
Descriptor: EICOSANE, RETINAL, Sodium pumping rhodopsin
Authors:Bertrand, Q, Kepa, M.W, Weinert, T, Wranik, M, Standfuss, J.
Deposit date:2023-02-16
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers.
Nat Commun, 14, 2023
8CLB
DownloadVisualize
BU of 8clb by Molmil
Colchicine bound to tubulin (T2R-TTL) complex
Descriptor: CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Wranik, M, Kepa, M.W, Bertrand, Q, Weinert, T, Steinmetz, M, Standfuss, J.
Deposit date:2023-02-16
Release date:2023-12-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers.
Nat Commun, 14, 2023
8CL6
DownloadVisualize
BU of 8cl6 by Molmil
Lysozyme in matrix of hydroxyethylcellulose (HEC)
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, LYSOZYME, ...
Authors:Bertrand, Q, Kepa, M.W, Weinert, T, Wranik, M, Standfuss, J.
Deposit date:2023-02-16
Release date:2023-12-13
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers.
Nat Commun, 14, 2023
8CLG
DownloadVisualize
BU of 8clg by Molmil
Epothilone A and Colchicine bound to tubulin (T2R-TTL) complex
Descriptor: CALCIUM ION, EPOTHILONE A, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Wranik, M, Bertrand, Q, Kepa, M.W, Weinert, T, Steinmetz, M, Standfuss, J.
Deposit date:2023-02-16
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers.
Nat Commun, 14, 2023

 

12>

218853

PDB entries from 2024-04-24

PDB statisticsPDBj update infoContact PDBjnumon