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4NFO
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BU of 4nfo by Molmil
Crystal Structure Analysis of the 16mer GCAGACUUAAGUCUGC
Descriptor: GCAGACUUAAGUCUGC, SPERMINE
Authors:Beal, P.A, Fisher, A.J, Phelps, K.J, Ibarra-Soza, J.M, Zheng, Y.
Deposit date:2013-10-31
Release date:2014-07-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Click Modification of RNA at Adenosine: Structure and Reactivity of 7-Ethynyl- and 7-Triazolyl-8-aza-7-deazaadenosine in RNA.
Acs Chem.Biol., 9, 2014
4NFP
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BU of 4nfp by Molmil
Crystal Structure Analysis of the 16mer GCAGNCUUAAGUCUGC containing 8-aza-7-deaza-7-ethynyl Adenosine
Descriptor: FORMAMIDE, GCAG(A7E)CUUAAGUCUGC
Authors:Beal, P.A, Fisher, A.J, Phelps, K.J, Ibarra-Soza, J.M, Zheng, Y.
Deposit date:2013-10-31
Release date:2014-07-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Click Modification of RNA at Adenosine: Structure and Reactivity of 7-Ethynyl- and 7-Triazolyl-8-aza-7-deazaadenosine in RNA.
Acs Chem.Biol., 9, 2014
4NFQ
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BU of 4nfq by Molmil
Crystal Structure Analysis of the 16mer GCAGNCUUAAGUCUGC containing 7-triazolyl-8-aza-7-deazaadenosine
Descriptor: GCAG(7AT)CUUAAGUCUGC
Authors:Beal, P.A, Fisher, A.J, Phelps, K.J, Ibarra-Soza, J.M, Zheng, Y.
Deposit date:2013-10-31
Release date:2014-07-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Click Modification of RNA at Adenosine: Structure and Reactivity of 7-Ethynyl- and 7-Triazolyl-8-aza-7-deazaadenosine in RNA.
Acs Chem.Biol., 9, 2014
8E0F
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BU of 8e0f by Molmil
Human Adenosine Deaminase Acting on dsRNA (ADAR2-RD) bound to dsRNA containing a G-G pair adjacent to the target site
Descriptor: Double-stranded RNA-specific editase 1, INOSITOL HEXAKISPHOSPHATE, RNA (5-R(*GP*CP*UP*CP*GP*CP*GP*AP*UP*GP*CP*GP*(8AZ)P*GP*AP*GP*GP*GP*CP* UP*CP*UP*GP*AP*UP*AP*GP*CP*UP*AP*CP*G)-3), ...
Authors:Wilcox, X.E, Fisher, A.J, Beal, P.A.
Deposit date:2022-08-09
Release date:2022-10-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:ADAR activation by inducing a syn conformation at guanosine adjacent to an editing site.
Nucleic Acids Res., 50, 2022
6BGB
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BU of 6bgb by Molmil
Crystal Structure of the 16mer GCAGNCUUAAGUCUGC containing BrPh 7-triazolyl-8-aza-7-deazaadenosine
Descriptor: (5'-R(*GP*CP*AP*GP*(A7C)P*CP*UP*UP*AP*AP*GP*UP*CP*UP*GP*C)-3')
Authors:Fisher, A.J, Beal, P.A, Mumbleau, M.M.
Deposit date:2017-10-27
Release date:2017-12-06
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Controlling miRNA-like off-target effects of an siRNA with nucleobase modifications.
Org. Biomol. Chem., 15, 2017
6D06
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BU of 6d06 by Molmil
Human ADAR2d E488Y mutant complexed with dsRNA containing an abasic site opposite the edited base
Descriptor: Double-stranded RNA-specific editase 1, INOSITOL HEXAKISPHOSPHATE, RNA (5'-R(*CP*AP*GP*AP*GP*CP*CP*CP*CP*CP*NP*AP*GP*CP*AP*UP*CP*GP*CP*GP*AP*GP*C)-3'), ...
Authors:Matthews, M.M, Fisher, A.J, Beal, P.A.
Deposit date:2018-04-10
Release date:2019-02-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:A Bump-Hole Approach for Directed RNA Editing.
Cell Chem Biol, 26, 2019
6VFF
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BU of 6vff by Molmil
Dimer of Human Adenosine Deaminase Acting on dsRNA (ADAR2) mutant E488Q bound to dsRNA sequence derived from human GLI1 gene
Descriptor: Double-stranded RNA-specific editase 1, INOSITOL HEXAKISPHOSPHATE, RNA (5-R(*GP*CP*UP*CP*GP*CP*GP*AP*UP*GP*CP*UP*(8AZ)P*GP*AP*GP*GP*GP*CP* UP*CP*UP*GP*AP*UP*AP*GP*CP*UP*AP*CP*G)-3), ...
Authors:Thuy-boun, A.S, Fisher, A.J, Beal, P.A.
Deposit date:2020-01-03
Release date:2020-07-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition.
Nucleic Acids Res., 48, 2020
5ED1
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BU of 5ed1 by Molmil
Human Adenosine Deaminase Acting on dsRNA (ADAR2) mutant E488Q bound to dsRNA sequence derived from S. cerevisiae BDF2 gene
Descriptor: Double-stranded RNA-specific editase 1, INOSITOL HEXAKISPHOSPHATE, RNA (5'-R(*GP*AP*CP*UP*GP*AP*AP*CP*GP*AP*CP*CP*AP*AP*UP*GP*UP*GP*GP*GP*GP*AP*A)-3'), ...
Authors:Matthews, M.M, Fisher, A.J, Beal, P.A.
Deposit date:2015-10-20
Release date:2016-04-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity.
Nat.Struct.Mol.Biol., 23, 2016
5HP2
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BU of 5hp2 by Molmil
Human Adenosine Deaminase Acting on dsRNA (ADAR2) bound to dsRNA sequence derived from S. cerevisiae BDF2 gene with AU basepair at reaction site
Descriptor: Double-stranded RNA-specific editase 1, INOSITOL HEXAKISPHOSPHATE, RNA (5'-R(*GP*AP*CP*UP*GP*AP*AP*CP*GP*AP*CP*UP*AP*AP*UP*GP*UP*GP*GP*GP*GP*AP*A)-3'), ...
Authors:Matthews, M.M, Fisher, A.J, Beal, P.A.
Deposit date:2016-01-20
Release date:2016-04-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.983 Å)
Cite:Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity.
Nat.Struct.Mol.Biol., 23, 2016
5HP3
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BU of 5hp3 by Molmil
Human Adenosine Deaminase Acting on dsRNA (ADAR2) bound to dsRNA sequence derived from S. cerevisiae BDF2 gene with AC mismatch at reaction site
Descriptor: Double-stranded RNA-specific editase 1, INOSITOL HEXAKISPHOSPHATE, RNA (5'-R(*GP*AP*CP*UP*GP*AP*AP*CP*GP*AP*CP*CP*AP*AP*UP*GP*UP*GP*GP*GP*GP*AP*A)-3'), ...
Authors:Matthews, M.M, Fisher, A.J, Beal, P.A.
Deposit date:2016-01-20
Release date:2016-04-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.091 Å)
Cite:Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity.
Nat.Struct.Mol.Biol., 23, 2016
6YRF
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BU of 6yrf by Molmil
Vip3Bc1 tetramer
Descriptor: Vegetative insecticidal protein
Authors:Thompson, R.F, Byrne, M.J, Iadanza, M.I, Arribas Perez, M, Maskell, D.P, George, R.M, Hesketh, E.L, Beales, P.A, Zack, M.D, Berry, C.
Deposit date:2020-04-20
Release date:2021-03-17
Last modified:2021-05-26
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structures of an insecticidal Bt toxin reveal its mechanism of action on the membrane.
Nat Commun, 12, 2021
7KFN
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BU of 7kfn by Molmil
Structure of Human Adenosine Deaminase Acting on dsRNA (ADAR2) bound to dsRNA containing a 2'-deoxy Benner's Base Z opposite the edited base
Descriptor: Double-stranded RNA-specific editase 1, Gli1 1W5 23mer RNA, Gli1 8AZ 23mer RNA, ...
Authors:Wilcox, X.E, Fisher, A.J, Beal, P.A.
Deposit date:2020-10-14
Release date:2021-06-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Rational Design of RNA Editing Guide Strands: Cytidine Analogs at the Orphan Position.
J.Am.Chem.Soc., 143, 2021
8E4X
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BU of 8e4x by Molmil
Human Adenosine Deaminase Acting on dsRNA (ADAR2-R2D) bound to dsRNA containing a G:3-deaza dA pair adjacent to the target site
Descriptor: Double-stranded RNA-specific editase 1, INOSITOL HEXAKISPHOSPHATE, RNA (5-R(*GP*CP*UP*CP*GP*CP*GP*AP*UP*GP*CP*GP*(8AZ)P*GP*AP*GP*GP*GP*CP* UP*CP*UP*GP*AP*UP*AP*GP*CP*UP*AP*CP*G)-3), ...
Authors:Fisher, A.J, Mendoza, H.G.
Deposit date:2022-08-19
Release date:2022-10-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:ADAR activation by inducing a syn conformation at guanosine adjacent to an editing site.
Nucleic Acids Res., 50, 2022
4X4T
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BU of 4x4t by Molmil
Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a G70A arginyl-tRNA minihelix ending in CCACCA
Descriptor: CCA-adding enzyme, DI(HYDROXYETHYL)ETHER, G70A tRNA minihelix ending in CCACCA, ...
Authors:Kuhn, C.-D, Joshua-Tor, L.
Deposit date:2014-12-03
Release date:2015-02-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:On-Enzyme Refolding Permits Small RNA and tRNA Surveillance by the CCA-Adding Enzyme.
Cell, 160, 2015
4X4Q
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BU of 4x4q by Molmil
Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a G70A arginyl-tRNA minihelix ending in CCAC and CTP
Descriptor: CCA-adding enzyme, CYTIDINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ...
Authors:Kuhn, C.-D, Joshua-Tor, L.
Deposit date:2014-12-03
Release date:2015-02-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:On-Enzyme Refolding Permits Small RNA and tRNA Surveillance by the CCA-Adding Enzyme.
Cell, 160, 2015
6VPC
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BU of 6vpc by Molmil
Structure of the SpCas9 DNA adenine base editor - ABE8e
Descriptor: CRISPR-associated endonuclease Cas9, Cas9 (SpCas9) single-guide RNA (sgRNA), DNA non-target strand (NTS), ...
Authors:Knott, G.J, Lapinaite, A, Doudna, J.A.
Deposit date:2020-02-03
Release date:2020-07-29
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:DNA capture by a CRISPR-Cas9-guided adenine base editor.
Science, 369, 2020
5ED2
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BU of 5ed2 by Molmil
Human Adenosine Deaminase Acting on dsRNA (ADAR2) mutant E488Q bound to dsRNA sequence derived from human GLI1 gene
Descriptor: Double-stranded RNA-specific editase 1, INOSITOL HEXAKISPHOSPHATE, RNA (5'-R(P*CP*AP*GP*AP*GP*CP*CP*CP*CP*CP*CP*AP*GP*CP*AP*UP*CP*GP*CP*GP*AP*GP*C)-3'), ...
Authors:Matthews, M.M, Fisher, A.J.
Deposit date:2015-10-20
Release date:2016-04-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity.
Nat.Struct.Mol.Biol., 23, 2016
5KI6
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BU of 5ki6 by Molmil
Human Argonaute-2 bound to a guide RNA with a nucleobase modification at position 1
Descriptor: PHENOL, Protein argonaute-2, miR-122
Authors:Schirle, N.T, MacRae, I.J.
Deposit date:2016-06-16
Release date:2016-07-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.153 Å)
Cite:Structure-Guided Control of siRNA Off-Target Effects.
J.Am.Chem.Soc., 138, 2016
6YRG
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BU of 6yrg by Molmil
Vip3Bc1 tetramer in processed, activated state
Descriptor: Vegetative insecticidal protein
Authors:Thompson, R.F, Byrne, M.J, Iadanza, M.I.
Deposit date:2020-04-20
Release date:2021-03-17
Last modified:2021-05-26
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Cryo-EM structures of an insecticidal Bt toxin reveal its mechanism of action on the membrane.
Nat Commun, 12, 2021
7NTX
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BU of 7ntx by Molmil
Vip3Bc1 tetramer in processed, activated state
Descriptor: Vegetative insecticidal protein
Authors:Thompson, R.F, Byrne, M.J, Iadanza, M.I.
Deposit date:2021-03-11
Release date:2021-04-14
Last modified:2021-05-26
Method:ELECTRON MICROSCOPY (4.75 Å)
Cite:Cryo-EM structures of an insecticidal Bt toxin reveal its mechanism of action on the membrane.
Nat Commun, 12, 2021
4X4P
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BU of 4x4p by Molmil
Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a G70A arginyl-tRNA minihelix ending in CCAC
Descriptor: CCA-adding enzyme, G70A tRNA minihelix ending in CCAC, SULFATE ION
Authors:Kuhn, C.-D, Joshua-Tor, L.
Deposit date:2014-12-03
Release date:2015-02-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:On-Enzyme Refolding Permits Small RNA and tRNA Surveillance by the CCA-Adding Enzyme.
Cell, 160, 2015
4X4O
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BU of 4x4o by Molmil
Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a G70A arginyl-tRNA minihelix and CTP
Descriptor: CCA-adding enzyme, CYTIDINE-5'-TRIPHOSPHATE, G70A tRNA minihelix, ...
Authors:Kuhn, C.-D, Joshua-Tor, L.
Deposit date:2014-12-03
Release date:2015-02-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.201 Å)
Cite:On-Enzyme Refolding Permits Small RNA and tRNA Surveillance by the CCA-Adding Enzyme.
Cell, 160, 2015
4X4S
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BU of 4x4s by Molmil
Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a G70A arginyl-tRNA minihelix ending in CCACC and CTP
Descriptor: CCA-adding enzyme, CYTIDINE-5'-TRIPHOSPHATE, D(-)-TARTARIC ACID, ...
Authors:Kuhn, C.-D, Joshua-Tor, L.
Deposit date:2014-12-03
Release date:2015-02-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:On-enzyme refolding permits small RNA and tRNA surveillance by the CCA-adding enzyme.
Cell, 160, 2015
4X4U
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BU of 4x4u by Molmil
Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a human MenBeta minihelix ending in CCACC
Descriptor: CCA-adding enzyme, DI(HYDROXYETHYL)ETHER, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ...
Authors:Kuhn, C.-D, Joshua-Tor, L.
Deposit date:2014-12-03
Release date:2015-02-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:On-Enzyme Refolding Permits Small RNA and tRNA Surveillance by the CCA-Adding Enzyme.
Cell, 160, 2015
4X4V
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BU of 4x4v by Molmil
Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a human MenBeta minihelix ending in CCACC and AMPcPP
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CCA-adding enzyme, D(-)-TARTARIC ACID, ...
Authors:Kuhn, C.-D, Joshua-Tor, L.
Deposit date:2014-12-03
Release date:2015-02-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:On-Enzyme Refolding Permits Small RNA and tRNA Surveillance by the CCA-Adding Enzyme.
Cell, 160, 2015

 

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