Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
1GYB
DownloadVisualize
BU of 1gyb by Molmil
N77Y point mutant of yNTF2 bound to FxFG nucleoporin repeat
Descriptor: NUCLEAR TRANSPORT FACTOR 2, NUCLEOPORIN
Authors:Bayliss, R, Stewart, M.
Deposit date:2002-04-22
Release date:2002-06-20
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis for the Interaction between Ntf2 and Nucleoporin Fxfg Repeats
Embo J., 21, 2002
1GY5
DownloadVisualize
BU of 1gy5 by Molmil
D92N,D94N double point mutant of human Nuclear Transport Factor 2 (NTF2)
Descriptor: NUCLEAR TRANSPORT FACTOR 2
Authors:Bayliss, R, Stewart, M.
Deposit date:2002-04-21
Release date:2002-06-20
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for the Interaction between Ntf2 and Nucleoporin Fxfg Repeats
Embo J., 21, 2002
1GY7
DownloadVisualize
BU of 1gy7 by Molmil
N77Y point mutant of S.Cerevisiae NTF2
Descriptor: NUCLEAR TRANSPORT FACTOR 2
Authors:Bayliss, R, Quimby, B.B, Corbett, A, Stewart, M.
Deposit date:2002-04-21
Release date:2002-06-20
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Basis for the Interaction between Ntf2 and Nucleoporin Fxfg Repeats
Embo J., 21, 2002
1GY6
DownloadVisualize
BU of 1gy6 by Molmil
NTF2 from rat, ammonium sulphate conditions
Descriptor: NUCLEAR TRANSPORT FACTOR 2
Authors:Bayliss, R, Stewart, M.
Deposit date:2002-04-21
Release date:2002-06-20
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Basis for the Interaction between Ntf2 and Nucleoporin Fxfg Repeats
Embo J., 21, 2002
1F59
DownloadVisualize
BU of 1f59 by Molmil
IMPORTIN-BETA-FXFG NUCLEOPORIN COMPLEX
Descriptor: FXFG NUCLEOPORIN REPEATS, IMPORTIN BETA-1
Authors:Bayliss, R, Littlewood, T, Stewart, M.
Deposit date:2000-06-13
Release date:2000-08-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking.
Cell(Cambridge,Mass.), 102, 2000
1O6P
DownloadVisualize
BU of 1o6p by Molmil
Importin Beta bound to a GLFG Nucleoporin peptide
Descriptor: IMPORTIN BETA-1 SUBUNIT, SYNTHETIC GLFG PEPTIDE
Authors:Bayliss, R, Stewart, M.
Deposit date:2002-10-10
Release date:2003-04-24
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Glfg and Fxfg Nucleoporins Bind to Overlapping Sites on Importin-Beta
J.Biol.Chem., 277, 2002
1O6O
DownloadVisualize
BU of 1o6o by Molmil
Importin Beta aa1-442 bound to five FxFG repeats from yeast Nsp1p. Second crystal form
Descriptor: IMPORTIN BETA-1 SUBUNIT, NUCLEOPORIN NSP1
Authors:Bayliss, R, Stewart, M.
Deposit date:2002-10-10
Release date:2003-10-17
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Glfg and Fxfg Nucleoporins Bind to Overlapping Sites on Importin-Beta
J.Biol.Chem., 277, 2002
1OL7
DownloadVisualize
BU of 1ol7 by Molmil
Structure of Human Aurora-A 122-403 phosphorylated on Thr287, Thr288
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, SERINE/THREONINE KINASE 6
Authors:Bayliss, R, Conti, E.
Deposit date:2003-08-06
Release date:2003-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural Basis of Aurora-A Activation by Tpx2 at the Mitotic Spindle
Mol.Cell, 12, 2003
1OL5
DownloadVisualize
BU of 1ol5 by Molmil
Structure of Aurora-A 122-403, phosphorylated on Thr287, Thr288 and bound to TPX2 1-43
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RESTRICTED EXPRESSION PROLIFERATION ASSOCIATED PROTEIN 100, ...
Authors:Bayliss, R, Conti, E.
Deposit date:2003-08-06
Release date:2003-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis of Aurora-A Activation by Tpx2 at the Mitotic Spindle
Mol.Cell, 12, 2003
1OL6
DownloadVisualize
BU of 1ol6 by Molmil
Structure of unphosphorylated D274N mutant of Aurora-A
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, SERINE/THREONINE KINASE 6
Authors:Bayliss, R, Conti, E.
Deposit date:2003-08-06
Release date:2003-10-30
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Basis of Aurora-A Activation by Tpx2 at the Mitotic Spindle.
Mol.Cell, 12, 2003
1QMA
DownloadVisualize
BU of 1qma by Molmil
Nuclear Transport Factor 2 (NTF2) W7A mutant
Descriptor: NUCLEAR TRANSPORT FACTOR 2
Authors:Bayliss, R, Ribbeck, K, Akin, D, Kent, H.M, Feldherr, C.M, Gorlich, D, Stewart, M.J.
Deposit date:1999-09-23
Release date:2000-02-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Interaction Betweeen Ntf2 and Xfxfg-Containing Nucleoporins is Required to Mediate Nuclear Import of Ran-Gdp
J.Mol.Biol., 293, 1999
2OFQ
DownloadVisualize
BU of 2ofq by Molmil
NMR Solution Structure of a complex between the VirB9/VirB7 interaction domains of the pKM101 type IV secretion system
Descriptor: TraN, TraO
Authors:Harris, R, Bayliss, R, Driscoll, P.C, Waksman, G.
Deposit date:2007-01-04
Release date:2007-01-23
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:NMR structure of a complex between the VirB9/VirB7 interaction domains of the pKM101 type IV secretion system
Proc.Natl.Acad.Sci.Usa, 104, 2007
2BHM
DownloadVisualize
BU of 2bhm by Molmil
Crystal structure of VirB8 from Brucella suis
Descriptor: TYPE IV SECRETION SYSTEM PROTEIN VIRB8
Authors:Bayliss, R, Baron, C, Waksman, G.
Deposit date:2005-01-14
Release date:2005-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of Two Core Subunits of the Bacterial Type Iv Secretion System, Virb8 from Brucella Suis and Comb10 from Helicobacter Pylori
Proc.Natl.Acad.Sci.USA, 102, 2005
4Z7G
DownloadVisualize
BU of 4z7g by Molmil
Crystal structure of human IRE1 cytoplasmic kinase-RNase region - apo
Descriptor: SODIUM ION, Serine/threonine-protein kinase/endoribonuclease IRE1
Authors:Bayliss, R, Joshi, A.
Deposit date:2015-04-07
Release date:2015-05-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular mechanisms of human IRE1 activation through dimerization and ligand binding.
Oncotarget, 6, 2015
6R4C
DownloadVisualize
BU of 6r4c by Molmil
Aurora-A in complex with shape-diverse fragment 57
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, CHLORIDE ION, ...
Authors:Bayliss, R, McIntyre, P.J.
Deposit date:2019-03-22
Release date:2019-05-01
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Construction of a Shape-Diverse Fragment Set: Design, Synthesis and Screen against Aurora-A Kinase.
Chemistry, 25, 2019
6R4A
DownloadVisualize
BU of 6r4a by Molmil
Aurora-A in complex with shape-diverse fragment 55
Descriptor: 2-(benzimidazol-1-yl)-~{N}-(2-phenylethyl)ethanamide, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:Bayliss, R, McIntyre, P.J.
Deposit date:2019-03-22
Release date:2019-05-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.937 Å)
Cite:Construction of a Shape-Diverse Fragment Set: Design, Synthesis and Screen against Aurora-A Kinase.
Chemistry, 25, 2019
6R4D
DownloadVisualize
BU of 6r4d by Molmil
Aurora-A in complex with shape-diverse fragment 58
Descriptor: (1~{S},10~{S})-12-cyclobutyl-5-methyl-1-oxidanyl-10-propan-2-yl-9,12-diazatricyclo[8.2.1.0^{2,7}]trideca-2(7),3,5-trien-11-one, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:Bayliss, R, McIntyre, P.J.
Deposit date:2019-03-22
Release date:2019-05-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.009 Å)
Cite:Construction of a Shape-Diverse Fragment Set: Design, Synthesis and Screen against Aurora-A Kinase.
Chemistry, 25, 2019
6R4B
DownloadVisualize
BU of 6r4b by Molmil
Aurora-A in complex with shape-diverse fragment 56
Descriptor: (6~{S})-6-[2,4-bis(fluoranyl)phenyl]-~{N},~{N},4-trimethyl-2-oxidanylidene-5,6-dihydro-1~{H}-pyrimidine-5-carboxamide, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:Bayliss, R, McIntyre, P.J.
Deposit date:2019-03-22
Release date:2019-05-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Construction of a Shape-Diverse Fragment Set: Design, Synthesis and Screen against Aurora-A Kinase.
Chemistry, 25, 2019
6R49
DownloadVisualize
BU of 6r49 by Molmil
Aurora-A in complex with shape-diverse fragment 39
Descriptor: (1~{S},10~{S})-12-cyclopropyl-1-oxidanyl-10-propan-2-yl-9,12-diazatricyclo[8.2.1.0^{2,7}]trideca-2(7),3,5-trien-11-one, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:Bayliss, R, McIntyre, P.J.
Deposit date:2019-03-22
Release date:2019-05-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.209 Å)
Cite:Construction of a Shape-Diverse Fragment Set: Design, Synthesis and Screen against Aurora-A Kinase.
Chemistry, 25, 2019
6HV0
DownloadVisualize
BU of 6hv0 by Molmil
IRE1 kinase/RNase in complex with imidazo[1,2-b]pyridazin-8-amine compound 33
Descriptor: 6-chloranyl-3-(2~{H}-indazol-5-yl)-~{N}-propan-2-yl-imidazo[1,2-b]pyridazin-8-amine, Serine/threonine-protein kinase/endoribonuclease IRE1
Authors:Bayliss, R, Bhatia, C, Collins, I.
Deposit date:2018-10-09
Release date:2019-02-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1 alpha Kinase-Endoribonuclease.
J.Med.Chem., 62, 2019
6SK9
DownloadVisualize
BU of 6sk9 by Molmil
Nek2 bound to purine compound 51
Descriptor: 3-[[6-(cyclohexylmethoxy)-7~{H}-purin-2-yl]amino]-~{N}-[3-(dimethylamino)propyl]benzenesulfonamide, GLYCEROL, Serine/threonine-protein kinase Nek2
Authors:Bayliss, R, Byrne, M.J, Mas-Droux, C.
Deposit date:2019-08-15
Release date:2020-06-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine.
Biochem.J., 477, 2020
6HJK
DownloadVisualize
BU of 6hjk by Molmil
Crystal Structure of Aurora-A L210C catalytic domain in complex with ASDO2
Descriptor: (~{E})-~{N}-[4-(4-azanyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl]-4-[4-fluoranyl-3-(trifluoromethyl)phenyl]-4-oxidanylidene-but-2-enamide, Aurora kinase A, CHLORIDE ION, ...
Authors:Bayliss, R, McIntyre, P.J.
Deposit date:2018-09-04
Release date:2018-10-03
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Type II Kinase Inhibitors Targeting Cys-Gatekeeper Kinases Display Orthogonality with Wild Type and Ala/Gly-Gatekeeper Kinases.
ACS Chem. Biol., 13, 2018
6HJJ
DownloadVisualize
BU of 6hjj by Molmil
Crystal structure of Aurora-A L210C catalytic domain in complex with ASDO6 ligand
Descriptor: 2,5,8,11-TETRAOXATRIDECANE, ACETATE ION, Aurora kinase A, ...
Authors:Bayliss, R, McIntyre, P.J.
Deposit date:2018-09-04
Release date:2018-10-03
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Type II Kinase Inhibitors Targeting Cys-Gatekeeper Kinases Display Orthogonality with Wild Type and Ala/Gly-Gatekeeper Kinases.
ACS Chem. Biol., 13, 2018
5M55
DownloadVisualize
BU of 5m55 by Molmil
Nek2 bound to arylaminopurine 71
Descriptor: 6-[(~{Z})-2-(diethylamino)ethenyl]-~{N}-phenyl-7~{H}-purin-2-amine, CHLORIDE ION, SULFATE ION, ...
Authors:Bayliss, R.
Deposit date:2016-10-20
Release date:2016-11-02
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure-guided design of purine-based probes for selective Nek2 inhibition.
Oncotarget, 8, 2017
5M51
DownloadVisualize
BU of 5m51 by Molmil
Nek2 bound to arylaminopurine compound 8
Descriptor: 3-[[6-(cyclohexylmethoxy)-9~{H}-purin-2-yl]amino]benzamide, Serine/threonine-protein kinase Nek2
Authors:Bayliss, R, Yeoh, S.
Deposit date:2016-10-20
Release date:2016-11-09
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:Structure-guided design of purine-based probes for selective Nek2 inhibition.
Oncotarget, 8, 2017

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon