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1YKE
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STRUCTURE OF THE MEDIATOR MED7/MED21 SUBCOMPLEX
分子名称:RNA polymerase II mediator complex protein MED7, RNA polymerase II holoenzyme component SRB7
著者Baumli, S., Hoeppner, S., Cramer, P.
登録日2005-01-18
公開日2005-02-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献A conserved mediator hinge revealed in the structure of the MED7.MED21 (Med7.Srb7) heterodimer.
J.Biol.Chem., 280, 2005
1YKH
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STRUCTURE OF THE MEDIATOR MED7/MED21 (MED7/SRB7) SUBCOMPLEX
分子名称:RNA polymerase II mediator complex protein MED7, RNA polymerase II holoenzyme component SRB7
著者Baumli, S., Hoeppner, S., Cramer, P.
登録日2005-01-18
公開日2005-02-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献A conserved mediator hinge revealed in the structure of the MED7.MED21 (Med7.Srb7) heterodimer.
J.Biol.Chem., 280, 2005
3BLH
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CRYSTAL STRUCTURE OF HUMAN CDK9/CYCLINT1
分子名称:Cell division protein kinase 9, Cyclin-T1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
著者Baumli, S., Lolli, G., Lowe, E.D., Johnson, L.N.
登録日2007-12-11
公開日2008-07-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation
Embo J., 27, 2008
3BLQ
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CRYSTAL STRUCTURE OF HUMAN CDK9/CYCLINT1 IN COMPLEX WITH ATP
分子名称:Cell division protein kinase 9, Cyclin-T1, MAGNESIUM ION, ...
著者Baumli, S., Lolli, G., Lowe, E.D., Johnson, L.N.
登録日2007-12-11
公開日2008-07-01
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation
Embo J., 27, 2008
3BLR
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CRYSTAL STRUCTURE OF HUMAN CDK9/CYCLINT1 IN COMPLEX WITH FLAVOPIRIDOL
分子名称:Cell division protein kinase 9, Cyclin-T1, PHOSPHATE ION, ...
著者Baumli, S., Lolli, G., Lowe, E.D., Johnson, L.N.
登録日2007-12-11
公開日2008-07-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation
Embo J., 27, 2008
3MY1
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STRUCTURE OF CDK9/CYCLINT1 IN COMPLEX WITH DRB
分子名称:Cell division protein kinase 9, Cyclin-T1, PHOSPHATE ION, ...
著者Baumli, S., Johnson, L.N.
登録日2010-05-09
公開日2010-09-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Halogen bonds form the basis for selective P-TEFb inhibition by DRB
Chem.Biol., 17, 2010
3MY5
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CDK2/CYCLINA IN COMPLEX WITH DRB
分子名称:Cell division protein kinase 2, Cyclin-A2, 5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole, ...
著者Baumli, S., Johnson, L.N.
登録日2010-05-09
公開日2010-09-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Halogen bonds form the basis for selective P-TEFb inhibition by DRB
Chem.Biol., 17, 2010
3TN8
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CDK9/CYCLIN T IN COMPLEX WITH CAN508
分子名称:Cyclin-dependent kinase 9, Cyclin-T1, PHOSPHATE ION, ...
著者Baumli, S., Hole, A.J., Endicott, J.E.
登録日2011-09-01
公開日2012-02-15
最終更新日2012-06-13
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508.
Acs Chem.Biol., 7, 2012
3TNH
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CDK9/CYCLIN T IN COMPLEX WITH CAN508
分子名称:Cyclin-dependent kinase 9, Cyclin-T1, 4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL
著者Baumli, S., Hole, A.J., Endicott, J.A.
登録日2011-09-01
公開日2012-02-15
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (3.202 Å)
主引用文献The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508.
Acs Chem.Biol., 7, 2012
3TNI
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STRUCTURE OF CDK9/CYCLIN T F241L
分子名称:Cyclin-dependent kinase 9, Cyclin-T1
著者Baumli, S., Hole, A.J., Endicott, J.A.
登録日2011-09-01
公開日2012-02-15
最終更新日2012-05-30
実験手法X-RAY DIFFRACTION (3.234 Å)
主引用文献The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508.
Acs Chem.Biol., 7, 2012
3TNW
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STRUCTURE OF CDK2/CYCLIN A IN COMPLEX WITH CAN508
分子名称:Cyclin-dependent kinase 2, Cyclin-A2, 4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL, ...
著者Baumli, S., Hole, A.J., Endicott, J.A.
登録日2011-09-02
公開日2012-02-15
最終更新日2012-05-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508.
Acs Chem.Biol., 7, 2012
4EC8
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STRUCTURE OF FULL LENGTH CDK9 IN COMPLEX WITH CYCLINT AND DRB
分子名称:Cyclin-dependent kinase 9, Cyclin-T1
著者Baumli, S., Hole, A.J., Endicott, J.A.
登録日2012-03-26
公開日2012-09-12
最終更新日2014-10-22
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献The CDK9 tail determines the reaction pathway of positive transcription elongation factor b.
Structure, 20, 2012
4EC9
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CRYSTAL STRUCTURE OF FULL-LENGTH CDK9 IN COMPLEX WITH CYCLIN T
分子名称:Cyclin-dependent kinase 9, Cyclin-T1
著者Baumli, S., Hole, A.J., Endicott, J.A.
登録日2012-03-26
公開日2012-09-12
最終更新日2013-01-02
実験手法X-RAY DIFFRACTION (3.21 Å)
主引用文献The CDK9 tail determines the reaction pathway of positive transcription elongation factor b.
Structure, 20, 2012
4BCG
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STRUCTURE OF CDK9 IN COMPLEX WITH CYCLIN T AND A 2-AMINO-4-HETEROARYL- PYRIMIDINE INHIBITOR
分子名称:CYCLIN-DEPENDENT KINASE 9, CYCLIN-T1, 2-[[3-(1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile, ...
著者Hole, A.J., Baumli, S., Wang, S., Endicott, J.A., Noble, M.E.M.
登録日2012-10-02
公開日2013-04-17
実験手法X-RAY DIFFRACTION (3.085 Å)
主引用文献Substituted 4-(Thiazol-5-Yl)-2-(Phenylamino)Pyrimidines are Highly Active Cdk9 Inhibitors: Synthesis, X-Ray Crystal Structure, Sar and Anti-Cancer Activities.
J.Med.Chem., 56, 2013
4BCP
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STRUCTURE OF CDK2 IN COMPLEX WITH CYCLIN A AND A 2-AMINO-4-HETEROARYL- PYRIMIDINE INHIBITOR
分子名称:CYCLIN-DEPENDENT KINASE 2, CYCLIN-A2, 2-[[3-(1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile, ...
著者Hole, A.J., Baumli, S., Wang, S., Endicott, J.A., Noble, M.E.M.
登録日2012-10-02
公開日2013-04-17
最終更新日2013-08-07
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Substituted 4-(Thiazol-5-Yl)-2-(Phenylamino)Pyrimidines are Highly Active Cdk9 Inhibitors: Synthesis, X-Ray Crystal Structure, Sar and Anti-Cancer Activities.
J.Med.Chem., 56, 2013
1ZP2
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STRUCTURE OF THE MEDIATOR SUBUNIT CYCLIN C
分子名称:RNA polymerase II holoenzyme cyclin-like subunit
著者Hoeppner, S., Baumli, S., Cramer, P.
登録日2005-05-16
公開日2005-07-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of the Mediator Subunit Cyclin C and its Implications for CDK8 Function.
J.Mol.Biol., 350, 2005
4BCF
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STRUCTURE OF CDK9 IN COMPLEX WITH CYCLIN T AND A 2-AMINO-4-HETEROARYL- PYRIMIDINE INHIBITOR
分子名称:CYCLIN-DEPENDENT KINASE 9, CYCLIN-T1, 2-[[3-(4-ethanoyl-1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile
著者Hole, A.J., Baumli, S., Wang, S., Endicott, J.A., Noble, M.E.M.
登録日2012-10-02
公開日2013-01-09
最終更新日2013-02-27
実験手法X-RAY DIFFRACTION (3.011 Å)
主引用文献Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
J.Med.Chem., 56, 2013
4BCH
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STRUCTURE OF CDK9 IN COMPLEX WITH CYCLIN T AND A 2-AMINO-4-HETEROARYL- PYRIMIDINE INHIBITOR
分子名称:CYCLIN-DEPENDENT KINASE 9, CYCLIN-T1, 4-(4-methyl-2-methylimino-3H-1,3-thiazol-5-yl)-2-[(4-methyl-3-morpholin-4-ylsulfonyl-phenyl)amino]pyrimidine-5-carbonitrile, ...
著者Hole, A.J., Baumli, S., Wang, S., Endicott, J.A., Noble, M.E.M.
登録日2012-10-02
公開日2013-01-09
最終更新日2013-02-27
実験手法X-RAY DIFFRACTION (2.958 Å)
主引用文献Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
J.Med.Chem., 56, 2013
4BCI
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STRUCTURE OF CDK9 IN COMPLEX WITH CYCLIN T AND A 2-AMINO-4-HETEROARYL- PYRIMIDINE INHIBITOR
分子名称:CYCLIN-DEPENDENT KINASE 9, CYCLIN-T1, 3-[[5-cyano-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]benzenesulfonamide
著者Hole, A.J., Baumli, S., Wang, S., Endicott, J.A., Noble, M.E.M.
登録日2012-10-02
公開日2013-01-09
最終更新日2013-02-27
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
J.Med.Chem., 56, 2013
4BCJ
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STRUCTURE OF CDK9 IN COMPLEX WITH CYCLIN T AND A 2-AMINO-4-HETEROARYL- PYRIMIDINE INHIBITOR
分子名称:CYCLIN-DEPENDENT KINASE 9, CYCLIN-T1, 2-[(3-hydroxyphenyl)amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile
著者Hole, A.J., Baumli, S., Wang, S., Endicott, J.A., Noble, M.E.M.
登録日2012-10-02
公開日2013-01-09
最終更新日2013-02-27
実験手法X-RAY DIFFRACTION (3.162 Å)
主引用文献Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
J.Med.Chem., 56, 2013
4BCK
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STRUCTURE OF CDK2 IN COMPLEX WITH CYCLIN A AND A 2-AMINO-4-HETEROARYL- PYRIMIDINE INHIBITOR
分子名称:CYCLIN-DEPENDENT KINASE 2, CYCLIN-A2, 3-[[5-cyano-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]benzenesulfonamide, ...
著者Hole, A.J., Baumli, S., Wang, S., Endicott, J.A., Noble, M.E.M.
登録日2012-10-02
公開日2013-03-06
実験手法X-RAY DIFFRACTION (2.052 Å)
主引用文献Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
J.Med.Chem., 56, 2013
4BCM
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STRUCTURE OF CDK2 IN COMPLEX WITH CYCLIN A AND A 2-AMINO-4-HETEROARYL- PYRIMIDINE INHIBITOR
分子名称:CYCLIN-DEPENDENT KINASE 2, CYCLIN-A2, 4-(4-methyl-2-methylimino-3H-1,3-thiazol-5-yl)-2-[(4-methyl-3-morpholin-4-ylsulfonyl-phenyl)amino]pyrimidine-5-carbonitrile, ...
著者Hole, A.J., Baumli, S., Wang, S., Endicott, J.A., Noble, M.E.M.
登録日2012-10-02
公開日2013-03-06
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
J.Med.Chem., 56, 2013
4BCN
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STRUCTURE OF CDK2 IN COMPLEX WITH CYCLIN A AND A 2-AMINO-4-HETEROARYL- PYRIMIDINE INHIBITOR
分子名称:CYCLIN-DEPENDENT KINASE 2, CYCLIN-A2, 2-[(3-hydroxyphenyl)amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile, ...
著者Hole, A.J., Baumli, S., Wang, S., Endicott, J.A., Noble, M.E.M.
登録日2012-10-02
公開日2013-03-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
J.Med.Chem., 56, 2013
4BCO
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STRUCTURE OF CDK2 IN COMPLEX WITH CYCLIN A AND A 2-AMINO-4-HETEROARYL- PYRIMIDINE INHIBITOR
分子名称:CYCLIN-DEPENDENT KINASE 2, CYCLIN-A2, 2-[[3-(4-ethanoyl-1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile, ...
著者Hole, A.J., Baumli, S., Wang, S., Endicott, J.A., Noble, M.E.M.
登録日2012-10-02
公開日2013-01-09
最終更新日2013-02-27
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
J.Med.Chem., 56, 2013
4BCQ
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STRUCTURE OF CDK2 IN COMPLEX WITH CYCLIN A AND A 2-AMINO-4-HETEROARYL- PYRIMIDINE INHIBITOR
分子名称:CYCLIN-DEPENDENT KINASE 2, CYCLIN-A2, 4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]-2-{[3-(morpholin-4-ylcarbonyl)phenyl]amino}pyrimidine-5-carbonitrile
著者Hole, A.J., Baumli, S., Wang, S., Endicott, J.A., Noble, M.E.M.
登録日2012-10-02
公開日2013-01-09
最終更新日2013-02-27
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
J.Med.Chem., 56, 2013
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