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1YKE
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BU of 1yke by Molmil
Structure of the mediator MED7/MED21 subcomplex
Descriptor: RNA polymerase II holoenzyme component SRB7, RNA polymerase II mediator complex protein MED7
Authors:Baumli, S, Hoeppner, S, Cramer, P.
Deposit date:2005-01-18
Release date:2005-02-22
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:A conserved mediator hinge revealed in the structure of the MED7.MED21 (Med7.Srb7) heterodimer.
J.Biol.Chem., 280, 2005
1YKH
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BU of 1ykh by Molmil
Structure of the mediator MED7/MED21 (Med7/Srb7) subcomplex
Descriptor: RNA polymerase II holoenzyme component SRB7, RNA polymerase II mediator complex protein MED7
Authors:Baumli, S, Hoeppner, S, Cramer, P.
Deposit date:2005-01-18
Release date:2005-02-22
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:A conserved mediator hinge revealed in the structure of the MED7.MED21 (Med7.Srb7) heterodimer.
J.Biol.Chem., 280, 2005
3MY1
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BU of 3my1 by Molmil
Structure of CDK9/cyclinT1 in complex with DRB
Descriptor: 5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole, Cell division protein kinase 9, Cyclin-T1, ...
Authors:Baumli, S, Johnson, L.N.
Deposit date:2010-05-09
Release date:2010-09-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Halogen bonds form the basis for selective P-TEFb inhibition by DRB
Chem.Biol., 17, 2010
3MY5
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BU of 3my5 by Molmil
CDk2/cyclinA in complex with DRB
Descriptor: 5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole, Cell division protein kinase 2, Cyclin-A2, ...
Authors:Baumli, S, Johnson, L.N.
Deposit date:2010-05-09
Release date:2010-09-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Halogen bonds form the basis for selective P-TEFb inhibition by DRB
Chem.Biol., 17, 2010
3BLQ
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BU of 3blq by Molmil
Crystal Structure of Human CDK9/cyclinT1 in Complex with ATP
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-TRIPHOSPHATE, Cell division protein kinase 9, ...
Authors:Baumli, S, Lolli, G, Lowe, E.D, Johnson, L.N.
Deposit date:2007-12-11
Release date:2008-07-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation
Embo J., 27, 2008
3BLH
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BU of 3blh by Molmil
Crystal Structure of Human CDK9/cyclinT1
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cell division protein kinase 9, Cyclin-T1
Authors:Baumli, S, Lolli, G, Lowe, E.D, Johnson, L.N.
Deposit date:2007-12-11
Release date:2008-07-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation
Embo J., 27, 2008
3BLR
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BU of 3blr by Molmil
Crystal Structure of Human CDK9/cyclinT1 in complex with Flavopiridol
Descriptor: 2-(2-CHLORO-PHENYL)-5,7-DIHYDROXY-8-(3-HYDROXY-1-METHYL-PIPERIDIN-4-YL)-4H-BENZOPYRAN-4-ONE, Cell division protein kinase 9, Cyclin-T1, ...
Authors:Baumli, S, Lolli, G, Lowe, E.D, Johnson, L.N.
Deposit date:2007-12-11
Release date:2008-07-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation
Embo J., 27, 2008
3TN8
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BU of 3tn8 by Molmil
CDK9/cyclin T in complex with CAN508
Descriptor: 4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL, Cyclin-T1, Cyclin-dependent kinase 9, ...
Authors:Baumli, S, Hole, A.J, Endicott, J.E.
Deposit date:2011-09-01
Release date:2012-02-15
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508.
Acs Chem.Biol., 7, 2012
3TNW
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BU of 3tnw by Molmil
Structure of CDK2/cyclin A in complex with CAN508
Descriptor: 4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL, Cyclin-A2, Cyclin-dependent kinase 2, ...
Authors:Baumli, S, Hole, A.J, Endicott, J.A.
Deposit date:2011-09-02
Release date:2012-02-15
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508.
Acs Chem.Biol., 7, 2012
3TNI
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BU of 3tni by Molmil
structure of CDK9/cyclin T F241L
Descriptor: Cyclin-T1, Cyclin-dependent kinase 9
Authors:Baumli, S, Hole, A.J, Endicott, J.A.
Deposit date:2011-09-01
Release date:2012-02-15
Last modified:2012-05-30
Method:X-RAY DIFFRACTION (3.234 Å)
Cite:The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508.
Acs Chem.Biol., 7, 2012
3TNH
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BU of 3tnh by Molmil
CDK9/cyclin T in complex with CAN508
Descriptor: 4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL, Cyclin-T1, Cyclin-dependent kinase 9
Authors:Baumli, S, Hole, A.J, Endicott, J.A.
Deposit date:2011-09-01
Release date:2012-02-15
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.202 Å)
Cite:The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508.
Acs Chem.Biol., 7, 2012
4EC8
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BU of 4ec8 by Molmil
Structure of full length CDK9 in complex with cyclinT and DRB
Descriptor: Cyclin-T1, Cyclin-dependent kinase 9
Authors:Baumli, S, Hole, A.J, Endicott, J.A.
Deposit date:2012-03-26
Release date:2012-09-12
Last modified:2014-10-22
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:The CDK9 tail determines the reaction pathway of positive transcription elongation factor b.
Structure, 20, 2012
4EC9
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BU of 4ec9 by Molmil
Crystal structure of full-length cdk9 in complex with cyclin t
Descriptor: Cyclin-T1, Cyclin-dependent kinase 9
Authors:Baumli, S, Hole, A.J, Endicott, J.A.
Deposit date:2012-03-26
Release date:2012-09-12
Last modified:2013-01-02
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:The CDK9 tail determines the reaction pathway of positive transcription elongation factor b.
Structure, 20, 2012
1ZP2
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BU of 1zp2 by Molmil
Structure of the Mediator subunit cyclin C
Descriptor: RNA polymerase II holoenzyme cyclin-like subunit
Authors:Hoeppner, S, Baumli, S, Cramer, P.
Deposit date:2005-05-16
Release date:2005-07-19
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the Mediator Subunit Cyclin C and its Implications for CDK8 Function.
J.Mol.Biol., 350, 2005
3LQ5
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BU of 3lq5 by Molmil
Structure of CDK9/CyclinT in complex with S-CR8
Descriptor: (2S)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol, Cell division protein kinase 9, Cyclin-T1
Authors:Hole, A.J, Endicott, J.A, Baumli, S.
Deposit date:2010-02-08
Release date:2011-01-19
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3 Å)
Cite:CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells
Genes Cancer, 1, 2010
4BCG
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BU of 4bcg by Molmil
Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor
Descriptor: 2-[[3-(1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile, CYCLIN-DEPENDENT KINASE 9, CYCLIN-T1, ...
Authors:Hole, A.J, Baumli, S, Wang, S, Endicott, J.A, Noble, M.E.M.
Deposit date:2012-10-02
Release date:2013-04-17
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (3.085 Å)
Cite:Substituted 4-(Thiazol-5-Yl)-2-(Phenylamino)Pyrimidines are Highly Active Cdk9 Inhibitors: Synthesis, X-Ray Crystal Structure, Sar and Anti-Cancer Activities.
J.Med.Chem., 56, 2013
4BCP
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BU of 4bcp by Molmil
Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
Descriptor: 2-[[3-(1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile, CYCLIN-A2, CYCLIN-DEPENDENT KINASE 2, ...
Authors:Hole, A.J, Baumli, S, Wang, S, Endicott, J.A, Noble, M.E.M.
Deposit date:2012-10-02
Release date:2013-04-17
Last modified:2013-08-07
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Substituted 4-(Thiazol-5-Yl)-2-(Phenylamino)Pyrimidines are Highly Active Cdk9 Inhibitors: Synthesis, X-Ray Crystal Structure, Sar and Anti-Cancer Activities.
J.Med.Chem., 56, 2013
4BCQ
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BU of 4bcq by Molmil
Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
Descriptor: 4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]-2-{[3-(morpholin-4-ylcarbonyl)phenyl]amino}pyrimidine-5-carbonitrile, CYCLIN-A2, CYCLIN-DEPENDENT KINASE 2
Authors:Hole, A.J, Baumli, S, Wang, S, Endicott, J.A, Noble, M.E.M.
Deposit date:2012-10-02
Release date:2013-01-09
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
J.Med.Chem., 56, 2013
4BCF
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BU of 4bcf by Molmil
Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor
Descriptor: 2-[[3-(4-ethanoyl-1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile, CYCLIN-DEPENDENT KINASE 9, CYCLIN-T1
Authors:Hole, A.J, Baumli, S, Wang, S, Endicott, J.A, Noble, M.E.M.
Deposit date:2012-10-02
Release date:2013-01-09
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (3.011 Å)
Cite:Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
J.Med.Chem., 56, 2013
4BCO
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BU of 4bco by Molmil
Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
Descriptor: 2-[[3-(4-ethanoyl-1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile, CYCLIN-A2, CYCLIN-DEPENDENT KINASE 2, ...
Authors:Hole, A.J, Baumli, S, Wang, S, Endicott, J.A, Noble, M.E.M.
Deposit date:2012-10-02
Release date:2013-01-09
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
J.Med.Chem., 56, 2013
4BCN
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BU of 4bcn by Molmil
Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
Descriptor: 2-[(3-hydroxyphenyl)amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile, CYCLIN-A2, CYCLIN-DEPENDENT KINASE 2, ...
Authors:Hole, A.J, Baumli, S, Wang, S, Endicott, J.A, Noble, M.E.M.
Deposit date:2012-10-02
Release date:2013-03-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
J.Med.Chem., 56, 2013
4BCM
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BU of 4bcm by Molmil
Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
Descriptor: 4-(4-methyl-2-methylimino-3H-1,3-thiazol-5-yl)-2-[(4-methyl-3-morpholin-4-ylsulfonyl-phenyl)amino]pyrimidine-5-carbonitrile, CYCLIN-A2, CYCLIN-DEPENDENT KINASE 2, ...
Authors:Hole, A.J, Baumli, S, Wang, S, Endicott, J.A, Noble, M.E.M.
Deposit date:2012-10-02
Release date:2013-03-06
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
J.Med.Chem., 56, 2013
4BCI
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BU of 4bci by Molmil
Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor
Descriptor: 3-[[5-cyano-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]benzenesulfonamide, CYCLIN-DEPENDENT KINASE 9, CYCLIN-T1
Authors:Hole, A.J, Baumli, S, Wang, S, Endicott, J.A, Noble, M.E.M.
Deposit date:2012-10-02
Release date:2013-01-09
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
J.Med.Chem., 56, 2013
4BCH
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BU of 4bch by Molmil
Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor
Descriptor: 4-(4-methyl-2-methylimino-3H-1,3-thiazol-5-yl)-2-[(4-methyl-3-morpholin-4-ylsulfonyl-phenyl)amino]pyrimidine-5-carbonitrile, CYCLIN-DEPENDENT KINASE 9, CYCLIN-T1, ...
Authors:Hole, A.J, Baumli, S, Wang, S, Endicott, J.A, Noble, M.E.M.
Deposit date:2012-10-02
Release date:2013-01-09
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.958 Å)
Cite:Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
J.Med.Chem., 56, 2013
4BCJ
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BU of 4bcj by Molmil
Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor
Descriptor: 2-[(3-hydroxyphenyl)amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile, CYCLIN-DEPENDENT KINASE 9, CYCLIN-T1
Authors:Hole, A.J, Baumli, S, Wang, S, Endicott, J.A, Noble, M.E.M.
Deposit date:2012-10-02
Release date:2013-01-09
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (3.162 Å)
Cite:Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
J.Med.Chem., 56, 2013

 

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