Author results

6BEM
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TERNARY COMPLEX CRYSTAL STRUCTURE OF DNA POLYMERASE BETA WITH S-ISOMER OF BETA-GAMMA-CHCL-DCTP
Descriptor:Template strand, Primer Strand, Downstream Primer Strand, ...
Authors:Batra, V.K., Wilson, S.H.
Deposit date:2017-10-25
Release date:2018-10-31
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Mapping Functional Substrate-Enzyme Interactions in the pol beta Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs.
Biochemistry, 57, 2018
1ZJM
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HUMAN DNA POLYMERASE BETA COMPLEXED WITH DNA CONTAINING AN A-A MISMATCHED PRIMER TERMINUS
Descriptor:d(*CP*CP*GP*AP*CP*CP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:Batra, V.K., Beard, W.A., Shock, D.D., Pedersen, L.C., Wilson, S.H.
Deposit date:2005-04-29
Release date:2005-08-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate.
STRUCTURE, 13, 2005
1ZJN
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HUMAN DNA POLYMERASE BETA COMPLEXED WITH DNA CONTAINING AN A-A MISMATCHED PRIMER TERMINUS WITH DGTP
Descriptor:d(*CP*CP*GP*AP*CP*CP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:Batra, V.K., Beard, W.A., Shock, D.D., Pedersen, L.C., Wilson, S.H.
Deposit date:2005-04-29
Release date:2005-08-16
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate.
STRUCTURE, 13, 2005
2FMP
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DNA POLYMERASE BETA WITH A TERMINATED GAPPED DNA SUBSTRATE AND DDCTP WITH SODIUM IN THE CATALYTIC SITE
Descriptor:5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:Batra, V.K., Beard, W.A., Shock, D.D., Krahn, J.M., Pedersen, L.C., Wilson, S.H.
Deposit date:2006-01-09
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Magnesium-induced assembly of a complete DNA polymerase catalytic complex.
Structure, 14, 2006
2FMQ
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SODIUM IN ACTIVE SITE OF DNA POLYMERASE BETA
Descriptor:5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:Batra, V.K., Beard, W.A., Shock, D.D., Krahn, J.M., Pedersen, L.C., Wilson, S.H.
Deposit date:2006-01-09
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Magnesium-induced assembly of a complete DNA polymerase catalytic complex.
Structure, 14, 2006
2FMS
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DNA POLYMERASE BETA WITH A GAPPED DNA SUBSTRATE AND DUMPNPP WITH MAGNESIUM IN THE CATALYTIC SITE
Descriptor:5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:Batra, V.K., Beard, W.A., Shock, D.D., Krahn, J.M., Pedersen, L.C., Wilson, S.H.
Deposit date:2006-01-09
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Magnesium-induced assembly of a complete DNA polymerase catalytic complex.
Structure, 14, 2006
2I9G
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DNA POLYMERASE BETA WITH A BENZO[C]PHENANTHRENE DIOL EPOXIDE ADDUCTED GUANINE BASE
Descriptor:5'-D(P*GP*TP*CP*GP*G)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3', 5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', ...
Authors:Batra, V.K., Wilson, S.H., Beard, W.A., Pedersen, L.C.
Deposit date:2006-09-05
Release date:2006-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features.
Proc.Natl.Acad.Sci.Usa, 103, 2006
3C2K
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DNA POLYMERASE BETA WITH A GAPPED DNA SUBSTRATE AND DUMPNPP WITH MANGANESE IN THE ACTIVE SITE
Descriptor:DNA (5'-D(*DCP*DCP*DGP*DAP*DCP*DAP*DGP*DCP*DGP*DCP*DAP*DTP*DCP*DAP*DGP*DC)-3'), DNA (5'-D(*DGP*DCP*DTP*DGP*DAP*DTP*DGP*DCP*DGP*DC)-3'), DNA (5'-D(P*DGP*DTP*DCP*DGP*DG)-3'), ...
Authors:Batra, V.K., Beard, W.A., Shock, D.D., Pedersen, L.C., Wilson, S.H.
Deposit date:2008-01-25
Release date:2008-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation.
Mol.Cell, 30, 2008
3C2L
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TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A C:DAPCPP MISMATCH IN THE ACTIVE SITE
Descriptor:DNA (5'-D(*DCP*DCP*DGP*DAP*DCP*DCP*DGP*DCP*DGP*DCP*DAP*DTP*DCP*DAP*DGP*DC)-3'), DNA (5'-D(*DGP*DCP*DTP*DGP*DAP*DTP*DGP*DCP*DGP*DC)-3'), DNA (5'-D(P*DGP*DTP*DCP*DGP*DG)-3'), ...
Authors:Batra, V.K., Beard, W.A., Shock, D.D., Pedersen, L.C., Wilson, S.H.
Deposit date:2008-01-25
Release date:2008-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation.
Mol.Cell, 30, 2008
3C2M
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TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A G:DAPCPP MISMATCH IN THE ACTIVE SITE
Descriptor:DNA (5'-D(*DCP*DCP*DGP*DAP*DCP*DGP*DGP*DCP*DGP*DCP*DAP*DTP*DCP*DAP*DGP*DC)-3'), DNA (5'-D(*DGP*DCP*DTP*DGP*DAP*DTP*DGP*DCP*DGP*DC)-3'), DNA (5'-D(P*DGP*DTP*DCP*DGP*DG)-3'), ...
Authors:Batra, V.K., Beard, W.A., Shock, D.D., Pedersen, L.C., Wilson, S.H.
Deposit date:2008-01-25
Release date:2008-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation.
Mol.Cell, 30, 2008
3JPN
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TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A DIDEOXY TERMINATED PRIMER AND 2'-DEOXYGUANOSINE 5'-BETA, GAMMA-DICHLORO METHYLENE TRIPHOSPHATE
Descriptor:DNA polymerase beta, 5'-D(P*GP*TP*CP*GP*G)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ...
Authors:Batra, V.K., Upton, J., Kashmerov, B., Beard, W.A., Wilson, S.H., Goodman, M.F., McKenna, C.E.
Deposit date:2009-09-04
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Halogenated beta,gamma-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase beta: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues.
J.Am.Chem.Soc., 132, 2010
3JPO
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TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A DIDEOXY TERMINATED PRIMER AND 2'-DEOXYGUANOSINE 5'-BETA, GAMMA-MONOCHLOROMETHYLENE TRIPHOSPHATE
Descriptor:DNA polymerase beta, 5'-D(P*GP*TP*CP*GP*G)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ...
Authors:Batra, V.K., Upton, J., Kashmerov, B., Beard, W.A., Wilson, S.H., Goodman, M.F., McKenna, C.E.
Deposit date:2009-09-04
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Halogenated beta,gamma-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase beta: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues.
J.Am.Chem.Soc., 132, 2010
3JPP
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TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A DIDEOXY TERMINATED PRIMER AND 2'-DEOXYGUANOSINE 5'-BETA, GAMMA-MONOMETHYL METHYLENE TRIPHOSPHATE
Descriptor:DNA polymerase beta, 5'-D(P*GP*TP*CP*GP*G)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ...
Authors:Batra, V.K., Upton, J., Kashmerov, B., Beard, W.A., Wilson, S.H., Goodman, M.F., McKenna, C.E.
Deposit date:2009-09-04
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Halogenated beta,gamma-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase beta: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues.
J.Am.Chem.Soc., 132, 2010
3JPQ
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TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A DIDEOXY TERMINATED PRIMER AND 2'-DEOXYGUANOSINE 5'-BETA, GAMMA-MONOBROMO METHYLENE TRIPHOSPHATE
Descriptor:DNA polymerase beta, 5'-D(P*GP*TP*CP*GP*G)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ...
Authors:Batra, V.K., Upton, J., Kashmerov, B., Beard, W.A., Wilson, S.H., Goodman, M.F., McKenna, C.E.
Deposit date:2009-09-04
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Halogenated beta,gamma-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase beta: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues.
J.Am.Chem.Soc., 132, 2010
3JPR
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TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A DIDEOXY TERMINATED PRIMER AND 2'-DEOXYGUANOSINE 5'-BETA, GAMMA-DIMETHYL METHYLENE TRIPHOSPHATE
Descriptor:DNA polymerase beta, 5'-D(P*GP*TP*CP*GP*G)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ...
Authors:Batra, V.K., Upton, J., Kashmerov, B., Beard, W.A., Wilson, S.H., Goodman, M.F., McKenna, C.E.
Deposit date:2009-09-04
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Halogenated beta,gamma-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase beta: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues.
J.Am.Chem.Soc., 132, 2010
3JPS
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TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A DIDEOXY TERMINATED PRIMER AND 2'-DEOXYGUANOSINE 5'-BETA, GAMMA-FLUORO METHYL METHYLENE TRIPHOSPHATE
Descriptor:DNA polymerase beta, 5'-D(P*GP*TP*CP*GP*G)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ...
Authors:Batra, V.K., Upton, J., Kashmerov, B., Beard, W.A., Wilson, S.H., Goodman, M.F., McKenna, C.E.
Deposit date:2009-09-04
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Halogenated beta,gamma-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase beta: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues.
J.Am.Chem.Soc., 132, 2010
3JPT
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TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A DIDEOXY TERMINATED PRIMER AND 2'-DEOXYGUANOSINE 5'-BETA, GAMMA-FLUORO CHLORO METHYLENE TRIPHOSPHATE
Descriptor:DNA polymerase beta, 5'-D(P*GP*TP*CP*GP*G)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ...
Authors:Batra, V.K., Upton, J., Kashmerov, B., Beard, W.A., Wilson, S.H., Goodman, M.F., McKenna, C.E.
Deposit date:2009-09-04
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Halogenated beta,gamma-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase beta: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues.
J.Am.Chem.Soc., 132, 2010
3MBY
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TERNARY COMPLEX OF DNA POLYMERASE BETA WITH TEMPLATE BASE A AND 8OXODGTP IN THE ACTIVE SITE WITH A DIDEOXY TERMINATED PRIMER
Descriptor:DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3'), ...
Authors:Batra, V.K., Beard, W.A., Hou, E.W., Pedersen, L.C., Prasad, R., Wilson, S.H.
Deposit date:2010-03-26
Release date:2010-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mutagenic conformation of 8-oxo-7,8-dihydro-2'-dGTP in the confines of a DNA polymerase active site.
Nat.Struct.Mol.Biol., 17, 2010
3RJE
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TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A GAPPED DNA CONTAINING 8ODG AT TEMPLATE POSITION
Descriptor:DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ...
Authors:Batra, V.K., Beard, W.A., Wilson, S.H.
Deposit date:2011-04-15
Release date:2012-01-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Binary complex crystal structure of DNA polymerase beta reveals multiple conformations of the templating 8-oxoguanine lesion
Proc.Natl.Acad.Sci.USA, 109, 2012
3RJF
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TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A GAPPED DNA CONTAINING (SYN)8ODG AT TEMPLATE POSITION PAIRED WITH NON-HYDROLYZABLE DATP ANALOG (DAPCPP)
Descriptor:DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ...
Authors:Batra, V.K., Beard, W.A., Wilson, S.H.
Deposit date:2011-04-15
Release date:2012-01-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Binary complex crystal structure of DNA polymerase beta reveals multiple conformations of the templating 8-oxoguanine lesion
Proc.Natl.Acad.Sci.USA, 109, 2012
3RJG
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BINARY COMPLEX OF DNA POLYMERASE BETA WITH A GAPPED DNA CONTAINING 8ODG:DA BASE-PAIR AT PRIMER TERMINUS
Descriptor:DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*GP*(8OG)P*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ...
Authors:Batra, V.K., Beard, W.A., Wilson, S.H.
Deposit date:2011-04-15
Release date:2012-01-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Binary complex crystal structure of DNA polymerase beta reveals multiple conformations of the templating 8-oxoguanine lesion
Proc.Natl.Acad.Sci.USA, 109, 2012
3RJH
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TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A GAPPED DNA CONTAINING (SYN)8ODG:DA AT PRIMER TERMINUS AND DG:DCMP(CF2)PPIN THE ACTIVE SITE
Descriptor:DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*GP*(8OG)P*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ...
Authors:Batra, V.K., Beard, W.A., Wilson, S.H.
Deposit date:2011-04-15
Release date:2012-01-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Binary complex crystal structure of DNA polymerase beta reveals multiple conformations of the templating 8-oxoguanine lesion
Proc.Natl.Acad.Sci.USA, 109, 2012
3RJI
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TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A GAPPED DNA CONTAINING 8ODG AT TEMPLATE POSITION PAIRED WITH NON-HYDROLYZABLE DCTP ANALOG (DCMP(CF2)PP)
Descriptor:DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ...
Authors:Batra, V.K., Beard, W.A., Wilson, S.H.
Deposit date:2011-04-15
Release date:2012-01-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Binary complex crystal structure of DNA polymerase beta reveals multiple conformations of the templating 8-oxoguanine lesion
Proc.Natl.Acad.Sci.USA, 109, 2012
3RJJ
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TERNARY COMPLEX CRYSTAL STRUCTURE OF DNA POLYMERASE BETA WITH TEMPLATE 8ODG PROVIDES INSIGHT INTO MUTAGENIC LESION BYPASS
Descriptor:DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*GP*(8OG)P*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ...
Authors:Batra, V.K., Beard, W.A., Wilson, S.H.
Deposit date:2011-04-15
Release date:2012-01-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Binary complex crystal structure of DNA polymerase beta reveals multiple conformations of the templating 8-oxoguanine lesion.
Proc.Natl.Acad.Sci.USA, 109, 2012
3RJK
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TERNARY COMPLEX OF DNA POLYMERASE BETA WITH A GAPPED DNA CONTAINING 8ODG:DC BASE PAIR AT PRIMER TERMINUS AND DG:DCMP(CF2)PP IN THE ACTIVE SITE
Descriptor:DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*GP*(8OG)P*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ...
Authors:Batra, V.K., Beard, W.A., Wilson, S.H.
Deposit date:2011-04-15
Release date:2012-01-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Binary complex crystal structure of DNA polymerase beta reveals multiple conformations of the templating 8-oxoguanine lesion.
Proc.Natl.Acad.Sci.USA, 109, 2012