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5K79
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STRUCTURE AND ANTI-HIV ACTIVITY OF CYT-CVNH, A NEW CYANOVIRIN-N HOMOLOG
Descriptor:Cyanovirin-N domain protein, DI(HYDROXYETHYL)ETHER, 1,2-ETHANEDIOL
Authors:Matei, E., Basu, R., Furey, W., Shi, J., Calnan, C., Aiken, C., Gronenborn, A.M.
Deposit date:2016-05-25
Release date:2016-07-20
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure and Glycan Binding of a New Cyanovirin-N Homolog.
J.Biol.Chem., 291, 2016
6D6V
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CRYOEM STRUCTURE OF TETRAHYMENA TELOMERASE WITH TELOMERIC DNA AT 4.8 ANGSTROM RESOLUTION
Descriptor:Telomerase reverse transcriptase, Telomerase-associated protein 82, Telomerase holoenzyme TEB heterotrimer Teb3 subunit, ...
Authors:Jiang, J., Wang, Y., Susac, L., Chan, H., Basu, R., Zhou, Z.H., Feigon, J.
Deposit date:2018-04-22
Release date:2018-05-30
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Structure of Telomerase with Telomeric DNA.
Cell, 173, 2018
4BAE
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OPTIMISATION OF PYRROLEAMIDES AS MYCOBACTERIAL GYRB ATPASE INHIBITORS: STRUCTURE ACTIVITY RELATIONSHIP AND IN VIVO EFFICACY IN THE MOUSE MODEL OF TUBERCULOSIS
Descriptor:DNA GYRASE SUBUNIT B, CALCIUM ION, 2-[(3S,4R)-4-[(3-bromanyl-4-chloranyl-5-methyl-1H-pyrrol-2-yl)carbonylamino]-3-methoxy-piperidin-1-yl]-4-(2-methyl-1,2,4-triazol-3-yl)-1,3-thiazole-5-carboxylic acid, ...
Authors:Read, J.A., Gingell, H.G., Madhavapeddi, P.
Deposit date:2012-09-13
Release date:2013-10-30
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Optimization of Pyrrolamides as Mycobacterial Gyrb ATPase Inhibitors: Structure Activity Relationship and in Vivo Efficacy in the Mouse Model of Tuberculosis.
Antimicrob.Agents Chemother., 58, 2014
3Q0A
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X-RAY CRYSTAL STRUCTURE OF THE TRANSCRIPTION INITIATION COMPLEX OF THE N4 MINI-VRNAP WITH P2 PROMOTER: MISMATCH COMPLEX
Descriptor:Virion RNA polymerase, DNA (5'-D(*TP*GP*CP*CP*TP*CP*CP*CP*AP*GP*GP*CP*A*GP*TP*CP*AP*AP*AP*AP*GP*AP*AP*GP*CP*GP*GP*AP*GP*CP*TP*TP*CP*TP*TP*C)-3'), PHOSPHATE ION, ...
Authors:Murakami, K.S.
Deposit date:2010-12-15
Release date:2011-02-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:X-ray crystal structures elucidate the nucleotidyl transfer reaction of transcript initiation using two nucleotides.
Proc.Natl.Acad.Sci.USA, 108, 2011
3Q22
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X-RAY CRYSTAL STRUCTURE OF THE N4 MINI-VRNAP AND P2_7A PROMOTER TRANSCRIPTION INITIATION COMPLEX WITH GTP AND MAGNESIUM: SUBSTRATE COMPLEX I
Descriptor:Virion RNA polymerase, DNA (5'-D(*TP*GP*CP*CP*TP*CP*CP*CP*AP*GP*GP*CP*AP*TP*CP*CP*AP*AP*AP*AP*GP*AP*AP*GP*CP*GP*GP*AP*GP*CP*TP*TP*CP*TP*TP*C)-3'), GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Gleghorn, M.L., Murakami, K.S.
Deposit date:2010-12-19
Release date:2011-02-16
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:X-ray crystal structures elucidate the nucleotidyl transfer reaction of transcript initiation using two nucleotides.
Proc.Natl.Acad.Sci.USA, 108, 2011
3Q23
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X-RAY CRYSTAL STRUCTURE OF THE N4 MINI-VRNAP AND P2_7A PROMOTER TRANSCRIPTION INITIATION COMPLEX WITH GMPCPP AND MANGANESE: SUSTRATE COMPLEX II
Descriptor:Virion RNA polymerase, DNA (5'-D(*TP*GP*CP*CP*TP*CP*CP*CP*AP*GP*GP*CP*AP*TP*CP*CP*AP*AP*AP*AP*GP*AP*AP*GP*CP*GP*GP*AP*GP*CP*TP*TP*CP*TP*TP*C)-3'), PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ...
Authors:Gleghorn, M.L., Murakami, K.S.
Deposit date:2010-12-19
Release date:2011-02-16
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-ray crystal structures elucidate the nucleotidyl transfer reaction of transcript initiation using two nucleotides.
Proc.Natl.Acad.Sci.USA, 108, 2011
3Q24
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X-RAY CRYSTAL STRUCTURE OF THE N4 MINI-VRNAP AND P2_7A PROMOTER TRANSCRIPTION INITIATION COMPLEX WITH PPPGPG AND PYROPHOSPHATE: PRODUCT COMPLEX
Descriptor:Virion RNA polymerase, DNA (5'-D(*TP*GP*CP*CP*TP*CP*CP*CP*AP*GP*GP*CP*AP*TP*CP*CP*AP*AP*AP*AP*GP*AP*AP*GP*CP*GP*GP*AP*GP*CP*TP*TP*CP*TP*TP*C)-3'), GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Gleghorn, M.L., Murakami, K.S.
Deposit date:2010-12-19
Release date:2011-02-16
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:X-ray crystal structures elucidate the nucleotidyl transfer reaction of transcript initiation using two nucleotides.
Proc.Natl.Acad.Sci.USA, 108, 2011
4B6C
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STRUCTURE OF THE M. SMEGMATIS GYRB ATPASE DOMAIN IN COMPLEX WITH AN AMINOPYRAZINAMIDE
Descriptor:DNA gyrase subunit B,DNA gyrase subunit B,DNA gyrase subunit B, 6-(3,4-dimethylphenyl)-3-[[4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]amino]pyrazine-2-carboxamide, SODIUM ION
Authors:Tucker, J.A., Shirude, P.S., Madhavapeddi, P., Hussein, S., Basu, R., Ghorpade, S.
Deposit date:2012-08-09
Release date:2013-01-23
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Aminopyrazinamides: novel and specific GyrB inhibitors that kill replicating and nonreplicating Mycobacterium tuberculosis.
ACS Chem. Biol., 8, 2013