Author results

3B4Y
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FGD1 (RV0407) FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:PROBABLE F420-DEPENDENT GLUCOSE-6-PHOSPHATE DEHYDROGENASE FGD1, COENZYME F420, CITRATE ANION
Authors:Bashiri, G., Squire, C.J., Moreland, N.M., Baker, E.N., TB Structural Genomics Consortium (TBSGC)
Deposit date:2007-10-25
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding
J.Biol.Chem., 283, 2008
3C8N
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CRYSTAL STRUCTURE OF APO-FGD1 FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Probable F420-dependent glucose-6-phosphate dehydrogenase FGD1
Authors:Bashiri, G., Squire, C.J., Moreland, N.J., Baker, E.N.
Deposit date:2008-02-12
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding.
J.Biol.Chem., 283, 2008
4XOM
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COENZYME F420:L-GLUTAMATE LIGASE (FBIB) FROM MYCOBACTERIUM TUBERCULOSIS (C-TERMINAL DOMAIN).
Descriptor:Coenzyme F420:L-glutamate ligase, SULFATE ION
Authors:Rehan, A.M., Bashiri, G., Baker, H.M., Baker, E.N., Squire, C.J.
Deposit date:2015-01-16
Release date:2016-02-17
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Elongation of the Poly-gamma-glutamate Tail of F420 Requires Both Domains of the F420: gamma-Glutamyl Ligase (FbiB) of Mycobacterium tuberculosis.
J.Biol.Chem., 291, 2016
4XOO
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FMN COMPLEX OF COENZYME F420:L-GLUTAMATE LIGASE (FBIB) FROM MYCOBACTERIUM TUBERCULOSIS (C-TERMINAL DOMAIN)
Descriptor:Coenzyme F420:L-glutamate ligase, FLAVIN MONONUCLEOTIDE
Authors:Rehan, A.M., Bashiri, G., Baker, H.M., Baker, E.N., Squire, C.J.
Deposit date:2015-01-16
Release date:2016-02-17
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Elongation of the Poly-gamma-glutamate Tail of F420 Requires Both Domains of the F420: gamma-Glutamyl Ligase (FbiB) of Mycobacterium tuberculosis.
J.Biol.Chem., 291, 2016
4XOQ
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F420 COMPLEX OF COENZYME F420:L-GLUTAMATE LIGASE (FBIB) FROM MYCOBACTERIUM TUBERCULOSIS (C-TERMINAL DOMAIN)
Descriptor:Coenzyme F420:L-glutamate ligase, COENZYME F420, SULFATE ION
Authors:Rehan, A.M., Bashiri, G., Baker, H.M., Baker, E.N., Squire, C.J.
Deposit date:2015-01-16
Release date:2016-02-17
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Elongation of the Poly-gamma-glutamate Tail of F420 Requires Both Domains of the F420: gamma-Glutamyl Ligase (FbiB) of Mycobacterium tuberculosis.
J.Biol.Chem., 291, 2016
5CWA
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STRUCTURE OF ANTHRANILATE SYNTHASE COMPONENT I (TRPE) FROM MYCOBACTERIUM TUBERCULOSIS WITH INHIBITOR BOUND
Descriptor:Anthranilate synthase component 1, SULFATE ION, GLYCEROL, ...
Authors:Johnston, J.M., Bashiri, G., Evans, G.L., Lott, J.S., Baker, E.N.
Deposit date:2015-07-28
Release date:2015-08-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex.
Acta Crystallogr.,Sect.D, 71, 2015
6EDW
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ICL2 IN THE APO FORM
Descriptor:Isocitrate lyase 2, GLYCEROL, MAGNESIUM ION
Authors:Bashiri, G., Bhusal, R., Leung, I.
Deposit date:2018-08-12
Release date:2019-08-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2
To Be Published
6EDZ
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ICL2 IN COMPLEX WITH ACETYL-COA, FORM I
Descriptor:Isocitrate lyase 2, ACETYL COENZYME *A
Authors:Bashiri, G., Bhusal, R., Leung, I.
Deposit date:2018-08-12
Release date:2019-08-14
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2
To Be Published
6EE1
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ICL2 IN COMPLEX WITH ACETYL-COA
Descriptor:Isocitrate lyase 2, ACETYL COENZYME *A, MAGNESIUM ION
Authors:Bashiri, G., Bhusal, R., Leung, I.
Deposit date:2018-08-12
Release date:2019-08-14
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2
To Be Published
6OVT
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CRYSTAL STRUCTURE OF ILVD FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Dihydroxy-acid dehydratase, MAGNESIUM ION, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Almo, S.C., Grove, T.L., Bonanno, J.B., Baker, E.N., Bashiri, G.
Deposit date:2019-05-08
Release date:2019-08-07
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Dihydroxyacid dehydratase (IlvD) from Mycobacterium tuberculosis is an essential biosynthetic enzyme with an Fe2-S2 cluster at its active site
J.Biol.Chem., 2019
4IDM
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CRYSTAL STRUCTURE OF THE DELTA-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Delta-1-pyrroline-5-carboxylate dehydrogenase
Authors:Lagautriere, T., Bashiri, G., Baker, E.N.
Deposit date:2012-12-12
Release date:2013-12-18
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Characterization of the proline-utilization pathway in Mycobacterium tuberculosis through structural and functional studies.
Acta Crystallogr.,Sect.D, 70, 2014
4IDS
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CRYSTAL STRUCTURE OF THE DELTA-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Delta-1-pyrroline-5-carboxylate dehydrogenase
Authors:Lagautriere, T., Bashiri, G., Baker, E.N.
Deposit date:2012-12-13
Release date:2013-12-18
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Characterization of the proline-utilization pathway in Mycobacterium tuberculosis through structural and functional studies.
Acta Crystallogr.,Sect.D, 70, 2014
4IHI
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CRYSTAL STRUCTURE OF THE DELTA-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE FROM MYCOBACTERIUM TUBERCULOSIS BOUND WITH NAD
Descriptor:Delta-1-pyrroline-5-carboxylate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Lagautriere, T., Bashiri, G., Baker, E.N.
Deposit date:2012-12-18
Release date:2013-12-18
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Characterization of the proline-utilization pathway in Mycobacterium tuberculosis through structural and functional studies.
Acta Crystallogr.,Sect.D, 70, 2014
4JDC
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CRYSTAL STRUCTURE OF THE DELTA-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:1-pyrroline-5-carboxylate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Lagautriere, T., Bashiri, G., Baker, E.N.
Deposit date:2013-02-24
Release date:2013-12-18
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Characterization of the proline-utilization pathway in Mycobacterium tuberculosis through structural and functional studies.
Acta Crystallogr.,Sect.D, 70, 2014
4LEM
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CRYSTAL STRUCTURE OF THE DELTA-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:1-pyrroline-5-carboxylate dehydrogenase, COBALAMIN, MAGNESIUM ION
Authors:Lagautriere, T., Bashiri, G., Baker, E.N.
Deposit date:2013-06-26
Release date:2014-05-14
Last modified:2015-03-04
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Use of a "silver bullet" to resolve crystal lattice dislocation disorder: A cobalamin complex of Delta (1)-pyrroline-5-carboxylate dehydrogenase from Mycobacterium tuberculosis.
J.Struct.Biol., 189, 2015
4NS3
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CRYSTAL STRUCTURE OF THE DELTA-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE FROM MYCOBACTERIUM TUBERCULOSIS BOUND WITH NAD AND COBALAMIN
Descriptor:Delta-1-pyrroline-5-carboxylate dehydrogenase, COBALAMIN, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Lagautriere, T., Bashiri, G., Baker, E.N.
Deposit date:2013-11-27
Release date:2015-01-14
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Use of a "silver bullet" to resolve crystal lattice dislocation disorder: A cobalamin complex of Delta (1)-pyrroline-5-carboxylate dehydrogenase from Mycobacterium tuberculosis.
J.Struct.Biol., 189, 2015
4QVH
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CRYSTAL STRUCTURE OF THE ESSENTIAL MYCOBACTERIUM TUBERCULOSIS PHOSPHOPANTETHEINYL TRANSFERASE PPTT, SOLVED AS A FUSION PROTEIN WITH MALTOSE BINDING PROTEIN
Descriptor:Maltose-binding periplasmic protein, 4'-phosphopantetheinyl transferase chimera, MALTOSE, ...
Authors:Jung, J., Bashiri, G., Johnston, J.M., Baker, E.N.
Deposit date:2014-07-15
Release date:2014-12-17
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of the essential Mycobacterium tuberculosis phosphopantetheinyl transferase PptT, solved as a fusion protein with maltose binding protein.
J.Struct.Biol., 188, 2014
5ERX
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CRYSTAL STRUCTURE OF APO MEND FROM M. TUBERCULOSIS - I222
Descriptor:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
Authors:Johnston, J.M., Jirgis, E.N.M., Bashiri, G., Bulloch, E.M.M., Baker, E.N.
Deposit date:2015-11-16
Release date:2016-06-22
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.729 Å)
Cite:Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms.
Structure, 24, 2016
5ERY
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CRYSTAL STRUCTURE OF APO MEND FROM M. TUBERCULOSIS - P212121
Descriptor:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
Authors:Johnston, J.M., Jirgis, E.N.M., Bashiri, G., Bulloch, E.M.M., Baker, E.N.
Deposit date:2015-11-16
Release date:2016-06-22
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms.
Structure, 24, 2016
5ESD
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CRYSTAL STRUCTURE OF M. TUBERCULOSIS MEND BOUND TO THDP AND MN2+
Descriptor:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, MANGANESE (II) ION, THIAMIN DIPHOSPHATE
Authors:Johnston, J.M., Jirgis, E.N.M., Bashiri, G., Bulloch, E.M.M., Baker, E.N.
Deposit date:2015-11-16
Release date:2016-06-22
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms.
Structure, 24, 2016
5ESO
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CRYSTAL STRUCTURE OF M. TUBERCULOSIS MEND WITH THDP, MG2+ AND ISOCHORISMATE BOUND
Descriptor:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, MAGNESIUM ION, (5S,6S)-5-[(1-carboxyethenyl)oxy]-6-hydroxycyclohexa-1,3-diene-1-carboxylic acid, ...
Authors:Johnston, J.M., Jirgis, E.N.M., Bashiri, G., Bulloch, E.M.M., Baker, E.N.
Deposit date:2015-11-16
Release date:2016-06-22
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms.
Structure, 24, 2016
5ESS
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CRYSTAL STRUCTURE OF M. TUBERCULOSIS MEND BOUND TO MG2+ AND COVALENT INTERMEDIATE I (A THDP AND DECARBOXYLATED 2-OXOGLUTARATE ADDUCT)
Descriptor:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, MAGNESIUM ION, FORMIC ACID, ...
Authors:Johnston, J.M., Jirgis, E.N.M., Bashiri, G., Bulloch, E.M.M., Baker, E.N.
Deposit date:2015-11-17
Release date:2016-06-22
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms.
Structure, 24, 2016
5ESU
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CRYSTAL STRUCTURE OF M. TUBERCULOSIS MEND BOUND TO MG2+ AND COVALENT INTERMEDIATE II (A THDP + DE-CARBOXYLATED 2-OXOGLUTARATE + ISOCHORISMATE ADDUCT)
Descriptor:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, MAGNESIUM ION, FORMIC ACID, ...
Authors:Johnston, J.M., Jirgis, E.N.M., Bashiri, G., Bulloch, E.M.M., Baker, E.N.
Deposit date:2015-11-17
Release date:2016-06-22
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms.
Structure, 24, 2016
6BWG
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CRYSTAL STRUCTURE OF NATIVE RV2983 FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:2-phospho-L-lactate guanylyltransferase
Authors:Jirgis, E.N.M., Baker, E.N.
Deposit date:2017-12-15
Release date:2018-12-19
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Crystal structure of native Rv2983 from Mycobacterium tuberculosis
To Be Published
6BWH
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CRYSTAL STRUCTURE OF MYCOIBACTERIUM TUBERCULOSIS RV2983 IN COMPLEX WITH PEP
Descriptor:2-phospho-L-lactate guanylyltransferase, PHOSPHOENOLPYRUVATE, MAGNESIUM ION
Authors:Jirgis, E.N.M., Baker, E.N.
Deposit date:2017-12-15
Release date:2018-12-19
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Crystal structure of Mycobacterium tuberculosis Rv2983 in complex with PEP
To Be Published
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