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2AM1
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SP PROTEIN LIGAND 1
分子名称:UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D-alanyl-D-alanine ligase, MurF protein, 2,4-DICHLORO-N-(3-CYANO-4,5,6,7-TETRAHYDRO-BENZOTHIOPHEN-2YL)-5-(MORPHOLINE-4-SULFONYL)-BENZAMIDE, ...
著者Longenecker, K.L., Stamper, G.F., Hajduk, P.J., Fry, E.H., Jakob, C.G., Harlan, J.E., Edalji, R., Bartley, D.M., Walter, K.A., Solomon, L.R.
登録日2005-08-08
公開日2006-01-24
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure
Protein Sci., 14, 2005
2AM2
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SP PROTEIN LIGAND 2
分子名称:UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D-alanyl-D-alanine ligase, MurF protein, 2-CHLORO-N-(3-CYANO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHEN-2-YL)-5-DIETHYLSULFAMOYL-BENZAMIDE
著者Longenecker, K.L., Stamper, G.F., Hajduk, P.J., Fry, E.H., Jakob, C.G., Harlan, J.E., Edalji, R., Bartley, D.M., Walter, K.A., Solomon, L.R.
登録日2005-08-08
公開日2006-01-24
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure
Protein Sci., 14, 2005
2QF6
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HSP90 COMPLEXED WITH A56322
分子名称:Heat shock protein HSP 90-alpha, 6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE
著者Park, C.H.
登録日2007-06-26
公開日2008-07-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.
Chem.Biol.Drug Des., 70, 2007
2QFO
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HSP90 COMPLEXED WITH A143571 AND A516383
分子名称:Heat shock protein HSP 90-alpha, 4-METHYL-6-(TRIFLUOROMETHYL)PYRIMIDIN-2-AMINE, (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one
著者Park, C.H.
登録日2007-06-27
公開日2008-07-01
最終更新日2014-04-16
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.
CHEM.BIOL.DRUG DES., 70, 2007
2QG0
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HSP90 COMPLEXED WITH A943037
分子名称:Heat shock protein HSP 90-alpha, N-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)METHYL]-3-{[(E)-(2-OXODIHYDROFURAN-3(2H)-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE
著者Park, C.H.
登録日2007-06-28
公開日2008-07-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.
Chem.Biol.Drug Des., 70, 2007
2QG2
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HSP90 COMPLEXED WITH A917985
分子名称:Heat shock protein HSP 90-alpha, 3-({2-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)ETHYNYL]BENZYL}AMINO)-1,3-OXAZOL-2(3H)-ONE
著者Park, C.H.
登録日2007-06-28
公開日2008-07-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.
Chem.Biol.Drug Des., 70, 2007