Author results

3D0B
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CRYSTAL STRUCTURE OF BENZAMIDE TETRAHYDRO-4H-CARBAZOL-4-ONE BOUND TO HSP90
Descriptor:Heat shock protein HSP 90-alpha, 2-[(2-methoxyethyl)amino]-4-(4-oxo-1,2,3,4-tetrahydro-9H-carbazol-9-yl)benzamide
Authors:Barta, T.E., Veal, J.M., Huang, K.H., Hall, S.H.
Deposit date:2008-05-01
Release date:2008-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90
BIOORG.MED.CHEM.LETT., 18, 2008
3O2X
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MMP-13 IN COMPLEX WITH SELECTIVE TETRAZOLE CORE INHIBITOR
Descriptor:Collagenase 3, N-hydroxy-1-(2-methoxyethyl)-4-{[4-(3-{5-[4-(trifluoromethoxy)phenyl]-2H-tetrazol-2-yl}propoxy)phenyl]sulfonyl}piperidine-4-carboxamide, ZINC ION, ...
Authors:Kiefer, J.R., Barta, T.E., Becker, D.P., Mathis, K.J., Williams, J.
Deposit date:2010-07-22
Release date:2011-08-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:MMP-13 in complex with selective tetrazole core inhibitor
To be Published
3KRY
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CRYSTAL STRUCTURE OF MMP-13 IN COMPLEX WITH SC-78080
Descriptor:Collagenase 3, ZINC ION, CALCIUM ION, ...
Authors:Kiefer, J.R., Williams, J.M., Becker, D.P.
Deposit date:2009-11-19
Release date:2010-10-06
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Orally-active MMP-1 sparing alpha-tetrahydropyranyl and alpha-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease
J.Med.Chem., 53, 2010
3MNR
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CRYSTAL STRUCTURE OF BENZAMIDE SNX-1321 BOUND TO HSP90
Descriptor:Heat shock protein HSP 90-alpha, 2-[(3,4,5-trimethoxyphenyl)amino]-4-(2,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)benzamide
Authors:Veal, J.M., Fadden, P., Huang, K.H., Rice, J., Hall, S.E., Haytstead, T.A.
Deposit date:2010-04-22
Release date:2010-08-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Application of Chemoproteomics to Drug Discovery: Identification of a Clinical Candidate Targeting Hsp90.
Chem.Biol., 17, 2010