Author results

2BIJ
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CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5 (STEP, STRIATUM ENRICHED ENRICHED PHOSPHATASE)
Descriptor:TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 5, SULFATE ION
Authors:Barr, A.J., Debreczeni, J.E., Eswaran, J., Smee, C., Burgess, N., Gileadi, O., Sundstrom, M., Arrowsmith, C., Edwards, A., Knapp, S., von Delft, F.
Deposit date:2005-01-21
Release date:2005-03-17
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
Biochem. J., 395, 2006
2CFV
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CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE J
Descriptor:HUMAN PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE J, NICKEL (II) ION, CHLORIDE ION
Authors:Debreczeni, J.E., Barr, A.J., Eswaran, J., Ugochukwu, E., Sundstrom, M., Weigelt, J., Arrowsmith, C., Edwards, A., Knapp, S.
Deposit date:2006-02-23
Release date:2006-03-09
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2CJZ
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CRYSTAL STRUCTURE OF THE C472S MUTANT OF HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5 (STEP, STRIATUM ENRICHED PHOSPHATASE) IN COMPLEX WITH PHOSPHOTYROSINE
Descriptor:HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5, O-PHOSPHOTYROSINE, 1,2-ETHANEDIOL
Authors:Debreczeni, J.E., Barr, A.J., Eswaran, J., Smee, C., Burgess, N., Gileadi, O., Savitsky, P., Sundstrom, M., Arrowsmith, C., Edwards, A., Weigelt, J., Knapp, S., von Delft, F.
Deposit date:2006-04-10
Release date:2006-05-16
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2JJD
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PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, E ISOFORM
Descriptor:RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE EPSILON, CHLORIDE ION
Authors:Elkins, J.M., Ugochukwu, E., Alfano, I., Barr, A.J., Bunkoczi, G., King, O.N.F., Filippakopoulos, P., Savitsky, P., Salah, E., Pike, A., Johansson, C., Das, S., Burgess-Brown, N.A., Gileadi, O., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Knapp, S.
Deposit date:2008-03-31
Release date:2008-04-08
Last modified:2012-06-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2BV5
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CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5 AT 1.8A RESOLUTION
Descriptor:TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 5, SULFATE ION, ...
Authors:Debreczeni, J.E., Barr, A.J., Eswaran, J., Smee, C., Burgess, N., Gileadi, O., von Delft, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Knapp, S.
Deposit date:2005-06-22
Release date:2005-07-14
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
Biochem. J., 395, 2006
2X57
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2
Descriptor:VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2
Authors:Pike, A.C.W., Barr, A.J., Quigley, A., Burgess Brown, N., de Riso, A., Bullock, A., Berridge, G., Muniz, J.R.C., Chaikaud, A., Vollmar, M., Krojer, T., Ugochukwu, E., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Carpenter, E.P.
Deposit date:2010-02-05
Release date:2010-03-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of the Extracellular Domain of Human Vasoactive Intestinal Polypeptide Receptor 2
To be Published
2XDG
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN GROWTH HORMONE RELEASING HORMONE RECEPTOR.
Descriptor:GROWTH HORMONE-RELEASING HORMONE RECEPTOR, MAGNESIUM ION, 1,2-ETHANEDIOL
Authors:Pike, A.C.W., Quigley, A., Barr, A.J., Burgess Brown, N., Shrestha, L., Yang, J., Chaikuad, A., Vollmar, M., Muniz, J.R.C., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Carpenter, E.P.
Deposit date:2010-04-30
Release date:2010-06-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of the Extracellular Domain of Human Growth Hormone Releasing Hormone Receptor.
To be Published
2XVT
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STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN RAMP2
Descriptor:RECEPTOR ACTIVITY-MODIFYING PROTEIN 2, CALCIUM ION
Authors:Quigley, A., Pike, A.C.W., Burgess-Brown, N., Krojer, T., Shrestha, L., Goubin, S., Kim, J., Das, S., Muniz, J.R.C., Canning, P., Chaikuad, A., Vollmar, M., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Bountra, C., Barr, A.J., Carpenter, E.P.
Deposit date:2010-10-31
Release date:2010-12-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure of the Extracellular Domain of Human Ramp2
To be Published
2XYN
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HUMAN ABL2 IN COMPLEX WITH AURORA KINASE INHIBITOR VX-680
Descriptor:TYROSINE-PROTEIN KINASE ABL2, SODIUM ION, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE, ...
Authors:Salah, E., Ugochukwu, E., Elkins, J.M., Barr, A.J., Shrestha, B., Savitsky, P., Mahajan, P., Muniz, J.R.C., Yue, W.W., Chaikuad, A., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2010-11-18
Release date:2010-12-01
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Crystal Structures of Abl-Related Gene (Abl2) in Complex with Imatinib, Tozasertib (Vx-680), and a Type I Inhibitor of the Triazole Carbothioamide Class.
J.Med.Chem., 54, 2011
4AYT
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STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10
Descriptor:ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10 MITOCHONDRIAL, GLYCINE, MAGNESIUM ION, ...
Authors:Pike, A.C.W., Shintre, C.A., Li, Q., Kim, J., von Delft, F., Barr, A.J., Das, S., Chaikuad, A., Xia, X., Quigley, A., Dong, Y., Dong, L., Krojer, T., Vollmar, M., Muniz, J.R.C., Bray, J.E., Berridge, G., Chalk, R., Gileadi, O., Burgess-Brown, N., Shrestha, L., Goubin, S., Yang, J., Mahajan, P., Mukhopadhyay, S., Bullock, A.N., Arrowsmith, C.H., Weigelt, J., Bountra, C., Edwards, A.M., Carpenter, E.P.
Deposit date:2012-06-22
Release date:2012-07-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structures of Abcb10, a Human ATP-Binding Cassette Transporter in Apo- and Nucleotide-Bound States
Proc.Natl.Acad.Sci.USA, 110, 2013
4AYW
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STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 (PLATE FORM)
Descriptor:ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Pike, A.C.W., Shintre, C.A., Li, Q., Kim, J., von Delft, F., Barr, A.J., Das, S., Chaikuad, A., Xia, X., Quigley, A., Dong, Y., Dong, L., Krojer, T., Vollmar, M., Muniz, J.R.C., Bray, J.E., Berridge, G., Chalk, R., Gileadi, O., Burgess-Brown, N., Shrestha, L., Goubin, S., Yang, J., Mahajan, P., Mukhopadhyay, S., Bullock, A.N., Arrowsmith, C.H., Weigelt, J., Bountra, C., Edwards, A.M., Carpenter, E.P.
Deposit date:2012-06-22
Release date:2012-07-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structures of Abcb10, a Human ATP-Binding Cassette Transporter in Apo- and Nucleotide-Bound States
Proc.Natl.Acad.Sci.USA, 110, 2013
4AYX
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STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 (ROD FORM B)
Descriptor:ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, GLYCINE, MAGNESIUM ION, ...
Authors:Pike, A.C.W., Shintre, C.A., Li, Q., Kim, J., von Delft, F., Barr, A.J., Das, S., Chaikuad, A., Xia, X., Quigley, A., Dong, Y., Dong, L., Krojer, T., Vollmar, M., Muniz, J.R.C., Bray, J.E., Berridge, G., Chalk, R., Gileadi, O., Burgess-Brown, N., Shrestha, L., Goubin, S., Yang, J., Mahajan, P., Mukhopadhyay, S., Bullock, A.N., Arrowsmith, C.H., Weigelt, J., Bountra, C., Edwards, A.M., Carpenter, E.P.
Deposit date:2012-06-22
Release date:2012-07-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of Abcb10, a Human ATP-Binding Cassette Transporter in Apo- and Nucleotide-Bound States
Proc.Natl.Acad.Sci.USA, 110, 2013
2AHS
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN TYROSINE RECEPTOR PHOSPHATASE BETA
Descriptor:Receptor-type tyrosine-protein phosphatase beta, CHLORIDE ION, SODIUM ION, ...
Authors:Ugochukwu, E., Eswaran, J., Barr, A., Gileadi, O., Sobott, F., Burgess, N., Ball, L., Bray, J., von Delft, F., Debreczeni, J., Bunkoczi, G., Turnbull, A., Das, S., Weigelt, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2005-07-28
Release date:2005-08-09
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2B49
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 3
Descriptor:protein tyrosine phosphatase, non-receptor type 3
Authors:Ugochukwu, E., Arrowsmith, C., Barr, A., Bunkoczi, G., Das, S., Debreczeni, J., Edwards, A., Eswaran, J., Knapp, S., Sundstrom, M., Turnbull, A., von Delft, F., Weigelt, J., Structural Genomics Consortium (SGC)
Deposit date:2005-09-23
Release date:2005-10-04
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2BZL
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CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE N14 AT 1. 65 A RESOLUTION
Descriptor:TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 14, SULFATE ION, ...
Authors:Debreczeni, J.E., Barr, A., Eswaran, J., Das, S., Burgess, N., Longman, E., Fedorov, O., Gileadi, O., von Delft, F., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Knapp, S.
Deposit date:2005-08-18
Release date:2005-09-13
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal Structure of Human Protein Tyrosine Phosphatase 14 (Ptpn14) at 1.65-A Resolution.
Proteins, 63, 2006
2GJT
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CRYSTAL STRUCTURE OF THE HUMAN RECEPTOR PHOSPHATASE PTPRO
Descriptor:Receptor-type tyrosine-protein phosphatase PTPRO, CHLORIDE ION
Authors:Barr, A., Ugochukwu, E., Eswaran, J., Das, S., Niesen, F., Savitsky, P., Turnbull, A., Sundstrom, M., Arrowsmith, C., Edwards, A., Weigelt, J., von Delft, F., Papagrigoriou, E., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2006-03-31
Release date:2006-05-02
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2H4V
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CRYSTAL STRUCTURE OF THE HUMAN TYROSINE RECEPTOR PHOSPHATASE GAMMA
Descriptor:Receptor-type tyrosine-protein phosphatase gamma, CHLORIDE ION, CITRATE ANION, ...
Authors:Ugochukwu, E., Barr, A., Das, S., Eswaran, J., Savitsky, P., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Debreczeni, J., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2006-05-25
Release date:2006-07-11
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2I75
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CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE N4 (PTPN4)
Descriptor:Tyrosine-protein phosphatase non-receptor type 4, SULFATE ION
Authors:Ugochukwu, E., Barr, A., Savitsky, P., Burgess, N., Das, S., Turnbull, A., von Delft, F., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2006-08-30
Release date:2006-10-17
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2NZ6
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CRYSTAL STRUCTURE OF THE PTPRJ INACTIVATING MUTANT C1239S
Descriptor:Receptor-type tyrosine-protein phosphatase eta, NICKEL (II) ION, PHOSPHATE ION, ...
Authors:Ugochukwu, E., Barr, A., Savitsky, P., Pike, A.C.W., Bunkoczi, G., Sundstrom, M., Weigelt, J., Arrowsmith, C.H., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2006-11-22
Release date:2006-12-12
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2OC3
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PROTEIN TYROSINE PHOSPHATASE NON-RECEPTOR TYPE 18
Descriptor:Tyrosine-protein phosphatase non-receptor type 18
Authors:Ugochukwu, E., Barr, A., Alfano, I., Gorrec, F., Umeano, C., Savitsky, P., Sobott, F., Eswaran, J., Papagrigoriou, E., Debreczeni, J.E., Turnbull, A., Bunkoczi, G., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2006-12-20
Release date:2007-01-30
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2OOQ
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CRYSTAL STRUCTURE OF THE HUMAN RECEPTOR PHOSPHATASE PTPRT
Descriptor:Receptor-type tyrosine-protein phosphatase T, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SODIUM ION, ...
Authors:Ugochukwu, E., Alfano, I., Barr, A., Keates, T., Eswaran, J., Salah, E., Savitsky, P., Bunkoczi, G., Edwards, A., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-01-26
Release date:2007-02-20
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2P6X
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CRYSTAL STRUCTURE OF HUMAN TYROSINE PHOSPHATASE PTPN22
Descriptor:Tyrosine-protein phosphatase non-receptor type 22, 1,2-ETHANEDIOL, CHLORIDE ION
Authors:Ugochukwu, E., Salah, E., Barr, A., Shrestha, L., Alfano, I., Burgess-Brown, N., King, O., Umeano, C., Papagrigoriou, E., Pike, A.C.W., Bunkoczi, G., Turnbull, A., Uppenberg, J., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-03-19
Release date:2007-04-03
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2PA5
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CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN9
Descriptor:Tyrosine-protein phosphatase non-receptor type 9, CHLORIDE ION, THIOCYANATE ION, ...
Authors:Ugochukwu, E., Barr, A., Pike, A.C.W., Savitsky, P., Papagrigoriou, E., Turnbull, A., Uppenberg, J., Bunkoczi, G., Salah, E., Das, S., von Delft, F., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-03-27
Release date:2007-05-15
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2QEP
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CRYSTAL STRUCTURE OF THE D1 DOMAIN OF PTPRN2 (IA2BETA)
Descriptor:Receptor-type tyrosine-protein phosphatase N2, CHLORIDE ION
Authors:Ugochukwu, E., Barr, A., Alfano, I., Berridge, G., Burgess-Brown, N., Das, S., Fedorov, O., King, O., Niesen, F., Watt, S., Savitsky, P., Salah, E., Pike, A.C.W., Bunkoczi, G., von Delft, F., Sundstrom, M., Edwards, A., Arrowsmith, C.H., Weigelt, J., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-06-26
Release date:2007-07-24
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
3B7O
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CRYSTAL STRUCTURE OF THE HUMAN TYROSINE PHOSPHATASE SHP2 (PTPN11) WITH AN ACCESSIBLE ACTIVE SITE
Descriptor:Tyrosine-protein phosphatase non-receptor type 11, D-MALATE
Authors:Ugochukwu, E., Barr, A., Patel, A., King, O., Niesen, F., Salah, E., Savitsky, P., Pilka, E.S., Elkins, J., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-10-31
Release date:2007-11-13
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
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