Author results

4DZT
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AQUALYSIN I: THE CRYSTAL STRUCTURE OF A SERINE PROTEASE FROM AN EXTREME THERMOPHILE, THERMUS AQUATICUS YT-1
Descriptor:Aqualysin-1, phenylmethanesulfonic acid, CALCIUM ION
Authors:Barnett, B.L., Green, P.R., Strickland, L.C., Oliver, J.D., Rydel, T., Sullivan, J.F.
Deposit date:2012-03-01
Release date:2012-03-28
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Aqualysin I: the crystal structure of a serine protease from an extreme thermophile, Thermus aquaticus YT-1
To be Published
4KFA
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CRYSTAL STRUCTURE OF HUMAN FARNESYL PYROPHOSPHATE SYNTHASE (T201A MUTANT) COMPLEXED WITH MG AND ZOLEDRONATE
Descriptor:Farnesyl pyrophosphate synthase, MAGNESIUM ION, ZOLEDRONIC ACID, ...
Authors:Barnett, B.L., Tsoumpra, M.K., Muniz, J.R.C., Walter, R.L.
Deposit date:2013-04-26
Release date:2014-04-30
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Crystal structure of human farnesyl pyrophosphate synthase (t201a mutant) complexed with mg and zoledronate
To be Published
4KPD
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CRYSTAL STRUCTURE OF HUMAN FARNESYL PYROPHOSPHATE SYNTHASE (Y204F) MUTANT COMPLEXED WITH MG, RISEDRONATE AND ISOPENTENYL PYROPHOSPHATE
Descriptor:Farnesyl pyrophosphate synthase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ...
Authors:Barnett, B.L., Tsoumpra, M.K., Muniz, J.R.C., Walter, R.L.
Deposit date:2013-05-13
Release date:2014-04-30
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal Structure of Human Farnesyl Pyrophosphate Synthase (Y204F) Mutant Complexed with Mg, Risedronate and Isopentenyl Pyrophosphate
To be Published
4KPJ
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CRYSTAL STRUCTURE OF FARNESYL PYROPHOSPHATE SYNTHASE (Y204A) MUTANT COMPLEXED WITH MG, PAMIDRONATE
Descriptor:Farnesyl pyrophosphate synthase, PAMIDRONATE, MAGNESIUM ION, ...
Authors:Barnett, B.L., Tsoumpra, M.K., Muniz, J.R.C., Walter, R.L.
Deposit date:2013-05-13
Release date:2014-04-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of Farnesyl Pyrophosphate Synthase (Y204A) Mutant complexed with Mg, Pamidronate
To be Published
4KQ5
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CRYSTAL STRUCTURE OF HUMAN FARNESYL PYROPHOSPHATE SYNTHASE MUTANT (Y204A) COMPLEXED WITH MG AND ZOLEDRONATE
Descriptor:Farnesyl pyrophosphate synthase, MAGNESIUM ION, ZOLEDRONIC ACID, ...
Authors:Barnett, B.L., Tsoumpra, M.K., Muniz, J.R.C.
Deposit date:2013-05-14
Release date:2014-04-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of Human Farnesyl Pyrophosphate Synthase Mutant (Y204A) Complexed with Mg and Zoledronate
To be Published
4KQS
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CRYSTAL STRUCTURE OF FARNESYL PYROPHOSPHATE SYNTHASE MUTANT (Y204A) COMPLEXED WITH MG, RISEDRONATE AND ISOPENTENYL PYROPHOSPHATE
Descriptor:Farnesyl pyrophosphate synthase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ...
Authors:Barnett, B.L., Tsoumpra, M.K., Muniz, J.R.C.
Deposit date:2013-05-15
Release date:2014-04-30
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Crystal Structure of Farnesyl Pyrophosphate Synthase Mutant (Y204A) Complexed with Mg, Risedronate and Isopentenyl Pyrophosphate
To be Published
4KQU
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CRYSTAL STRUCTURE OF FARNESYL SYNTHASE MUTANT (Y204A) COMPLEXED WITH MG, ALENDRONATE AND ISOPENTENYL PYROPHOSPHATE
Descriptor:Farnesyl pyrophosphate synthase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ...
Authors:Barnett, B.L., Tsoumpra, M.K., Muniz, J.R.C., Walter, R.L.
Deposit date:2013-05-15
Release date:2014-04-30
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Crystal Structure of Farnesyl Synthase Mutant (Y204A) Complexed with Mg, Alendronate and Isopentenyl Pyrophosphate
To be Published
1B3D
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STROMELYSIN-1
Descriptor:STROMELYSIN-1, ZINC ION, CALCIUM ION, ...
Authors:Chen, L., Rydel, T.J., Dunaway, C.M., Pikul, S., Dunham, K.M., Gu, F., Barnett, B.L.
Deposit date:1998-12-09
Release date:1999-12-10
Last modified:2012-05-02
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the stromelysin catalytic domain at 2.0 A resolution: inhibitor-induced conformational changes.
J.Mol.Biol., 293, 1999
1BIW
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DESIGN AND SYNTHESIS OF CONFORMATIONALLY-CONSTRAINED MMP INHIBITORS
Descriptor:PROTEIN (STROMELYSIN-1 COMPLEX), ZINC ION, CALCIUM ION, ...
Authors:Natchus, M.G., Cheng, M., Wahl, C.T., Pikul, S., Almstead, N.G., Bradley, R.S., Taiwo, Y.O., Mieling, G.E., Dunaway, C.M., Snider, C.E., McIver, J.M., Barnett, B.L., McPhail, S.J., Anastasio, M.B., De, B.
Deposit date:1998-06-19
Release date:1999-07-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Design and synthesis of conformationally-constrained MMP inhibitors.
Bioorg.Med.Chem.Lett., 8, 1998
1CQR
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CRYSTAL STRUCTURE OF THE STROMELYSIN CATALYTIC DOMAIN AT 2.0 A RESOLUTION
Descriptor:STROMELYSIN-1, ZINC ION, CALCIUM ION
Authors:Chen, L., Rydel, T.J., Gu, F., Dunaway, C.M., Pikul, S., Dunham, K.M., Barnett, B.L.
Deposit date:1999-08-11
Release date:2000-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the stromelysin catalytic domain at 2.0 A resolution: inhibitor-induced conformational changes.
J.Mol.Biol., 293, 1999
1S02
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EFFECTS OF ENGINEERED SALT BRIDGES ON THE STABILITY OF SUBTILISIN BPN'
Descriptor:SUBTILISIN BPN', CALCIUM ION, SULFATE ION
Authors:Erwin, C.R., Barnett, B.L., Oliver, J.D., Sullivan, J.F.
Deposit date:1991-02-20
Release date:1992-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Effects of engineered salt bridges on the stability of subtilisin BPN'.
Protein Eng., 4, 1990
2RAH
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HUMAN FDPS SYNTHASE IN COMPLEX WITH NOVEL INHIBITOR
Descriptor:Farnesyl pyrophosphate synthetase, MAGNESIUM ION, SULFATE ION, ...
Authors:Evdokimov, A.G., Barnett, B.L., Ebetino, F.H., Pokross, M.
Deposit date:2007-09-15
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Human FDPS synthase in complex with novel inhibitor
To be Published
2VF6
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HUMAN FDPS SYNTHASE IN COMPLEX WITH MINODRONATE
Descriptor:FARNESYL PYROPHOSPHATE SYNTHETASE, (1-HYDROXY-2-IMIDAZO[1,2-A]PYRIDIN-3-YLETHANE-1,1-DIYL)BIS(PHOSPHONIC ACID), MAGNESIUM ION
Authors:Evdokimov, A.G., Barnett, B.L., Ebetino, F.H., Pokross, M.
Deposit date:2007-10-31
Release date:2007-11-06
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human Fdps Synthase in Complex with Novel Inhibitor
To be Published
3CP6
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CRYSTAL STRUCTURE OF HUMAN FARNESYL DIPHOSPHATE SYNTHASE (T201A MUTANT) COMPLEXED WITH MG AND BIPHOSPHONATE INHIBITOR
Descriptor:Farnesyl pyrophosphate synthetase, MAGNESIUM ION, (4aS,7aR)-octahydro-1H-cyclopenta[b]pyridine-6,6-diylbis(phosphonic acid)
Authors:Pilka, E.S., Dunford, J.E., Guo, K., Pike, A.C.W., von Delft, F., Barnett, B.L., Ebetino, F.H., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Russell, R.G.G., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-03-31
Release date:2008-04-15
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Human farnesyl diphosphate synthase (T201A mutant) complexed with Mg and biphosphonate inhibitor.
To be Published
3RYE
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HUMAN FDPS SYNTHASE IN COMPLEX WITH A N-METHYL PYRIDINUM BISPHOSPHONATE
Descriptor:Farnesyl pyrophosphate synthase, 3-(2-hydroxy-2,2-diphosphonoethyl)-1-methylpyridinium, MAGNESIUM ION, ...
Authors:Evdokimov, A.G., Barnett, B.L., Ebetino, F.H., Pokross, M.
Deposit date:2011-05-11
Release date:2011-06-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human FDPS Synthase in Complex with a N-Methyl Pyridinum Bisphosphonate
To be Published
3S4J
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HUMAN FDPS SYNTHASE IN COMPLEX WITH A RIGID ANALOG OF RISEDRONATE
Descriptor:Farnesyl pyrophosphate synthase, 6,7-dihydro-5H-cyclopenta[b]pyridine-6,6-diylbis(phosphonic acid), MAGNESIUM ION, ...
Authors:Evdokimov, A.G., Barnett, B.L., Ebetino, F.H., Pokross, M.
Deposit date:2011-05-19
Release date:2011-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Human FDPS Synthase in Complex with a Rigid Analog of Risedronate
To be Published
4N9U
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THE ROLE OF LYSINE 200 IN THE HUMAN FARNESYL PYROPHOSPHATE SYNTHASE CATALYTIC MECHANISM AND THE MODE OF INHIBITION BY THE NITROGEN-CONTAINING BISPHOSPHONATES
Descriptor:Farnesyl pyrophosphate synthase, MAGNESIUM ION, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, ...
Authors:Tsoumpra, M.K., Muniz, J.R.C., Barnett, B.L., Pilka, E., Kwaasi, A.A., Kavanagh, K.L., Evdokimov, A., Walter, R.L., Ebetino, F.H., Oppermann, U., Russell, R.G.G., Dunford, J.E.
Deposit date:2013-10-21
Release date:2014-10-22
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:The role of lysine 200 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates
TO BE PUBLISHED
4NG6
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THE EFFECTS OF LYSINE 200 AND PHENYLALANINE 239 FARNESYL PYROPHOSPHATE SYNTHASE (FPPS) MUTATIONS ON THE CATALYTIC ACTIVITY, CRYSTAL STRUCTURE AND INHIBITION BY NITROGEN CONTAINING BISPHOSPHONATES
Descriptor:Farnesyl pyrophosphate synthase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ...
Authors:Tsoumpra, M.K., Muniz, J.R.C., Barnett, B.L., Pilka, E., Kwaasi, A.A., Kavanagh, K.L., Evdokimov, A., Walter, R.L., Ebetino, F.H., Oppermann, U., Russell, R.G.G., Dunford, J.E.
Deposit date:2013-11-01
Release date:2014-11-19
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
TO BE PUBLISHED
4NKE
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THE EFFECTS OF LYSINE 200 AND PHENYLALANINE 239 FARNESYL PYROPHOSPHATE SYNTHASE (FPPS) MUTATIONS ON THE CATALYTIC ACTIVITY, CRYSTAL STRUCTURE AND INHIBITION BY NITROGEN CONTAINING BISPHOSPHONATES
Descriptor:Farnesyl pyrophosphate synthase, MAGNESIUM ION, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, ...
Authors:Tsoumpra, M.K., Barnett, B.L., Muniz, J.R.C., Walter, R.L., Ebetino, F.H., von Delft, F., Russell, R.G.G., Oppermann, U., Dunford, J.E.
Deposit date:2013-11-12
Release date:2014-11-19
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
To be Published
4NKF
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THE EFFECTS OF LYSINE 200 AND PHENYLALANINE 239 FARNESYL PYROPHOSPHATE SYNTHASE (FPPS) MUTATIONS ON THE CATALYTIC ACTIVITY, CRYSTAL STRUCTURE AND INHIBITION BY NITROGEN CONTAINING BISPHOSPHONATES
Descriptor:Farnesyl pyrophosphate synthase, MAGNESIUM ION, PAMIDRONATE, ...
Authors:Tsoumpra, M.K., Barnett, B.L., Muniz, J.R.C., Walter, R.L., Ebetino, F.H., von Delft, F., Russell, R.G.G., Oppermann, U., Dunford, J.E.
Deposit date:2013-11-12
Release date:2014-11-19
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
To be Published
4NUA
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THE EFFECTS OF LYSINE 200 AND PHENYLALANINE 239 FARNESYL PYROPHOSPHATE SYNTHASE (FPPS) MUTATIONS ON THE CATALYTIC ACTIVITY, CRYSTAL STRUCTURE AND INHIBITION BY NITROGEN CONTAINING BISPHOSPHONATES
Descriptor:Farnesyl pyrophosphate synthase, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, MAGNESIUM ION, ...
Authors:Tsoumpra, M.K., Barnett, B.L., Muniz, J.R.C., Walter, R.L., Ebetino, F.H., von Delft, F., Russell, R.G.G., Oppermann, U., Dunford, J.E.
Deposit date:2013-12-03
Release date:2014-11-19
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
To be Published
4OGU
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THE EFFECTS OF LYSINE 200 AND PHENYLALANINE 239 FARNESYL PYROPHOSPHATE SYNTHASE (FPPS) MUTATIONS ON THE CATALYTIC ACTIVITY, CRYSTAL STRUCTURE AND INHIBITION BY NITROGEN CONTAINING BISPHOSPHONATES
Descriptor:Farnesyl pyrophosphate synthase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ...
Authors:Tsoumpra, M.K., Barnett, B.L., Muniz, J.R.C., Walter, R.L., Ebetino, F.H., von Delft, F., Russell, R.G.G., Oppermann, U., Dunford, J.E.
Deposit date:2014-01-16
Release date:2015-01-21
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
To be Published
4Q23
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THE ROLE OF THREONINE 201 AND TYROSINE 204 IN THE HUMAN FARNESYL PYROPHOSPHATE SYNTHASE CATALYTIC MECHANISM AND THE MODE OF INHIBITION BY THE NITROGEN-CONTAINING BISPHOSPHONATES
Descriptor:Farnesyl pyrophosphate synthase, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, MAGNESIUM ION, ...
Authors:Tsoumpra, M.K., Muniz, J.R.C., Barnett, B.L., Kwaasi, A.A., Pilka, E.S., Kavanagh, K.L., Evdokimov, A., Walter, R.L., Ebetino, F.H., von Delft, F., Oppermann, U., Russell, R.G.G., Dunford, J.E.
Deposit date:2014-04-05
Release date:2015-03-18
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:The role of threonine 201 and tyrosine 204 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates
To be Published
4QPF
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NEW LOWER BONE AFFINITY BISPHOSPHONATE DRUG DESIGN FOR EFFECTIVE USE IN DISEASES CHARACTERIZED BY ABNORMAL BONE RESORPTION
Descriptor:Farnesyl pyrophosphate synthase, [1-fluoro-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl]bis(phosphonic acid), MAGNESIUM ION
Authors:Ebetino, F.H., Lundy, M., Kwaasi, A.A., Dunford, J.E., Duan, Z., Triffitt, J., Mazur, A., Jeans, G., Barnett, B.L., Russell, R.G.G.
Deposit date:2014-06-23
Release date:2015-06-24
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:New lower bone affinity bisphosphonate drug design for effective use in diseases characterized by abnormal bone resorption
To be Published
2GG0
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NOVEL BACTERIAL METHIONINE AMINOPEPTIDASE INHIBITORS
Descriptor:Methionine aminopeptidase, COBALT (II) ION, SODIUM ION, ...
Authors:Evdokimov, A.G., Pokross, M.E., Walter, R.L., Mekel, M.
Deposit date:2006-03-23
Release date:2006-06-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
Proteins, 66, 2007
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