Author results

5JH7
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TUBULIN-ERIBULIN COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Doodhi, H., Prota, A.E., Rodriguez-Garcia, R., Xiao, H., Custar, D.W., Bargsten, K., Katrukha, E.A., Hilbert, M., Hua, S., Jiang, K., Grigoriev, I., Yang, C.-P.H., Cox, D., Band Horwitz, S., Kapitein, L.C., Akhmanova, A., Steinmetz, M.O.
登録日2016-04-20
公開日2016-06-29
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Termination of Protofilament Elongation by Eribulin Induces Lattice Defects that Promote Microtubule Catastrophes.
Curr.Biol., 26, 2016
4I50
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CRYSTAL STRUCTURE OF TUBULIN-STATHMIN-TTL-EPOTHILONE A COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Prota, A.E., Bargsten, K., Zurwerra, D., Field, J.J., Diaz, J.F., Altmann, K.H., Steinmetz, M.O.
登録日2012-11-28
公開日2013-01-23
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents.
Science, 339, 2013
4I55
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CRYSTAL STRUCTURE OF TUBULIN-STATHMIN-TTL COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Prota, A.E., Bargsten, K., Zurwerra, D., Field, J.J., Diaz, J.F., Altmann, K.H., Steinmetz, M.O.
登録日2012-11-28
公開日2013-01-23
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents.
Science, 339, 2013
4IHJ
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CRYSTAL STRUCTURE OF TUBULIN-STATHMIN-TTL-ADP COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Prota, A.E., Magiera, M.M., Kuijpers, M., Bargsten, K., Frey, D., Wieser, M., Jaussi, R., Hoogenraad, C.C., Kammerer, R.A., Janke, C., Steinmetz, M.O.
登録日2012-12-18
公開日2013-02-13
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis of tubulin tyrosination by tubulin tyrosine ligase.
J.Cell Biol., 200, 2013
4IIJ
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CRYSTAL STRUCTURE OF TUBULIN-STATHMIN-TTL-APO COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Prota, A.E., Magiera, M.M., Kuijpers, M., Bargsten, K., Frey, D., Wieser, M., Jaussi, R., Hoogenraad, C.C., Kammerer, R.A., Janke, C., Steinmetz, M.O.
登録日2012-12-20
公開日2013-01-30
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis of tubulin tyrosination by tubulin tyrosine ligase.
J.Cell Biol., 200, 2013
4O2A
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TUBULIN-BAL27862 COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Prota, A.E., Franck, D., Bachmann, F., Bargsten, K., Buey, R.M., Pohlmann, J., Reinelt, S., Lane, H., Steinmetz, M.O.
登録日2013-12-17
公開日2014-03-05
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization.
J.Mol.Biol., 426, 2014
4O2B
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TUBULIN-COLCHICINE COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Prota, A.E., Franck, D., Bachmann, F., Bargsten, K., Buey, R.M., Pohlmann, J., Reinelt, S., Lane, H., Steinmetz, M.O.
登録日2013-12-17
公開日2014-03-05
最終更新日2014-04-16
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization.
J.Mol.Biol., 426, 2014
4O4H
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TUBULIN-LAULIMALIDE COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Prota, A.E., Bargsten, K., Northcote, P.T., Marsh, M., Altmann, K.H., Miller, J.H., Diaz, J.F., Steinmetz, M.O.
登録日2013-12-18
公開日2014-03-05
最終更新日2014-03-12
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis of microtubule stabilization by laulimalide and peloruside a.
Angew.Chem.Int.Ed.Engl., 53, 2014
4O4I
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TUBULIN-LAULIMALIDE-EPOTHILONE A COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Prota, A.E., Bargsten, K., Northcote, P.T., Marsh, M., Altmann, K.H., Miller, J.H., Diaz, J.F., Steinmetz, M.O.
登録日2013-12-18
公開日2014-03-12
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis of microtubule stabilization by laulimalide and peloruside a.
Angew.Chem.Int.Ed.Engl., 53, 2014
4O4J
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TUBULIN-PELORUSIDE A COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Prota, A.E., Bargsten, K., Northcote, P.T., Marsh, M., Altmann, K.H., Miller, J.H., Diaz, J.F., Steinmetz, M.O.
登録日2013-12-18
公開日2014-03-26
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis of microtubule stabilization by laulimalide and peloruside A.
Angew.Chem.Int.Ed.Engl., 53, 2014
4O4L
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TUBULIN-PELORUSIDE A-EPOTHILONE A COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Prota, A.E., Bargsten, K., Northcote, P.T., Marsh, M., Altmann, K.H., Miller, J.H., Diaz, J.F., Steinmetz, M.O.
登録日2013-12-18
公開日2014-03-26
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis of microtubule stabilization by laulimalide and peloruside a.
Angew.Chem.Int.Ed.Engl., 53, 2014
4TUY
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TUBULIN-RHIZOXIN COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Prota, A.E., Bargsten, K., Diaz, J.F., Marsh, M., Cuevas, C., Liniger, M., Neuhaus, C., Andreu, J.M., Altmann, K.H., Steinmetz, M.O.
登録日2014-06-25
公開日2014-08-27
最終更新日2014-10-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs.
Proc.Natl.Acad.Sci.USA, 111, 2014
4TV8
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TUBULIN-MAYTANSINE COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Prota, A.E., Bargsten, K., Diaz, J.F., Marsh, M., Cuevas, C., Liniger, M., Neuhaus, C., Andreu, J.M., Altmann, K.H., Steinmetz, M.O.
登録日2014-06-26
公開日2014-08-27
最終更新日2014-10-01
実験手法X-RAY DIFFRACTION (2.103 Å)
主引用文献A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs.
Proc.Natl.Acad.Sci.USA, 111, 2014
4TV9
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TUBULIN-PM060184 COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Prota, A.E., Bargsten, K., Diaz, J.F., Marsh, M., Cuevas, C., Liniger, M., Neuhaus, C., Andreu, J.M., Altmann, K.H., Steinmetz, M.O.
登録日2014-06-26
公開日2014-08-20
最終更新日2014-10-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs.
Proc.Natl.Acad.Sci.USA, 111, 2014
5FW1
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CRYSTAL STRUCTURE OF SPYCAS9 VARIANT VQR BOUND TO SGRNA AND TGAG PAM TARGET DNA
分子名称:SGRNA, CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, TARGET DNA STRAND, ...
著者Anders, C., Bargsten, K., Jinek, M.
登録日2016-02-11
公開日2016-04-20
実験手法X-RAY DIFFRACTION (2.499 Å)
主引用文献Structural Plasticity of Pam Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9.
Mol.Cell, 61, 2016
5FW2
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CRYSTAL STRUCTURE OF SPCAS9 VARIANT EQR BOUND TO SGRNA AND TGAG PAM TARGET DNA
分子名称:SGRNA, CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, TARGET DNA STRAND, ...
著者Anders, C., Bargsten, K., Jinek, M.
登録日2016-02-11
公開日2016-06-15
実験手法X-RAY DIFFRACTION (2.676 Å)
主引用文献Structural Plasticity of Pam Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9.
Mol.Cell, 61, 2016
5FW3
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CRYSTAL STRUCTURE OF SPCAS9 VARIANT VRER BOUND TO SGRNA AND TGCG PAM TARGET DNA
分子名称:SGRNA, CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, TARGET DNA STRAND, ...
著者Anders, C., Bargsten, K., Jinek, M.
登録日2016-02-11
公開日2016-06-15
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Plasticity of Pam Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9.
Mol.Cell, 61, 2016
5IYZ
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TUBULIN-MMAE COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Waight, A.B., Bargsten, K., Doronina, S., Steinmetz, M.O., Sussman, D., Prota, A.E.
登録日2016-03-24
公開日2016-08-17
最終更新日2016-12-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics.
Plos One, 11, 2016
5J2T
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TUBULIN-VINBLASTINE COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Waight, A.B., Bargsten, K., Doronina, S., Steinmetz, M.O., Sussman, D., Prota, A.E.
登録日2016-03-30
公開日2016-08-17
最終更新日2016-08-31
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics.
Plos One, 11, 2016
5J2U
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TUBULIN-MMAF COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Waight, A.B., Bargsten, K., Doronina, S., Steinmetz, M.O., Sussman, D., Prota, A.E.
登録日2016-03-30
公開日2016-08-17
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics.
Plos One, 11, 2016
5JVD
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TUBULIN-TUB092 COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Canela, M.-D., Noppen, S., Bueno, O., Prota, A.E., Bargsten, K., Saez-Calvo, G., Jimeno, M.-L., Benkheil, M., Ribatti, D., Velazquez, S., Camarasa, M.-J., Diaz, J.F., Steinmetz, M.O., Priego, E.-M., Perez-Perez, M.-J., Liekens, S.
登録日2016-05-11
公開日2016-06-08
最終更新日2017-09-06
実験手法X-RAY DIFFRACTION (2.393 Å)
主引用文献Antivascular and antitumor properties of the tubulin-binding chalcone TUB091.
Oncotarget, 8, 2017
5LA6
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TUBULIN-PIRONETIN COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Prota, A.E., Setter, J., Waight, A.B., Bargsten, K., Murga, J., Diaz, J.F., Steinmetz, M.O.
登録日2016-06-13
公開日2016-07-20
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Pironetin Binds Covalently to alpha Cys316 and Perturbs a Major Loop and Helix of alpha-Tubulin to Inhibit Microtubule Formation.
J.Mol.Biol., 428, 2016
5MF4
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TUBULIN-DICTYOSTATIN COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Trigili, C., Barasoain, I., Sanchez-Murcia, P.A., Bargsten, K., Redondo-Horcajo, M., Nogales, A., Gardner, N.M., Meyer, A., Naylor, G.J., Gomez-Rubio, E., Gago, F., Steinmetz, M.O., Paterson, I., Prota, A.E., Diaz, J.F.
登録日2016-11-17
公開日2017-09-20
最終更新日2018-08-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells.
ACS Omega, 1, 2016
6O16
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CRYSTAL STRUCTURE OF MURINE DHX37 IN COMPLEX WITH RNA
分子名称:DEAH (Asp-Glu-Ala-His) box polypeptide 37, RNA (5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3')
著者Boneberg, F., Brandmann, T., Kobel, L., van den Heuvel, J., Bargsten, K., Bammert, L., Kutay, U., Jinek, M.
登録日2019-02-18
公開日2019-04-17
実験手法X-RAY DIFFRACTION (2.875 Å)
主引用文献Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14 in ribosome biogenesis.
RNA, 2019
4I4T
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CRYSTAL STRUCTURE OF TUBULIN-RB3-TTL-ZAMPANOLIDE COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Prota, A.E., Steinmetz, M.O.
登録日2012-11-28
公開日2013-01-23
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents.
Science, 339, 2013
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