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3NEW
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P38-ALPHA COMPLEXED WITH COMPOUND 10
分子名称:Mitogen-activated protein kinase 14, 4-(trifluoromethyl)-3-[3-(trifluoromethyl)phenyl]-1,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one
著者Goedken, E.R., Comess, K.M., Sun, C., Argiriadi, M., Jia, Y., Quinn, C.M., Banach, D.L., Marcotte, D., Borhani, D.
登録日2010-06-09
公開日2010-12-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Discovery and Characterization of Non-ATP Site Inhibitors of the Mitogen Activated Protein (MAP) Kinases.
Acs Chem.Biol., 6, 2011
3KA0
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MK2 COMPLEX WITH INHIBITOR 6-(5-(2-AMINOPYRIMIDIN-4-YLAMINO)-2-HYDROXYPHENYL)-N-METHYLBENZO[B]THIOPHENE-2-CARBOXAMIDE
分子名称:MAP kinase-activated protein kinase 2, 6-{5-[(2-aminopyrimidin-4-yl)amino]-2-hydroxyphenyl}-N-methylidene-1-benzothiophene-2-carboxamide
著者Argiriadi, M.A., Talanian, R.V., Borhani, D.W.
登録日2009-10-16
公開日2010-01-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode.
Bioorg.Med.Chem.Lett., 20, 2010
3KC3
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MK2 COMPLEXED TO INHIBITOR N4-(7-(BENZOFURAN-2-YL)-1H-INDAZOL-5-YL)PYRIMIDINE-2,4-DIAMINE
分子名称:MAP kinase-activated protein kinase 2, N~4~-[7-(1-benzofuran-2-yl)-1H-indazol-5-yl]pyrimidine-2,4-diamine
著者Argiriadi, M.A., Talanian, R.V., Borhani, D.W.
登録日2009-10-20
公開日2010-01-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode.
Bioorg.Med.Chem.Lett., 20, 2010
4QPS
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CRYSTAL STRUCTURE OF JAK3 COMPLEXED TO N-[3-(6-PHENYLAMINO-PYRAZIN-2-YL)-3H-BENZOIMIDAZOL-5-YL]-ACRYLAMIDE
分子名称:Tyrosine-protein kinase JAK3, N-{1-[6-(phenylamino)pyrazin-2-yl]-1H-benzimidazol-6-yl}prop-2-enamide
著者Argiriadi, M.A., Goedken, E.R.
登録日2014-06-24
公開日2015-01-14
最終更新日2015-03-11
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Tricyclic Covalent Inhibitors Selectively Target Jak3 through an Active Site Thiol.
J.Biol.Chem., 290, 2015