Author results

4CNI
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CRYSTAL STRUCTURE OF THE FAB PORTION OF OLOKIZUMAB IN COMPLEX WITH IL- 6
分子名称:OLOKIZUMAB HEAVY CHAIN, FAB PORTION, OLOKIZUMAB LIGHT CHAIN, ...
著者Shaw, S., Bourne, T., Meier, C., Carrington, B., Gelinas, R., Henry, A., Popplewell, A., Adams, R., Baker, T., Rapecki, S., Marshall, D., Neale, H., Lawson, A.
登録日2014-01-22
公開日2014-04-30
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery and Characterization of Olokizumab: A Humanized Antibody Targeting Interleukin-6 and Neutralizing Gp130-Signaling.
Mabs, 6, 2014
5F72
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DE NOVO DESIGN AND CRYSTALLOGRAPHIC VALIDATION OF ANTIBODIES TARGETING A PRE-SELECTED EPITOPE
分子名称:Kelch-like ECH-associated protein 1, Single chain Fv from a Fab
著者Liu, X., Taylor, R.D., Griffin, L., Coker, S., Adams, R., Ceska, T., Shi, J., Lawson, A.D.G., Baker, T.
登録日2015-12-07
公開日2016-12-14
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献De novo design and crystallographic validation of antibodies targeting a pre-selected epitope
To Be Published
5URF
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THE STRUCTURE OF HUMAN BOCAVIRUS 1
分子名称:viral protein 3
著者Mietzsch, M., Kailasan, S., Garrison, J., Ilyas, M., Chipman, P., Kandola, K., Jansen, M., Spear, J., Sousa, D., McKenna, R., Soderlund-Venermo, M., Baker, T., Agbandje-McKenna, M.
登録日2017-02-10
公開日2017-03-29
最終更新日2017-05-24
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural Insights into Human Bocaparvoviruses.
J. Virol., 91, 2017
5FUO
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EXTENDING THE HALF-LIFE OF A FAB FRAGMENT THROUGH GENERATION OF A HUMANISED ANTI-HUMAN SERUM ALBUMIN (HSA) FV DOMAIN: AN INVESTIGATION INTO THE CORRELATION BETWEEN AFFINITY AND SERUM HALF-LIFE
分子名称:SERUM ALBUMIN, FAB HEAVY CHAIN, FAB LIGHT CHAIN
著者Adams, R., Ceska, T.
登録日2016-01-28
公開日2016-06-29
最終更新日2016-11-09
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Extending the Half-Life of a Fab Fragment Through Generation of a Humanized Anti-Human Serum Albumin Fv Domain: An Investigation Into the Correlation between Affinity and Serum Half-Life.
Mabs, 8, 2016
5FUZ
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EXTENDING THE HALF-LIFE OF A FAB FRAGMENT THROUGH GENERATION OF A HUMANISED ANTI-HUMAN SERUM ALBUMIN (HSA) FV DOMAIN: AN INVESTIGATION INTO THE CORRELATION BETWEEN AFFINITY AND SERUM HALF-LIFE
分子名称:645 FAB, HEAVY CHAIN, LIGHT CHAIN
著者Adams, R., Ceska, T.
登録日2016-02-01
公開日2016-06-29
最終更新日2016-11-09
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Extending the Half-Life of a Fab Fragment Through Generation of a Humanized Anti-Human Serum Albumin Fv Domain: An Investigation Into the Correlation between Affinity and Serum Half-Life.
Mabs, 8, 2016
2L3Y
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SOLUTION STRUCTURE OF MOUSE IL-6
分子名称:Interleukin-6
著者Veverka, V., Redpath, N.T., Carrington, B., Muskett, F.W., Taylor, R.J., Henry, A.J., Carr, M.D.
登録日2010-09-25
公開日2011-09-28
最終更新日2013-01-02
実験手法SOLUTION NMR
主引用文献Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention.
J.Biol.Chem., 287, 2012
4N5T
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THE 1.7A CRYSTAL STRUCTURE OF MDMX WITH A STAPLED PEPTIDE, ATSP-7041
分子名称:Protein Mdm4, ATSP-7041 stapled-peptide
著者Graves, B.J., Lukacs, C., Janson, C.A.
登録日2013-10-10
公開日2013-11-20
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Stapled alpha-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy.
Proc.Natl.Acad.Sci.USA, 110, 2013
5US7
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HUMAN BOCAVIRUS 3
分子名称:VP2
著者Mietzsch, M., Agbandje-McKenna, M.
登録日2017-02-13
公開日2017-03-29
最終更新日2017-05-24
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structural Insights into Human Bocaparvoviruses.
J. Virol., 91, 2017
5US9
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HUMAN BOCAVIRUS 4
分子名称:Capsid protein VP2
著者Mietzsch, M., Agbandje-McKenna, M.
登録日2017-02-13
公開日2017-03-29
最終更新日2017-05-24
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural Insights into Human Bocaparvoviruses.
J. Virol., 91, 2017