Author results

2XWT
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CRYSTAL STRUCTURE OF THE TSH RECEPTOR IN COMPLEX WITH A BLOCKING TYPE TSHR AUTOANTIBODY
分子名称:THYROID BLOCKING HUMAN AUTOANTIBODY K1-70 HEAVY CHAIN, THYROID BLOCKING HUMAN AUTOANTIBODY K1-70 LIGHT CHAIN, THYROTROPIN RECEPTOR, ...
著者Sanders, J., Sanders, P., Young, S., Kabelis, K., Baker, S., Sullivan, A., Evans, M., Clark, J., Wilmot, J., Hu, X., Roberts, E., Powell, M., Nunez Miguel, R., Furmaniak, J., Rees Smith, B.
登録日2010-11-05
公開日2011-03-09
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal Structure of the Tsh Receptor (Tshr) Bound to a Blocking-Type Tshr Autoantibody.
J.Mol.Endocrinol., 46, 2011
2V0C
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LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A SULPHAMOYL ANALOGUE OF LEUCYL-ADENYLATE IN THE SYNTHETIC SITE AND AN ADDUCT OF AMP WITH 5-FLUORO-1,3-DIHYDRO-1-HYDROXY-2,1-BENZOXABOROLE (AN2690) IN THE EDITING SITE
分子名称:AMINOACYL-TRNA SYNTHETASE, LEUCINE, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDRO-2-FURANYL]METHYL SULFAMATE, ...
著者Rock, F., Mao, W., Yaremchuk, A., Tukalo, M., Crepin, T., Zhou, H., Zhang, Y., Hernandez, V., Akama, T., Baker, S., Plattner, J., Shapiro, L., Martinis, S.A., Benkovic, S.J., Cusack, S., Alley, M.R.K.
登録日2007-05-14
公開日2007-07-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site.
Science, 316, 2007
2V0G
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LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A TRNA(LEU) TRANSCRIPT WITH 5-FLUORO-1,3-DIHYDRO-1-HYDROXY-2,1- BENZOXABOROLE (AN2690) FORMING AN ADDUCT TO THE RIBOSE OF ADENOSINE- 76 IN THE ENZYME EDITING SITE.
分子名称:AMINOACYL-TRNA SYNTHETASE, TRNALEU, LEUCINE, ...
著者Rock, F., Mao, W., Yaremchuk, A., Tukalo, M., Crepin, T., Zhou, H., Zhang, Y., Hernandez, V., Akama, T., Baker, S., Plattner, J., Shapiro, L., Martinis, S.A., Benkovic, S.J., Cusack, S., Alley, M.R.K.
登録日2007-05-14
公開日2007-07-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site.
Science, 316, 2007
1JKX
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UNEXPECTED FORMATION OF AN EPOXIDE-DERIVED MULTISUBSTRATE ADDUCT INHIBITOR ON THE ACTIVE SITE OF GAR TRANSFORMYLASE
分子名称:PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE, N-[5'-O-PHOSPHONO-RIBOFURANOSYL]-2-[2-HYDROXY-2-[4-[GLUTAMIC ACID]-N-CARBONYLPHENYL]-3-[2-AMINO-4-HYDROXY-QUINAZOLIN-6-YL]-PROPANYLAMINO]-ACETAMIDE
著者Greasley, S.E., Marsilje, T.H., Cai, H., Baker, S., Benkovic, S.J., Boger, D.L., Wilson, I.A.
登録日2001-07-13
公開日2001-11-30
最終更新日2018-05-30
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase.
Biochemistry, 40, 2001
3G04
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CRYSTAL STRUCTURE OF THE TSH RECEPTOR IN COMPLEX WITH A THYROID-STIMULATING AUTOANTIBODY
分子名称:HUMAN THYROID STIMULATING AUTOANTIBODY M22 LIGHT CHAIN, HUMAN THYROID STIMULATING AUTOANTIBODY M22 HEAVY CHAIN, Thyrotropin receptor, ...
著者Sanders, J., Chirgadze, D.Y., Sanders, P., Baker, S., Sullivan, A., Bhardwaja, A., Bolton, J., Reeve, M., Nakatake, N., Evans, M., Richards, T., Powell, M., Miguel, R.N., Blundell, T.L., Furmaniak, J., Smith, B.R.
登録日2009-01-27
公開日2009-08-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody
Thyroid, 17, 2007
4EZJ
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POTENT AND SELECTIVE INHIBITORS OF PI3K-DELTA: OBTAINING ISOFORM SELECTIVITY FROM THE AFFINITY POCKET AND TRYPTOPHAN SHELF
分子名称:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 2-(1-{[2-(5-fluoro-1H-indol-4-yl)-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidin-6-yl]methyl}piperidin-4-yl)propan-2-ol
著者Murray, J.M.
登録日2012-05-02
公開日2013-04-17
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献Potent and selective inhibitors of PI3K-delta: obtaining isoform selectivity from the affinity pocket and tryptophan shelf
Bioorg.Med.Chem.Lett., 22, 2012
4EZK
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POTENT AND SELECTIVE INHIBITORS OF PI3K-DELTA: OBTAINING ISOFORM SELECTIVITY FROM THE AFFINITY POCKET AND TRYPTOPHAN SHELF
分子名称:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 2-(1-{[2-(2H-indazol-4-yl)-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidin-6-yl]methyl}piperidin-4-yl)propan-2-ol
著者Murray, J.M.
登録日2012-05-02
公開日2013-04-17
実験手法X-RAY DIFFRACTION (2.803 Å)
主引用文献Potent and selective inhibitors of PI3K-delta: obtaining isoform selectivity from the affinity pocket and tryptophan shelf
Bioorg.Med.Chem.Lett., 22, 2012
4EZL
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POTENT AND SELECTIVE INHIBITORS OF PI3K-DELTA: OBTAINING ISOFORM SELECTIVITY FROM THE AFFINITY POCKET AND TRYPTOPHAN SHELF
分子名称:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 2-(1-{[2-(2-aminopyrimidin-5-yl)-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidin-6-yl]methyl}piperidin-4-yl)propan-2-ol
著者Murray, J.M.
登録日2012-05-02
公開日2013-04-17
実験手法X-RAY DIFFRACTION (2.94 Å)
主引用文献Potent and selective inhibitors of PI3K-delta: obtaining isoform selectivity from the affinity pocket and tryptophan shelf
Bioorg.Med.Chem.Lett., 22, 2012