Author results

4CNI
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CRYSTAL STRUCTURE OF THE FAB PORTION OF OLOKIZUMAB IN COMPLEX WITH IL- 6
Descriptor:OLOKIZUMAB HEAVY CHAIN, FAB PORTION, OLOKIZUMAB LIGHT CHAIN, ...
Authors:Shaw, S., Bourne, T., Meier, C., Carrington, B., Gelinas, R., Henry, A., Popplewell, A., Adams, R., Baker, T., Rapecki, S., Marshall, D., Neale, H., Lawson, A.
Deposit date:2014-01-22
Release date:2014-04-30
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery and Characterization of Olokizumab: A Humanized Antibody Targeting Interleukin-6 and Neutralizing Gp130-Signaling.
Mabs, 6, 2014
5F72
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DE NOVO DESIGN AND CRYSTALLOGRAPHIC VALIDATION OF ANTIBODIES TARGETING A PRE-SELECTED EPITOPE
Descriptor:Kelch-like ECH-associated protein 1, Single chain Fv from a Fab
Authors:Liu, X., Taylor, R.D., Griffin, L., Coker, S., Adams, R., Ceska, T., Shi, J., Lawson, A.D.G., Baker, T.
Deposit date:2015-12-07
Release date:2016-12-14
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:De novo design and crystallographic validation of antibodies targeting a pre-selected epitope
To Be Published
5URF
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THE STRUCTURE OF HUMAN BOCAVIRUS 1
Descriptor:viral protein 3
Authors:Mietzsch, M., Kailasan, S., Garrison, J., Ilyas, M., Chipman, P., Kandola, K., Jansen, M., Spear, J., Sousa, D., McKenna, R., Soderlund-Venermo, M., Baker, T., Agbandje-McKenna, M.
Deposit date:2017-02-10
Release date:2017-03-29
Last modified:2017-05-24
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural Insights into Human Bocaparvoviruses.
J. Virol., 91, 2017
5FUO
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EXTENDING THE HALF-LIFE OF A FAB FRAGMENT THROUGH GENERATION OF A HUMANISED ANTI-HUMAN SERUM ALBUMIN (HSA) FV DOMAIN: AN INVESTIGATION INTO THE CORRELATION BETWEEN AFFINITY AND SERUM HALF-LIFE
Descriptor:SERUM ALBUMIN, FAB HEAVY CHAIN, FAB LIGHT CHAIN
Authors:Adams, R., Ceska, T.
Deposit date:2016-01-28
Release date:2016-06-29
Last modified:2016-11-09
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Extending the Half-Life of a Fab Fragment Through Generation of a Humanized Anti-Human Serum Albumin Fv Domain: An Investigation Into the Correlation between Affinity and Serum Half-Life.
Mabs, 8, 2016
5FUZ
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EXTENDING THE HALF-LIFE OF A FAB FRAGMENT THROUGH GENERATION OF A HUMANISED ANTI-HUMAN SERUM ALBUMIN (HSA) FV DOMAIN: AN INVESTIGATION INTO THE CORRELATION BETWEEN AFFINITY AND SERUM HALF-LIFE
Descriptor:645 FAB, HEAVY CHAIN, LIGHT CHAIN
Authors:Adams, R., Ceska, T.
Deposit date:2016-02-01
Release date:2016-06-29
Last modified:2016-11-09
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Extending the Half-Life of a Fab Fragment Through Generation of a Humanized Anti-Human Serum Albumin Fv Domain: An Investigation Into the Correlation between Affinity and Serum Half-Life.
Mabs, 8, 2016
2L3Y
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SOLUTION STRUCTURE OF MOUSE IL-6
Descriptor:Interleukin-6
Authors:Veverka, V., Redpath, N.T., Carrington, B., Muskett, F.W., Taylor, R.J., Henry, A.J., Carr, M.D.
Deposit date:2010-09-25
Release date:2011-09-28
Last modified:2013-01-02
Method:SOLUTION NMR
Cite:Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention.
J.Biol.Chem., 287, 2012
4N5T
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THE 1.7A CRYSTAL STRUCTURE OF MDMX WITH A STAPLED PEPTIDE, ATSP-7041
Descriptor:Protein Mdm4, ATSP-7041 stapled-peptide
Authors:Graves, B.J., Lukacs, C., Janson, C.A.
Deposit date:2013-10-10
Release date:2013-11-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Stapled alpha-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy.
Proc.Natl.Acad.Sci.USA, 110, 2013
5US7
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HUMAN BOCAVIRUS 3
Descriptor:VP2
Authors:Mietzsch, M., Agbandje-McKenna, M.
Deposit date:2017-02-13
Release date:2017-03-29
Last modified:2017-05-24
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural Insights into Human Bocaparvoviruses.
J. Virol., 91, 2017
5US9
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HUMAN BOCAVIRUS 4
Descriptor:Capsid protein VP2
Authors:Mietzsch, M., Agbandje-McKenna, M.
Deposit date:2017-02-13
Release date:2017-03-29
Last modified:2017-05-24
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural Insights into Human Bocaparvoviruses.
J. Virol., 91, 2017