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2VRO
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CRYSTAL STRUCTURE OF ALDEHYDE DEHYDROGENASE FROM BURKHOLDERIA XENOVORANS LB400
Descriptor:ALDEHYDE DEHYDROGENASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ...
Authors:Bains, J., Boulanger, M.J.
Deposit date:2008-04-09
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and Biochemical Characterization of a Novel Aldehyde Dehydrogenase Encoded by the Benzoate Oxidation (Box) Pathway in Burkholderia Xenovorans Lb400
J.Mol.Biol., 379, 2008
2W3P
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BOXC CRYSTAL STRUCTURE
Descriptor:BENZOYL-COA-DIHYDRODIOL LYASE, BETA-MERCAPTOETHANOL, GLYCEROL
Authors:Bains, J., Boulanger, M.J.
Deposit date:2008-11-13
Release date:2009-04-14
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural and Biophysical Characterization of Boxc from Burkholderia Xenovorans Lb400: A Novel Ring-Cleaving Enzyme in the Crotonase Superfamily.
J.Biol.Chem., 284, 2009
2XUA
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CRYSTAL STRUCTURE OF THE ENOL-LACTONASE FROM BURKHOLDERIA XENOVORANS LB400
Descriptor:3-OXOADIPATE ENOL-LACTONASE, LAEVULINIC ACID
Authors:Bains, J., Kaufman, L., Farnell, B., Boulanger, M.J.
Deposit date:2010-10-17
Release date:2011-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A Product Analog Bound Form of 3-Oxoadipate-Enol- Lactonase (Pcad) Reveals a Multifunctional Role for the Divergent CAP Domain.
J.Mol.Biol., 406, 2011
2Y51
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CRYSTAL STRUCTURE OF E167A MUTANT OF THE BOX PATHWAY ENCODED ALDH FROM BURKHOLDERIA XENOVORANS LB400
Descriptor:ALDEHYDE DEHYDROGENASE (BOX PATHWAY), GLYCEROL
Authors:Bains, J., Leon, R., Temke, K.G., Boulanger, M.J.
Deposit date:2011-01-11
Release date:2011-06-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Elucidating the Reaction Mechanism of the Benzoate Oxidation Pathway Encoded Aldehyde Dehydrogenase from Burkholderia Xenovorans Lb400.
Protein Sci., 20, 2011
2Y52
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CRYSTAL STRUCTURE OF E496A MUTANT OF THE BOX PATHWAY ENCODED ALDH FROM BURKHOLDERIA XENOVORANS LB400
Descriptor:ALDEHYDE DEHYDROGENASE (BOX PATHWAY), GLYCEROL
Authors:Bains, J., Leon, R., Temke, K.G., Boulanger, M.J.
Deposit date:2011-01-11
Release date:2011-06-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Elucidating the Reaction Mechanism of the Benzoate Oxidation Pathway Encoded Aldehyde Dehydrogenase from Burkholderia Xenovorans Lb400.
Protein Sci., 20, 2011
2Y53
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CRYSTAL STRUCTURE OF E257Q MUTANT OF THE BOX PATHWAY ENCODED ALDH FROM BURKHOLDERIA XENOVORANS LB400
Descriptor:ALDEHYDE DEHYDROGENASE (BOX PATHWAY), GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Bains, J., Leon, R., Temke, K.G., Boulanger, M.J.
Deposit date:2011-01-11
Release date:2011-06-01
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Elucidating the Reaction Mechanism of the Benzoate Oxidation Pathway Encoded Aldehyde Dehydrogenase from Burkholderia Xenovorans Lb400.
Protein Sci., 20, 2011
2Y5D
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CRYSTAL STRUCTURE OF C296A MUTANT OF THE BOX PATHWAY ENCODED ALDH FROM BURKHOLDERIA XENOVORANS LB400
Descriptor:ALDEHYDE DEHYDROGENASE (BOX PATHWAY), GLYCEROL, HEXAETHYLENE GLYCOL, ...
Authors:Bains, J., Leon, R., Temke, K.G., Boulanger, M.J.
Deposit date:2011-01-12
Release date:2011-06-01
Last modified:2013-01-23
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Elucidating the Reaction Mechanism of the Benzoate Oxidation Pathway Encoded Aldehyde Dehydrogenase from Burkholderia Xenovorans Lb400.
Protein Sci., 20, 2011
4ATY
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CRYSTAL STRUCTURE OF A TEREPHTHALATE 1,2-CIS-DIHYDRODIOLDEHYDROGENASE FROM BURKHOLDERIA XENOVORANS LB400
Descriptor:TEREPHTHALATE 1,2-CIS-DIHYDRODIOL DEHYDROGENASE, ZINC ION, BETA-MERCAPTOETHANOL
Authors:Bains, J., Boulanger, M.J.
Deposit date:2012-05-11
Release date:2012-08-22
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Investigating Terephthalate Biodegradation: Structural Characterization of a Putative Decarboxylating Cis-Dihydrodiol Dehydrogenase.
J.Mol.Biol., 423, 2012
2V7B
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CRYSTAL STRUCTURES OF A BENZOATE COA LIGASE FROM BURKHOLDERIA XENOVORANS LB400
Descriptor:BENZOATE-COENZYME A LIGASE, BENZOIC ACID
Authors:J Boulanger, M., Bains, J.
Deposit date:2007-07-27
Release date:2007-10-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Biochemical and Structural Characterization of the Paralogous Benzoate Coa Ligases from Burkholderia Xenovorans Lb400: Defining the Entry Point Into the Novel Benzoate Oxidation (Box) Pathway.
J.Mol.Biol., 373, 2007
3JPV
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CRYSTAL STRUCTURE OF HUMAN PROTO-ONCOGENE SERINE THREONINE KINASE (PIM1) IN COMPLEX WITH A CONSENSUS PEPTIDE AND A PYRROLO[2,3-A]CARBAZOLE LIGAND
Descriptor:Proto-oncogene serine/threonine-protein kinase Pim-1, Peptide (PIMTIDE) ARKRRRHPSGPPTA, 1,10-dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde
Authors:Filippakopoulos, P., Bullock, A.N., Fedorov, O., Akue-Gedu, R., Rossignol, E., Azzaro, S., Bain, J., Cohen, P., Prudhomme, M., Moreau, P., Amizon, F., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2009-09-04
Release date:2009-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new pim kinase inhibitors.
J.Med.Chem., 52, 2009
1UU3
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STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH LY333531
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, SULFATE ION, ...
Authors:Komander, D., Kular, G.S., Schuttelkopf, A.W., Deak, M., Prakash, K.R., Bain, J., Elliot, M., Garrido-Franco, M., Kozikowski, A.P., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2003-12-15
Release date:2004-03-04
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12, 2004
1UU7
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STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-2
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, 3-(1H-INDOL-3-YL)-4-(1-{2-[(2S)-1-METHYLPYRROLIDINYL]ETHYL}-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, ...
Authors:Komander, D., Kular, G.S., Schuttelkopf, A.W., Deak, M., Prakash, K.R., Bain, J., Elliot, M., Garrido-Franco, M., Kozikowski, A.P., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2003-12-16
Release date:2004-03-04
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12, 2004
1UU8
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STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-1
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, SULFATE ION, ...
Authors:Komander, D., Kular, G.S., Schuttelkopf, A.W., Deak, M., Prakash, K.R., Bain, J., Elliot, M., Garrido-Franco, M., Kozikowski, A.P., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2003-12-16
Release date:2004-03-04
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12, 2004
1UU9
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STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-3
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, SULFATE ION, ...
Authors:Komander, D., Kular, G.S., Schuttelkopf, A.W., Deak, M., Prakash, K.R., Bain, J., Elliot, M., Garrido-Franco, M., Kozikowski, A.P., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2003-12-16
Release date:2004-03-04
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12, 2004
1UVR
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STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-8
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, SULFATE ION, ...
Authors:Komander, D., Garrido-Franco, M., Kular, G.S., Schuttelkopf, A.W., Deak, M., Prakash, K.R., Bain, J., Elliot, M., Kozikowski, A.P., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2004-01-22
Release date:2004-03-04
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12, 2004
1OM1
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CRYSTAL STRUCTURE OF MAIZE CK2 ALPHA IN COMPLEX WITH IQA
Descriptor:Casein kinase II, alpha chain, (5-OXO-5,6-DIHYDRO-INDOLO[1,2-A]QUINAZOLIN-7-YL)-ACETIC ACID
Authors:Battistutta, R., De Moliner, E., Zanotti, G.
Deposit date:2003-02-24
Release date:2004-02-24
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA).
Biochem.J., 374, 2003
3FL5
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PROTEIN KINASE CK2 IN COMPLEX WITH THE INHIBITOR QUINALIZARIN
Descriptor:Casein kinase II subunit alpha, DI(HYDROXYETHYL)ETHER, 1,2,5,8-tetrahydroxyanthracene-9,10-dione
Authors:Mazzorana, M., Franchin, C., Battistutta, R.
Deposit date:2008-12-18
Release date:2009-08-18
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2
Biochem.J., 421, 2009
1OKY
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STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH STAUROSPORINE
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1, GLYCEROL, SULFATE ION, ...
Authors:Komander, D., Kular, G.S., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2003-08-01
Release date:2004-07-29
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for Ucn-01 (7-Hydroxystaurosporine) Specificity and Pdk1 (3-Phosphoinositide-Dependent Protein Kinase-1) Inhibition
Biochem.J., 375, 2003
1OKZ
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STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH UCN-01
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1, GLYCEROL, SULFATE ION, ...
Authors:Komander, D., Kular, G.S., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2003-08-01
Release date:2004-07-29
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structural Basis for Ucn-01 (7-Hydroxystaurosporine) Specificity and Pdk1 (3-Phosphoinositide-Dependent Protein Kinase-1) Inhibition
Biochem.J., 375, 2003
3KXG
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CRYSTAL STRUCTURE OF Z. MAYS CK2 KINASE ALPHA SUBUNIT IN COMPLEX WITH THE INHIBITOR 3,4,5,6,7-PENTABROMO-1H-INDAZOLE (K64)
Descriptor:Casein kinase II subunit alpha, 3,4,5,6,7-pentabromo-1H-indazole
Authors:Papinutto, E., Franchin, C., Battistutta, R.
Deposit date:2009-12-03
Release date:2010-11-17
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:ATP site-directed inhibitors of protein kinase CK2: an update.
Curr Top Med Chem, 11, 2011
3KXH
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CRYSTAL STRUCTURE OF Z. MAYS CK2 KINASE ALPHA SUBUNIT IN COMPLEX WITH THE INHIBITOR (2-DYMETHYLAMMINO-4,5,6,7-TETRABROMOBENZOIMIDAZOL-1YL-ACETIC ACID (K66)
Descriptor:Casein kinase II subunit alpha, [4,5,6,7-tetrabromo-2-(dimethylamino)-1H-benzimidazol-1-yl]acetic acid, DI(HYDROXYETHYL)ETHER
Authors:Papinutto, E., Franchin, C., Battistutta, R.
Deposit date:2009-12-03
Release date:2010-11-17
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:ATP site-directed inhibitors of protein kinase CK2: an update.
Curr Top Med Chem, 11, 2011
3KXM
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CRYSTAL STRUCTURE OF Z. MAYS CK2 KINASE ALPHA SUBUNIT IN COMPLEX WITH THE INHIBITOR K74
Descriptor:Casein kinase II subunit alpha, N-methyl-2-[(4,5,6,7-tetrabromo-1-methyl-1H-benzimidazol-2-yl)sulfanyl]acetamide
Authors:Papinutto, E., Franchin, C., Battistutta, R.
Deposit date:2009-12-03
Release date:2010-11-17
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:ATP site-directed inhibitors of protein kinase CK2: an update.
Curr Top Med Chem, 11, 2011
3KXN
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CRYSTAL STRUCTURE OF Z. MAYS CK2 KINASE ALPHA SUBUNIT IN COMPLEX WITH THE INHIBITOR TETRAIODOBENZIMIDAZOLE (K88)
Descriptor:Casein kinase II subunit alpha, 4,5,6,7-tetraiodo-1H-benzimidazole
Authors:Papinutto, E., Franchin, C., Battistutta, R.
Deposit date:2009-12-03
Release date:2010-11-17
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:ATP site-directed inhibitors of protein kinase CK2: an update.
Curr Top Med Chem, 11, 2011
3PVG
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CRYSTAL STRUCTURE OF Z. MAYS CK2 ALPHA SUBUNIT IN COMPLEX WITH THE INHIBITOR 4,5,6,7-TETRABROMO-1-CARBOXYMETHYLBENZIMIDAZOLE (K68)
Descriptor:Casein kinase II subunit alpha, (4,5,6,7-tetrabromo-1H-benzimidazol-1-yl)acetic acid
Authors:Papinutto, E., Franchin, C., Battistutta, R.
Deposit date:2010-12-07
Release date:2010-12-15
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:ATP site-directed inhibitors of protein kinase CK2: an update.
Curr Top Med Chem, 11, 2011
3PE1
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CRYSTAL STRUCTURE OF HUMAN PROTEIN KINASE CK2 ALPHA SUBUNIT IN COMPLEX WITH THE INHIBITOR CX-4945
Descriptor:Casein kinase II subunit alpha, 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid, SULFATE ION
Authors:Battistutta, R., Papinutto, E., Lolli, G., Pierre, F., Haddach, M., Ryckman, D.M.
Deposit date:2010-10-25
Release date:2011-09-07
Last modified:2012-01-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer.
Biochemistry, 50, 2011
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