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6BF8
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CRYO-EM STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH INSULIN
Descriptor:Insulin-degrading enzyme
Authors:Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J.
Deposit date:2017-10-26
Release date:2018-04-04
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
6BF6
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CRYO-EM STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME
Descriptor:Insulin-degrading enzyme
Authors:Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J.
Deposit date:2017-10-26
Release date:2018-02-07
Last modified:2018-04-18
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
6BF7
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CRYO-EM STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH FAB H11-E HEAVY CHAIN, FAB H11-E LIGHT CHAIN
Descriptor:Insulin-degrading enzyme, Fab H11-E heavy chain, Fab H11-E light chain
Authors:Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J.
Deposit date:2017-10-26
Release date:2018-02-07
Last modified:2018-04-11
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
6BF9
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CRYO-EM STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH FAB H11-E HEAVY CHAIN, FAB H11-E LIGHT CHAIN
Descriptor:Insulin-degrading enzyme, Fab H11-E heavy chain, Fab H11-E light chain
Authors:Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J.
Deposit date:2017-10-26
Release date:2018-02-07
Last modified:2018-04-11
Method:ELECTRON MICROSCOPY (7.2 Å)
Cite:Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
6AYZ
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CRYSTAL STRUCTURE OF ASF1-FAB 12E COMPLEX
Descriptor:Fab Heavy Chain, Fab Light Chain, Histone chaperone ASF1
Authors:Bailey, L.J., Kossiakoff, A.A.
Deposit date:2017-09-08
Release date:2018-01-17
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.096 Å)
Cite:Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.
J. Mol. Biol., 430, 2018
5UEA
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STRUCTURE OF ANTIGEN-FAB COMPLEX WITH HISTONE CHAPERONE ASF1
Descriptor:Fab Heavy Chain, Histone chaperone ASF1, Fab Light Chain
Authors:Bailey, L.J., Kossiakoff, A.A.
Deposit date:2016-12-29
Release date:2018-01-10
Method:X-RAY DIFFRACTION (1.701 Å)
Cite:Antibody Switch Residue Engineering for Improved Crystallization Chaperones
To Be Published
5UEK
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STRUCTURE OF ANTIGEN-FAB 12E COMPLEX WITH HISTONE CHAPERONE ASF1
Descriptor:Histone chaperone ASF1, Fab 12E Heavy Chain, Fab 12E Light Chain
Authors:Bailey, L.J., Kossiakoff, A.A.
Deposit date:2017-01-02
Release date:2018-01-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Antibody Switch Residue Engineering for Improved Crystallization Chaperones
To Be Published
6AZ2
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CRYSTAL STRUCTURE OF ASF1-FAB 12E COMPLEX
Descriptor:Fab Heavy Chain, Histone chaperone ASF1, Fab Light Chain
Authors:Bailey, L.J., Kossiakoff, A.A.
Deposit date:2017-09-09
Release date:2018-01-10
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.477 Å)
Cite:Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.
J. Mol. Biol., 430, 2018
6B7Z
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CRYO-EM STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH FAB H11 HEAVY CHAIN AND FAB H11 LIGHT CHAIN
Descriptor:Insulin-degrading enzyme, FAB H11 heavy chain, FAB H11 light chain
Authors:Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J.
Deposit date:2017-10-05
Release date:2018-01-10
Last modified:2018-04-11
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
5UCB
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STRUCTURE OF ANTIGEN-FAB COMPLEX WITH ENGINEERED SWITCH RESIDUE REGION.
Descriptor:Fab Heavy Chain, Fab Light Chain, Histone chaperone ASF1
Authors:Bailey, L.J., Kossiakoff, A.A., Chaperone-Enabled Studies of Epigenetic Regulation Enzymes (CEBS)
Deposit date:2016-12-22
Release date:2017-12-27
Method:X-RAY DIFFRACTION (1.521 Å)
Cite:Antibody Switch Residue Engineering for Improved Crystallization Chaperones
To Be Published
6B14
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CRYSTAL STRUCTURE OF SPINACH RNA APTAMER IN COMPLEX WITH FAB BL3-6S97N
Descriptor:Heavy chain of Fab BL3-6S97N, Light chain of Fab BL3-6S97N, RNA (86-MER), ...
Authors:DasGupta, S., Shelke, S.A., Piccirilli, J.A.
Deposit date:2017-09-16
Release date:2017-12-27
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Affinity maturation of a portable Fab-RNA module for chaperone-assisted RNA crystallography.
Nucleic Acids Res., 46, 2018
6B3K
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CRYSTAL STRUCTURE OF MUTANT SPINACH RNA APTAMER IN COMPLEX WITH FAB BL3-6
Descriptor:Heavy chain of Fab BL3-6, Light chain of Fab BL3-6, RNA (83-MER),RNA (83-MER), ...
Authors:DasGupta, S., Koirala, D., Shelke, S.A., Piccirilli, J.A.
Deposit date:2017-09-22
Release date:2017-12-27
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Affinity maturation of a portable Fab-RNA module for chaperone-assisted RNA crystallography.
Nucleic Acids Res., 46, 2018
6B70
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CRYO-EM STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH FAB H11-E HEAVY CHAIN, FAB H11-E LIGHT CHAIN AND INSULIN
Descriptor:Insulin-degrading enzyme, FAB H11-E heavy chain, FAB H11-E light chain, ...
Authors:Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J.
Deposit date:2017-10-03
Release date:2017-12-27
Last modified:2018-04-11
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
6BFC
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CRYO-EM STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH INSULIN
Descriptor:Insulin-degrading enzyme, Insulin
Authors:Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J.
Deposit date:2017-10-26
Release date:2017-12-27
Last modified:2018-04-11
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
6B3Q
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CRYO-EM STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH INSULIN
Descriptor:Insulin-degrading enzyme, Insulin
Authors:Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J.
Deposit date:2017-09-22
Release date:2017-11-22
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
6B7Y
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CRYO-EM STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME
Descriptor:Insulin-degrading enzyme
Authors:Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J.
Deposit date:2017-10-05
Release date:2017-11-08
Last modified:2018-04-11
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
5N85
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STRUCTURE OF RPA70N IN COMPLEX WITH PRIMPOL (FRAGMENT 514-525)
Descriptor:Replication protein A 70 kDa DNA-binding subunit, DNA-directed primase/polymerase protein
Authors:Brissett, N.C., Doherty, A.J.
Deposit date:2017-02-23
Release date:2017-06-07
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis for PrimPol recruitment to replication forks by RPA.
Nat Commun, 8, 2017
5N8A
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STRUCTURE OF RPA70N IN COMPLEX WITH PRIMPOL (FRAGMENT 480-560)
Descriptor:DNA-directed primase/polymerase protein, Replication protein A 70 kDa DNA-binding subunit
Authors:Brissett, N.C., Doherty, A.J.
Deposit date:2017-02-23
Release date:2017-06-07
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Molecular basis for PrimPol recruitment to replication forks by RPA.
Nat Commun, 8, 2017
5TDS
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TOLUENE BOUND IN THE RESTING ACTIVE SITE OF TOLUENE 4-MONOOXYGENASE (T4MOH)
Descriptor:Toluene-4-monooxygenase system protein A, Toluene-4-monooxygenase system protein E, Toluene-4-monooxygenase system protein B, ...
Authors:Acheson, J.F., Fox, B.G.
Deposit date:2016-09-19
Release date:2017-03-22
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.719 Å)
Cite:In-crystal reaction cycle of a toluene-bound diiron hydroxylase.
Nature, 544, 2017
5TDT
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OXYGENATED TOLUENE INTERMEDIATE IN TOLUENE 4-MONOOXYGENASE (T4MOHD) AFTER REACTION IN THE CRYSTAL
Descriptor:Toluene-4-monooxygenase system protein A, Toluene-4-monooxygenase system protein E, Toluene-4-monooxygenase system protein B, ...
Authors:Acheson, J.F., Fox, B.G.
Deposit date:2016-09-19
Release date:2017-03-22
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.818 Å)
Cite:In-crystal reaction cycle of a toluene-bound diiron hydroxylase.
Nature, 544, 2017
5TDU
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TOLUENE 4-MONOOXYGENASE (T4MOHD) BOUND TO PRODUCT AFTER TURNOVER IN CRYSTAL
Descriptor:Toluene-4-monooxygenase system protein A, Toluene-4-monooxygenase system protein E, Toluene-4-monooxygenase system protein B, ...
Authors:Acheson, J.F., Fox, B.G.
Deposit date:2016-09-19
Release date:2017-03-22
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.742 Å)
Cite:In-crystal reaction cycle of a toluene-bound diiron hydroxylase.
Nature, 544, 2017
5TDV
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INTERMEDIATE O2 DIIRON COMPLEX IN THE Q228A VARIANT OF TOLUENE 4-MOONOXYGENASE (T4MOHD)
Descriptor:Toluene-4-monooxygenase system protein A, Toluene-4-monooxygenase system protein E, Toluene-4-monooxygenase system protein B, ...
Authors:Bailey, L.J., Acheson, J.F., Fox, B.G.
Deposit date:2016-09-19
Release date:2017-03-22
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:In-crystal reaction cycle of a toluene-bound diiron hydroxylase.
Nature, 544, 2017
5EII
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STRUCTURAL DETERMINATION OF AN PROTEIN COMPLEX OF A FAB WITH INCREASED SOLUBILITY
Descriptor:Fab Heavy Chain, Fab Light Chain, Histone chaperone ASF1
Authors:Bailey, L.J., Kossiakoff, A.A., Chaperone-Enabled Studies of Epigenetic Regulation Enzymes (CEBS)
Deposit date:2015-10-29
Release date:2016-11-09
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Structural determination of an protein complex of a Fab with increased solubility
To Be Published
5CJO
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CRYSTAL STRUCTURE ANALYSIS OF ELBOW-ENGINEERED-FAB-BOUND HUMAN INSULIN DEGRADING ENZYME (IDE) IN COMPLEX WITH INSULIN
Descriptor:Insulin-degrading enzyme, FAB Heavy chain with engineered elbow, FAB light chain, ...
Authors:liang, w.g., bailey, L., tang, w.j.
Deposit date:2015-07-14
Release date:2016-07-20
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (3.287 Å)
Cite:Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.
J. Mol. Biol., 2017
4P1B
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CRYSTAL STRUCTURE OF THE TOLUENE 4-MONOOXYGENASE HYDROXYLASE-FERREDOXIN C7S E16C C84A C85A VARIANT ELECTRON-TRANSFER COMPLEX
Descriptor:Toluene-4-monooxygenase system protein A, Toluene-4-monooxygenase system protein E, Toluene-4-monooxygenase system protein B, ...
Authors:Acheson, J.F., Fox, B.G.
Deposit date:2014-02-25
Release date:2014-10-01
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis for biomolecular recognition in overlapping binding sites in a diiron enzyme system.
Nat Commun, 5, 2014
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