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3GIC
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BU of 3gic by Molmil
Structure of thrombin mutant delta(146-149e) in the free form
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombin heavy chain, Thrombin light chain
Authors:Bah, A, Carrell, C.J, Chen, Z, Gandhi, P.S, Di Cera, E.
Deposit date:2009-03-05
Release date:2009-06-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Stabilization of the E* form turns thrombin into an anticoagulant.
J.Biol.Chem., 284, 2009
2MX4
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BU of 2mx4 by Molmil
NMR structure of Phosphorylated 4E-BP2
Descriptor: Eukaryotic translation initiation factor 4E-binding protein 2
Authors:Bah, A, Forman-Kay, J, Vernon, R, Siddiqui, Z, Krzeminski, M, Muhandiram, R, Zhao, C, Sonenberg, N, Kay, L.
Deposit date:2014-12-10
Release date:2015-01-07
Last modified:2015-03-18
Method:SOLUTION NMR
Cite:Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch.
Nature, 519, 2015
2PV9
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BU of 2pv9 by Molmil
Crystal structure of murine thrombin in complex with the extracellular fragment of murine PAR4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Proteinase-activated receptor 4, Thrombin heavy chain, ...
Authors:Bah, A, Chen, Z, Bush-Pelc, L.A, Mathews, F.S, Di Cera, E.
Deposit date:2007-05-09
Release date:2007-07-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2PUX
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BU of 2pux by Molmil
Crystal structure of murine thrombin in complex with the extracellular fragment of murine PAR3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Proteinase-activated receptor 3, Thrombin heavy chain, ...
Authors:Bah, A, Chen, Z, Bush-Pelc, L.A, Mathews, F.S, Di Cera, E.
Deposit date:2007-05-09
Release date:2007-07-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4.
Proc.Natl.Acad.Sci.Usa, 104, 2007
3E6P
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BU of 3e6p by Molmil
Crystal structure of human meizothrombin desF1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-PHENYLALANYL-N-[(1S)-4-{[(Z)-AMINO(IMINO)METHYL]AMINO}-1-(CHLOROACETYL)BUTYL]-L-PROLINAMIDE, Prothrombin, ...
Authors:Papaconstantinou, M.E, Gandhi, P, Chen, Z, Bah, A, Di Cera, E.
Deposit date:2008-08-15
Release date:2008-11-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Na(+) binding to meizothrombin desF1.
Cell.Mol.Life Sci., 65, 2008
3JZ1
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BU of 3jz1 by Molmil
Crystal structure of human thrombin mutant N143P in E:Na+ form
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, NITRATE ION, ...
Authors:Niu, W, Chen, Z, Bush-Pelc, L.A, Bah, A, Gandhi, P.S, Di Cera, E.
Deposit date:2009-09-22
Release date:2009-10-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Mutant N143P reveals how Na+ activates thrombin
J.Biol.Chem., 284, 2009
3JZ2
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BU of 3jz2 by Molmil
Crystal structure of human thrombin mutant N143P in E* form
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Thrombin heavy chain, ...
Authors:Niu, W, Chen, Z, Bush-Pelc, L.A, Bah, A, Gandhi, P.S, Di Cera, E.
Deposit date:2009-09-22
Release date:2009-10-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Mutant N143P reveals how Na+ activates thrombin
J.Biol.Chem., 284, 2009
3R3G
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BU of 3r3g by Molmil
Structure of human thrombin with residues 145-150 of murine thrombin.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, Thrombin Heavy Chain, ...
Authors:Pozzi, N, Chen, R, Chen, Z, Bah, A, Di Cera, E.
Deposit date:2011-03-15
Release date:2011-05-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Rigidification of the autolysis loop enhances Na(+) binding to thrombin.
Biophys.Chem., 159, 2011
2LCB
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BU of 2lcb by Molmil
Solution Structure of a Minor and Transiently Formed State of a T4 Lysozyme Mutant
Descriptor: Lysozyme
Authors:Bouvignies, G, Vallurupalli, P, Hansen, D, Correia, B, Lange, O, Bah, A, Vernon, R.M, Dahlquist, F.W, Baker, D, Kay, L.E.
Deposit date:2011-04-26
Release date:2011-08-17
Last modified:2011-09-07
Method:SOLUTION NMR
Cite:Solution structure of a minor and transiently formed state of a T4 lysozyme mutant.
Nature, 477, 2011
2LC9
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BU of 2lc9 by Molmil
Solution Structure of a Minor and Transiently Formed State of a T4 Lysozyme Mutant
Descriptor: Lysozyme
Authors:Bouvignies, G, Vallurupalli, P, Hansen, D, Correia, B, Lange, O, Bah, A, Vernon, R.M, Dahlquist, F.W, Baker, D, Kay, L.E.
Deposit date:2011-04-26
Release date:2011-08-17
Last modified:2011-09-07
Method:SOLUTION NMR
Cite:Solution structure of a minor and transiently formed state of a T4 lysozyme mutant.
Nature, 477, 2011
2GP9
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BU of 2gp9 by Molmil
Crystal structure of the slow form of thrombin in a self-inhibited conformation
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Prothrombin
Authors:Pineda, A, Chen, Z, Mathews, F.S, Di Cera, E.
Deposit date:2006-04-17
Release date:2006-09-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Crystal structure of thrombin in a self-inhibited conformation.
J.Biol.Chem., 281, 2006
3BEF
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BU of 3bef by Molmil
Crystal structure of thrombin bound to the extracellular fragment of PAR1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Proteinase-activated receptor 1, Prothrombin
Authors:Gandhi, P.S, Bah, A, Chen, Z, Mathews, F.S, Di Cera, E.
Deposit date:2007-11-17
Release date:2008-01-01
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural identification of the pathway of long-range communication in an allosteric enzyme.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3NXP
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BU of 3nxp by Molmil
Crystal structure of human prethrombin-1
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
Authors:Chen, Z, Bush-Pelc, L.A, Di Cera, E.
Deposit date:2010-07-14
Release date:2010-11-10
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of prethrombin-1.
Proc.Natl.Acad.Sci.USA, 107, 2010
3QGN
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BU of 3qgn by Molmil
The allosteric E*-E equilibrium is a key property of the trypsin fold
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, IODIDE ION, ...
Authors:Niu, W, Gohara, D, Chen, Z, Di Cera, E.
Deposit date:2011-01-24
Release date:2011-07-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystallographic and kinetic evidence of allostery in a trypsin-like protease.
Biochemistry, 50, 2011

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