Author results

1EAN
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THE RUNX1 RUNT DOMAIN AT 1.70A RESOLUTION: A STRUCTURAL SWITCH AND SPECIFICALLY BOUND CHLORIDE IONS MODULATE DNA BINDING
Descriptor:RUNT-RELATED TRANSCRIPTION FACTOR 1, CHLORIDE ION
Authors:Backstrom, S., Wolf-Watz, M., Grundstrom, C., Hard, T., Grundstrom, T., Sauer, U.H.
Deposit date:2001-07-13
Release date:2002-09-12
Last modified:2017-03-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Runx1 Runt Domain at 1.25 A Resolution: A Structural Switch and Specifically Bound Chloride Ions Modulate DNA Binding
J.Mol.Biol., 322, 2002
1EAO
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THE RUNX1 RUNT DOMAIN AT 1.4A RESOLUTION: A STRUCTURAL SWITCH AND SPECIFICALLY BOUND CHLORIDE IONS MODULATE DNA BINDING
Descriptor:RUNT-RELATED TRANSCRIPTION FACTOR 1, BROMIDE ION
Authors:Backstrom, S., Wolf-Watz, M., Grundstrom, C., Hard, T.H., Grundstrom, T., Sauer, U.H.
Deposit date:2001-07-14
Release date:2002-09-12
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Runx1 Runt Domain at 1.25A Resolution: A Structural Switch and Specifically Bound Chloride Ions Modulate DNA Binding
J.Mol.Biol., 322, 2002
1EAQ
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THE RUNX1 RUNT DOMAIN AT 1.25A RESOLUTION: A STRUCTURAL SWITCH AND SPECIFICALLY BOUND CHLORIDE IONS MODULATE DNA BINDING
Descriptor:RUNT-RELATED TRANSCRIPTION FACTOR 1, CHLORIDE ION
Authors:Backstrom, S., Wolf-Watz, M., Grundstrom, C., Hard, T., Grundstrom, T., Sauer, U.H.
Deposit date:2001-07-14
Release date:2002-09-12
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:The Runx1 Runt Domain at 1.25 A Resolution: A Structural Switch and Specifically Bound Chloride Ions Modulate DNA Binding
J.Mol.Biol., 322, 2002
4CSJ
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THE DISCOVERY OF POTENT SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS, SUITABLE FOR INHALATION
Descriptor:GLUCOCORTICOID RECEPTOR, NUCLEAR RECEPTOR COACTIVATOR 2, 1,2-ETHANEDIOL, ...
Authors:Edman, K., Ahlgren, R., Bengtsson, M., Bladh, H., Backstrom, S., Dahmen, J., Henriksson, K., Hillertz, P., Hulikal, V., Jerre, A., Kinchin, L., Kase, C., Lepisto, M., Mile, I., Nilsson, S., Smailagic, A., Taylor, J., Tjornebo, A., Wissler, L., Hansson, T.
Deposit date:2014-03-07
Release date:2014-05-07
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Discovery of Potent and Selective Non-Steroidal Glucocorticoid Receptor Modulators, Suitable for Inhalation.
Bioorg.Med.Chem.Lett., 24, 2014
2G2N
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CRYSTAL STRUCTURE OF E.COLI TRANSTHYRETIN-RELATED PROTEIN WITH BOUND ZN
Descriptor:Transthyretin-like protein, ZINC ION, SULFATE ION
Authors:Lundberg, E., Backstrom, S., Sauer, U.H., Sauer-Eriksson, A.E.
Deposit date:2006-02-16
Release date:2006-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The transthyretin-related protein: structural investigation of a novel protein family
J.Struct.Biol., 155, 2006
2G2P
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CRYSTAL STRUCTURE OF E.COLI TRANSTHYRETIN-RELATED PROTEIN WITH BOUND ZN AND BR
Descriptor:Transthyretin-like protein, ZINC ION, BROMIDE ION, ...
Authors:Lundberg, E., Backstrom, S., Sauer, U.H., Sauer-Eriksson, A.E.
Deposit date:2006-02-16
Release date:2006-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The transthyretin-related protein: structural investigation of a novel protein family
J.Struct.Biol., 155, 2006
2YOP
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LONG WAVELENGTH S-SAD STRUCTURE OF FAM3B PANDER
Descriptor:PROTEIN FAM3B, GLYCEROL
Authors:Johansson, P., Bernstrom, J., Gorman, T., Oster, L., Backstrom, S., Schweikart, F., Xu, B., Xue, Y., Holmberg Schiavone, L.
Deposit date:2012-10-26
Release date:2013-01-30
Last modified:2013-02-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Fam3B Pander and Fam3C Ilei Represent a Distinct Class of Signaling Molecules with a Non-Cytokine-Like Fold.
Structure, 21, 2013
2YOQ
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STRUCTURE OF FAM3B PANDER E30 CONSTRUCT
Descriptor:PROTEIN FAM3B, GLYCEROL
Authors:Johansson, P., Bernstrom, J., Gorman, T., Oster, L., Backstrom, S., Schweikart, F., Xu, B., Xue, Y., Holmberg Schiavone, L.
Deposit date:2012-10-26
Release date:2013-01-30
Last modified:2013-02-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Fam3B Pander and Fam3C Ilei Represent a Distinct Class of Signaling Molecules with a Non-Cytokine-Like Fold.
Structure, 21, 2013
4UDA
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MR IN COMPLEX WITH DEXAMETHASONE
Descriptor:MINERALOCORTICOID RECEPTOR, NUCLEAR RECEPTOR COACTIVATOR 1, GLYCEROL, ...
Authors:Edman, K., Hogner, A., Hussein, A., Bjursell, M., Aagaard, A., Backstrom, S., Bodin, C., Wissler, L., Jellesmark-Jensen, T., Cavallin, A., Karlsson, U., Nilsson, E., Lecina, D., Takahashi, R., Grebner, C., Lepisto, M., Guallar, V.
Deposit date:2014-12-09
Release date:2015-11-25
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints.
Structure, 23, 2015
4UDB
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MR IN COMPLEX WITH DESISOBUTYRYLCICLESONIDE
Descriptor:MINERALOCORTICOID RECEPTOR, NUCLEAR RECEPTOR COACTIVATOR 1, DIMETHYL SULFOXIDE, ...
Authors:Edman, K., Hogner, A., Hussein, A., Aagaard, A., Backstrom, S., Bodin, C., Wissler, L., JellesmarkJensen, T., Cavallin, A., Nilsson, E., Lepisto, M., Guallar, V.
Deposit date:2014-12-09
Release date:2015-11-25
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints.
Structure, 23, 2015
4UDC
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GR IN COMPLEX WITH DEXAMETHASONE
Descriptor:GLUCOCORTICOID RECEPTOR, NUCLEAR RECEPTOR COACTIVATOR 2, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ...
Authors:Edman, K., Hogner, A., Hussein, A., Bjursell, M., Aagaard, A., Backstrom, S., Bodin, C., Wissler, L., Jellesmark-Jensen, T., Cavallin, A., Karlsson, U., Nilsson, E., Lecina, D., Takahashi, R., Grebner, C., Lepisto, M., Guallar, V.
Deposit date:2014-12-09
Release date:2015-11-25
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints.
Structure, 23, 2015
4UDD
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GR IN COMPLEX WITH DESISOBUTYRYLCICLESONIDE
Descriptor:GLUCOCORTICOID RECEPTOR, NUCLEAR RECEPTOR COACTIVATOR 2, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ...
Authors:Edman, K., Hogner, A., Hussein, A., Bjursell, M., Aagaard, A., Backstrom, S., Bodin, C., Wissler, L., Jellesmark-Jensen, T., Cavallin, A., Karlsson, U., Nilsson, E., Lecina, D., Takahashi, R., Grebner, C., Lepisto, M., Guallar, V.
Deposit date:2014-12-09
Release date:2015-11-25
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints.
Structure, 23, 2015
5FP0
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LIGAND COMPLEX STRUCTURE OF SOLUBLE EPOXIDE HYDROLASE
Descriptor:BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE, N-cyclopentyl-2-[4-(trifluoromethyl)phenyl]-3H-benzimidazole-4-sulfonamide
Authors:Xue, Y., Olsson, T., Johansson, C.A., Oster, L., Beisel, H.G., Rohman, M., Karis, D., Backstrom, S.
Deposit date:2015-11-26
Release date:2016-03-02
Last modified:2016-03-16
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Fragment Screening of Soluble Epoxide Hydrolase for Lead Generation-Structure-Based Hit Evaluation and Chemistry Exploration.
Chemmedchem, 11, 2016
5L7E
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MCR IN COMPLEX WITH LIGAND
Descriptor:Mineralocorticoid receptor, NCOA1 peptide, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ...
Authors:Edman, K., Aagaard, A., Backstrom, S., Xue, Y.
Deposit date:2016-06-03
Release date:2016-12-07
Last modified:2017-01-18
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structure-Based Drug Design of Mineralocorticoid Receptor Antagonists to Explore Oxosteroid Receptor Selectivity.
ChemMedChem, 12, 2017
5L7G
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MCR IN COMPLEX WITH LIGAND
Descriptor:Mineralocorticoid receptor, NCOA1 peptide, 1,2-ETHANEDIOL, ...
Authors:Edman, K., Aagaard, A., Backstrom, S., Xue, Y.
Deposit date:2016-06-03
Release date:2016-12-07
Last modified:2017-01-18
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structure-Based Drug Design of Mineralocorticoid Receptor Antagonists to Explore Oxosteroid Receptor Selectivity.
ChemMedChem, 12, 2017
5L7H
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MCR IN COMPLEX WITH LIGAND
Descriptor:Mineralocorticoid receptor, NCOA1 peptide, 3-methyl-5,8-dioxa-17lambda-thia-4,18-diazatetracyclo[18.2.2.1,.0]pentacosa-1(22),2(6),3,9,11,13(25),20,23-octaene-17,17-dione, ...
Authors:Xue, Y., Aagaard, A., Backstrom, S., Edman, K.
Deposit date:2016-06-03
Release date:2016-12-07
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structure-Based Drug Design of Mineralocorticoid Receptor Antagonists to Explore Oxosteroid Receptor Selectivity.
ChemMedChem, 12, 2017
5MWP
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THE STRUCTURE OF MR IN COMPLEX WITH AZD9977.
Descriptor:Mineralocorticoid receptor, NCOA1 peptide, 2-[(3~{S})-7-fluoranyl-4-[(3-oxidanylidene-4~{H}-1,4-benzoxazin-6-yl)carbonyl]-2,3-dihydro-1,4-benzoxazin-3-yl]-~{N}-methyl-ethanamide
Authors:Edman, K., Aagaard, A., Backstrom, S.
Deposit date:2017-01-19
Release date:2018-03-07
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion.
PLoS ONE, 13, 2018
5MWY
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THE STRUCTURE OF MR IN COMPLEX WITH EPLERENONE.
Descriptor:Mineralocorticoid receptor, NCOA1, eplerenone
Authors:Edman, K., Aagaard, A., Backstrom, S.
Deposit date:2017-01-20
Release date:2018-03-07
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion.
PLoS ONE, 13, 2018