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2HDR
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BU of 2hdr by Molmil
AmpC beta-lactamase in complex with 4-Amino-3-hydroxybenzoic acid
Descriptor: 4-AMINO-3-HYDROXYBENZOIC ACID, Beta-lactamase, PHOSPHATE ION
Authors:Babaoglu, K, Shoichet, B.K.
Deposit date:2006-06-20
Release date:2006-11-07
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Deconstructing fragment-based inhibitor discovery
Nat.Chem.Biol., 2, 2006
2HDS
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BU of 2hds by Molmil
AmpC beta-lactamase in complex with 4-Methanesulfonylamino benzoic acid
Descriptor: 4-[(METHYLSULFONYL)AMINO]BENZOIC ACID, Beta-lactamase, PHOSPHATE ION, ...
Authors:Babaoglu, K, Shoichet, B.K.
Deposit date:2006-06-20
Release date:2006-11-07
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:Deconstructing fragment-based inhibitor discovery
Nat.Chem.Biol., 2, 2006
2HDU
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BU of 2hdu by Molmil
AmpC beta-lactamase in complex with 2-acetamidothiophene-3-carboxylic acid
Descriptor: 2-(ACETYLAMINO)THIOPHENE-3-CARBOXYLIC ACID, Beta-lactamase, PHOSPHATE ION, ...
Authors:Babaoglu, K, Shoichet, B.K.
Deposit date:2006-06-20
Release date:2006-11-07
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Deconstructing fragment-based inhibitor discovery
Nat.Chem.Biol., 2, 2006
2HDQ
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BU of 2hdq by Molmil
AmpC beta-lactamase in complex with 2-carboxythiophene
Descriptor: Beta-lactamase, THIOPHENE-2-CARBOXYLIC ACID
Authors:Babaoglu, K, Shoichet, B.K.
Deposit date:2006-06-20
Release date:2006-11-07
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Deconstructing fragment-based inhibitor discovery
Nat.Chem.Biol., 2, 2006
2PU4
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BU of 2pu4 by Molmil
AmpC beta-lacamase with bound covalent oxadiazole inhibitor
Descriptor: Beta-lactamase, DIMETHYL SULFOXIDE, SULFATE ION, ...
Authors:Babaoglu, K, Shoichet, B.K.
Deposit date:2007-05-08
Release date:2008-04-15
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase.
J.Med.Chem., 51, 2008
2PU2
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BU of 2pu2 by Molmil
AmpC beta-lactamase with bound Phthalamide inhibitor
Descriptor: 2-[(1R)-1-CARBOXY-2-(4-HYDROXYPHENYL)ETHYL]-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID, Beta-lactamase, PHOSPHATE ION
Authors:Babaoglu, K, Shoichet, B.K.
Deposit date:2007-05-08
Release date:2008-04-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase.
J.Med.Chem., 51, 2008
2R9X
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BU of 2r9x by Molmil
AmpC beta-lactamase with bound Phthalamide inhibitor
Descriptor: 2-[(1R)-2-carboxy-1-(naphthalen-1-ylmethyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid, Beta-lactamase, DIMETHYL SULFOXIDE, ...
Authors:Babaoglu, K, Shoichet, B.K.
Deposit date:2007-09-13
Release date:2008-04-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase.
J.Med.Chem., 51, 2008
2R9W
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BU of 2r9w by Molmil
AmpC beta-lactamase with bound Phthalamide inhibitor
Descriptor: 2-[(1R)-1-carboxy-2-naphthalen-1-ylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid, Beta-lactamase, PHOSPHATE ION
Authors:Babaoglu, K, Shoichet, B.K.
Deposit date:2007-09-13
Release date:2008-04-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase.
J.Med.Chem., 51, 2008
1TWW
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BU of 1tww by Molmil
Dihydropteroate Synthetase, With Bound Substrate Analogue PtPP, From Bacillus anthracis
Descriptor: 6-HYDROXYMETHYLPTERIN-DIPHOSPHATE, DHPS, Dihydropteroate synthase, ...
Authors:Babaoglu, K, Qi, J, Lee, R.E, White, S.W.
Deposit date:2004-07-01
Release date:2004-09-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of 7,8-Dihydropteroate Synthase from Bacillus anthracis; Mechanism and Novel Inhibitor Design.
STRUCTURE, 12, 2004
1TX0
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BU of 1tx0 by Molmil
Dihydropteroate Synthetase, With Bound Product Analogue Pteroic Acid, From Bacillus anthracis
Descriptor: DHPS, Dihydropteroate synthase, PTEROIC ACID, ...
Authors:Babaoglu, K, Qi, J, Lee, R.E, White, S.W.
Deposit date:2004-07-01
Release date:2004-09-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal Structure of 7,8-Dihydropteroate Synthase from Bacillus anthracis; Mechanism and Novel Inhibitor Design.
STRUCTURE, 12, 2004
1TWS
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BU of 1tws by Molmil
Dihydropteroate Synthetase From Bacillus anthracis
Descriptor: DHPS, Dihydropteroate synthase, SULFATE ION
Authors:Babaoglu, K, Qi, J, Lee, R.E, White, S.W.
Deposit date:2004-07-01
Release date:2004-09-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of 7,8-Dihydropteroate Synthase from Bacillus anthracis; Mechanism and Novel Inhibitor Design.
STRUCTURE, 12, 2004
1TX2
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BU of 1tx2 by Molmil
Dihydropteroate Synthetase, With Bound Inhibitor MANIC, From Bacillus anthracis
Descriptor: 6-METHYLAMINO-5-NITROISOCYTOSINE, DHPS, Dihydropteroate synthase, ...
Authors:Babaoglu, K, Qi, J, Lee, R.E, White, S.W.
Deposit date:2004-07-01
Release date:2004-09-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Crystal Structure of 7,8-Dihydropteroate Synthase from Bacillus anthracis; Mechanism and Novel Inhibitor Design.
STRUCTURE, 12, 2004
1TWZ
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BU of 1twz by Molmil
Dihydropteroate Synthetase, With Bound Substrate Analogue PtP, From Bacillus anthracis
Descriptor: DHPS, Dihydropteroate synthase, PTERIN-6-YL-METHYL-MONOPHOSPHATE, ...
Authors:Babaoglu, K, Qi, J, Lee, R.L, White, S.W.
Deposit date:2004-07-01
Release date:2004-09-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal Structure of 7,8-Dihydropteroate Synthase from Bacillus anthracis; Mechanism and Novel Inhibitor Design.
STRUCTURE, 12, 2004
2P9V
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BU of 2p9v by Molmil
Structure of AmpC beta-lactamase with cross-linked active site after exposure to small molecule inhibitor
Descriptor: Beta-lactamase, PHOSPHATE ION
Authors:Babaoglu, K, Wyrembak, P.N, Pelto, R.B, Shoichet, B.K, Pratt, R.F.
Deposit date:2007-03-26
Release date:2007-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:O-Aryloxycarbonyl Hydroxamates: New beta-Lactamase Inhibitors That Cross-Link the Active Site.
J.Am.Chem.Soc., 129, 2007
5UNH
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BU of 5unh by Molmil
Synchrotron structure of human angiotensin II type 2 receptor in complex with compound 2 (N-[(furan-2-yl)methyl]-N-(4-oxo-2-propyl-3-{[2'-(2H-tetrazol-5-yl)[1,1'- biphenyl]-4-yl]methyl}-3,4-dihydroquinazolin-6-yl)benzamide)
Descriptor: N-[(furan-2-yl)methyl]-N-(4-oxo-2-propyl-3-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-3,4-dihydroquinazolin-6-yl)benzamide, Soluble cytochrome b562,Type-2 angiotensin II receptor
Authors:Zhang, H, Han, G.W, Batyuk, A, Ishchenko, A, White, K.L, Patel, N, Sadybekov, A, Zamlynny, B, Rudd, M.T, Hollenstein, K, Tolstikova, A, White, T.A, Hunter, M.S, Weierstall, U, Liu, W, Babaoglu, K, Moore, E.L, Katz, R.D, Shipman, J.M, Garcia-Calvo, M, Sharma, S, Sheth, P, Soisson, S.M, Stevens, R.C, Katritch, V, Cherezov, V.
Deposit date:2017-01-30
Release date:2017-04-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for selectivity and diversity in angiotensin II receptors.
Nature, 544, 2017
5UNG
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BU of 5ung by Molmil
XFEL structure of human angiotensin II type 2 receptor (Orthorhombic form) in complex with compound 1 (N-benzyl-N-(2-ethyl-4-oxo-3-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl] methyl}-3,4-dihydroquinazolin-6-yl)thiophene-2-carboxamide)
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Chimera protein of Type-2 angiotensin II receptor and Soluble cytochrome b562, N-benzyl-N-(2-ethyl-4-oxo-3-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-3,4-dihydroquinazolin-6-yl)thiophene-2-carboxamide, ...
Authors:Zhang, H, Han, G.W, Batyuk, A, Ishchenko, A, White, K.L, Patel, N, Sadybekov, A, Zamlynny, B, Rudd, M.T, Hollenstein, K, Tolstikova, A, White, T.A, Hunter, M.S, Weierstall, U, Liu, W, Babaoglu, K, Moore, E.L, Katz, R.D, Shipman, J.M, Garcia-Calvo, M, Sharma, S, Sheth, P, Soisson, S.M, Stevens, R.C, Katritch, V, Cherezov, V.
Deposit date:2017-01-30
Release date:2017-04-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for selectivity and diversity in angiotensin II receptors.
Nature, 544, 2017
5UNF
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BU of 5unf by Molmil
XFEL structure of human angiotensin II type 2 receptor (Monoclinic form) in complex with compound 1 (N-benzyl-N-(2-ethyl-4-oxo-3-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl])
Descriptor: Chimera protein of Type-2 angiotensin II receptor and Soluble cytochrome b562, N-benzyl-N-(2-ethyl-4-oxo-3-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-3,4-dihydroquinazolin-6-yl)thiophene-2-carboxamide
Authors:Zhang, H, Han, G.W, Batyuk, A, Ishchenko, A, White, K.L, Patel, N, Sadybekov, A, Zamlynny, B, Rudd, M.T, Hollenstein, K, Tolstikova, A, White, T.A, Hunter, M.S, Weierstall, U, Liu, W, Babaoglu, K, Moore, E.L, Katz, R.D, Shipman, J.M, Garcia-Calvo, M, Sharma, S, Sheth, P, Soisson, S.M, Stevens, R.C, Katritch, V, Cherezov, V.
Deposit date:2017-01-30
Release date:2017-04-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for selectivity and diversity in angiotensin II receptors.
Nature, 544, 2017
1Q32
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BU of 1q32 by Molmil
Crystal Structure Analysis of the Yeast Tyrosyl-DNA Phosphodiesterase
Descriptor: tyrosyl-DNA phosphodiesterase
Authors:He, X, Babaoglu, K, Price, A, Nitiss, K.C, Nitiss, J.L, White, S.W.
Deposit date:2003-07-28
Release date:2004-09-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Mutation of a conserved active site residue converts tyrosyl-DNA phosphodiesterase I into a DNA topoisomerase I-dependent poison
J.Mol.Biol., 372, 2007
1PM7
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BU of 1pm7 by Molmil
RmlC (dTDP-6-DEOXY-D-XYLO-4-HEXULOSE 3,5-EPIMERASE)STRUCTURE FROM MYCOBACTERIUM TUBERCULOSIS AND INHIBITOR DESIGN. THE APO STRUCTURE.
Descriptor: ACETATE ION, GLYCEROL, RFBC
Authors:Dong, C, Naismith, J.H, TB Structural Genomics Consortium (TBSGC)
Deposit date:2003-06-10
Release date:2003-12-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Novel inhibitors of an emerging target in Mycobacterium tuberculosis; substituted thiazolidinones as inhibitors of dTDP-rhamnose synthesis.
Bioorg.Med.Chem.Lett., 13, 2003
6MOA
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BU of 6moa by Molmil
C-terminal bromodomain of human BRD2 in complex with 4-(2-cyclopropyl-7-(6-methylquinolin-5-yl)-1H-benzo[d]imidazol-5-yl)-3,5-dimethylisoxazole inhibitor
Descriptor: 4-(2-cyclopropyl-7-(6-methylquinolin-5-yl)-1H-benzo[d]imidazol-5-yl)-3,5-dimethylisoxazole, Bromodomain-containing protein 2, GLYCEROL
Authors:Lansdon, E.B, Newby, Z.E.R.
Deposit date:2018-10-04
Release date:2019-01-23
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.271 Å)
Cite:Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.
Bioorg. Med. Chem., 27, 2019
6MO7
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BU of 6mo7 by Molmil
N-terminal bromodomain of human BRD2 with N-((4-(3-(N-cyclopentylsulfamoyl)-4-methylphenyl)-3-methylisoxazol-5-yl)methyl)acetamide inhibitor
Descriptor: Bromodomain-containing protein 2, N-({4-[3-(cyclopentylsulfamoyl)-4-methylphenyl]-3-methyl-1,2-oxazol-5-yl}methyl)acetamide
Authors:Lansdon, E.B, Newby, Z.E.R.
Deposit date:2018-10-04
Release date:2019-01-23
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.
Bioorg. Med. Chem., 27, 2019
6MO9
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BU of 6mo9 by Molmil
N-terminal bromodomain of human BRD2 in complex with N-cyclopentyl-7-(3,5-dimethylisoxazol-4-yl)quinoline-5-sulfonamide inhibitor
Descriptor: Bromodomain-containing protein 2, N-cyclopentyl-7-(3,5-dimethyl-1,2-oxazol-4-yl)quinoline-5-sulfonamide
Authors:Lansdon, E.B, Newby, Z.E.R.
Deposit date:2018-10-04
Release date:2019-01-23
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.
Bioorg. Med. Chem., 27, 2019
6MO8
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BU of 6mo8 by Molmil
N-terminal bromodomain of human BRD2 in complex with 4,4'-(quinoline-5,7-diyl)bis(3,5-dimethylisoxazole) inhibitor
Descriptor: 5,7-bis(3,5-dimethyl-1,2-oxazol-4-yl)quinoline, Bromodomain-containing protein 2, SULFATE ION
Authors:Lansdon, E.B, Newby, Z.E.R.
Deposit date:2018-10-04
Release date:2019-01-23
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.
Bioorg. Med. Chem., 27, 2019
4ZJC
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BU of 4zjc by Molmil
Structures of the human OX1 orexin receptor bound to selective and dual antagonists
Descriptor: OLEIC ACID, [5-(2-fluorophenyl)-2-methyl-1,3-thiazol-4-yl]{(2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]pyrrolidin-1-yl}methanone, human OX1R fusion protein to P.abysii glycogen synthase
Authors:Yin, J, Brautigam, C.A, Shao, Z, Clark, L, Harrell, C.M, Gotter, A.L, Coleman, P.J, Renger, J.J, Rosenbaum, D.M.
Deposit date:2015-04-29
Release date:2016-03-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.832 Å)
Cite:Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
Nat.Struct.Mol.Biol., 23, 2016
4ZJ8
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BU of 4zj8 by Molmil
Structures of the human OX1 orexin receptor bound to selective and dual antagonists
Descriptor: OLEIC ACID, [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone, human OX1R fusion protein to P.abysii glycogen synthase
Authors:Yin, J, Brautigam, C.A, Shao, Z, Clark, L, Harrell, C.M, Gotter, A.L, Coleman, P, Renger, J.J, Rosenbaum, D.M.
Deposit date:2015-04-29
Release date:2016-03-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.751 Å)
Cite:Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
Nat.Struct.Mol.Biol., 23, 2016

 

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