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1AYE
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BU of 1aye by Molmil
HUMAN PROCARBOXYPEPTIDASE A2
Descriptor: PROCARBOXYPEPTIDASE A2, ZINC ION
Authors:Garcia-Saez, I, Reverte, D, Vendrell, J, Aviles, F.X, Coll, M.
Deposit date:1997-11-03
Release date:1999-01-13
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The three-dimensional structure of human procarboxypeptidase A2. Deciphering the basis of the inhibition, activation and intrinsic activity of the zymogen.
EMBO J., 16, 1997
3OSL
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BU of 3osl by Molmil
Structure of bovine thrombin-activatable fibrinolysis inhibitor in complex with tick carboxypeptidase inhibitor
Descriptor: Carboxypeptidase B2, Carboxypeptidase inhibitor, ZINC ION
Authors:Valnickova, Z, Sanglas, L, Arolas, J.L, Petersen, S.V, Schar, C, Otzen, D, Aviles, F.X, Gomis-Ruth, F.X, Enghild, J.J.
Deposit date:2010-09-09
Release date:2010-09-29
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (6 Å)
Cite:Flexibility of the Thrombin-activatable Fibrinolysis Inhibitor Pro-domain Enables Productive Binding of Protein Substrates.
J.Biol.Chem., 285, 2010
2PCU
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BU of 2pcu by Molmil
Human carboxypeptidase A4 in complex with a cleaved hexapeptide.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ASPARTIC ACID, Carboxypeptidase A4, ...
Authors:Bayes, A, Fernandez, D, Sola, M, Marrero, A, Garcia-Pique, S, Aviles, F.X, Vendrell, J, Gomis-Ruth, F.X.
Deposit date:2007-03-30
Release date:2007-04-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Caught after the Act: a human A-type metallocarboxypeptidase in a product complex with a cleaved hexapeptide.
Biochemistry, 46, 2007
2V77
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BU of 2v77 by Molmil
Crystal Structure of Human Carboxypeptidase A1
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CARBOXYPEPTIDASE A1, OCTANE-1,3,5,7-TETRACARBOXYLIC ACID, ...
Authors:Pallares, I, Fernandez, D, Comellas-Bigler, M, Fernandez-Recio, J, Ventura, S, Aviles, F.X, Vendrell, J.
Deposit date:2007-07-27
Release date:2008-07-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.603 Å)
Cite:Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid).
Acta Crystallogr. D Biol. Crystallogr., D64, 2008
5OM9
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BU of 5om9 by Molmil
Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with a thiirane mechanism-based inhibitor
Descriptor: (2~{R})-4-methyl-2-[(1~{S})-1-sulfanylethyl]pentanoic acid, Carboxypeptidase A1, ZINC ION
Authors:Gallego, P, Granados, C, Fernandez, D, Pallares, I, Covaleda, G, Aviles, F.X, Vendrell, J, Reverter, D.
Deposit date:2017-07-28
Release date:2017-08-09
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of Mechanism-Based Inactivators for Human Pancreatic Carboxypeptidase A from a Focused Synthetic Library.
ACS Med Chem Lett, 8, 2017
3LMS
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BU of 3lms by Molmil
Structure of human activated thrombin-activatable fibrinolysis inhibitor, TAFIa, in complex with tick-derived funnelin inhibitor, TCI.
Descriptor: CALCIUM ION, CHLORIDE ION, Carboxypeptidase B2, ...
Authors:Sanglas, L, Arolas, J.L, Valnickova, Z, Aviles, F.X, Enghild, J.J, Gomis-Ruth, F.X.
Deposit date:2010-02-01
Release date:2010-02-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insights into the molecular inactivation mechanism of human activated thrombin-activatable fibrinolysis inhibitor
J.Thromb.Haemost., 8, 2010
3MN8
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BU of 3mn8 by Molmil
Structure of Drosophila melanogaster carboxypeptidase D isoform 1B short
Descriptor: (2-GUANIDINOETHYLMERCAPTO)SUCCINIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
Authors:Tanco, S, Arolas, J.L, Guevara, T, Lorenzo, J, Aviles, F.X, Gomis-Ruth, F.X.
Deposit date:2010-04-21
Release date:2010-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure-Function Analysis of the Short Splicing Variant Carboxypeptidase Encoded by Drosophila melanogaster silver.
J.Mol.Biol., 401, 2010
2BOA
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BU of 2boa by Molmil
Human procarboxypeptidase A4.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CARBOXYPEPTIDASE A4, ...
Authors:Garcia-Castellanos, R, Bonet-Figueredo, R, Pallares, I, Ventura, S, Aviles, F.X, Vendrell, J, Gomis-Ruth, F.X.
Deposit date:2005-04-08
Release date:2005-12-13
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Detailed Molecular Comparison between the Inhibition Mode of A/B-Type Carboxypeptidases in the Zymogen State and by the Endogenous Inhibitor Latexin.
Cell.Mol.Life Sci., 62, 2005
1H8L
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BU of 1h8l by Molmil
Duck Carboxypeptidase D Domain II in complex with GEMSA
Descriptor: (2-GUANIDINOETHYLMERCAPTO)SUCCINIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gomis-Rueth, F.X, Coll, M, Aviles, F.X, Vendrell, J, Fricker, L.D.
Deposit date:2001-02-09
Release date:2002-02-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structure of the inhibitor-complexed carboxypeptidase D domain II and the modeling of regulatory carboxypeptidases.
J. Biol. Chem., 276, 2001
3D4U
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BU of 3d4u by Molmil
Bovine thrombin-activatable fibrinolysis inhibitor (TAFIa) in complex with tick-derived carboxypeptidase inhibitor.
Descriptor: ACETATE ION, Carboxypeptidase B2, Carboxypeptidase inhibitor, ...
Authors:Sanglas, L, Valnickova, Z, Arolas, J.L, Pallares, I, Guevara, T, Sola, M, Kristensen, T, Enghild, J.J, Aviles, F.X, Gomis-Ruth, F.X.
Deposit date:2008-05-15
Release date:2008-08-19
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of activated thrombin-activatable fibrinolysis inhibitor, a molecular link between coagulation and fibrinolysis.
Mol.Cell, 31, 2008
3DWC
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BU of 3dwc by Molmil
Trypanosoma Cruzi Metallocarboxypeptidase 1
Descriptor: ALANINE, COBALT (II) ION, GLYCEROL, ...
Authors:Niemirowicz, G, Fernandez, D, Sola, M, Cazzulo, J.J, Aviles, F.X, Gomis-Ruth, F.X.
Deposit date:2008-07-22
Release date:2008-09-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The molecular analysis of Trypanosoma cruzi metallocarboxypeptidase 1 provides insight into fold and substrate specificity
Mol.Microbiol., 70, 2008
3FJU
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BU of 3fju by Molmil
Ascaris suum carboxypeptidase inhibitor in complex with human carboxypeptidase A1
Descriptor: ACETATE ION, CACODYLATE ION, Carboxypeptidase A inhibitor, ...
Authors:Sanglas, L, Aviles, F.X, Huber, R, Gomis-Ruth, F.X, Arolas, J.L.
Deposit date:2008-12-15
Release date:2008-12-30
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Mammalian metallopeptidase inhibition at the defense barrier of Ascaris parasite
Proc.Natl.Acad.Sci.USA, 106, 2009
1ZFL
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BU of 1zfl by Molmil
Solution structure of III-A, the major intermediate in the oxidative folding of leech carboxypeptidase inhibitor
Descriptor: Metallocarboxypeptidase inhibitor
Authors:Arolas, J.L, D'Silva, L, Popowicz, G.M, Aviles, F.X, Holak, T.A, Ventura, S.
Deposit date:2005-04-20
Release date:2005-09-13
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:NMR structural characterization and computational predictions of the major intermediate in oxidative folding of leech carboxypeptidase inhibitor
STRUCTURE, 13, 2005
2ABZ
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BU of 2abz by Molmil
Crystal structure of C19A/C43A mutant of leech carboxypeptidase inhibitor in complex with bovine carboxypeptidase A
Descriptor: Carboxypeptidase A1, Metallocarboxypeptidase inhibitor, ZINC ION
Authors:Arolas, J.L, Popowicz, G.M, Bronsoms, S, Aviles, F.X, Huber, R, Holak, T.A, Ventura, S.
Deposit date:2005-07-18
Release date:2006-01-31
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Study of a major intermediate in the oxidative folding of leech carboxypeptidase inhibitor: contribution of the fourth disulfide bond
J.Mol.Biol., 352, 2005
4UEE
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BU of 4uee by Molmil
Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Leu-Ala-Y(PO2CH2)-homoPhe-OH
Descriptor: (2S)-2-{[(R)-{(1R)-1-[(N-acetyl-L-leucyl)amino]ethyl}(hydroxy)phosphoryl]methyl}-4-phenylbutanoic acid, CARBOXYPEPTIDASE A1, ZINC ION
Authors:Gallego, P, Covaleda, G, Costenaro, L, Devel, L, Dive, V, Aviles, F.X, Reverter, D.
Deposit date:2014-12-17
Release date:2016-01-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Crystal Structure of the Human Carboxypeptidase A1 in Complex with Phosphinic Inhibitors
To be Published
4UEZ
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BU of 4uez by Molmil
Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Leu-Phe-Y(PO2CH2)-Phe-OH
Descriptor: (2S)-3-[(R)-{(1R)-1-[(N-acetyl-L-leucyl)amino]-2-phenylethyl}(hydroxy)phosphoryl]-2-benzylpropanoic acid, HUMAN CARBOXYPEPTIDASE A1, ZINC ION
Authors:Gallego, P, Covaleda, G, Costenaro, L, Devel, L, Dive, V, Aviles, F.X, Reverter, D.
Deposit date:2014-12-22
Release date:2016-01-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Crystal Structure of the Human Carboxypeptidase A1 in Complex with Phosphinic Inhibitors
To be Published
1PYT
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BU of 1pyt by Molmil
TERNARY COMPLEX OF PROCARBOXYPEPTIDASE A, PROPROTEINASE E, AND CHYMOTRYPSINOGEN C
Descriptor: CALCIUM ION, CHYMOTRYPSINOGEN C, PROCARBOXYPEPTIDASE A, ...
Authors:Gomis-Ruth, F.X, Gomez, M, Bode, W, Huber, R, Aviles, F.X.
Deposit date:1995-06-21
Release date:1997-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The three-dimensional structure of the native ternary complex of bovine pancreatic procarboxypeptidase A with proproteinase E and chymotrypsinogen C.
EMBO J., 14, 1995
5MRV
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BU of 5mrv by Molmil
Crystal structure of human carboxypeptidase O in complex with NvCI
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Carboxypeptidase O, Metallocarboxypeptidase inhibitor, ...
Authors:Garcia-Pardo, J, Garcia-Guerrero, M.C, Fernandez-Alvarez, R, Lyons, P, Aviles, F.X, Lorenzo, J, Reverter, D.
Deposit date:2016-12-27
Release date:2018-01-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.854 Å)
Cite:Crystal structure and mechanism of human carboxypeptidase O: Insights into its specific activity for acidic residues.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5AQ0
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BU of 5aq0 by Molmil
The structure of the Transthyretin-like domain of the first catalytic domain of the HUMAN Carboxypeptidase D
Descriptor: CARBOXYPEPTIDASE D, GLYCEROL
Authors:Gallego, P, Garcia-Pardo, J, Lorenzo, J, Aviles, F.X, Ventura, S, Reverter, D.
Deposit date:2015-09-18
Release date:2016-09-28
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:The Structure of the Ttldomain of the Human Carboxypeptidase D
To be Published
2BO9
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BU of 2bo9 by Molmil
Human carboxypeptidase A4 in complex with human latexin.
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETONE, ...
Authors:Pallares, I, Bonet, R, Garcia-Castellanos, R, Ventura, S, Aviles, F.X, Vendrell, J, Gomis-Rueth, F.X.
Deposit date:2005-04-08
Release date:2005-04-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of Human Carboxypeptidase A4 with its Endogenous Protein Inhibitor, Latexin.
Proc.Natl.Acad.Sci.USA, 102, 2005
1DTV
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BU of 1dtv by Molmil
NMR STRUCTURE OF THE LEECH CARBOXYPEPTIDASE INHIBITOR (LCI)
Descriptor: CARBOXYPEPTIDASE INHIBITOR
Authors:Reverter, D, Fernandez-Catalan, C, Bode, W, Holak, T.A, Aviles, F.X.
Deposit date:2000-01-13
Release date:2000-07-19
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2.
Nat.Struct.Biol., 7, 2000
1DTD
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BU of 1dtd by Molmil
CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE LEECH CARBOXYPEPTIDASE INHIBITOR AND THE HUMAN CARBOXYPEPTIDASE A2 (LCI-CPA2)
Descriptor: CARBOXYPEPTIDASE A2, GLUTAMIC ACID, METALLOCARBOXYPEPTIDASE INHIBITOR, ...
Authors:Reverter, D, Fernandez-Catalan, C, Bode, W, Holak, T.A, Aviles, F.X.
Deposit date:2000-01-12
Release date:2000-07-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2.
Nat.Struct.Biol., 7, 2000
1ZFI
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BU of 1zfi by Molmil
Solution structure of the leech carboxypeptidase inhibitor
Descriptor: Metallocarboxypeptidase inhibitor
Authors:Arolas, J.L, D'Silva, L, Popowicz, G.M, Aviles, F.X, Holak, T.A, Ventura, S.
Deposit date:2005-04-20
Release date:2005-09-13
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:NMR structural characterization and computational predictions of the major intermediate in oxidative folding of leech carboxypeptidase inhibitor
STRUCTURE, 13, 2005
1ZLI
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BU of 1zli by Molmil
Crystal structure of the tick carboxypeptidase inhibitor in complex with human carboxypeptidase B
Descriptor: Carboxypeptidase B, ZINC ION, carboxypeptidase inhibitor
Authors:Arolas, J.L, Popowicz, G.M, Lorenzo, J, Sommerhoff, C.P, Huber, R, Aviles, F.X, Holak, T.A.
Deposit date:2005-05-06
Release date:2005-07-05
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:The Three-Dimensional Structures of Tick Carboxypeptidase Inhibitor in Complex with A/B Carboxypeptidases Reveal a Novel Double-headed Binding Mode
J.Mol.Biol., 350, 2005
1ZLH
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BU of 1zlh by Molmil
Crystal structure of the tick carboxypeptidase inhibitor in complex with bovine carboxypeptidase A
Descriptor: Carboxypeptidase A1, ZINC ION, carboxypeptidase inhibitor
Authors:Arolas, J.L, Popowicz, G.M, Lorenzo, J, Sommerhoff, C.P, Huber, R, Aviles, F.X, Holak, T.A.
Deposit date:2005-05-06
Release date:2005-07-05
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Three-Dimensional Structures of Tick Carboxypeptidase Inhibitor in Complex with A/B Carboxypeptidases Reveal a Novel Double-headed Binding Mode
J.Mol.Biol., 350, 2005

 

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