Author results

3OSL
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STRUCTURE OF BOVINE THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR IN COMPLEX WITH TICK CARBOXYPEPTIDASE INHIBITOR
Descriptor:Carboxypeptidase B2, Carboxypeptidase inhibitor, ZINC ION
Authors:Valnickova, Z., Sanglas, L., Arolas, J.L., Petersen, S.V., Schar, C., Otzen, D., Aviles, F.X., Gomis-Ruth, F.X., Enghild, J.J.
Deposit date:2010-09-09
Release date:2010-09-29
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (6 Å)
Cite:Flexibility of the Thrombin-activatable Fibrinolysis Inhibitor Pro-domain Enables Productive Binding of Protein Substrates.
J.Biol.Chem., 285, 2010
1H8L
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DUCK CARBOXYPEPTIDASE D DOMAIN II IN COMPLEX WITH GEMSA
Descriptor:CARBOXYPEPTIDASE GP180 RESIDUES 503-882, (2-GUANIDINOETHYLMERCAPTO)SUCCINIC ACID, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Gomis-Rueth, F.X., Coll, M., Aviles, F.X., Vendrell, J., Fricker, L.D.
Deposit date:2001-02-09
Release date:2002-02-08
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structure of the inhibitor-complexed carboxypeptidase D domain II and the modeling of regulatory carboxypeptidases.
J. Biol. Chem., 276, 2001
1PYT
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TERNARY COMPLEX OF PROCARBOXYPEPTIDASE A, PROPROTEINASE E, AND CHYMOTRYPSINOGEN C
Descriptor:PROCARBOXYPEPTIDASE A, PROPROTEINASE E, CHYMOTRYPSINOGEN C, ...
Authors:Gomis-Ruth, F.X., Gomez, M., Bode, W., Huber, R., Aviles, F.X.
Deposit date:1995-06-21
Release date:1997-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The three-dimensional structure of the native ternary complex of bovine pancreatic procarboxypeptidase A with proproteinase E and chymotrypsinogen C.
EMBO J., 14, 1995
2BOA
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HUMAN PROCARBOXYPEPTIDASE A4.
Descriptor:CARBOXYPEPTIDASE A4, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
Authors:Garcia-Castellanos, R., Bonet-Figueredo, R., Pallares, I., Ventura, S., Aviles, F.X., Vendrell, J., Gomis-Ruth, F.X.
Deposit date:2005-04-08
Release date:2005-12-13
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Detailed Molecular Comparison between the Inhibition Mode of A/B-Type Carboxypeptidases in the Zymogen State and by the Endogenous Inhibitor Latexin.
Cell.Mol.Life Sci., 62, 2005
1AYE
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HUMAN PROCARBOXYPEPTIDASE A2
Descriptor:PROCARBOXYPEPTIDASE A2, ZINC ION
Authors:Garcia-Saez, I., Reverte, D., Vendrell, J., Aviles, F.X., Coll, M.
Deposit date:1997-11-03
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The three-dimensional structure of human procarboxypeptidase A2. Deciphering the basis of the inhibition, activation and intrinsic activity of the zymogen.
EMBO J., 16, 1997
1ZFL
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SOLUTION STRUCTURE OF III-A, THE MAJOR INTERMEDIATE IN THE OXIDATIVE FOLDING OF LEECH CARBOXYPEPTIDASE INHIBITOR
Descriptor:Metallocarboxypeptidase inhibitor
Authors:Arolas, J.L., D'Silva, L., Popowicz, G.M., Aviles, F.X., Holak, T.A., Ventura, S.
Deposit date:2005-04-20
Release date:2005-09-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structural characterization and computational predictions of the major intermediate in oxidative folding of leech carboxypeptidase inhibitor
STRUCTURE, 13, 2005
2ABZ
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CRYSTAL STRUCTURE OF C19A/C43A MUTANT OF LEECH CARBOXYPEPTIDASE INHIBITOR IN COMPLEX WITH BOVINE CARBOXYPEPTIDASE A
Descriptor:Carboxypeptidase A1, Metallocarboxypeptidase inhibitor, ZINC ION
Authors:Arolas, J.L., Popowicz, G.M., Bronsoms, S., Aviles, F.X., Huber, R., Holak, T.A., Ventura, S.
Deposit date:2005-07-18
Release date:2006-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Study of a major intermediate in the oxidative folding of leech carboxypeptidase inhibitor: contribution of the fourth disulfide bond
J.Mol.Biol., 352, 2005
1GVL
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HUMAN PROKALLIKREIN 6 (HK6)/ PROZYME/ PROPROTEASE M/ PRONEUROSIN
Descriptor:KALLIKREIN 6
Authors:Gomis-Ruth, F.X., Bayes, A., Sotiropoulou, G., Pampalakis, G., Tsetsenis, T., Villegas, V., Aviles, F.X., Coll, M.
Deposit date:2002-02-14
Release date:2002-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Structure of Human Prokallikrein 6 Reveals a Novel Activation Mechanism for the Kallikrein Family.
J.Biol.Chem., 277, 2002
1QMU
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DUCK CARBOXYPEPTIDASE D DOMAIN II
Descriptor:CARBOXYPEPTIDASE GP180 RESIDUES 503-882, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Gomis-Rueth, F.X., Coll, M., Aviles, F.X., Vendrell, J., Fricker, L.D.
Deposit date:1999-10-06
Release date:2000-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of Avian Carboxypeptidase D Domain II : A Prototype for the Regulatory Metallocarboxypeptidase Subfamily
Embo J., 18, 1999
2BO9
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HUMAN CARBOXYPEPTIDASE A4 IN COMPLEX WITH HUMAN LATEXIN.
Descriptor:CARBOXYPEPTIDASE A4, HUMAN LATEXIN, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Pallares, I., Bonet, R., Garcia-Castellanos, R., Ventura, S., Aviles, F.X., Vendrell, J., Gomis-Rueth, F.X.
Deposit date:2005-04-08
Release date:2005-04-15
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of Human Carboxypeptidase A4 with its Endogenous Protein Inhibitor, Latexin.
Proc.Natl.Acad.Sci.USA, 102, 2005
2PCU
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HUMAN CARBOXYPEPTIDASE A4 IN COMPLEX WITH A CLEAVED HEXAPEPTIDE.
Descriptor:Carboxypeptidase A4, peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Bayes, A., Fernandez, D., Sola, M., Marrero, A., Garcia-Pique, S., Aviles, F.X., Vendrell, J., Gomis-Ruth, F.X.
Deposit date:2007-03-30
Release date:2007-04-17
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Caught after the Act: a human A-type metallocarboxypeptidase in a product complex with a cleaved hexapeptide.
Biochemistry, 46, 2007
3D4U
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BOVINE THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR (TAFIA) IN COMPLEX WITH TICK-DERIVED CARBOXYPEPTIDASE INHIBITOR.
Descriptor:Carboxypeptidase B2, Carboxypeptidase inhibitor, ZINC ION, ...
Authors:Sanglas, L., Valnickova, Z., Arolas, J.L., Pallares, I., Guevara, T., Sola, M., Kristensen, T., Enghild, J.J., Aviles, F.X., Gomis-Ruth, F.X.
Deposit date:2008-05-15
Release date:2008-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of activated thrombin-activatable fibrinolysis inhibitor, a molecular link between coagulation and fibrinolysis.
Mol.Cell, 31, 2008
3DWC
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TRYPANOSOMA CRUZI METALLOCARBOXYPEPTIDASE 1
Descriptor:Metallocarboxypeptidase, COBALT (II) ION, SULFATE ION, ...
Authors:Niemirowicz, G., Fernandez, D., Sola, M., Cazzulo, J.J., Aviles, F.X., Gomis-Ruth, F.X.
Deposit date:2008-07-22
Release date:2008-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The molecular analysis of Trypanosoma cruzi metallocarboxypeptidase 1 provides insight into fold and substrate specificity
Mol.Microbiol., 70, 2008
3FJU
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ASCARIS SUUM CARBOXYPEPTIDASE INHIBITOR IN COMPLEX WITH HUMAN CARBOXYPEPTIDASE A1
Descriptor:Carboxypeptidase A1, Carboxypeptidase A inhibitor, ZINC ION, ...
Authors:Sanglas, L., Aviles, F.X., Huber, R., Gomis-Ruth, F.X., Arolas, J.L.
Deposit date:2008-12-15
Release date:2008-12-30
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Mammalian metallopeptidase inhibition at the defense barrier of Ascaris parasite
Proc.Natl.Acad.Sci.USA, 106, 2009
3LMS
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STRUCTURE OF HUMAN ACTIVATED THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR, TAFIA, IN COMPLEX WITH TICK-DERIVED FUNNELIN INHIBITOR, TCI.
Descriptor:Carboxypeptidase B2, Carboxypeptidase inhibitor, ZINC ION, ...
Authors:Sanglas, L., Arolas, J.L., Valnickova, Z., Aviles, F.X., Enghild, J.J., Gomis-Ruth, F.X.
Deposit date:2010-02-01
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insights into the molecular inactivation mechanism of human activated thrombin-activatable fibrinolysis inhibitor
J.Thromb.Haemost., 8, 2010
3MN8
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STRUCTURE OF DROSOPHILA MELANOGASTER CARBOXYPEPTIDASE D ISOFORM 1B SHORT
Descriptor:LP15968p, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
Authors:Tanco, S., Arolas, J.L., Guevara, T., Lorenzo, J., Aviles, F.X., Gomis-Ruth, F.X.
Deposit date:2010-04-21
Release date:2010-07-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure-Function Analysis of the Short Splicing Variant Carboxypeptidase Encoded by Drosophila melanogaster silver.
J.Mol.Biol., 401, 2010
1PBA
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THE NMR STRUCTURE OF THE ACTIVATION DOMAIN ISOLATED FROM PORCINE PROCARBOXYPEPTIDASE B
Descriptor:PROCARBOXYPEPTIDASE B
Authors:Vendrell, J., Wider, G., Billeter, M., Aviles, F.X., Wuthrich, K.
Deposit date:1991-11-18
Release date:1993-10-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The NMR structure of the activation domain isolated from porcine procarboxypeptidase B.
EMBO J., 10, 1991
1PCA
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THREE DIMENSIONAL STRUCTURE OF PORCINE PANCREATIC PROCARBOXYPEPTIDASE A. A COMPARISON OF THE A AND B ZYMOGENS AND THEIR DETERMINANTS FOR INHIBITION AND ACTIVATION
Descriptor:PROCARBOXYPEPTIDASE A PCPA, ZINC ION, CITRIC ACID, ...
Authors:Guasch, A., Coll, M., Aviles, F.X., Huber, R.
Deposit date:1991-10-28
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Three-dimensional structure of porcine pancreatic procarboxypeptidase A. A comparison of the A and B zymogens and their determinants for inhibition and activation.
J.Mol.Biol., 224, 1992
1ZFI
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SOLUTION STRUCTURE OF THE LEECH CARBOXYPEPTIDASE INHIBITOR
Descriptor:Metallocarboxypeptidase inhibitor
Authors:Arolas, J.L., D'Silva, L., Popowicz, G.M., Aviles, F.X., Holak, T.A., Ventura, S.
Deposit date:2005-04-20
Release date:2005-09-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structural characterization and computational predictions of the major intermediate in oxidative folding of leech carboxypeptidase inhibitor
STRUCTURE, 13, 2005
1ZLH
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CRYSTAL STRUCTURE OF THE TICK CARBOXYPEPTIDASE INHIBITOR IN COMPLEX WITH BOVINE CARBOXYPEPTIDASE A
Descriptor:Carboxypeptidase A1, carboxypeptidase inhibitor, ZINC ION
Authors:Arolas, J.L., Popowicz, G.M., Lorenzo, J., Sommerhoff, C.P., Huber, R., Aviles, F.X., Holak, T.A.
Deposit date:2005-05-06
Release date:2005-07-05
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Three-Dimensional Structures of Tick Carboxypeptidase Inhibitor in Complex with A/B Carboxypeptidases Reveal a Novel Double-headed Binding Mode
J.Mol.Biol., 350, 2005
1ZLI
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CRYSTAL STRUCTURE OF THE TICK CARBOXYPEPTIDASE INHIBITOR IN COMPLEX WITH HUMAN CARBOXYPEPTIDASE B
Descriptor:Carboxypeptidase B, carboxypeptidase inhibitor, ZINC ION
Authors:Arolas, J.L., Popowicz, G.M., Lorenzo, J., Sommerhoff, C.P., Huber, R., Aviles, F.X., Holak, T.A.
Deposit date:2005-05-06
Release date:2005-07-05
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:The Three-Dimensional Structures of Tick Carboxypeptidase Inhibitor in Complex with A/B Carboxypeptidases Reveal a Novel Double-headed Binding Mode
J.Mol.Biol., 350, 2005
1DTD
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE LEECH CARBOXYPEPTIDASE INHIBITOR AND THE HUMAN CARBOXYPEPTIDASE A2 (LCI-CPA2)
Descriptor:CARBOXYPEPTIDASE A2, METALLOCARBOXYPEPTIDASE INHIBITOR, ZINC ION, ...
Authors:Reverter, D., Fernandez-Catalan, C., Bode, W., Holak, T.A., Aviles, F.X.
Deposit date:2000-01-12
Release date:2000-07-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2.
Nat.Struct.Biol., 7, 2000
1DTV
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NMR STRUCTURE OF THE LEECH CARBOXYPEPTIDASE INHIBITOR (LCI)
Descriptor:CARBOXYPEPTIDASE INHIBITOR
Authors:Reverter, D., Fernandez-Catalan, C., Bode, W., Holak, T.A., Aviles, F.X.
Deposit date:2000-01-13
Release date:2000-07-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2.
Nat.Struct.Biol., 7, 2000
1H20
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SOLUTION STRUCTURE OF THE POTATO CARBOXYPEPTIDASE INHIBITOR
Descriptor:METALLOCARBOXYPEPTIDASE INHIBITOR
Authors:Gonzalez, C., Neira, J.L., Ventura, S., Bronsoms, S., Aviles, F.X., Rico, M.
Deposit date:2002-07-29
Release date:2003-05-09
Last modified:2011-12-28
Method:SOLUTION NMR
Cite:Structure and Dynamics of the Potato Carboxypeptidase Inhibitor by 1H and 15N NMR.
Proteins, 50, 2003
1JQG
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CRYSTAL STRUCTURE OF THE CARBOXYPEPTIDASE A FROM HELICOVERPA ARMIGERA
Descriptor:carboxypeptidase A, ZINC ION
Authors:Estebanez-Perpina, E., Bayes, A., Vendrell, J., Jongsma, M.A., Bown, D.P., Gatehouse, J.A., Huber, R., Bode, W., Aviles, F.X., Reverter, D.
Deposit date:2001-08-07
Release date:2002-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a novel mid-gut procarboxypeptidase from the cotton pest Helicoverpa armigera.
J.Mol.Biol., 313, 2001
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