Author results

2PZE
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MINIMAL HUMAN CFTR FIRST NUCLEOTIDE BINDING DOMAIN AS A HEAD-TO-TAIL DIMER
分子名称:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
著者Atwell, S., Conners, K., Emtage, S., Gheyi, T., Glenn, N.R., Hendle, J., Lewis, H.A., Lu, F., Rodgers, L.A., Romero, R., Sauder, J.M., Smith, D., Tien, H., Wasserman, S.R., Zhao, X.
登録日2007-05-17
公開日2007-10-09
最終更新日2018-11-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng.Des.Sel., 23, 2010
2PZF
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MINIMAL HUMAN CFTR FIRST NUCLEOTIDE BINDING DOMAIN AS A HEAD-TO-TAIL DIMER WITH DELTA F508
分子名称:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
著者Atwell, S., Conners, K., Emtage, S., Gheyi, T., Glenn, N.R., Hendle, J., Lewis, H.A., Lu, F., Rodgers, L.A., Romero, R., Sauder, J.M., Smith, D., Tien, H., Wasserman, S.R., Zhao, X.
登録日2007-05-18
公開日2007-10-09
最終更新日2018-11-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng.Des.Sel., 23, 2010
2PZG
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MINIMAL HUMAN CFTR FIRST NUCLEOTIDE BINDING DOMAIN AS A MONOMER
分子名称:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Atwell, S., Conners, K., Emtage, S., Gheyi, T., Glenn, N.R., Hendle, J., Lewis, H.A., Lu, F., Rodgers, L.A., Romero, R., Sauder, J.M., Smith, D., Tien, H., Wasserman, S.R., Zhao, X.
登録日2007-05-18
公開日2007-10-09
最終更新日2018-11-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng.Des.Sel., 23, 2010
3GD7
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CRYSTAL STRUCTURE OF HUMAN NBD2 COMPLEXED WITH N6-PHENYLETHYL-ATP (P-ATP)
分子名称:Fusion complex of Cystic fibrosis transmembrane conductance regulator, residues 1193-1427 and Maltose/maltodextrin import ATP-binding protein malK, residues 219-371, ...
著者Atwell, S., Antonysamy, S., Conners, K., Emtage, S., Gheyi, T., Lewis, H.A., Lu, F., Sauder, J.M., Wasserman, S.R., Zhao, X.
登録日2009-02-23
公開日2010-03-02
最終更新日2018-11-21
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of human NBD2 complexed with N6-Phenylethyl-ATP (P-ATP)
To be Published
1AXI
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STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE
分子名称:GROWTH HORMONE, GROWTH HORMONE RECEPTOR, SULFATE ION
著者Atwell, S., Ultsch, M., De Vos, A.M., Wells, J.A.
登録日1997-10-15
公開日1998-01-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural plasticity in a remodeled protein-protein interface.
Science, 278, 1997
1JES
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CRYSTAL STRUCTURE OF A COPPER-MEDIATED BASE PAIR IN DNA
分子名称:5'-D(*CP*GP*CP*GP*(DPY)P*AP*TP*(DRP)P*CP*GP*CP*G)-3', COPPER (II) ION
著者Atwell, S., Meggers, E., Spraggon, G., Schultz, P.G.
登録日2001-06-18
公開日2001-11-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure of a Copper-Mediated Base Pair in DNA
J.Am.Chem.Soc., 123, 2001
1XBA
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CRYSTAL STRUCTURE OF APO SYK TYROSINE KINASE DOMAIN
分子名称:Tyrosine-protein kinase SYK
著者Atwell, S., Adams, J.M., Badger, J., Buchanan, M.D., Feil, I.K., Froning, K.J., Gao, X., Hendle, J., Keegan, K., Leon, B.C., Muller-Deickmann, H.J., Nienaber, V.L., Noland, B.W., Post, K., Rajashankar, K.R., Ramos, A., Russell, M., Burley, S.K., Buchanan, S.G.
登録日2004-08-30
公開日2004-11-02
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase.
J.Biol.Chem., 279, 2004
3COI
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CRYSTAL STRUCTURE OF P38DELTA KINASE
分子名称:Mitogen-activated protein kinase 13
著者Atwell, S., Burley, S.K., Houle, A., Ramos, A., Sauder, J.M., New York SGX Research Center for Structural Genomics (NYSGXRC)
登録日2008-03-28
公開日2008-04-15
最終更新日2018-11-14
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Crystal structure of p38delta kinase.
To be Published
3COK
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CRYSTAL STRUCTURE OF PLK4 KINASE
分子名称:Serine/threonine-protein kinase PLK4, SULFATE ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Atwell, S., Burley, S.K., Houle, A., Leon, B., Pelletier, L.A., Sauder, J.M., New York SGX Research Center for Structural Genomics (NYSGXRC)
登録日2008-03-28
公開日2008-04-15
最終更新日2018-11-14
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Crystal structure of PLK4 kinase.
To be Published
3COM
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CRYSTAL STRUCTURE OF MST1 KINASE
分子名称:Serine/threonine-protein kinase 4
著者Atwell, S., Burley, S.K., Dickey, M., Leon, B., Sauder, J.M., New York SGX Research Center for Structural Genomics (NYSGXRC)
登録日2008-03-28
公開日2008-04-15
最終更新日2018-11-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of Mst1 kinase.
To be Published
5DI8
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FC KNOB-HOLE HETERODIMER T366W + T366S/L368A/Y407V
分子名称:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
著者Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Secrist, E., Demarest, S.J., Kuhlman, B.
登録日2015-08-31
公開日2016-03-30
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJ0
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FC HETERODIMER DESIGN 11.2 Y349S/K370Y + E357D/S364Q
分子名称:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
著者Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
登録日2015-09-01
公開日2016-03-30
最終更新日2016-04-27
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJ2
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FC HETERODIMER DESIGN 7.4 Y407A + T366V/K409V
分子名称:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
著者Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Secrist, E., Demarest, S.J., Kuhlman, B.
登録日2015-09-01
公開日2016-03-30
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.56 Å)
主引用文献Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJ6
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FC HETERODIMER DESIGN 6.1 F405W/Y407A + T366M
分子名称:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
著者Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
登録日2015-09-01
公開日2016-03-30
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJ8
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FC HETERODIMER DESIGN 7.7 D399M/Y407A + T366V/K409I
分子名称:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
著者Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Secrist, E., Demarest, S.J., Kuhlman, B.
登録日2015-09-01
公開日2016-03-30
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJA
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FC HETERODIMER DESIGN 9.1 Y407M + T366I
分子名称:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
著者Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
登録日2015-09-01
公開日2016-03-30
最終更新日2016-04-27
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJC
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FC HETERODIMER DESIGN 8.1 L368V/Y407A + T366V/K409F
分子名称:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
著者Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Secrist, E., Demarest, S.J., Kuhlman, B.
登録日2015-09-01
公開日2016-03-30
最終更新日2016-04-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJD
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FC HETERODIMER DESIGN 5.1 T366V + Y407F
分子名称:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
著者Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
登録日2015-09-02
公開日2016-03-30
最終更新日2016-04-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJX
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FC HETERODIMER DESIGN 2.9 L368M/K370E + E357A/S364G
分子名称:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
著者Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
登録日2015-09-02
公開日2016-03-30
最終更新日2016-04-27
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJY
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FC HETERODIMER DESIGN 20.8 Y349S/T366V/K370Y/K409V + E357D/S364Q/Y407A
分子名称:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
著者Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
登録日2015-09-02
公開日2016-03-30
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJZ
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FC HETERODIMER DESIGN 7.8 D399M/Y407A + T366V/K409V
分子名称:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
著者Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
登録日2015-09-02
公開日2016-03-30
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DK0
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FC HETERODIMER DESIGN 20.8.34 Y349S/T366M/K370Y/K409V + E356G/E357D/S364Q/Y407A
分子名称:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
著者Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
登録日2015-09-02
公開日2016-03-30
最終更新日2016-04-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DK2
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FC HETERODIMER E356K/D399K + K392D/K409D
分子名称:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
著者Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
登録日2015-09-02
公開日2016-03-30
最終更新日2016-04-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DVK
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FC DESIGN 7.7 B CHAIN HOMODIMER T366V/K409I
分子名称:Ig gamma-1 chain C region
著者Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
登録日2015-09-21
公開日2016-03-30
最終更新日2016-04-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DVL
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FC DESIGN 20.8.37 A CHAIN HOMODIMER Y349S/T366M/K370Y/K409V
分子名称:Ig gamma-1 chain C region, Fc-III peptide
著者Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
登録日2015-09-21
公開日2016-03-30
最終更新日2016-07-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016