Author results

2PZE
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MINIMAL HUMAN CFTR FIRST NUCLEOTIDE BINDING DOMAIN AS A HEAD-TO-TAIL DIMER
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Atwell, S., Conners, K., Emtage, S., Gheyi, T., Glenn, N.R., Hendle, J., Lewis, H.A., Lu, F., Rodgers, L.A., Romero, R., Sauder, J.M., Smith, D., Tien, H., Wasserman, S.R., Zhao, X.
Deposit date:2007-05-17
Release date:2007-10-09
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng.Des.Sel., 23, 2010
2PZF
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MINIMAL HUMAN CFTR FIRST NUCLEOTIDE BINDING DOMAIN AS A HEAD-TO-TAIL DIMER WITH DELTA F508
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Atwell, S., Conners, K., Emtage, S., Gheyi, T., Glenn, N.R., Hendle, J., Lewis, H.A., Lu, F., Rodgers, L.A., Romero, R., Sauder, J.M., Smith, D., Tien, H., Wasserman, S.R., Zhao, X.
Deposit date:2007-05-18
Release date:2007-10-09
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng.Des.Sel., 23, 2010
2PZG
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MINIMAL HUMAN CFTR FIRST NUCLEOTIDE BINDING DOMAIN AS A MONOMER
Descriptor:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Atwell, S., Conners, K., Emtage, S., Gheyi, T., Glenn, N.R., Hendle, J., Lewis, H.A., Lu, F., Rodgers, L.A., Romero, R., Sauder, J.M., Smith, D., Tien, H., Wasserman, S.R., Zhao, X.
Deposit date:2007-05-18
Release date:2007-10-09
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng.Des.Sel., 23, 2010
3GD7
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CRYSTAL STRUCTURE OF HUMAN NBD2 COMPLEXED WITH N6-PHENYLETHYL-ATP (P-ATP)
Descriptor:Fusion complex of Cystic fibrosis transmembrane conductance regulator, residues 1193-1427 and Maltose/maltodextrin import ATP-binding protein malK, residues 219-371, ...
Authors:Atwell, S., Antonysamy, S., Conners, K., Emtage, S., Gheyi, T., Lewis, H.A., Lu, F., Sauder, J.M., Wasserman, S.R., Zhao, X.
Deposit date:2009-02-23
Release date:2010-03-02
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of human NBD2 complexed with N6-Phenylethyl-ATP (P-ATP)
To be Published
1AXI
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STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE
Descriptor:GROWTH HORMONE, GROWTH HORMONE RECEPTOR, SULFATE ION
Authors:Atwell, S., Ultsch, M., De Vos, A.M., Wells, J.A.
Deposit date:1997-10-15
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural plasticity in a remodeled protein-protein interface.
Science, 278, 1997
1JES
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CRYSTAL STRUCTURE OF A COPPER-MEDIATED BASE PAIR IN DNA
Descriptor:5'-D(*CP*GP*CP*GP*(DPY)P*AP*TP*(DRP)P*CP*GP*CP*G)-3', COPPER (II) ION
Authors:Atwell, S., Meggers, E., Spraggon, G., Schultz, P.G.
Deposit date:2001-06-18
Release date:2001-11-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of a Copper-Mediated Base Pair in DNA
J.Am.Chem.Soc., 123, 2001
1XBA
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CRYSTAL STRUCTURE OF APO SYK TYROSINE KINASE DOMAIN
Descriptor:Tyrosine-protein kinase SYK
Authors:Atwell, S., Adams, J.M., Badger, J., Buchanan, M.D., Feil, I.K., Froning, K.J., Gao, X., Hendle, J., Keegan, K., Leon, B.C., Muller-Deickmann, H.J., Nienaber, V.L., Noland, B.W., Post, K., Rajashankar, K.R., Ramos, A., Russell, M., Burley, S.K., Buchanan, S.G.
Deposit date:2004-08-30
Release date:2004-11-02
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase.
J.Biol.Chem., 279, 2004
3COI
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CRYSTAL STRUCTURE OF P38DELTA KINASE
Descriptor:Mitogen-activated protein kinase 13
Authors:Atwell, S., Burley, S.K., Houle, A., Ramos, A., Sauder, J.M., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2008-03-28
Release date:2008-04-15
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Crystal structure of p38delta kinase.
To be Published
3COK
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CRYSTAL STRUCTURE OF PLK4 KINASE
Descriptor:Serine/threonine-protein kinase PLK4, SULFATE ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Atwell, S., Burley, S.K., Houle, A., Leon, B., Pelletier, L.A., Sauder, J.M., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2008-03-28
Release date:2008-04-15
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of PLK4 kinase.
To be Published
3COM
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CRYSTAL STRUCTURE OF MST1 KINASE
Descriptor:Serine/threonine-protein kinase 4
Authors:Atwell, S., Burley, S.K., Dickey, M., Leon, B., Sauder, J.M., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2008-03-28
Release date:2008-04-15
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of Mst1 kinase.
To be Published
5DI8
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FC KNOB-HOLE HETERODIMER T366W + T366S/L368A/Y407V
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Secrist, E., Demarest, S.J., Kuhlman, B.
Deposit date:2015-08-31
Release date:2016-03-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJ0
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FC HETERODIMER DESIGN 11.2 Y349S/K370Y + E357D/S364Q
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-01
Release date:2016-03-30
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJ2
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FC HETERODIMER DESIGN 7.4 Y407A + T366V/K409V
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Secrist, E., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-01
Release date:2016-03-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJ6
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FC HETERODIMER DESIGN 6.1 F405W/Y407A + T366M
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-01
Release date:2016-03-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJ8
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FC HETERODIMER DESIGN 7.7 D399M/Y407A + T366V/K409I
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Secrist, E., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-01
Release date:2016-03-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJA
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FC HETERODIMER DESIGN 9.1 Y407M + T366I
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-01
Release date:2016-03-30
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJC
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FC HETERODIMER DESIGN 8.1 L368V/Y407A + T366V/K409F
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Secrist, E., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-01
Release date:2016-03-30
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJD
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FC HETERODIMER DESIGN 5.1 T366V + Y407F
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-02
Release date:2016-03-30
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJX
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FC HETERODIMER DESIGN 2.9 L368M/K370E + E357A/S364G
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-02
Release date:2016-03-30
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJY
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FC HETERODIMER DESIGN 20.8 Y349S/T366V/K370Y/K409V + E357D/S364Q/Y407A
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-02
Release date:2016-03-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJZ
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FC HETERODIMER DESIGN 7.8 D399M/Y407A + T366V/K409V
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-02
Release date:2016-03-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DK0
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FC HETERODIMER DESIGN 20.8.34 Y349S/T366M/K370Y/K409V + E356G/E357D/S364Q/Y407A
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-02
Release date:2016-03-30
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DK2
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FC HETERODIMER E356K/D399K + K392D/K409D
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-02
Release date:2016-03-30
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DVK
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FC DESIGN 7.7 B CHAIN HOMODIMER T366V/K409I
Descriptor:Ig gamma-1 chain C region
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-21
Release date:2016-03-30
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DVL
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FC DESIGN 20.8.37 A CHAIN HOMODIMER Y349S/T366M/K370Y/K409V
Descriptor:Ig gamma-1 chain C region, Fc-III peptide
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-21
Release date:2016-03-30
Last modified:2016-07-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016