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2FLD
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I-MSOI RE-DESIGNED FOR ALTERED DNA CLEAVAGE SPECIFICITY
Descriptor:5'-D(*GP*CP*AP*GP*AP*AP*GP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*CP*GP*TP*TP*CP*CP*G)-3', 5'-D(*CP*GP*GP*AP*AP*CP*GP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*CP*TP*TP*CP*TP*GP*C)-3', DNA ENDONUCLEASE I-MSOI, ...
Authors:Ashworth, J., Duarte, C.M., Havranek, J.J., Sussman, D., Monnat, R.J., Stoddard, B.L., Baker, D.
Deposit date:2006-01-05
Release date:2006-06-06
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Computational redesign of endonuclease DNA binding and cleavage specificity.
Nature, 441, 2006
3KO2
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I-MSOI RE-DESIGNED FOR ALTERED DNA CLEAVAGE SPECIFICITY (-7C)
Descriptor:Site-specific DNA endonuclease I-MsoI, 5'-D(*GP*CP*AP*GP*AP*CP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*CP*CP*G)-3', 5'-D(*CP*GP*GP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*GP*TP*CP*TP*GP*C)-3', ...
Authors:Taylor, G.K., Stoddard, B.L.
Deposit date:2009-11-13
Release date:2010-05-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs.
Nucleic Acids Res., 38, 2010
3MIP
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I-MSOI RE-DESIGNED FOR ALTERED DNA CLEAVAGE SPECIFICITY (-8GCG)
Descriptor:Mso-8G, DNA (5'-D(*GP*CP*AP*GP*GP*CP*GP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*CP*GP*CP*TP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*AP*GP*CP*GP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*CP*GP*CP*CP*TP*GP*C)-3'), ...
Authors:Taylor, G.K., Stoddard, B.L.
Deposit date:2010-04-11
Release date:2010-05-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs.
Nucleic Acids Res., 38, 2010
3MIS
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I-MSOI RE-DESIGNED FOR ALTERED DNA CLEAVAGE SPECIFICITY (-8G)
Descriptor:Mso-8G, DNA (5'-D(*GP*CP*AP*GP*GP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*CP*TP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*AP*GP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*CP*CP*TP*GP*C)-3'), ...
Authors:Taylor, G.K., Stoddard, B.L.
Deposit date:2010-04-12
Release date:2010-05-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs.
Nucleic Acids Res., 38, 2010
2HZY
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MOUSE FUMARYLACETOACETATE HYDROLASE COMPLEXES WITH A TRANSITION-STATE MIMIC OF THE COMPLETE SUBSTRATE
Descriptor:Fumarylacetoacetase, SODIUM ION, MANGANESE (II) ION, ...
Authors:Hurley, T.D., Timm, D.E.
Deposit date:2006-08-09
Release date:2006-08-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: kinetics, crystal structure and pharmacokinetics.
Biochem.J., 402, 2007