Author results

3BUT
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CRYSTAL STRUCTURE OF PROTEIN AF_0446 FROM ARCHAEOGLOBUS FULGIDUS
Descriptor:Uncharacterized protein Af_0446
Authors:Bonanno, J.B., Patskovsky, Y., Ozyurt, S., Ashok, S., Zhang, F., Groshong, C., Wasserman, S.R., Sauder, J.M., Burley, S.K., Almo, S.C., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2008-01-03
Release date:2008-01-15
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Crystal structure of protein Af_0446 from Archaeoglobus fulgidus.
To be Published
3LMA
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CRYSTAL STRUCTURE OF THE STAGE V SPORULATION PROTEIN AD (SPOVAD) FROM BACILLUS LICHENIFORMIS. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET BIR6.
Descriptor:Stage V sporulation protein AD (SpoVAD)
Authors:Vorobiev, S., Ashok, S., Seetharaman, J., Belote, R.L., Ciccosanti, C., Patel, D.J., Janjua, H., Acton, T.B., Xiao, R., Everett, J.K., Montelione, G.T., Tong, L., Hunt, J.F., Northeast Structural Genomics Consortium (NESG)
Deposit date:2010-01-29
Release date:2010-02-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.993 Å)
Cite:Crystal structure of the stage V sporulation protein AD (SpoVAD) from Bacillus licheniformis.
To be Published
3LMC
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CRYSTAL STRUCTURE OF ZINC-DEPENDENT PEPTIDASE FROM METHANOCORPUSCULUM LABREANUM (STRAIN Z), NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET MUR16
Descriptor:Peptidase, zinc-dependent, FE (III) ION, ...
Authors:Kuzin, A., Ashok, S., Vorobiev, S., Seetharaman, J., Patel, P., Xiao, R., Ciccosanti, C., Lee, D., Everett, J.K., Nair, R., Acton, T.B., Rost, B., Montelione, G.T., Tong, L., Hunt, J.F., Northeast Structural Genomics Consortium (NESG)
Deposit date:2010-01-29
Release date:2010-02-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.997 Å)
Cite:Northeast Structural Genomics Consortium Target MuR16
To be published
4MI5
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CRYSTAL STRUCTURE OF THE EZH2 SET DOMAIN
Descriptor:Histone-lysine N-methyltransferase EZH2, SULFATE ION, ZINC ION
Authors:Antonysamy, S., Condon, B., Druzina, Z., Bonanno, J., Gheyi, T., Macewan, I., Zhang, A., Ashok, S., Russell, M., Luz, J.G.
Deposit date:2013-08-30
Release date:2014-01-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain.
Plos One, 8, 2013
6E5V
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HUMAN MGLU8 RECEPTOR AMINO TERMINAL DOMAIN IN COMPLEX WITH (S)-3,4-DICARBOXYPHENYLGLYCINE (DCPG)
Descriptor:Metabotropic glutamate receptor 8, 4-[(S)-amino(carboxy)methyl]benzene-1,2-dicarboxylic acid, CHLORIDE ION
Authors:Chen, Q., Ho, J.D., Ashok, S., Vargas, M.C., Wang, J., Atwell, S., Bures, M., Schkeryantz, J.M., Monn, J.A., Hao, J.
Deposit date:2018-07-23
Release date:2018-11-07
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural Basis for ( S)-3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu8Receptor.
J. Med. Chem., 61, 2018
4I5I
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CRYSTAL STRUCTURE OF THE SIRT1 CATALYTIC DOMAIN BOUND TO NAD AND AN EX527 ANALOG
Descriptor:NAD-dependent protein deacetylase sirtuin-1, (6S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Zhao, X., Allison, D., Condon, B., Zhang, F., Gheyi, T., Zhang, A., Ashok, S., Russell, M., Macewan, I., Qian, Y., Jamison, J.A., Luz, J.G.
Deposit date:2012-11-28
Release date:2013-01-23
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The 2.5 angstrom crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition.
J.Med.Chem., 56, 2013
6CCY
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CRYSTAL STRUCTURE OF AKT1 IN COMPLEX WITH A SELECTIVE INHIBITOR
Descriptor:RAC-alpha serine/threonine-protein kinase,PIFtide, (5R)-4-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[2-(pyrrolidin-1-yl)ethyl]-1H-imidazol-2-yl}piperidin-1-yl)-5-methyl-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one
Authors:Wang, Y., Stout, S.
Deposit date:2018-02-07
Release date:2018-05-02
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT.
Bioorg. Med. Chem. Lett., 28, 2018