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6JOD
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BU of 6jod by Molmil
Angiotensin II type 2 receptor with ligand
Descriptor: Angiotensin II, Heavy chain of 4A03Fab, Light chain of 4A03Fab, ...
Authors:Asada, H, Iwata, S, Hirata, K, Shimamura, T.
Deposit date:2019-03-20
Release date:2020-01-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone.
Structure, 28, 2020
5XJM
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BU of 5xjm by Molmil
Complex structure of angiotensin II type 2 receptor with Fab
Descriptor: FabH, FabL, Sar1, ...
Authors:Asada, H, Horita, S, Shimamura, T, Iwata, S.
Deposit date:2017-05-02
Release date:2018-07-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog
Nat. Struct. Mol. Biol., 25, 2018
5XLI
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BU of 5xli by Molmil
Structure of anti-Angiotensin II type2 receptor antibody (D5711-4A03)
Descriptor: FabH, FabL
Authors:Asada, H, Horita, S, Iwata, S, Hirata, K.
Deposit date:2017-05-10
Release date:2018-07-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.696 Å)
Cite:Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog.
Nat. Struct. Mol. Biol., 25, 2018
7XRR
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BU of 7xrr by Molmil
Crystal structure of the human OX2R bound to the insomnia drug lemborexant.
Descriptor: (1~{R},2~{S})-2-[(2,4-dimethylpyrimidin-5-yl)oxymethyl]-~{N}-(5-fluoranylpyridin-2-yl)-2-(3-fluorophenyl)cyclopropane-1-carboxamide, Orexin receptor type 2
Authors:Asada, H, Im, D, Iwata, S.
Deposit date:2022-05-11
Release date:2022-11-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Molecular basis for anti-insomnia drug design from structure of lemborexant-bound orexin 2 receptor.
Structure, 30, 2022
8WDT
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BU of 8wdt by Molmil
Crystal structure of the human adenosine A2A receptor in complex with photoresponsive ligand photoNECA(blue)
Descriptor: (2S,3S,4R,5R)-5-(6-amino-2-((E)-phenyldiazenyl)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxytetrahydrofuran-2-carboxamide, Adenosine receptor A2a, Antibody Fab fragment heavy chain, ...
Authors:Araya, T, Asada, H, Iwata, S, Im, D.H.
Deposit date:2023-09-16
Release date:2024-01-17
Method:X-RAY DIFFRACTION (3.34 Å)
Cite:Crystal structure reveals the binding mode and selectivity of a photoswitchable ligand for the adenosine A 2A receptor.
Biochem.Biophys.Res.Commun., 695, 2023
7C6A
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BU of 7c6a by Molmil
Crystal structure of AT2R-BRIL and SRP2070_Fab complex
Descriptor: IgG Light Chain, IgG heavy chain, SAR1, ...
Authors:Suzuki, M, Miyagi, H, Asada, H, Yasunaga, M, Suno, C, Takahashi, Y, Saito, J, Iwata, S.
Deposit date:2020-05-21
Release date:2020-07-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The discovery of a new antibody for BRIL-fused GPCR structure determination.
Sci Rep, 10, 2020
3UON
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BU of 3uon by Molmil
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
Descriptor: (3R)-1-azabicyclo[2.2.2]oct-3-yl hydroxy(diphenyl)acetate, CHLORIDE ION, Human M2 muscarinic acetylcholine, ...
Authors:Haga, K, Kruse, A.C, Asada, H, Yurugi-Kobayashi, T, Shiroishi, M, Zhang, C, Weis, W.I, Okada, T, Kobilka, B.K, Haga, T, Kobayashi, T.
Deposit date:2011-11-16
Release date:2012-02-01
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist.
Nature, 482, 2012
7XRZ
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BU of 7xrz by Molmil
Crystal structure of BRIL and SRP2070_Fab complex
Descriptor: IGG HEAVY CHAIN, IGG LIGHT CHAIN, Soluble cytochrome b562
Authors:Suzuki, M, Miyagi, H, Yasunaga, M, Asada, H, Iwata, S, Saito, J.
Deposit date:2022-05-12
Release date:2023-05-10
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insight into an anti-BRIL Fab as a G-protein-coupled receptor crystallization chaperone.
Acta Crystallogr D Struct Biol, 79, 2023
7YFC
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BU of 7yfc by Molmil
Cryo-EM structure of the histamine-bound histamine H4 receptor and Gq complex
Descriptor: CHOLESTEROL, Engineered G-alpha-q, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Im, D, Iwata, S, Asada, H.
Deposit date:2022-07-08
Release date:2023-10-25
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into the agonists binding and receptor selectivity of human histamine H4 receptor.
Nat Commun, 14, 2023
7YFD
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BU of 7yfd by Molmil
Cryo-EM structure of the imetit-bound histamine H4 receptor and Gq complex
Descriptor: 2-(1~{H}-imidazol-5-yl)ethyl carbamimidothioate, CHOLESTEROL, Engineered G-alpha-q, ...
Authors:Im, D, Iwata, S, Asada, H.
Deposit date:2022-07-08
Release date:2023-10-25
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insights into the agonists binding and receptor selectivity of human histamine H4 receptor.
Nat Commun, 14, 2023
7C61
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BU of 7c61 by Molmil
Crystal structure of 5-HT1B-BRIL and SRP2070_Fab complex
Descriptor: 5-hydroxytryptamine receptor 1B,Soluble cytochrome b562,5-hydroxytryptamine receptor 1B, Ergotamine, IGG HEAVY CHAIN, ...
Authors:Suzuki, M, Miyagi, H, Asada, H, Yasunaga, M, Suno, C, Takahashi, Y, Saito, J, Iwata, S.
Deposit date:2020-05-21
Release date:2020-07-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:The discovery of a new antibody for BRIL-fused GPCR structure determination.
Sci Rep, 10, 2020
6A94
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BU of 6a94 by Molmil
Crystal structure of 5-HT2AR in complex with zotepine
Descriptor: 2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(3-chloranylbenzo[b][1]benzothiepin-5-yl)oxy-N,N-dimethyl-ethanamine, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, ...
Authors:Kimura, T.K, Asada, H, Inoue, A, Kadji, F.M.N, Im, D, Mori, C, Arakawa, T, Hirata, K, Nomura, Y, Nomura, N, Aoki, J, Iwata, S, Shimamura, T.
Deposit date:2018-07-11
Release date:2019-02-13
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of the 5-HT2Areceptor in complex with the antipsychotics risperidone and zotepine.
Nat.Struct.Mol.Biol., 26, 2019
6A93
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BU of 6a93 by Molmil
Crystal structure of 5-HT2AR in complex with risperidone
Descriptor: 3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, CHOLESTEROL, ...
Authors:Kimura, T.K, Asada, H, Inoue, A, Kadji, F.M.N, Im, D, Mori, C, Arakawa, T, Hirata, K, Nomura, Y, Nomura, N, Aoki, J, Iwata, S, Shimamura, T.
Deposit date:2018-07-11
Release date:2019-02-13
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of the 5-HT2Areceptor in complex with the antipsychotics risperidone and zotepine.
Nat.Struct.Mol.Biol., 26, 2019
6KS2
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BU of 6ks2 by Molmil
Structure of anti-Ghrelin receptor antibody
Descriptor: Fab7881 Heavy Chain (FabH), Fab7881 Light Chain (FabL)
Authors:Shiimura, Y, Horita, S, Asada, H, Hirata, K, Iwata, S, Kojima, M.
Deposit date:2019-08-23
Release date:2020-08-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.753 Å)
Cite:Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode.
Nat Commun, 11, 2020
6KO5
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BU of 6ko5 by Molmil
Complex structure of Ghrelin receptor with Fab
Descriptor: 6-(4-bromanyl-2-fluoranyl-phenoxy)-2-methyl-3-[[(3~{S})-1-propan-2-ylpiperidin-3-yl]methyl]pyrido[3,2-d]pyrimidin-4-one, Chimera of Soluble cytochrome b562 and Growth hormone secretagogue receptor type 1, Fab7881 Heavy Chain, ...
Authors:Shiimura, Y, Horita, S, Asada, H, Hirata, K, Iwata, S, Kojima, M.
Deposit date:2019-08-08
Release date:2020-08-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode.
Nat Commun, 11, 2020
7C4S
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BU of 7c4s by Molmil
Sphingosine-1-phosphate receptor 3 with a natural ligand.
Descriptor: (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, ...
Authors:Iwata, S, Maeda, S, Luo, F, Nango, E, hirata, K, Asada, H.
Deposit date:2020-05-18
Release date:2021-06-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Endogenous agonist-bound S1PR3 structure reveals determinants of G protein-subtype bias.
Sci Adv, 7, 2021
8GNG
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BU of 8gng by Molmil
Crystal structure of human adenosine A2A receptor in complex with istradefylline.
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 8-[(~{E})-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6-dione, Adenosine receptor A2a, ...
Authors:Suzuki, M, Saito, J, Miyagi, H, Yasunaga, M.
Deposit date:2022-08-23
Release date:2023-03-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:In Vitro Pharmacological Profile of KW-6356, a Novel Adenosine A 2A Receptor Antagonist/Inverse Agonist.
Mol.Pharmacol., 103, 2023
8GNE
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BU of 8gne by Molmil
Crystal structure of human adenosine A2A receptor in complex with an insurmountable inverse agonist, KW-6356.
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Adenosine receptor A2a,Soluble cytochrome b562, ...
Authors:Suzuki, M, Saito, J, Miyagi, H, Yasunaga, M.
Deposit date:2022-08-23
Release date:2023-03-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:In Vitro Pharmacological Profile of KW-6356, a Novel Adenosine A 2A Receptor Antagonist/Inverse Agonist.
Mol.Pharmacol., 103, 2023
5YFI
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BU of 5yfi by Molmil
Crystal structure of the anti-human prostaglandin E receptor EP4 antibody Fab fragment
Descriptor: Heavy chain of Fab fragment, Light chain of Fab fragment, ZINC ION
Authors:Toyoda, Y, Morimoto, K, Suno, R, Horita, S, Iwata, S, Kobayashi, T.
Deposit date:2017-09-21
Release date:2018-12-05
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.848 Å)
Cite:Ligand binding to human prostaglandin E receptor EP4at the lipid-bilayer interface.
Nat. Chem. Biol., 15, 2019
5YHL
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BU of 5yhl by Molmil
Crystal structure of the human prostaglandin E receptor EP4 in complex with Fab and an antagonist Br-derivative
Descriptor: 4-[2-[[(2R)-2-(4-bromanylnaphthalen-1-yl)propanoyl]amino]-4-cyano-phenyl]butanoic acid, Heavy chain of Fab fragment, Light chain of Fab fragment, ...
Authors:Toyoda, Y, Morimoto, K, Suno, R, Horita, S, Iwata, S, Kobayashi, T.
Deposit date:2017-09-28
Release date:2018-12-05
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Ligand binding to human prostaglandin E receptor EP4at the lipid-bilayer interface.
Nat. Chem. Biol., 15, 2019
5YWY
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BU of 5ywy by Molmil
Crystal structure of the human prostaglandin E receptor EP4 in complex with Fab and ONO-AE3-208
Descriptor: 4-[4-cyano-2-[[(2R)-2-(4-fluoranylnaphthalen-1-yl)propanoyl]amino]phenyl]butanoic acid, Heavy chain of Fab fragment, Light chain of Fab fragment, ...
Authors:Toyoda, Y, Morimoto, K, Suno, R, Horita, S, Iwata, S, Kobayashi, T.
Deposit date:2017-11-30
Release date:2018-12-05
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Ligand binding to human prostaglandin E receptor EP4at the lipid-bilayer interface.
Nat. Chem. Biol., 15, 2019
7DFP
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BU of 7dfp by Molmil
Human dopamine D2 receptor in complex with spiperone
Descriptor: 8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one, D(2) dopamine receptor,Soluble cytochrome b562, FabH, ...
Authors:Im, D, Shimamura, T, Iwata, S.
Deposit date:2020-11-09
Release date:2020-12-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the dopamine D 2 receptor in complex with the antipsychotic drug spiperone.
Nat Commun, 11, 2020

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