Author results

4KM3
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DISCOVERY OF A NOVEL STRUCTURAL MOTIF IN METHIONINE AMINOPEPTIDASE FROM STREPTOCOCCI WITH POSSIBLE POST-TRANSLATIONAL MODIFICATION
Descriptor:Methionine aminopeptidase
Authors:Arya, T., Addlagatta, A.
Deposit date:2013-05-08
Release date:2014-01-15
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Discovery of a new genetic variant of methionine aminopeptidase from streptococci with possible post-translational modifications: biochemical and structural characterization.
Plos One, 8, 2013
4U1B
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HSMETAP IN COMPLEX WITH (1-AMINO-2-PROPYLPENTYL)PHOSPHONIC ACID
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, GLYCEROL, ...
Authors:Arya, T., Addlagatta, A.
Deposit date:2014-07-15
Release date:2015-03-25
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
J.Med.Chem., 58, 2015
4U69
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HSMETAP COMPLEX WITH (1-AMINO-2-METHYLPENTYL)PHOSPHONIC ACID
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, POTASSIUM ION, ...
Authors:Arya, T., Addlagatta, A.
Deposit date:2014-07-28
Release date:2015-03-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
J.Med.Chem., 58, 2015
4U6C
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HSMETAP IN COMPLEX WITH [(1R)-1-AMINO-3-CYCLOPENTYLPROPYL]PHOSPHONIC ACID
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, POTASSIUM ION, ...
Authors:Arya, T., Addlagatta, A.
Deposit date:2014-07-28
Release date:2015-03-25
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
J.Med.Chem., 58, 2015
4U6E
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HSMETAP IN COMPLEX WITH (AMINO(PHENYL)METHYL)PHOSPHONIC ACID
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, [(R)-amino(phenyl)methyl]phosphonic acid
Authors:Arya, T., Addlagatta, A.
Deposit date:2014-07-28
Release date:2015-03-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
J.Med.Chem., 58, 2015
4U6J
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HSMETAP IN COMPLEX WITH METHIONINE
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, POTASSIUM ION, ...
Authors:Arya, T., Addlagatta, A.
Deposit date:2014-07-29
Release date:2015-03-25
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
J.Med.Chem., 58, 2015
4U6W
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HSMETAP (F220M) IN COMPLEX WITH 1-AMINO-2-PROPYLPENTYL]PHOSPHONIC ACID
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, POTASSIUM ION, ...
Authors:Arya, T., Addlagatta, A.
Deposit date:2014-07-30
Release date:2015-03-25
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
J.Med.Chem., 58, 2015
4U6Z
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HSMETAP(F309M) IN COMPLEX WITH 1-AMINO-2-PROPYLPENTYL)PHOSPHONIC ACID
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, POTASSIUM ION, ...
Authors:Arya, T., Addlagatta, A.
Deposit date:2014-07-30
Release date:2015-04-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
J.Med.Chem., 58, 2015
4U70
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HSMETAP (F309M) IN COMPLEX WITH (1-AMINO-2-CYCLOHEXYLETHYL)PHOSPHONIC ACID
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, POTASSIUM ION, ...
Authors:Arya, T., Addlagatta, A.
Deposit date:2014-07-30
Release date:2015-03-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
J.Med.Chem., 58, 2015
4U71
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HSMETAP(F309M) IN COMPLEX WITH 1- AMINO(CYCLOHEXYL)METHY)PHOSPHONIC ACID
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, POTASSIUM ION, ...
Authors:Arya, T., Addlagatta, A.
Deposit date:2014-07-30
Release date:2015-03-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
J.Med.Chem., 58, 2015
4U73
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HSMETAP(F309M) IN COMPLEX WITH (AMINO(PHENYL)METHYL)PHOSPHONIC ACID
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, POTASSIUM ION, ...
Authors:Arya, T., Addlagatta, A.
Deposit date:2014-07-30
Release date:2015-03-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
J.Med.Chem., 58, 2015
4U75
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HSMETAP (F309M) IN COMPLEX WITH METHIONINE
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, POTASSIUM ION, ...
Authors:Arya, T., Addlagatta, A.
Deposit date:2014-07-30
Release date:2015-03-25
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
J.Med.Chem., 58, 2015
4U76
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HSMETAP (F309M) HOLO FORM
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, POTASSIUM ION, ...
Authors:Arya, T., Addlagatta, A.
Deposit date:2014-07-30
Release date:2015-03-25
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
J.Med.Chem., 58, 2015
5JBS
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CONFORMATIONAL CHANGES DURING MONOMER-TO-DIMER TRANSITION OF BRUCELLA SUIS VIRB8
Descriptor:Type IV secretion system protein virB8, CHLORIDE ION, GLYCEROL, ...
Authors:Arya, T., Sharifahmadian, M., Sygusch, J., Baron, B.
Deposit date:2016-04-13
Release date:2017-03-01
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:NMR analyses, X-ray crystallography and small-molecule probing reveal conformational shifts during monomer-to-dimer transition of Brucella suis VirB8
To Be Published
6BGE
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HELICOBACTER PYLORI ATPASE, HP0525, IN COMPLEX WITH 1G4 COMPOUND
Descriptor:VirB11-like protein, SULFATE ION, GLYCEROL, ...
Authors:Arya, T., Casu, B., Baron, C.
Deposit date:2017-10-27
Release date:2018-10-31
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:CagAlpha in complex with hexamer inhibitor
To Be Published
5YKP
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HUMAN METHIONINE AMINOPEPTIDASE TYPE 1B (F309M MUTANT) IN COMPLEX WITH OVALICIN
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, POTASSIUM ION, ...
Authors:Arya, T., Pillalamarri, V., Addlagatta, A.
Deposit date:2017-10-15
Release date:2018-10-17
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Discovery of natural product ovalicin sensitive type 1 methionine aminopeptidases: molecular and structural basis.
Biochem. J., 476, 2019
5YR4
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HUMAN METHIONINE AMINOPEPTIDASE TYPE 1B (F309M MUTANT) IN COMLEX WITH TNP470
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, POTASSIUM ION, ...
Authors:Arya, T., Pillalamarri, V., Addlagatta, A.
Deposit date:2017-11-08
Release date:2018-11-14
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Discovery of natural product ovalicin sensitive type 1 methionine aminopeptidases: molecular and structural basis.
Biochem. J., 476, 2019
4IKR
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CRYSTAL STRUCTURE OF TYPE 1 HUMAN METHIONINE AMINOPEPTIDASE IN COMPLEX WITH 2-(4-(5-CHLORO-6-METHYL-2-(PYRIDIN-2-YL)PYRIMIDIN-4-YL)PIPERAZIN-1-YL)ETHANOL
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, 2-{4-[5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl]piperazin-1-yl}ethanol, ...
Authors:Addlagatta, A., Kishor, C., Arya, T.
Deposit date:2012-12-28
Release date:2013-12-11
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases
J.Med.Chem., 56, 2013
4IKS
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CRYSTAL STRUCTURE OF TRUNCATED (DELTA 1-89) HUMAN METHIONINE AMINOPEPTIDASE TYPE 1 IN COMPLEX WITH N1-(5-CHLORO-6-METHYL-2-(PYRIDIN-2-YL)PYRIMIDIN-4-YL)-N2-(6-(TRIFLUOROMETHYL)PYRIDIN-2-YL)ETHANE-1,2-DIAMINE
Descriptor:Methionine aminopeptidase 1, N-[5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl]-N'-[6-(trifluoromethyl)pyridin-2-yl]ethane-1,2-diamine, COBALT (II) ION, ...
Authors:Addlagatta, A., Kishor, C., Arya, T.
Deposit date:2012-12-28
Release date:2013-12-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases
J.Med.Chem., 56, 2013
4IKT
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CRYSTAL STRUCTURE OF TRUNCATED (DELTA 1-89) HUMAN METHIONINE AMINOPEPTIDASE TYPE 1 IN COMPLEX WITH N1-(5-CHLORO-6-METHYL-2-(PYRIDIN-2-YL)PYRIMIDIN-4-YL)-N2-(5-(TRIFLUOROMETHYL)PYRIDIN-2-YL)ETHANE-1,2-DIAMINE
Descriptor:Methionine aminopeptidase 1, N-[5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl]-N'-[5-(trifluoromethyl)pyridin-2-yl]ethane-1,2-diamine, COBALT (II) ION, ...
Authors:Addlagatta, A., Kishor, C., Arya, T.
Deposit date:2012-12-28
Release date:2013-12-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases
J.Med.Chem., 56, 2013
4IKU
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CRYSTAL STRUCTURE OF TRUNCATED (DELTA 1-89) HUMAN METHIONINE AMINOPEPTIDASE TYPE 1 IN COMPLEX WITH 2-((5-CHLORO-6-METHYL-2-(PYRIDIN-2-YL)PYRIMIDIN-4-YL)AMINO)-3-PHENYLPROPANAMIDE
Descriptor:Methionine aminopeptidase 1, Nalpha-[5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl]-D-phenylalaninamide, COBALT (II) ION, ...
Authors:Addlagatta, A., Kishor, C., Arya, T.
Deposit date:2012-12-28
Release date:2013-12-11
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases
J.Med.Chem., 56, 2013
5WIC
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TRAE PROTEIN IN COMPLEX WITH 2-FUROIC ACID (FOA)
Descriptor:Conjugal transfer protein, 2-FUROIC ACID
Authors:Casu, B., Arya, T., Bessette, B., Baron, C.
Deposit date:2017-07-19
Release date:2017-11-15
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Fragment-based screening identifies novel targets for inhibitors of conjugative transfer of antimicrobial resistance by plasmid pKM101.
Sci Rep, 7, 2017
5WII
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TRAE PROTEIN IN COMPLEX WITH 2-CHLOROISONICOTINIC ACID
Descriptor:Conjugal transfer protein, 2-chloropyridine-4-carboxylic acid
Authors:Casu, B., Arya, T., Bessette, B., Baron, C.
Deposit date:2017-07-19
Release date:2017-11-15
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Fragment-based screening identifies novel targets for inhibitors of conjugative transfer of antimicrobial resistance by plasmid pKM101.
Sci Rep, 7, 2017
5WIO
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TRAE PROTEIN IN COMPLEX WITH 4-(1H-PYRROL-1-YL)PYRIDINE-2-CARBOXYLIC ACID
Descriptor:Conjugal transfer protein, 4-(1H-pyrrol-1-yl)pyridine-2-carboxylic acid
Authors:Casu, B., Arya, T., Bessette, B., Baron, C.
Deposit date:2017-07-19
Release date:2017-11-15
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Fragment-based screening identifies novel targets for inhibitors of conjugative transfer of antimicrobial resistance by plasmid pKM101.
Sci Rep, 7, 2017
5WIP
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TRAE PROTEIN IN COMPLEX WITH 2-(2-FURYL)ISONICOTINIC ACID
Descriptor:Conjugal transfer protein, 2-(furan-2-yl)pyridine-4-carboxylic acid
Authors:Casu, B., Arya, T., Bessette, B., Baron, C.
Deposit date:2017-07-19
Release date:2017-11-15
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Fragment-based screening identifies novel targets for inhibitors of conjugative transfer of antimicrobial resistance by plasmid pKM101.
Sci Rep, 7, 2017
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