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7K0C
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BU of 7k0c by Molmil
Structure of Secretory IgM Core
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin J chain, Immunoglobulin heavy constant mu, ...
Authors:Kumar, N, Arthur, C.P, Ciferri, C, Matsumoto, M.L.
Deposit date:2020-09-04
Release date:2021-01-20
Last modified:2021-06-16
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure of the human secretory immunoglobulin M core.
Structure, 29, 2021
6WJ5
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BU of 6wj5 by Molmil
Structure of human TRPA1 in complex with inhibitor GDC-0334
Descriptor: (4R,5S)-4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-({5-(trifluoromethyl)-2-[2-(trifluoromethyl)pyrimidin-5-yl]pyridin-4-yl}methyl)-L-prolinamide, Transient receptor potential cation channel subfamily A member 1
Authors:Rohou, A, Rouge, L, Arthur, C.P, Volgraf, M, Chen, H.
Deposit date:2020-04-11
Release date:2021-02-17
Last modified:2021-08-11
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment.
J.Exp.Med., 218, 2021
6XIW
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BU of 6xiw by Molmil
Cryo-EM structure of the sodium leak channel NALCN-FAM155A complex
Descriptor: (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kschonsak, M, Chua, H.C, Noland, C.L, Weidling, C, Clairfeuille, T, Bahlke, O.O, Ameen, A.O, Li, Z.R, Arthur, C.P, Ciferri, C, Pless, S.A, Payandeh, J.
Deposit date:2020-06-22
Release date:2020-07-29
Last modified:2020-11-25
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structure of the human sodium leak channel NALCN.
Nature, 587, 2020
7LBE
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BU of 7lbe by Molmil
CryoEM structure of the HCMV Trimer gHgLgO in complex with neutralizing fabs 13H11 and MSL-109
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein H, ...
Authors:Kschonsak, M, Rouge, L, Arthur, C.P, Hoangdung, H, Patel, N, Kim, I, Johnson, M, Kraft, E, Rohou, A.L, Gill, A, Martinez-Martin, N, Payandeh, J, Ciferri, C.
Deposit date:2021-01-07
Release date:2021-03-10
Last modified:2021-03-17
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structures of HCMV Trimer reveal the basis for receptor recognition and cell entry.
Cell, 184, 2021
7LBG
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BU of 7lbg by Molmil
CryoEM structure of the HCMV Trimer gHgLgO in complex with human Transforming growth factor beta receptor type 3 and neutralizing fabs 13H11 and MSL-109
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein H, ...
Authors:Kschonsak, M, Rouge, L, Arthur, C.P, Hoangdung, H, Patel, N, Kim, I, Johnson, M, Kraft, E, Rohou, A.L, Gill, A, Martinez-Martin, N, Payandeh, J, Ciferri, C.
Deposit date:2021-01-07
Release date:2021-03-10
Last modified:2021-03-17
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structures of HCMV Trimer reveal the basis for receptor recognition and cell entry.
Cell, 184, 2021
7LBF
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BU of 7lbf by Molmil
CryoEM structure of the HCMV Trimer gHgLgO in complex with human Platelet-derived growth factor receptor alpha and neutralizing fabs 13H11 and MSL-109
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein H, ...
Authors:Kschonsak, M, Rouge, L, Arthur, C.P, Hoangdung, H, Patel, N, Kim, I, Johnson, M, Kraft, E, Rohou, A.L, Gill, A, Martinez-Martin, N, Payandeh, J, Ciferri, C.
Deposit date:2021-01-07
Release date:2021-03-10
Last modified:2021-03-17
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structures of HCMV Trimer reveal the basis for receptor recognition and cell entry.
Cell, 184, 2021
6N4Q
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BU of 6n4q by Molmil
CryoEM structure of Nav1.7 VSD2 (actived state) in complex with the gating modifier toxin ProTx2
Descriptor: Beta/omega-theraphotoxin-Tp2a, Fab heavy chain, Fab light chain, ...
Authors:Xu, H, Rohou, A, Arthur, C.P, Estevez, A, Ciferri, C, Payandeh, J, Koth, C.M.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.
Cell, 176, 2019
6N2P
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BU of 6n2p by Molmil
Helical assembly of the CARD9 CARD
Descriptor: Caspase recruitment domain-containing protein 9
Authors:Holliday, M.J, Rohou, A, Arthur, C.P, Dueber, E.C, Fairbrother, W.J.
Deposit date:2018-11-13
Release date:2019-07-03
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation.
Nat Commun, 10, 2019
6N4R
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BU of 6n4r by Molmil
CryoEM structure of Nav1.7 VSD2 (deactived state) in complex with the gating modifier toxin ProTx2
Descriptor: Beta/omega-theraphotoxin-Tp2a, Fab heavy chain, Fab light chain, ...
Authors:Xu, H, Rohou, A, Arthur, C.P, Estevez, A, Ciferri, C, Payandeh, J, Koth, C.M.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.
Cell, 176, 2019
3NRX
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BU of 3nrx by Molmil
Insights into anti-parallel microtubule crosslinking by PRC1, a conserved non-motor microtubule binding protein
Descriptor: Protein regulator of cytokinesis 1
Authors:Kapoor, T.M, Subramanian, R, Wilson-Kubalek, E.M, Arthur, C.P, Bick, M.J, Campbell, E.A, Darst, S.A, Milligan, R.A.
Deposit date:2010-06-30
Release date:2010-08-18
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Insights into Antiparallel Microtubule Crosslinking by PRC1, a Conserved Nonmotor Microtubule Binding Protein.
Cell(Cambridge,Mass.), 142, 2010
3NRY
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BU of 3nry by Molmil
Insights into anti-parallel microtubule crosslinking by PRC1, a conserved microtubule binding protein
Descriptor: Protein regulator of cytokinesis 1
Authors:Kapoor, T.M, Subramanian, R, Wilson-Kubalek, E.M, Arthur, C.P, Bick, M.J, Campbell, E.A, Darst, S.A, Milligan, R.A.
Deposit date:2010-07-01
Release date:2010-08-25
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights into Antiparallel Microtubule Crosslinking by PRC1, a Conserved Nonmotor Microtubule Binding Protein.
Cell(Cambridge,Mass.), 142, 2010
6UE7
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BU of 6ue7 by Molmil
Structure of dimeric sIgA complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin J chain, ...
Authors:Kumar, N, Arthur, C.P, Ciferri, C, Matsumoto, M.L.
Deposit date:2019-09-20
Release date:2020-02-19
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure of the secretory immunoglobulin A core.
Science, 367, 2020
6UEA
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BU of 6uea by Molmil
Structure of pentameric sIgA complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin J chain, ...
Authors:Kumar, N, Arthur, C.P, Ciferri, C, Matsumoto, M.L.
Deposit date:2019-09-20
Release date:2020-02-19
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of the secretory immunoglobulin A core.
Science, 367, 2020
6UE8
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BU of 6ue8 by Molmil
Structure of tetrameric sIgA complex (Class 1)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin J chain, ...
Authors:Kumar, N, Arthur, C.P, Ciferri, C, Matsumoto, M.L.
Deposit date:2019-09-20
Release date:2020-02-19
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of the secretory immunoglobulin A core.
Science, 367, 2020
6UE9
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BU of 6ue9 by Molmil
Structure of tetrameric sIgA complex (Class 2)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin J chain, ...
Authors:Kumar, N, Arthur, C.P, Ciferri, C, Matsumoto, M.L.
Deposit date:2019-09-20
Release date:2020-02-19
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure of the secretory immunoglobulin A core.
Science, 367, 2020
6UPH
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BU of 6uph by Molmil
Structure of a Yeast Centromeric Nucleosome at 2.7 Angstrom resolution
Descriptor: DNA (119-MER), Histone H2A, Histone H2B.1, ...
Authors:Migl, D, Kschonsak, M, Arthur, C.P, Khin, Y, Harrison, S.C, Ciferri, C, Dimitrova, Y.N.
Deposit date:2019-10-17
Release date:2019-11-06
Last modified:2022-11-16
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Cryoelectron Microscopy Structure of a Yeast Centromeric Nucleosome at 2.7 angstrom Resolution.
Structure, 28, 2020
8F0Q
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BU of 8f0q by Molmil
Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the acylsulfonamide inhibitor GDC-0310
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-cyclopropyl-4-({1-[(1S)-1-(3,5-dichlorophenyl)ethyl]piperidin-4-yl}methoxy)-2-fluoro-N-(methanesulfonyl)benzamide, ...
Authors:Kschonsak, M, Jao, C.C, Arthur, C.P, Rohou, A.L, Bergeron, P, Ortwine, D, McKerall, S.J, Hackos, D.H, Deng, L, Chen, J, Sutherlin, D, Dragovich, P.S, Volgraf, M, Wright, M.R, Payandeh, J, Ciferri, C, Tellis, J.C.
Deposit date:2022-11-03
Release date:2023-04-12
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Cryo-EM reveals an unprecedented binding site for Na V 1.7 inhibitors enabling rational design of potent hybrid inhibitors.
Elife, 12, 2023
8F0P
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BU of 8f0p by Molmil
Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the hybrid inhibitor GNE-1305
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
Authors:Kschonsak, M, Jao, C.C, Arthur, C.P, Rohou, A.L, Bergeron, P, Ortwine, D, McKerall, S.J, Hackos, D.H, Deng, L, Chen, J, Sutherlin, D, Dragovich, P.S, Volgraf, M, Wright, M.R, Payandeh, J, Ciferri, C, Tellis, J.C.
Deposit date:2022-11-03
Release date:2023-04-12
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Cryo-EM reveals an unprecedented binding site for Na V 1.7 inhibitors enabling rational design of potent hybrid inhibitors.
Elife, 12, 2023
8F0S
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BU of 8f0s by Molmil
Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the hybrid inhibitor GNE-9296
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kschonsak, M, Jao, C.C, Arthur, C.P, Rohou, A.L, Bergeron, P, Ortwine, D, McKerall, S.J, Hackos, D.H, Deng, L, Chen, J, Sutherlin, D, Dragovich, P.S, Volgraf, M, Wright, M.R, Payandeh, J, Ciferri, C, Tellis, J.C.
Deposit date:2022-11-03
Release date:2023-04-12
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM reveals an unprecedented binding site for Na V 1.7 inhibitors enabling rational design of potent hybrid inhibitors.
Elife, 12, 2023
8F0R
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BU of 8f0r by Molmil
Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the arylsulfonamide inhibitor GNE-3565
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-4-({(1S,2S,4S)-2-(dimethylamino)-4-[3-(trifluoromethyl)phenyl]cyclohexyl}amino)-2-fluoro-N-(pyrimidin-4-yl)benzene-1-sulfonamide, ...
Authors:Kschonsak, M, Jao, C.C, Arthur, C.P, Rohou, A.L, Bergeron, P, Ortwine, D, McKerall, S.J, Hackos, D.H, Deng, L, Chen, J, Sutherlin, D, Dragovich, P.S, Volgraf, M, Wright, M.R, Payandeh, J, Ciferri, C, Tellis, J.C.
Deposit date:2022-11-03
Release date:2023-04-12
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Cryo-EM reveals an unprecedented binding site for Na V 1.7 inhibitors enabling rational design of potent hybrid inhibitors.
Elife, 12, 2023
7SX4
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BU of 7sx4 by Molmil
Human NALCN-FAM155A-UNC79-UNC80 channelosome with CaM bound, conformation 2/2
Descriptor: (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kschonsak, M, Chua, H.C, Weidling, C, Chakouri, N, Noland, C.L, Schott, K, Chang, T, Tam, C, Patel, N, Arthur, C.P, Leitner, A, Ben-Johny, M, Ciferri, C, Pless, S.A, Payandeh, J.
Deposit date:2021-11-22
Release date:2021-12-29
Last modified:2022-03-16
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural architecture of the human NALCN channelosome.
Nature, 603, 2022
7SX3
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BU of 7sx3 by Molmil
Human NALCN-FAM155A-UNC79-UNC80 channelosome with CaM bound, conformation 1/2
Descriptor: (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kschonsak, M, Chua, H.C, Weidling, C, Chakouri, N, Noland, C.L, Schott, K, Chang, T, Tam, C, Patel, N, Arthur, C.P, Leitner, A, Ben-Johny, M, Ciferri, C, Pless, S.A, Payandeh, J.
Deposit date:2021-11-22
Release date:2021-12-29
Last modified:2022-03-16
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural architecture of the human NALCN channelosome.
Nature, 603, 2022
7T4R
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BU of 7t4r by Molmil
CryoEM structure of the HCMV Pentamer gH/gL/UL128/UL130/UL131A in complex with THBD and neutralizing fabs MSL-109 and 13H11
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein H, Envelope glycoprotein L, ...
Authors:Kschonsak, M, Johnson, M.C, Schelling, R, Green, E.M, Rouge, L, Ho, H, Patel, N, Kilic, C, Kraft, E, Arthur, C.P, Rohou, A.L, Comps-Agrar, L, Martinez-Martin, N, Perez, L, Payandeh, J, Ciferri, C.
Deposit date:2021-12-10
Release date:2022-03-23
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for HCMV Pentamer receptor recognition and antibody neutralization.
Sci Adv, 8, 2022
7T4Q
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BU of 7t4q by Molmil
CryoEM structure of the HCMV Pentamer gH/gL/UL128/UL130/UL131A in complex with neutralizing fabs 2C12, 7I13 and 13H11
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein H, Envelope glycoprotein L, ...
Authors:Kschonsak, M, Johnson, M.C, Schelling, R, Green, E.M, Rouge, L, Ho, H, Patel, N, Kilic, C, Kraft, E, Arthur, C.P, Rohou, A.L, Comps-Agrar, L, Martinez-Martin, N, Perez, L, Payandeh, J, Ciferri, C.
Deposit date:2021-12-10
Release date:2022-03-23
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for HCMV Pentamer receptor recognition and antibody neutralization.
Sci Adv, 8, 2022
7T4S
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BU of 7t4s by Molmil
CryoEM structure of the HCMV Pentamer gH/gL/UL128/UL130/UL131A in complex with NRP2 and neutralizing fabs 8I21 and 13H11
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Envelope glycoprotein H, ...
Authors:Kschonsak, M, Johnson, M.C, Schelling, R, Green, E.M, Rouge, L, Ho, H, Patel, N, Kilic, C, Kraft, E, Arthur, C.P, Rohou, A.L, Comps-Agrar, L, Martinez-Martin, N, Perez, L, Payandeh, J, Ciferri, C.
Deposit date:2021-12-10
Release date:2022-03-23
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for HCMV Pentamer receptor recognition and antibody neutralization.
Sci Adv, 8, 2022

 

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