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2K0N
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BU of 2k0n by Molmil
Solution Structure of Yeast Gal11p kix domain
Descriptor: Mediator of RNA polymerase II transcription subunit 15
Authors:Arthanari, H, Frueh, D.P, Wagner, G.K, Naar, A.M.
Deposit date:2008-02-04
Release date:2008-03-25
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:A nuclear receptor-like pathway regulating multidrug resistance in fungi.
Nature, 452, 2008
5A4H
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BU of 5a4h by Molmil
Solution structure of the lipid droplet anchoring peptide of CGI-58 bound to DPC micelles
Descriptor: 1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE ABHD5
Authors:Boeszoermenyi, A, Arthanari, H, Wagner, G, Nagy, H.M, Zangger, K, Lindermuth, H, Oberer, M.
Deposit date:2015-06-09
Release date:2015-09-16
Last modified:2015-12-02
Method:SOLUTION NMR
Cite:Structure of a Cgi-58 Motif Provides the Molecular Basis of Lipid Droplet Anchoring.
J.Biol.Chem., 290, 2015
4D7X
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BU of 4d7x by Molmil
Solution Structure of the Mediator Gall11 KIX Domain of C. Glabrata
Descriptor: MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15
Authors:Boeszoermenyi, A, Wagner, G, Naar, A.M, Arthanari, H.
Deposit date:2014-11-30
Release date:2015-12-09
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Inhibiting Fungal Multidrug Resistance by Disrupting an Activator-Mediator Interaction.
Nature, 530, 2016
5BXV
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BU of 5bxv by Molmil
eIF4E complex
Descriptor: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1
Authors:Sekiyama, N, Arthanari, H, Papdopoulos, E, Rodriguez-Mias, R.A, Wagner, G, Leger-Abraham, M.
Deposit date:2015-06-09
Release date:2015-07-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1.
Proc.Natl.Acad.Sci.USA, 112, 2015
5WB5
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BU of 5wb5 by Molmil
Leishmania IF4E-1 bound to Leishmania 4E-IP1
Descriptor: DI(HYDROXYETHYL)ETHER, Putative eukaryotic translation initiation factor eIF-4E, Uncharacterized protein
Authors:Leger-Abraham, M, Meleppattu, S, Arthanari, H, Zinoviev, A, Boeszoermenyi, A, Wagner, G, Shapira, M.
Deposit date:2017-06-27
Release date:2018-03-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for LeishIF4E-1 modulation by an interacting protein in the human parasite Leishmania major.
Nucleic Acids Res., 46, 2018
5A3G
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BU of 5a3g by Molmil
Structure of herpesvirus nuclear egress complex subunit M50
Descriptor: M50
Authors:Leigh, K.E, Boeszoermenyi, A, Mansueto, M.S, Sharma, M, Filman, D.J, Coen, D.M, Wagner, G, Hogle, J.M, Arthanari, H.
Deposit date:2015-06-01
Release date:2015-07-15
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure of a Herpesvirus Nuclear Egress Complex Subunit Reveals an Interaction Groove that is Essential for Viral Replication
Proc.Natl.Acad.Sci.USA, 112, 2015
5IJ4
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BU of 5ij4 by Molmil
Solution structure of AN1-type zinc finger domain from Cuz1 (Cdc48 associated ubiquitin-like/zinc-finger protein-1)
Descriptor: CDC48-associated ubiquitin-like/zinc finger protein 1, ZINC ION
Authors:Sun, Z.-Y.J, Hanna, J, Wagner, G, Bhanu, M.K, Allan, M, Arthanari, H.
Deposit date:2016-03-01
Release date:2016-10-05
Last modified:2019-12-11
Method:SOLUTION NMR
Cite:Solution Structure of the Cuz1 AN1 Zinc Finger Domain: An Exposed LDFLP Motif Defines a Subfamily of AN1 Proteins.
Plos One, 11, 2016
2LYC
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BU of 2lyc by Molmil
Structure of C-terminal domain of Ska1
Descriptor: Spindle and kinetochore-associated protein 1 homolog
Authors:Boeszoermenyi, A, Schmidt, J.C, Markus, M, Oberer, M, Cheeseman, I.M, Wagner, G, Arthanari, H.
Deposit date:2012-09-14
Release date:2012-10-24
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The kinetochore-bound ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments.
Dev.Cell, 23, 2012
2ROQ
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BU of 2roq by Molmil
Solution Structure of the thiolation-thioesterase di-domain of enterobactin synthetase component F
Descriptor: Enterobactin synthetase component F
Authors:Frueh, D.P, Arthanari, H, Koglin, A, Vosburg, D.A, Bennett, A.E, Walsh, C.T, Wagner, G.
Deposit date:2008-04-05
Release date:2008-08-12
Last modified:2021-11-10
Method:SOLUTION NMR
Cite:Dynamic thiolation-thioesterase structure of a non-ribosomal peptide synthetase
Nature, 454, 2008
5H7U
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BU of 5h7u by Molmil
NMR structure of eIF3 36-163
Descriptor: Eukaryotic translation initiation factor 3 subunit C
Authors:Nagata, T, Obayashi, E.
Deposit date:2016-11-21
Release date:2017-05-31
Method:SOLUTION NMR
Cite:Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5.
Cell Rep, 18, 2017
7P2G
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BU of 7p2g by Molmil
Identification of low micromolar SARS-CoV-2 Mpro inhibitors from hits identified by in silico screens
Descriptor: (4~{R})-~{N}-(4-iodophenyl)-2-oxidanylidene-3,4-dihydro-1~{H}-quinoline-4-carboxamide, 3C-like proteinase
Authors:Rempel, S, Halazonetis, T.D.
Deposit date:2021-07-05
Release date:2022-05-04
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Non-covalent SARS-CoV-2 M pro inhibitors developed from in silico screen hits.
Sci Rep, 12, 2022
7U20
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BU of 7u20 by Molmil
Crystal structure of human METTL1 and WDR4 complex
Descriptor: SULFATE ION, tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
Authors:Li, J, Nowak, R.P, Fischer, E.S, Gregory, R.
Deposit date:2022-02-22
Release date:2022-12-07
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4.
Nature, 613, 2023
8CTH
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BU of 8cth by Molmil
Cryo-EM structure of human METTL1-WDR4-tRNA(Phe) complex
Descriptor: Phe-tRNA, S-ADENOSYL-L-HOMOCYSTEINE, tRNA (guanine-N(7)-)-methyltransferase, ...
Authors:Li, J, Wang, L, Fontana, P, Hunkeler, M, Roy-Burman, S.S, Wu, H, Fishcer, E.S, Gregory, R.I.
Deposit date:2022-05-14
Release date:2022-12-07
Last modified:2023-01-25
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4.
Nature, 613, 2023
8CTI
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BU of 8cti by Molmil
Cryo-EM structure of human METTL1-WDR4-tRNA(Val) complex
Descriptor: tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4, tRNA-Val-TAC-2-1
Authors:Li, J, Wang, L, Fontana, P, Hunkeler, M, Roy-Burman, S.S, Wu, H, Fischer, E.S, Gregory, R.I.
Deposit date:2022-05-14
Release date:2022-12-07
Last modified:2023-01-25
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4.
Nature, 613, 2023
8CN3
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BU of 8cn3 by Molmil
hDLG1-PDZ2 in complex with a TAX1 peptide from HTLV-1
Descriptor: Disks large homolog 1, GLU-THR-GLU-VAL
Authors:Maseko, S, Sogues, A, Volkov, A, Remaut, H, Twizere, J.C.
Deposit date:2023-02-21
Release date:2023-08-02
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Identification of small molecule antivirals against HTLV-1 by targeting the hDLG1-Tax-1 protein-protein interaction.
Antiviral Res., 217, 2023
8CN1
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BU of 8cn1 by Molmil
hDLG1-PDZ1 in complex with a TAX1 peptide from HTLV-1
Descriptor: Disks large homolog 1, GLU-THR-GLU-VAL, SULFATE ION
Authors:Maseko, S, Sogues, A, Volkov, A, Remaut, H, Twizere, J.C.
Deposit date:2023-02-21
Release date:2023-08-02
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Identification of small molecule antivirals against HTLV-1 by targeting the hDLG1-Tax-1 protein-protein interaction.
Antiviral Res., 217, 2023
7MYX
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BU of 7myx by Molmil
Crystal structure of the PH domain (R86A) of Akt1
Descriptor: RAC-alpha serine/threonine-protein kinase
Authors:Bae, H, Park, E, Cole, P.A, Eck, M.J.
Deposit date:2021-05-22
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:PH domain-mediated autoinhibition and oncogenic activation of Akt.
Elife, 11, 2022
2RVH
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BU of 2rvh by Molmil
NMR structure of eIF1
Descriptor: Eukaryotic translation initiation factor eIF-1
Authors:Nagata, T, Obayashi, E, Asano, K.
Deposit date:2015-10-16
Release date:2016-10-26
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5
Cell Rep, 18, 2017
6MF8
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BU of 6mf8 by Molmil
TCR alpha transmembrane domain
Descriptor: T-cell receptor alpha chain C region
Authors:Brazin, K.N, Reinherz, E.L.
Deposit date:2018-09-10
Release date:2018-12-12
Last modified:2019-12-18
Method:SOLUTION NMR
Cite:The T Cell Antigen Receptor alpha Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations.
Immunity, 49, 2018
8DTU
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BU of 8dtu by Molmil
The complex of nanobody 5344N74D with BCL11A ZF6.
Descriptor: B-cell lymphoma/leukemia 11A, Nanobody 5344N74D, ZINC ION
Authors:Yin, M, Tenglin, K, Zhai, L, Dassama, L.M, Orkin, S.H.
Deposit date:2022-07-26
Release date:2023-02-01
Method:X-RAY DIFFRACTION (2.447 Å)
Cite:Evolution of nanobodies specific for BCL11A.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DTN
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BU of 8dtn by Molmil
The complex of nanobody 6101 with BCL11A ZF6
Descriptor: B-cell lymphoma/leukemia 11A, MAGNESIUM ION, Nanobody 6101, ...
Authors:Yin, M, Tenglin, K, Zhai, L, Dassama, L.M, Orkin, S.H.
Deposit date:2022-07-26
Release date:2023-02-01
Method:X-RAY DIFFRACTION (2.199 Å)
Cite:Evolution of nanobodies specific for BCL11A.
Proc.Natl.Acad.Sci.USA, 120, 2023
4TQC
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BU of 4tqc by Molmil
The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G
Descriptor: (2S)-3-(4-amino-3-nitrophenyl)-2-{2-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazinyl}propanoic acid, 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, Eukaryotic translation initiation factor 4E
Authors:Papadopoulos, E, Jenni, S, Wagner, G.
Deposit date:2014-06-10
Release date:2014-08-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G.
Proc.Natl.Acad.Sci.USA, 111, 2014
4TPW
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BU of 4tpw by Molmil
The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G
Descriptor: (2E)-2-{2-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene}-3-(2-nitrophenyl)propanoic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Papadopoulos, E, Jenni, S, Wagner, G.
Deposit date:2014-06-09
Release date:2014-08-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G.
Proc.Natl.Acad.Sci.USA, 111, 2014
4TQB
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BU of 4tqb by Molmil
The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G
Descriptor: (2E)-2-{2-[4-(4-bromophenyl)-1,3-thiazol-2-yl]hydrazinylidene}-3-(2-nitrophenyl)propanoic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Papadopoulos, E, Jenni, S, Wagner, G.
Deposit date:2014-06-10
Release date:2014-08-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G.
Proc.Natl.Acad.Sci.USA, 111, 2014
7JVX
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BU of 7jvx by Molmil
Crystal structure of PTEN (aa 7-353 followed by spacer TGGGSGGTGGGSGGTGGGCY ligated to peptide pSDpTpTDpSDPENEPFDED)
Descriptor: PHOSPHATE ION, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Authors:Dempsey, D, Phan, K, Cole, P, Gabelli, S.B.
Deposit date:2020-08-24
Release date:2021-08-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The structural basis of PTEN regulation by multi-site phosphorylation.
Nat.Struct.Mol.Biol., 28, 2021

 

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