4I5U
| Crystal structure of a fungal chimeric cellobiohydrolase Cel6A | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Chimeric cel6A, ... | Authors: | Arnold, F.H, Wu, I. | Deposit date: | 2012-11-29 | Release date: | 2013-04-03 | Last modified: | 2017-08-09 | Method: | X-RAY DIFFRACTION (1.22 Å) | Cite: | Engineered thermostable fungal Cel6A and Cel7A cellobiohydrolases hydrolyze cellulose efficiently at elevated temperatures. Biotechnol.Bioeng., 110, 2013
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4I5R
| Crystal structure of a fungal chimeric cellobiohydrolase Cel6A | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Chimeric cel6A, ... | Authors: | Arnold, F.H, Wu, I. | Deposit date: | 2012-11-28 | Release date: | 2013-04-03 | Last modified: | 2017-08-09 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Engineered thermostable fungal Cel6A and Cel7A cellobiohydrolases hydrolyze cellulose efficiently at elevated temperatures. Biotechnol.Bioeng., 110, 2013
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4WG2
| P411BM3-CIS T438S I263F regioselective C-H amination catalyst | Descriptor: | Bifunctional P-450/NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | Authors: | Hyster, T.K, Farwell, C.C, Buller, A.R, McIntosh, J.A, Arnold, F.H. | Deposit date: | 2014-09-17 | Release date: | 2014-11-05 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | Enzyme-controlled nitrogen-atom transfer enables regiodivergent C-h amination. J.Am.Chem.Soc., 136, 2014
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4TPO
| High-resolution structure of TxtE with bound tryptophan substrate | Descriptor: | GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, Putative P450-like protein, ... | Authors: | Cahn, J.K.B, Dodani, S.C, Brinkmann-Chen, S, Heinsich, T, McIntosh, J.A, Arnold, F.H. | Deposit date: | 2014-06-08 | Release date: | 2014-09-10 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.225 Å) | Cite: | Structural, Functional, and Spectroscopic Characterization of the Substrate Scope of the Novel Nitrating Cytochrome P450 TxtE. Chembiochem, 15, 2014
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4TPN
| High-resolution structure of TxtE in the absence of substrate | Descriptor: | GLYCEROL, LITHIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Cahn, J.K.B, Dodani, S.C, Brinkmann-Chen, S, Heinsich, T, McIntosh, J.A, Arnold, F.H. | Deposit date: | 2014-06-08 | Release date: | 2014-09-10 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.18 Å) | Cite: | Structural, Functional, and Spectroscopic Characterization of the Substrate Scope of the Novel Nitrating Cytochrome P450 TxtE. Chembiochem, 15, 2014
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4TSK
| Ketol-acid reductoisomerase from Alicyclobacillus acidocaldarius | Descriptor: | Ketol-acid reductoisomerase, L(+)-TARTARIC ACID, MAGNESIUM ION, ... | Authors: | Cahn, J.K.B, Brinkmann-Chen, S, Arnold, F.H. | Deposit date: | 2014-06-18 | Release date: | 2014-07-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Uncovering rare NADH-preferring ketol-acid reductoisomerases. Metab. Eng., 26C, 2014
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5D40
| Crystal structure of the 5-selective H176Y mutant of Cytochrome TxtE | Descriptor: | CHLORIDE ION, GLYCEROL, P450-like protein, ... | Authors: | Cahn, J.K.B, Dodani, S.C, Arnold, F.H. | Deposit date: | 2015-08-06 | Release date: | 2016-06-22 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Discovery of a regioselectivity switch in nitrating P450s guided by molecular dynamics simulations and Markov models. Nat.Chem., 8, 2016
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5DW0
| TrpB from Pyrococcus furiosus with L-serine bound as the external aldimine | Descriptor: | SODIUM ION, Tryptophan synthase beta chain 1, [3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE | Authors: | Buller, A.R, Arnold, F.H. | Deposit date: | 2015-09-22 | Release date: | 2015-11-11 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Directed evolution of the tryptophan synthase beta-subunit for stand-alone function recapitulates allosteric activation. Proc.Natl.Acad.Sci.USA, 112, 2015
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5DW3
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5E4R
| Crystal structure of domain-duplicated synthetic class II ketol-acid reductoisomerase 2Ia_KARI-DD | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Ketol-acid reductoisomerase, ... | Authors: | Cahn, J.K.B, Brinkmann-Chen, S, Buller, A.R, Arnold, F.H. | Deposit date: | 2015-10-07 | Release date: | 2015-12-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Artificial domain duplication replicates evolutionary history of ketol-acid reductoisomerases. Protein Sci., 25, 2016
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5DVZ
| Holo TrpB from Pyrococcus furiosus | Descriptor: | PHOSPHATE ION, SODIUM ION, Tryptophan synthase beta chain 1 | Authors: | Buller, A.R, Arnold, F.H. | Deposit date: | 2015-09-21 | Release date: | 2016-02-03 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Directed evolution of the tryptophan synthase beta-subunit for stand-alone function recapitulates allosteric activation. Proc.Natl.Acad.Sci.USA, 112, 2015
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5E0K
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8DSG
| P411-PFA carbene transferase | Descriptor: | 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cytochrome P450-BM3 variant P411-PFA, ... | Authors: | Maggiolo, A.O, Porter, N.J, Zhang, J, Arnold, F.H. | Deposit date: | 2022-07-22 | Release date: | 2023-03-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Chemodivergent C(sp3)-H and C(sp2)-H cyanomethylation using engineered carbene transferases Nat Catal, 6, 2023
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8EH0
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8EH1
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8EGY
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8EGZ
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5IXJ
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4XDZ
| Holo structure of ketol-acid reductoisomerase from Ignisphaera aggregans | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, Ketol-acid reductoisomerase, ... | Authors: | Cahn, J.K.B, Brinkmann-Chen, S, Arnold, F.H. | Deposit date: | 2014-12-20 | Release date: | 2015-04-22 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Cofactor specificity motifs and the induced fit mechanism in class I ketol-acid reductoisomerases. Biochem.J., 468, 2015
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4XDY
| Structure of NADH-preferring ketol-acid reductoisomerase from an uncultured archean | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLYCEROL, Ketol-acid reductoisomerase, ... | Authors: | Cahn, J.K.B, Brinkmann-Chen, S, Arnold, F.H. | Deposit date: | 2014-12-20 | Release date: | 2015-04-22 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.535 Å) | Cite: | Cofactor specificity motifs and the induced fit mechanism in class I ketol-acid reductoisomerases. Biochem.J., 468, 2015
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4XEH
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6WK3
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5T6M
| Structure of the tryptophan synthase b-subunit from Pyroccus furiosus with b-methyltryptophan non-covalently bound | Descriptor: | (betaS)-beta-methyl-L-tryptophan, PHOSPHATE ION, SODIUM ION, ... | Authors: | Buller, A.R, van Roye, P, Arnold, F.H. | Deposit date: | 2016-09-01 | Release date: | 2016-12-21 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Tryptophan Synthase Uses an Atypical Mechanism To Achieve Substrate Specificity. Biochemistry, 55, 2016
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4DU2
| cytochrome P450 BM3h-B7 MRI sensor bound to dopamine | Descriptor: | L-DOPAMINE, PROTOPORPHYRIN IX CONTAINING FE, cytochrome P450 BM3 variant B7 | Authors: | Brustad, E.M, Lelyveld, V.S, Snow, C.D, Crook, N, Martinez, F.M, Scholl, T.J, Jasanoff, A, Arnold, F.H. | Deposit date: | 2012-02-21 | Release date: | 2012-06-13 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure-guided directed evolution of highly selective p450-based magnetic resonance imaging sensors for dopamine and serotonin. J.Mol.Biol., 422, 2012
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4DTZ
| cytochrome P450 BM3h-8C8 MRI sensor bound to dopamine | Descriptor: | L-DOPAMINE, PROTOPORPHYRIN IX CONTAINING FE, cytochrome P450 BM3 variant 8C8 | Authors: | Brustad, E.M, Lelyveld, V.S, Snow, C.D, Crook, N, Martinez, F.M, Scholl, T.J, Jasanoff, A, Arnold, F.H. | Deposit date: | 2012-02-21 | Release date: | 2012-06-13 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structure-guided directed evolution of highly selective p450-based magnetic resonance imaging sensors for dopamine and serotonin. J.Mol.Biol., 422, 2012
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